Zusammenfassung
Das Kapitel gibt eine umfassende Darstellung der nichtneoplastischen und neoplastischen Erkrankungen der Hypophyse. Die Tumoren werden auf der Basis der WHO-Klassifikation vorgestellt und hinsichtlich ihrer Biologie und Morphologie charakterisiert. Dabei kommen auch die seltenen und ungewöhnlichen Tumoren zur Sprache. Eine umfangreiche Bebilderungen begleitet die morphologische Darstellung der Tumoren.
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Abbass SAA, Asa SL, Ezzat S (1997) Altered expression of fibroblast growth factor receptors in human pituitary adenomas. J Clin Endocrinol Metab 82:1160–1166
Abboud CF (2002) Anterior pituitary failure. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 349–404
Ahumada JG, del Castillo EB (1932) Sobre un caso de amenorrea y galactorrea. Bol Soc Obstet Gynecol 11:64–66
Argonz J, del Castillo EB (1953) A syndrome characterized by estrogen insufficiency and decreased urinary gonadotropin. J Clin Endocrinol Metab 13:79–87
Asa SL (1998) Tumors of the pituitary gland. Armed Forces Institute of Pathology, Washington D.C.
Asa SL (2011) Pituitary adenomas. In: Silverberg SG, Gardner WA, Sobin LH (Hrsg) Tumors of the pituitary gland. Armed Forces Institute of Pathology, Washington D.C., S 55–172
Asa SL (2011) The normal pituitary gland. In: Silverberg SG, Gardner WA, Sobin LH (Hrsg) Tumors of the pituitary gland. Armed Forces Institute of Pathology, Washington D.C., S 1–40
Asa SL (2011) Tumors of the hypothalamus and neurohypophysis. In: Silverberg SG, Gardner WA, Sobin LH (Hrsg) Tumors of the pituitary gland. Armed Forces Institute of Pathology, Washington D.C., S 181–206
Asa SL, Bamberger AM, Cao B, Wong M, Parker KL, Ezzat S (1996) The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph. J Clin Endocrinol Metab 81:2165–2170
Asa SL, Ezzat S (2002) The pathogenesis of pituitary tumours. Nature Reviews Cancer 2:836–849
Asa SL, Kovacs K, Bilbao JM (1983) The pars tuberalis of the human pituitary. A histologic, immunohistochemical, ultrastructural and immunoelectron microscopic analysis. Virchows Arch A Pathol Anat Histopath 399:49–59
Asa SL, Kovacs K, Stefaneanu L, Horvath E, Billestrup N, Gonzalez-Manchon C, Vale W (1992) Pituitary adenomas in mice transgenic for growth hormone – releasing hormone. Endocrinology 131:2083–2089
Asa SL, Kovacs K, Tindall GT, Barrow DL, Horvath E, Vecsei P (1984) Cushing’s disease associated with an intrasellar gangliocytoma producing corticotropin-releasing factor. Ann Intern Med 101:789–793
Asa SL, Puy LA, Lew AM, Sundmark VC, Elsholtz HP (1993) Cell type-specific expression of the pituitary transcription activator pit-1 in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab 77:1275–1280
Asa SL, Somers K, Ezzat S (1998) The MEN-1 gene is rarely down-regulated in pituitary adenomas. J Clin Endocrinol Metab 83:3210–3212
Atherton F, Newman CPS, Casemore DP (1995) An outbreak of waterborne cryptosporidiosis associated with a public water supply in the UK. Epidemiol Infect 115:123–131
Bamberger CM, Fehn M, Bamberger AM, Lüdecke DK, Beil FU, Saeger W, Schulte HM (1999) Reduced expression levels of the cell-cycle inhibitor p27(Kip1) in human pituitary adenomas. Eur J Endocrin 140:250–255
Bello MJ, de Campos JM, Kusak ME, Vaquero J, Sarasa JL, Rey JA (2001) Chromosomal abnormalities in pituitary adenomas. Cancer Genet Cytogenet 124:76–79
Bensing S, Fetissov SO, Mulder J, Perheentupa J, Gustafsson J, Husebye ES, Oscarson M, Ekwall O, Crock PA, Hoekfelt T, Hulting AL, Kaempe O (2007) Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1. Proc Natl Acad Sci USA 104:949–954
Bergeron C, Kovacs K (1978) Pituitary siderosis; a histologic, immunocytologic and ultrastructural study. Amer J Pathol 93:295–309
Bertagna X, Raux-Demay MC, Guilhaume B, Girard F, Luton JP (2002) Cushing’s disease. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 496–560
Bertherat J, Chanson P, Montminy M (1995) The cyclic adenosine 3’,5’-monophosphate-responsive factor CREB is consecutively activated in human somatotroph adenomas. Mol Endocrinol 9:777–783
Boikos S, Stratakis CA (2006) Pituitary pathology in patients with Carney complex: growth hormone producing hyperplasia or tumors and their association with other abnormalities. Pituitary 9:203–209
Brat DJ, Scheithauer BW, Staugaitis SM, Holtzman RNN, Morgello S, Burger PC (2000) Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Amer J Surg Pathol 24:362–368
Braunstein GD (2002) The hypothalamus. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 317–348
