Zusammenfassung
Das Kapitel behandelt die wesentlichen Aspekte der nichtneoplastischen Erkrankungen der ableitenden Harnwege. Ein kurzer Abriss über anatomische Besonderheiten und Grundlagen für das Verständnis dieser Erkrankungen wird vorangestellt. Es folgen als Schwerpunkte die Missbildungen und die entzündlichen Erkrankungen. Für jede Erkrankung werden neben den allgemeinen Aspekten die makroskopischen und mikroskopischen Besonderheiten aufgeführt. Tabellen und ausgewähltes Bildmaterial erleichtern das Verständnis und erlauben eine Systematisierung der nichtneoplastischen Erkrankungen.
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Literatur
Agliano AM, Gazzaniga P, Cervigni M, Gradilone A, Napolitano M, Pastore LI, Manzari V, Frati L, Vecchione A (1994) Detection of human papillomavirus type 16 DNA sequences in paraffin-embedded tissues from the female urinary tract. Urol Int 52:208–212
Ahlstrand C, Tiselius HG (1990) Recurrences during a 10-year follow-up after first renal stone episode. Urol Res 18:397–399
Hazmi AH, Dreux S, Delezoide AL, Dommergues M, Lortat-Jacob S, Oury JF, El Ghoneimi A, Muller F (2012) Outcome of prenatally detected bilateral higher urinary tract obstruction or megacystis: sex-related study on a series of 709 cases. Prenat Diagn 32:649–654
Al Kadhi S, Venkiteswaran KP, Al Ansari A, Shamsudini A, Al Bozom I, Kiliyanni AS (2007) Primary vesical actinomycosis: a case report and literature review. Int J Urol 14:969–971
Alexander RE, Kum JB, Idrees M (2012) Bladder diverticulum: clinicopathologic spectrum in pediatric patients. Pediatr Dev Pathol 15:281–285
Alonso A, Ikinger U, Kartenbeck J (2009) Staining patterns of keratins in the human urinary tract. Histol Histopathol 24:1425–1437
Aydin A, Ucak R, Karakok M, Guldur ME, Kocer NE (2002) Vascular plexus is a differentation criterion for muscularis mucosa from muscularis propria in small biopsies and transurethral resection materials of urinary bladder? Int Urol Nephrol 34:315–319
Balaji KC, Menon M (1997) Mechanism of stone formation. Urol Clin North Am 24:1–11
Barber BR, Weber MA, Bockenhauer D, Hiorns MP, McHugh K (2011) Postmortem MRI of bladder agenesis. Pediatr Radiol 41:110–112
Bartoletti R, Cai T, Mondaini N, Melone F, Travaglini F, Carini M, Rizzo M (2007) Epidemiology and risk factors in urolithiasis. Urol Int 79(Suppl 1):3–7
Bates AW, Fegan AW, Baithun SI (1998) Xanthogranulomatous cystitis associated with malignant neoplasms of the bladder. Histopathology 33:212–215
Berney DM, Thompson I, Sheaff M, Baithun SI (1996) Alkaline encrusted cystitis associated with malakoplakia. Histopathology 28:253–256
Bovio IM, Al Quran SZ, Rosser CJ, Algood CB, Drew PA, Allan RW (2010) Smoothelin immunohistochemistry is a useful adjunct for assessing muscularis propria invasion in bladder carcinoma. Histopathology 56:951–956
Brinkmann OA, Hertle L (2000) Pathogenese der interstitiellen Zystitis – viele Hypothesen, aber Entstehung weiter unklar. Urologe A 39:520–526
Bullock PS, Thoni DE, Murphy WM (1987) The significance of colonic mucosa (intestinal metaplasia) involving the urinary tract. Cancer 59:2086–2090
Buse S, Lynch TH, Martinez-Pineiro L, Plas E, Serafetinides E, Turkeri L, Santucci RA, Sauerland S, Hohenfellner M (2005) Verletzungen der ableitenden Harnwege bei polytraumatisierten Patienten. Unfallchirurg 108:821–828
Caso J, Qin D, Sexton WJ (2010) Eosinophilic cystitis following immediate post-resection intravesical instillation of mitomycin-C. Can J Urol 17:5223–5225
Cheng L, Lopez-Beltran A, Bostwick DG (2012) Inflammatory and infectious conditions. In: Bladder pathology. Wiley-Blackwell, Hoboken, NJ, S 17–44
Cheng L, Lopez-Beltran A, Bostwick DG (2012) Normal anatomy and histology. In: Bladder pathology. Wiley-Blackwell, Hoboken, NJ, S 1–16
Cheng L, Lopez-Beltran A, Bostwick DG (2012) Treatment effects. In: Bladder pathology. Wiley-Blackwell, Hoboken, NJ, S 507–523