Brue T, Vallette S, Pellegrini-Bouiller I, Enjalbert A (1997) Les déficits anté-hypophysaires associés congénitaux. Une approche de l’ontogenèse hypophysaire. Ann Endocrinol (Paris) 58:436–450
Brzana JA, Yedinak CG, Delashaw JB, Gultelkin HS, Cook D, Fleseriu M (2012) Discordant growth hormone and IGF-1 levels post pituitary surgery in patients with acromegaly naive to medical therapy and radiation: what to follow, GH or IGF-1 values? Pituitary 15:562–570
Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnrubl F, Hahnen E, Kreutzer J, Fahlbusch R (2005) Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathologica 109:589–597
Buurman H, Saeger W (2006) Subclinical adenomas in postmortem pituitaries: classification and correlation to clinical data. Europ J Endocrin 154:753–758
Cai WY, Alexander JM, Hedley-Whyte ET, Scheithauer BW, Jameson JL, Zervas NT, Klibanski A (1994) Ras mutations in human prolactinomas and pituitary carcinomas. J Clin Endocrinol Metab 78:89–93
Cenacchi G, Giovenali P, Castrioto C, Giangaspero F (2001) Pituicytoma: Ultrastructural evidence of a possible origin from Folliculo-Stellate cells of the adenohypophysis. Ultrastruct Pathol 25:309–312
Chiari JBVL, Braun C, Späth J (1855) Klinik der Geburthilfe und Gynäkologie. Enke, Erlangen, S 371–372
Cohen-Gadol AA, Pichelmann MA, Link MJ, Scheithauer BW, Krecke KN, Young WF, Hardy J, Giannini C (2003) Granular cell tumor of the sellar and suprasellar region: Clinicopathologic study of 11 cases and literature review. Mayo Clin Proc 78:567–573
Coons SW, Estrada SI, Gamez R, White WL (2005) Cytokeratin CK 7 and CK 20 expression in pituitary adenomas. Endocr Pathol 16:201–210
Corbetta S, Ballare E, Mantovani G, Lania A, Losa M, di BAM, Spada A (2001) Somatostatin receptor subtype 2 and 5 in human GH- secreting pituitary adenomas: analysis of gene sequence and mRNA expression. Eur J Clin Invest 31:208–214
Covington MF, Chin SS, Osborn AG (2011) Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893. Am J Neuroradiol 32:2067–2072
Crock PA (1998) Cytosolic autoantigens in lymphocytic hypophysitis. J Clin Endocrinol Metabolism 83:609–618
Crooke AC (1935) A change in the basophil cells of the pituitary gland common to conditions which wxhibit the syndrome attributed to basophil adenoma. J Pathol Bacteriol 41:339–349
Crooke AC, Russell DS (1935) The pituitary gland in Addison’s disease. J Pathol Bacteriol 40:255–283
Deodhare SS, Bilbao JM, Kovacs K, Horvath E, Nomikos P, Buchfelder M, Reschke K, Lehnert H (1999) Xanthomatous hypophysitis: A novel entity of obscure etiology. Endocr Pathol 10:237–241
Dillard T, Yedinak CG, Alumkal J, Fleseriu M (2010) Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes. Pituitary 13:29–38
Ernestus R-I (2002) Operative Behandlung von Hypophysentumoren. In: Jockenhövel F (Hrsg) Erkrankungen von Hypophyse und Hypothalamus. Uni-Med, Berlin, S 196–211
Ezzat S (2001) The role of hormones, growth factors and their receptors in pituitary tumorigenesis. Brain Pathol 11:356–370
Fehn M, Bettendorf M, Lüdecke DK, Sommer C, Saeger W (1999) Lymphocytic hypophysitis masking a suprasellar germinoma in a 12 year old girl – a case report. Pituitary 1:303–307
Folkerth RD, Price DL, Schwartz M, Black PM, Degirolami U (1998) Xanthomatous hypophysitis. Am J Surg Pathol 22:736–741
Forbes AP, Hennemann PH, Griswald GC, Albright F (1954) Syndrome characterized by galactorrea, amenorrhea and low urinary FSH: comparison with acromegaly and normal lactation. J Clin Endocrinol Metab 14:265–271
Frommel R (1882) Über puerperale Atrophie des Uterus. Zsch Geburtsh Gynäkol 7:305–314
Gaffey TA, Scheithauer BW, Lloyd RV, Burger PC, Robbins P, Fereidooni F, Horvath E, Kovacs K, Kuroki T, Young WF, Sebo TJ, Riehle DL, Belzberg AJ (2002) Corticotroph carcinoma of the pituitary: a clinicopathological study. J Neurosurg 96:352–360
Gartman JJJr, Powers SK, Fortune M (1989) Pseudotumor of the sellar and parasellar areas. Neurosurgery 24:896–901
George DH, Scheithauer BW, Kovacs K, Horvath E, Young WF, Lloyd RV, Meyer FB (2003) Crooke’s cell adenoma of the pituitary – An aggressive variant of corticotroph adenoma. Amer J Surg Pathol 27:1330–1336
George DH, Scheithauer BW, Kovacs K, Horvath E, Young WF, Lloyd RV, Meyer FB (2003) Crooke’s cell adenoma of the pituitary – An aggressive variant of corticotroph adenoma. American Journal of Surgical Pathology 27:1330–1336
Gold E (1981) Epidemiology of pituitary adenomas. Epidemiol Rev 3:163–183
Greenman Y, Melmed S (2002) Thyrotropin-secreting pituitary tumors. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 561–574
Hardy J (1973) Transsphenoidal surgery of hypersecreting pituitary tumors. In: Kohler PO, Ross GT (Hrsg) Diagnosis and treatment of pituitary tumors. Excerpta Medica, Amsterdam, S 179–194
Heitz PU, Staub JJ (1981) Paraneoplastische endokrine Syndrome. In: Doerr W, Seifert G (Hrsg) Pathologie der endokrine Organe, Teil 2. Springer, Berlin, S 1205–1272
Hori M, Makita N, Andoh T, Takiyama H, Yajima Y, Sakatani T, Fukumoto S, Iiri T, Fujita T (2010) Long-term clinical course of IgG4-related systemic disease accompanied by hypophysitis. Endocrine J 57:485–492
Horvath E, Kovacs K (1991) The adenohypophysis. In: Kovacs KASL (Hrsg) Functional endocrine pathology. Blackwell Scientific, London, S 245–282
Horvath E, Kovacs K (2002) Folliculo-stellate cells of the human pituitary: A type of adult stem cell? Ultrastruct Pathol 26:219–228
Horvath E, Kovacs K, Smyth HS, Cusimano M, Singer W (2005) Silent adenoma subtype 3 of the pituitary - Immunohistochemical and ultrastructural classification: A review of 29 cases. Ultrastruct Pathol 29:511–524
Horvath E, Lloyd RV, Kovacs K (1990) Propylthiouracyl-induced hypothyroidism results in reversible transdifferentiation of somatotrophs into thyroidectomy cells. A morphologic study of the rat pituitary including immunoelectron microscopy. Lab Invest 63:511–520
Hui KS, Williams JC, Borit A, Rosenberg HS (1975) The endocrine glands in Pompe’s disease. Arch Pathol Lab Med 109:921–925
Husain N, Husain M, Rao P (2008) Pituitary tuberculosis mimicking idiopathic granulomatous hypophysitis. Pituitary 11:313–315
Inoue T, Matsushima T, Fukui M, Iwaki T, Takeshita I, Kuromatsu C (1988) Immunohistochemical study of intracranial cysts. Neurosurgery 23:576–581
Janzer RC, Burger PC, Giangaspero F, Paulus W, Warzok RW, Vogelgesang S, Feiden W, Shuangshoti S (2000) Tumours of the sellar region. In: Kleihues P, Cavenee WK (Hrsg) Pathology and genetics: Tumours of the nervous system. International Agency for Research and Cancer. IARC, Lyon, S 243–248
Jin L, Burguera B, Couce ME, Scheithauer BW, Lamsan J, Eberhardt NL, Kulig E, Lloyd RV (2001) Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab 84:2903–2911
Jin L, Tsumanuma I, Ruebel KH, Bayliss JM, Lloyd RV (2001) Analysis of homogeneous populations of anterior pituitary folliculostellate cells by laser capture microdissection and reverse transcription-polymerase chain reaction. Endocrinology 142:1703–1709
Jockenhövel F, Gerhards J, Weber MM (2002) Erkrankungen der Hypophyse. In: Jockenhövel F (Hrsg) Erkrankungen von Hypophyse und Hypothalamus. Uni-Med, Bremen, S 68–171
Kasper M, Stosiek P, van Muijen GN, Moll R (1989) Cell type heterogeneity of intermediate filament expression in epithelia of the human pituitary gland. Histochem 93:93–103
Katsuta T, Inoue T, Nakagaki H, Takeshita M, Morimoto K, Iwaki T (2003) Distinctions between pituicytoma and ordinary pilocytic astrocytoma – Case report. J Neurosurg 98:404–406
Kim JE, Kim JH, Kim OL, Paek SH, Kim DG, Chi JG, Jung HW (2004) Surgical treatment of symptomatic Rathke cleft cysts: clinical features and results with special attention to recurrence. J Neurosurg 100:33–40
Kim K, Arai K, Sanno N, Osamura RY, Teramoto A, Shibasaki T (2001) Ghrelin and growth hormone (GH) secretagogue receptor (GHSR) mRNA expression in human pituitary adenomas. Clin Endorin 54:759–768
Kim K, Sanno N, Arai K, Takano K, Yasufuku-Takano J, Teramoto A, Shibasaki T (2003) Ghrelin mRNA and GH secretagogue receptor mRNA in human GH-producing pituitary adenomas is affected by mutations in the alpha subunit of G protein. Clin Endorin 59:630–636
Kirsch M, Morz M, Pinzer T, Schackert HK, Schackert G (2009) Frequent Loss of the CDKN2C (p18(INK4c)) Gene Product in Pituitary Adenomas. Genes Chromosomes & Cancer 48:143–154
Klatt EC, Nichols L, Noguchi TT (1994) Evolving trends revealed by autopsies of patients with the acquired immunodeficiency syndrome. 565 autopsies in adults with the acquired immunodeficiency syndrome, Los Angeles,Calif, 1992- 1993. Arch Pathol Lab Med 118:884–890
Kovacs K (1972) Metastatic cancer of the pituitary gland. Oncology 27:533–542
Kovacs K, Giannini C, Scheithauer BW, Stefaneanu L, Lloyd RV, Horvath E (1997) Pituitary change in ataxia-teleangiectasia syndrome: an immunocytochemical, in situ hybridization, and DNA cytometric study of three cases. Endocr Pathol 8:195–203
Kovacs K, Horvath E (1986) Tumors of the pituitary gland. Armed Forces Institute of Pathology, Washington D.C.