Cheng L, Lopez-Beltran A, Bostwick DG (2012) Urothelial metaplasia and hyperplasia. In: Bladder pathology. Wiley-Blackwell, Hoboken, NJ, S 45–70
Choe JM, Kirkemo AK, Sirls LT (1995) Intravesical thiotepa-induced eosinophilic cystitis. Urology 46:729–731
Chu PG, Weiss LM (2002) Keratin expression in human tissues and neoplasms. Histopathology 40:403–439
Coker AM, Allshouse MJ, Koyle MA (2008) Complete duplication of bladder and urethra in a sagittal plane in a male infant: case report and literature review. J Pediatr Urol 4:255–259
Corica FA, Husmann DA, Churchill BM, Young RH, Pacelli A, Lopez-Beltran A, Bostwick DG (1997) Intestinal metaplasia is not a strong risk factor for bladder cancer: study of 53 cases with long-term follow-up. Urology 50:427–431
DeFoor W, Minevich E, Sheldon C (2002) Unusual bladder masses in children. Urology 60:911
DeGraff DJ, Clark PE, Cates JM, Yamashita H, Robinson VL, Yu X, Smolkin ME, Chang SS, Cookson MS, Herrick MK, Shariat SF, Steinberg GD, Frierson HF, Wu XR, Theodorescu D, Matusik RJ (2012) Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation. PLoS One 7:e36669
Delnay KM, Stonehill WH, Goldman H, Jukkola AF, Dmochowski RR (1999) Bladder histological changes associated with chronic indwelling urinary catheter. J Urol 161:1106–1108
Domingue GJ, Ghoniem GM, Bost KL, Fermin C, Human LG (1995) Dormant microbes in interstitial cystitis. J Urol 153:1321–1326
Ekici S, Dogan EI, Ruacan S, Midi A (2010) Xanthogranulomatous cystitis: a challenging imitator of bladder cancer. ScientificWorldJournal 10:1169–1173
Elbadawi A (1997) Interstitial cystitis: a critique of current concepts with a new proposal for pathologic diagnosis and pathogenesis. Urology 49:14–40
Fajardo LF, Berthrong M (1978) Radiation injury in surgical pathology. Part I. Am J Surg Pathol 2:159–199
Feki W, Ghozzi S, Khiari R, Ghorbel J, Elarbi H, Khouni H, Ben Rais N (2008) Multiple unusual locations of hydatid cysts including bladder, psoas muscle and liver. Parasitol Int 57:83–86
Fernandes ET, Manivel JC, Reddy PK, Ercole CJ (1996) Cyclophosphamide associated bladder cancer – a highly aggressive disease: analysis of 12 cases. J Urol 156:1931–1933
Fetissof F, Dubois MP, Arbeille-Brassart B, Lanson Y, Boivin F, Jobard P (1983) Endocrine cells in the prostate gland, urothelium and Brenner tumors. Immunohistological and ultrastructural studies. Virchows Arch B Cell Pathol Incl Mol Pathol 42:53–64
Figueiredo AA, Lucon AM (2008) Urogenital tuberculosis: update and review of 8961 cases from the world literature. Rev Urol 10:207–217
Figueiredo AA, Lucon AM, Junior RF, Srougi M (2008) Epidemiology of urogenital tuberculosis worldwide. Int J Urol 15:827–832
Foxman B (2002) Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med 113(Suppl 1A):5S–13S
Francis RS, Shackelford GD (1974) Cyclophosphamide cystitis with bladder wall calcification. J Can Assoc Radiol 25:324–326
Gaisa NT, Braunschweig T, Reimer N, Bornemann J, Eltze E, Siegert S, Toma M, Villa L, Hartmann A, Knuechel R (2011) Different immunohistochemical and ultrastructural phenotypes of squamous differentiation in bladder cancer. Virchows Arch 458:301–312
Galli SJ (1993) New concepts about the mast cell. N Engl J Med 328:257–265
Gillenwater JY, Wein AJ (1988) Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on Interstitial Cystitis, National Institutes of Health, Bethesda, Maryland, August 28–29, 1987. J Urol 140:203–206
Hanash KA, Pool TL (1970) Interstitial and hemorrhagic cystitis: viral, bacterial and fungal studies. J Urol 104:705–706
Hang L, Wullt B, Shen Z, Karpman D, Svanborg C (1998) Cytokine repertoire of epithelial cells lining the human urinary tract. J Urol 159:2185–2192
Hanno PM, Landis JR, Matthews-Cook Y, Kusek J, Nyberg L, Jr. (1999) The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis Database study. J Urol 161:553–557