Kovacs K, Horvath E, Thorner MO, Rogol AD (1984) Mammosomatotroph hyperplasia associated with acromegaly and hyperprolactinemia in a patient with the McCune-Albright syndrome; a histologic, imunocytologic and ultrastructural study of the surgically-removed adenohypophysis. Virchows Arch A Pathol Anat Histopath 403:77–86
Kraus EJ (1926) Die Hypophyse Drüsen mit innerer Sekretion. Springer, Berlin, S 810–950
Kreutzer J, Vance ML, Lopes MBS, Laws ER (2001) Surgical management of GH-secreting pituitary adenomas: An outcome study using modern remission criteria. J Clin Endocrinol Metab 86:4072–4077
Kurosaki M, Saeger W, Lüdecke DK (2001) Immunohistochemical localization of cytokeratins in craniopharyngioma. acta neurochir (Wien) 143:147–151
Kurosaki M, Watanabe T, Saeger W, Lüdecke DK (2002) Intrasellar gangliocytomas associated with acromegaly. Brain Tum Pathol 19:63–67
Kwon MJ, Suh YL (2011) Pituicytoma with unusual histological features. Pathol Inter 61:598–602
Landolt AM, Heitz PU (1986) Alpha-subunit-producing pituitary adenomas. Immunocytochemical and ultrastructural studies. Virchows Arch A Pathol Anat Histopath 409:417–431
Lederbogen S, Windeck R, Rauhut F, Benker G (1988) Das Syndrom der inappropriaten Sekretion von ADH (SIADH) bei Hypophysentumoren. Med Klin 83:307–308
Lee EB, Tihan T, Scheithauer BW, Zhang PJ, Gonatas NK (2009) Thyroid Transcription Factor 1 Expression in Sellar Tumors: A Histogenetic Marker? J Neuropath exper Neurol 68:482–488
Levy A, Lightman S (2003) Molecular defects in the pathogenesis of pituitary tumours. Frontiers in Neuroendocrinology 24:94–127
Liuzzi A, Tassi V, Pirro MT, Zingrillo M, Ghiggi MR, Chiodini I, Oppizzi G, Barberis M (1996) Nonfunctioning adenomas of the pituitary. Metab 45:80–82
Lloyd RV (1993) Surgical pathology of the pituitary gland. W.B.Saunders, Philadelphia
Lloyd RV, Douglas BR, Young WF Jr. (2002) Pituitary gland. In: de Lellis RA, LiVolsi VA (Hrsg) Endocrine diseases. Armed Forces Institute of Pathology, Washington D.C., S 1–44
Lloyd RV, Kovacs K, Young WF Jr., Farrell WE, Asa SL, Trouillas J, Kontogeorgos G, Sano T, Scheithauer BW, Horvath E, Watson RE Jr., Lindell EP, Barkan AL, Saeger W, Nosé V, Osamura RY, Ezzat S, Yamada S, Roncaroli F, Lopes MBS, Ruibal VS (2004) Tumours of the pituitary. In: DeLellis RA, Lloyd RV, Heitz PU (Hrsg) Pathology and Genetics. Tumours of Endocrine Tumours. International Agency for Research and Cancer (IARC), Lyon, S 9–48
Losa M, Saeger W, Mortini P, Pandolfi C, Terreni MR, Taccagni G, Giovanelli M (2000) Acromegaly associated with a granular cell tumor of the neurohypophysis: a clinical and histological study – Case report. J Neurosurg 93:121–126
Lupi I, Broman KW, Tzou SC, Gutenberg A, Martino E, Caturegli P (2008) Novel autoantigens in autoimmune hypophysitis. Clin Endorin 69:269–278
Ma WB, Ikeda H, Yoshimoto T (2002) Clinicopathologic study of 123 cases of prolactin- secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas. Cancer 95:258–266
Marin F, Stefaneanu L, Kovacs K (1991) Folliculostellate cells of the pituitary. Endocr Pathol 2:180–192
Matsuno A, Teramoto A, Takekoshi S, Sanno N, Osamura RY, Kirino T (1995) HGH, PRL, and ACTH gene expression in clinically nonfunctioning adenomas detected with nonisotopic in situ hybridization method. Endocr Pathol 6:13–20
McCabe CJ, Boelaert K, Tannahill LA, Heaney AP, Stratford AL, Khaira JS, Hussain S, Sheppard MC, Franklyn JA, Gittoes NJL (2002) Vascular endothelial growth factor, its receptor KDR/Flk- 1, and pituitary tumor transforming gene in pituitary tumors. J Clin Endocrinol Metab 87:4238–4244
McCormick WF, Halmi NS (1970) The hypophysis in patients with coma depasse („respirator brain“). Am J Clin Pathol 54:374–383
McKeever PE, Blaivas M, Sima AAF (1993) Neoplasms of the sellar region. In: Lloyd RV (Hrsg) Surgical pathology of the pituitary gland. W.B. Saunders, Philadelphia, S 141–210
McLendon R, Tien RD (1989) Tumors and tumor-like lesions of maldevelopmental origin. In: Russell DS, Rubinstein LJ (Hrsg) Pathology of tumours of the nervous system. Edward Arnold, London, S 295–370
Mete OASL (2013) Therapeutic implications of accurate classification of pituitary adenomas. Semin Diagn Pathol 30:158–164
Mete O, Lopes MB, Asa SL (2013) Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. Amer J Surg Pathol 37:1694–1699
Mikami S, Kameyama K, Takahashi S, Yoshida K, Kawase T, Sano T, Mukai M (2008) Combined gangliocytoma and prolactinoma of the pituitary gland. Endocr Pathol 19:117–121
Mindermann T, Wilson CB (1993) Thyrotropin-producing pituitary adenomas. J Neurosurg 79:521–527
Minematsu T, Suzuki M, Sanno N, Takekoshi S, Teramoto A, Osamura RY (2006) PTTG overexpression is correlated with angiogenesis in human pituitary adenomas. Endocr Pathol 17:143–153
Missale C, Spano P (1998) Nerve growth factor in pituitary development and pituitary tumors. Front Neuroendocrinol 19:128–150
Molitch ME (2002) Prolactin. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 119–171
Molitch ME (2002) Prolactinoma. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 455–495
Mudd PA, Hohensee S, Lillehei KO, Kingdom TT, Kleinschmidt-de Masters BK (2012) Ectopic pituitary adenoma of the clivus presenting with apoplexy: case report and review of the Literature. Clin Neuropath 31:24–30
Morris DG, Musat M, Czirjak S, Hanzely Z, Lillington DM, Korbonits M, Grossman AB (2005) Differential gene expression in pituitary adenomas by oligonucleotide array analysis. Eur J Endocrin 153:143–151
Murakami M, Nishioka H, Izawa H, Ikeda Y, Haraoka J (2008) Granulomatous hypophysistis associated with Rathke’s cleft cyst: A case report. Minimally Invasive Neurosurgery 51:169–172
Nagashima AC, Giacomini D, Castro CP, Pereda MP, Renner U, Stalla GK, Arzt E (2003) Transcriptional regulation of interleukin-6 in pituitary folliculo-stellate TtT/GF cells. Mol Cell Endocrinol 201:47–56
Nelson DH, Meakin JW, Dealy JW, Matson DD, Emerson K, Thorn GW (1958) ACTH producing tumor of the pituitary gland. New Engl J Med 259:161–164
Nowak M, Rebuffat P, Andreis PG, Nowak KW, Nussdorfer GG, Malendowicz LK (1997) Dose-dependent biphasic efect of glucagon on aldosterone secretion in rats: in vitro and in vivo studies. Med Sci Res 24:795–796
Nussbaum CE, Okawara SH, Jacobs LS (1991) Lymphocytic hypophysitis with involvement of the cavernous sinus and hypothalamus. Neurosurgery 28:440–444
Ogawa A, Sugihara S, Nakanishi Y, Suzuki S, Sasaki A, Hirato J, Nakazato Y (1990) Intermediate filament expression in non-neoplastic pituitary cells. Virchows Arch B Cell Pathol 58:331–340
Oliveira MC, Marroni CP, Pizarro CB, Pereira-Lima JF, Barbosa-Coutinho LM, Ferreira NP (2002) Expression of p53 protein in pituitary adenomas. Braz J Med Biol Res 35:561–565
Onofri C, Losa M, Uhl E, Stalla GK, Renner U (2008) Immunohistochemical analysis of VEGF-C/VEGFR-3 system and lymphatic vessel extent in normal and adenomatous human pituitary tissues. Exper clin Endocr Metab 116:152–157
Paramo C, de la Fuente J, Nodar A, Miramontes S, Quintela JL, Garcia-Mayor RV (2002) Intrasellar tuberculoma – A difficult diagnosis. Infection 30:35–37
Pei L, Melmed S, Scheithauer BW, Kovacs K, Benedict WF, Prager D (1995) Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB 1. Cancer Res 55:1613–1616
Petersenn S, Heyens M, Lüdecke DK, Beil FU, Schulte HM (2000) Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas. Clin Endorin 52:35–42
Pistol-Tanase C, Ogrezeanu I, Badiu C (2011) Signal transduction. In: Pistol-Tanase C, Ogrezeanu I, Badiu C (Hrsg) Molecular pathology of pituitary adenomas. Elsevier, Amsterdam, S 53–82
Puchner MJA, Lüdecke DK, Saeger W (1994) The anterior pituitary lobe in patients with cystic craniopharyngiomas: three cases of associated lymphocytic hypophysitis. acta neurochir (Wien) 126:38–43
Puchner MJA, Lüdecke DK, Valdueza JM, Saeger W, Willig RP, Stalla GK, Odink RJ, Kovacs K, Oyesiku NM, Tindall GT (1993) Cushing’s disease in a child caused by a corticotropin- releasing hormone secreting intrasellar gangliocytoma associated with an adrenocorticotropic hormone secreting pituitary adenoma. Neurosurgery 33:920–925
Püschel W, Wernert N, Hinkeldey KKM, Brittner-Flemmer V, Remberger K (1992) Granulomatöse Hypophysitis. Bericht über drei Fälle und Literaturübersicht. Pathologe 13:100–103
Puy LA, Ciocca DR (1986) Human pharyngeal and sellar pituitary glands: differences and similarities revealed by an immunocytochemical study. J Endocrinol 108:231–238
Ravid M, Gafni J, Sohar E, Missmahl HP (1967) Incidence and origin of non-systemic microdeposits of amyloid. J clin Pathol 20:15–20
Reuss W, Saeger W, Lüdecke DK (1991) Electron microscopical morphometry of well-differentiated and undifferentiated ACTH secreting adenomas in Cushing’s disease and Nelson’s syndrome. Virchows Archiv 419:395–401
Reuss WA, Saeger W, Lüdecke DK (1991) Electron microscopical morphometry of well-differentiated and undifferentiated ACTH secreting adenomas in Cushing’s disease and Nelson’s syndrome. Virchows Arch A Pathol Anat Histopath 419:395–401
Rienstein S, Adams EF, Pilzer D, Goldring AA, Goldman B, Friedman E (2003) Comparative genomic hybridization analysis of craniopharyngiomas. J Neurosurg 98:162–164
Riss D, Jin L, Qian X, Bayliss J, Scheithauer BW, Young WF, Vidal S, Kovacs K, Raz A, Lloyd RV (2003) Differential expression of galectin-3 in pituitary tumors. Cancer Res 63:2251–2255
Röcken C, Eick B, Saeger W (1996) Senile amyloidoses of the pituitary and adrenal glands – Morphological and statistical investigations. Virchows Archiv 429:293–299
Roelfsema F, Biermasz NR, Pereira AM (2012) Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis. Pituitary 15:71–83
Romeis B (1940) Hypophyse. Springer, Berlin
Roncaroli F, Scheithauer BW (2007) Papillary tumor of the pineal region and spindle cell oncocytoma of the pituitary: New tumor entities in the 2007 WHO classification. Brain Pathology 17:314–318
Ruebel KH, Jin L, Zhang SY, Scheithauer BW, Lloyd RV (2001) Inactivation of the p16 gene in human pituitary nonfunctioning tumors by hypermethylation is more common in null cell adenomas. Endocr Pathol 12:281–289
Saeger W (1981) Hypophyse. In: Doerr W, Seifert G (Hrsg) Pathologie der endokrinen Organe, Teil 2. Springer, Berlin, S 1–226
Saeger W (1995) Latent hyperplasias and adenomas in post-mortem pituitaries. Endocrine Pathology 6:379–380
Saeger W (2000) Commentary: Expression of growth factors in normal and neoplatic pituitary tissues. Endocr Pathol 11:295–300
Saeger W (2002) Tumor-like lesions of the pituitary and sellar region. Endocrinologist 12:300–314
Saeger W (2003) Hypophysentumoren. Pathologe 24:255–264
Saeger W (2003) Raumfordernde Prozesse der Sellaregion unter besonderer Berücksichtigung Tumor-ähnlicher Läsionen. Pathologe 24:247–254
Harrison MJ, Morgello S, Post KD (1994) Epithelial cystic lesions of the sellar and parasellar region: A continuum of ectodermal derivates? J Neurosurg 80:1018–1025
Saeger W (2010) Bericht über das Hypophysentumorregister im Jahre 2009 der Arbeitsgemeinschaft Hypophyse und Hypophysentumore der DGE. Endokrinol Informat 34:3,59–67
Saeger W, Geisler F, Lüdecke DK (1988) Pituitary pathology in Cushing’s disease. Pathol Res Pract 183:592–595
Saeger W, Hanke D (1978) Nekrosen der Hypophyse und ihre Beziehung zum Schock. Verh Dtsch Ges Path 62:301–306
Saeger W, Hofmann BM, Buslei R, Buchfelder M (2007) Silent ACTH cell adenoma in coincidence with granulomatous hypophysitis - a case report. Pathol Res Pract 203:221–225
Saeger W, Lübke D (1996) Pituitary carcinoma: a review. Endocr Pathol 7:21–35
Saeger W, Lüdecke DK (1982) Pituitary adenomas with hyperfunction of TSH. Frequency, histological classification, immunocytochemistry and ultrastructure. Virchows Archiv 394:255–267
Saeger W, Lüdecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S (2006) Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol 156:205–217
Saeger W, Riedel M, Schröder H (1985) Metastasen in der Hypophyse und der Sella. Pathologe 6:308–312
Saeger W, Riesner K, Lücking T (1982) Hereditärer selektiver Hypopituitarismus. Immunhistologische Untersuchungen an zwei Fällen mit STH-Zell- bzw. ACTH- Zellhypoplasie. Verh Dtsch Ges Path 66:419–422
Saeger W, Schmidt W (1994) Classification and immunohistology of clinically silent adenomas in postmortem pituitaries. In: Levy E (Hrsg) Advances in Pathology (anatomic and clinical), Bd. 2. Pergamonn Press, Oxford, S 343–347
Saeger W, Schröder H (1985) ACTH-Zellhyperplasien der Adeno- und der Neurohypophyse und ihre Beziehungen zur arteriellen Hypertonie. Pathologe 6:141–148
Saeger W, Warner R, Missmahl HP (1983) Amyloidosen der Hypophyse im Sektionsgut. Häufigkeit, Verteilung und Korrelationen zum Alter und zu Grundkrankheiten. Pathologe 4:177–182
Saeger W, Wilczak P, Lüdecke DK, Buchfelder M, Fahlbusch R (2003) Hormone markers in pituitary adenomas: Changes within last decade resulting from improved method. Endocr Pathol 14:49–54
Salehi F, Kovacs K, Scheithauer BW, Pfeifer EA, Cusimano M (2007) Histologic study of the human pituitary gland in acute traumatic brain injury. Brain Injury 21:651–656
Sandte S, Saeger W, Hanke D (2000) Hypophysennekrosen: abnehmende Inzidenz durch moderne Intensivtherapie? Pathologe 21:292–295
Sano T, Kovacs K, Scheithauer BW, Young WF Jr. (1993) Aging and the human pituitary gland. Mayo Clin Proc 68:971–977
Sano T, Mader R, Asa SL, Qian ZR, Hino A, Yamada S (2003) „Honeycomb Golgi“ in pituitary adenomas: Not a marker of gonadotroph adenomas. Endocr Pathol 14:363–368
Sano T, Yang P (1998) Ectopic hormone production. In: Kovacs KASL (Hrsg) Functional endocrine pathology. Blackwell Science, London, S 984–996
Sarapura VD, Samuels MH, Ridgway EC (2002) Thyroid-stimulating hormone. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 172–215
Sautner D, Saeger W (1991) Invasiveness of pituitary adenomas. Pathol Res Pract 187:632–636
Sautner D, Saeger W, Lüdecke DK, Jansen V, Puchner MJA (1995) Hypophysitis in surgical and autoptical specimens. Acta Neuropath (Wien) 90:637–644
Scheithauer BW (1985) Pathology of the pituitary and sellar region: exclusive of pituitary adenomas. In: Sommers CJ, Rosen PP (Hrsg) Pathology Annual. Appleton-Century-Crofts, Norwalk, S 67–155
Scheithauer BW (1989) The pituitary and sellar region. In: Sternberg SS (Hrsg) Diagnostic surgical pathology. Raven Press, New York, S 371–393
Scheithauer BW (1991) The hypothalamus and neurohypophysis. In: Kovacs K, Asa SL (Hrsg) Functional Endocrine Pathology. Blackwell Scientific, London, S 170–245
Scheithauer BW (1998) The hypothalamus and neurohypophysis. In: Kovacs K, Asa SL (Hrsg) Functional Endocrine Pathology. Blackwell Scientific, London, S 171–246
Scheithauer BW, Horvath E, Kovacs K (1992) Ultrastructure of the neurohypophysis. Microsc Res Techn 20:177–186
Scheithauer BW, Horvath E, Lloyd RV, Kovacs K (2001) Pathology of pituitary adenomas and pituitary hyperplasia. In: Thapar K, Kovacs K, Scheithauer BW, Lloyd RV (Hrsg) Diagnosis and management pituitary tumors. Humana Press, Totowa, NJ, S 91–154
Scheithauer BW, Jaap AJ, Horvath E, Kovacs K, Lloyd RV, Meyer FB, Laws ER, Young WF (2000) Clinically silent corticotroph tumors of the pituitary gland. Neurosurgery 47:723–729
Scheithauer BW, Kovacs K, Randall RV (1983) The pituitary gland in untreated Addison’s disease. A histologic and immunocytologic study of 18 adenohypophyses. Arch Pathol Lab Med 107:484–487
Scheithauer BW, Kovacs K, Randall RV, Horvath E, Laws ER Jr. (1986) Pathology of excessive production of growth hormone. Clin Endocrinol Metab 15:655–681
Scheithauer BW, Kovacs K, Randall RV, Ryan N (1985) Pituitary gland in hypothyroidism. Histologic and immunocytologic study. Arch Pathol Lab Med 109:499–504
Scheithauer BW, Swearingen B, Whyte ETH, Auluck PK, Stemmer-Rachamimov AO (2009) Ependymoma of the sella turcica: a variant of pituicytoma. Hum Pathol 40:435–440
Schochet SS, McCormick WF, Halmi NS (1974) Pituitary gland in patients with Hurler syndrome; light and electron microscopic study. Arch Path 97:96–99
Schreiber S, Saeger W, Lüdecke DK (1999) Proliferation markers in different types of clinically non-secreting pituitary adenomas. Pituitary 1:213–220
Schwartz WB, Bennett W, Curelop S, Bartter FC (1957) A syndrome of renal sodium loss and hyponatriemia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med 23:529–542
Schwartz WB, Tassel D, Bartter FC (1960) Further observations on hyponatriemia and renal sodium loss probably resulting from inappropriate secretion of antidiuretic hormone. N Engl J Med 262:743–748
Seemann N, Kuhn D, Wrocklage C, Keyvani K, Hackl W, Buchfelder M, Fahlbusch R, Paulus W (2001) CDKN2A/p16 inactivation is related to pituitary adenoma type and size. J Pathol 193:491–497
Sheehan HL (1937) Post-partum necrosis of the anterior pituitary. J Pathol Bacteriol 45:189–214
Sheehan HL, Davis JC (1968) Pituitary necrosis. Brit Med Bull 24:59–70
Shimatsu A, Oki Y, Fujisawa I, Sano T (2009) Pituitary and Stalk Lesions (Infundibulo-hypophysitis) Associated with Immunoglobulin G4-related Systemic Disease: an Emerging Clinical Entity. Endocr J 56:1033–1041
Shimon I, Melmed S (2001) Pathogenesis and molecular biology of pituitary tumors. In: Thapar K, Kovacs K, Scheithauer BW, Lloyd RV (Hrsg) Diagnosis and management pituitary tumors. Humana Press, Totowa, NJ, S 71–80
Simmonds M (1914) Über Hypophysisschwund mit tödlichem Ausgang. Dtsch Med Wochenschr 40:322–323
Snyder PJ (2002) Gonadotroph adenomas. In: Melmed S (Hrsg) The pituitary. Blackwell Science, London, S 575–591
Solcia E, Klöppel G, Sobin LH, Capella C, de Lellis RA, Heitz PU, Horvath E, Kovacs K, Lack EE, Lloyd RJ, Rosai J, Scheithauer BW (2000) Histological typing of endocrine tumours. Springer, Berlin
Spada A, Vallar L, Faglia G (1993) G-proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations. Front Neuroendocrinol 14:214–232
Stefaneanu L, Kovacs K, Horvath E, Scheithauer BW (2000) The adenohypophysis. In: Stefaneanu L, Sasano H, Kovacs K (Hrsg) Molecular and cellular endocrine pathology. Arnold, London, S 75–118
Stefaneanu L, Ryan N, Kovacs K (1988) Immunocytochemical localization of synaptophysin in human hypophyses and pituitary adenomas. Arch Pathol Lab Med 112:801–804
Takao T, Nanamiya W, Matsumoto R, Asaba K, Okabayashi T, Hashimoto K (2001) Antipituitary antibodies in patients with lymphocytic hypophysitis. Horm Res 55:288–292
Takei Y, Seyama S, Pearl GS, Tindall GT (1980) Ultrastructural study of the human neurohypophysis. II. Cellular elements of parenchyma, the pituicytes. Cell Tissue Res 205:273–287
Tallen G, Fehr S, Saeger W, Uhlig H, Lüdecke DK (1993) Detection of growth hormone, prolactin and human b-chorionic gonadotropin mRNA in growth hormone-secreting pituitary adenomas by in situ-hybridization using a non-isotopic detection method. Acta endocr (Kbh ) 128:411–417
Tanaka S, Tatsumi K, Kimura M, Takano T, Murakami Y, Takao T, Hashimoto K, Kato Y, Amino N (2002) Detection of autoantibodies against the pituitary-specific proteins in patients with lymphocytic hypophysitis. Eur J Endocrin 147:767–775
Terzolo M, Osella G, Ali A, Borretta G, Magro GP, Termine A, Paccotti P, Angeli A (1996) Different patterns of steroid secretion in patients with adrenal incidentaloma. J Clin Endocrinol Metab 81:740–744
Thapar K, Kovacs K (1998) Neoplasms of the sellar region. In: Bigner DD, McLendon RE, Bruner JM, Tamariz AS (Hrsg) Part II Pathologic Anatomy. Russell and Rubinstein’s pathology of tumors of the nervous system, Bd. 2. Arnold, London, S 561–680
Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin M, Johanson A, Vale W, Horvath E, Kovacs K (1982) Somatotroph hyperplasia: successfull treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone- releasing factor. J Clin Invest 70:965–977
Tomita T, Gates E (1999) Pituitary adenomas and granular cell tumors – Incidence, cell type, and location of tumor in 100 pituitary glands at autopsy. Am J Clin Pathol 111:817–825
Tönnis W (1962) Kraniopharyngiome. In: Olivecrona H, Tönnis W (Hrsg) Klinik und Behandlung der raumbeengenden intrakraniellen Prozesse. Springer, Berlin, S 186–196
Tziortzioti V, Ruebel KH, Kuroki T, Jin L, Scheithauer BW, Lloyd RV (2001) Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues. Endocr Pathol 12:125–136
Uhlig H, Saeger W, Fehr S, Lüdecke DK (1991) Detection of growth hormone, prolactin and human b-chorionic ganadotropin messenger RNA in growth-hormone-secreting pituitary adenomas by in situ hybridization. Virchows Archiv 418:539–546
Vajtai I, Beck J, Kappeler A, Hewer E (2011) Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells. Acta Neuropathologica 122:253–258
Voit D, Saeger W, Lüdecke DK (1999) Folliculo-stellate cells in pituitary adenomas of patients with acromegaly. Pathol Res Pract 195:143–147
Walker JD, Grossman A, Anderson JV, Ur E, Trainer PJ, Benn J, Lowy C, Sonksen PH, Plowman PN, Lowe DG, Doniach I, Wass JAH, Besser GM (1993) Malignant prolactinoma with extracranial metastases – A report of three cases. Clin Endorin 4:411–419
Woloschak M, Yu AQ, Post KD (1997) Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol Carcinogen 19:221–224
Wong S, Lam WY, Wong WK, Lee KC (2007) Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease. Hum Pathol 38:1720–1723
Yasuo S, Koff HW (2011) The hypophysial pars tuberalis transduces photoperiodic signals via multiple pathways and messenger molecules. General and Comparative Endocrinology 172:15–22
Young WF, Jr., Scheithauer BW, Gharib H, Laws ER Jr, Carpenter PC (1988) Cushing’s syndrome due to primary multinodular corticotrope hyperplasia. Mayo Clin Proc 63:256–262
Zada G, Woodmansee WW, Ramkissoon S, Amadio J, Nose V, Laws ER (2011) Atypical pituitary adenomas: incidence, clinical characteristics, and implications Clinical article. J Neurosurg 114:336–344
Zhang X, Sun HP, Danila DC, Johnson SR, Zhou YL, Swearingen B, Klibanski A (2002) Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: Implications for tumorigenesis. J Clin Endocrinol Metab 87:1262–1267
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Saeger, W. (2016). Hypophyse. In: Amann, K., Kain, R., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04566-0_18
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