Harik LR, O’Toole KM (2012) Nonneoplastic lesions of the prostate and bladder. Arch Pathol Lab Med 136:721–734
Hayashi N, Wada T, Kiyota H, Ueda M, Oishi Y (2003) Xanthogranulomatous cystitis. Int J Urol 10:498–500
Hellstrom HR, Davis BK, Shonnard JW (1979) Eosinophilic cystitis. A study of 16 cases. Am J Clin Pathol 72:777–784
Hendricksen K, Witjes JA (2007) Current strategies for first and second line intravesical therapy for nonmuscle invasive bladder cancer. Curr Opin Urol 17:352–357
Hesse A, Brandle E, Wilbert D, Kohrmann KU, Alken P (2003) Study on the prevalence and incidence of urolithiasis in Germany comparing the years 1979 vs. 2000. Eur Urol 44:709–713
Heyns CF, van der MA (2008) Bladder cancer in Africa. Can J Urol 15:3899–3908
Hietala SO, Winblad B, Hassler O (1975) Vascular and morphological changes in the urinary bladder wall after irradiation. Int Urol Nephrol 7:119–129
Hill GS (1989) Uropathology. Churchill Livingstone, New York
Hinev A, Anakievski D, Krasnaliev I (2010) Gangrenous cystitis: report of a case and review of the literature. Urol Int 85:479–481
Hofland CA, Eron LJ, Washecka RM (2004) Hemorrhagic adenovirus cystitis after renal transplantation. Transplant Proc 36:3025–3027
Hohenfellner M, Nunes L, Schmidt RA, Lampel A, Thuroff JW, Tanagho EA (1992) Interstitial cystitis: increased sympathetic innervation and related neuropeptide synthesis. J Urol 147:587–591
Hunner GL (1915) A rare type of bladder ulcer in women: report of cases. Boston Med Surg J 172:660–664
Ito N, Hirose M, Shirai T, Tsuda H, Nakanishi K, Fukushima S (1981) Lesions of the urinary bladder epithelium in 125 autopsy cases. Acta Pathol Jpn 31:545–557
Jankovic VL, Katic V, Hattori T, Kushima R, Marjanovic G, Stefanovic V (2007) Differences in the expression of mucins in various forms of cystitis glandularis. Pathol Res Pract 203:653–658
Keay SK, Warren JW (2002) Is interstitial cystitis an infectious disease? Int J Antimicrob Agents 19:480–483
Khalaf I, Shokeir A, Shalaby M (2012) Urologic complications of genitourinary schistosomiasis. World J Urol 30:31–38
Kliesch S (2000) Epidemiologie der interstitiellen Zystitis. Urologe A 39:527–529
Knight A, Askling J, Granath F, Sparen P, Ekbom A (2004) Urinary bladder cancer in Wegener’s granulomatosis: risks and relation to cyclophosphamide. Ann Rheum Dis 63:1307–1311
Larsen MS, Mortensen S, Nordling J, Horn T (2008) Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis. BJU Int 102:204–207
Lenk S, Schroeder J (2001) Genitourinary tuberculosis. Curr Opin Urol 11:93–98
Lin JI, Yong HS, Tseng CH, Marsidi PS, Choy C, Pilloff B (1980) Diffuse cystitis glandularis. Associated with adenocarcinomatous change. Urology 15:411–415
Long ED, Shepherd RT (1983) The incidence and significance of vaginal metaplasia of the bladder trigone in adult women. Br J Urol 55:189–194
Lopez-Beltran A (1999) Bladder treatment. Immunotherapy and chemotherapy. Urol Clin North Am 26:535–554
Marks LB, Carroll PR, Dugan TC, Anscher MS (1995) The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy. Int J Radiat Oncol Biol Phys 31:1257–1280
McClure J (1983) Malakoplakia. J Pathol 140:275–330
Medlar EM, Spain DM, Holliday RW (1949) Post-mortem compared with clinical diagnosis of genito-urinary tuberculosis in adult males. J Urol 61:1078–1088
Meria P, Desgrippes A, Arfi C, Le Duc A (1998) Encrusted cystitis and pyelitis. J Urol 160:3–9
Mlinaric-Missoni E, Lipozencic J, Marinovic-Kulisic S, Mlinaric-Dzepina A (2004) Fungal infections of urogenital system. Acta Dermatovenerol Croat 12:77–83
Møller JC, Skriver E, Olsen S, Maunsbach AB (1984) Ultrastructural analysis of human proximal tubules and cortical interstitium in chronic renal disease (hydronephrosis). Virchows Arch A Pathol Anat Histopathol 402:209–237
Morton MJ, Zhang S, Lopez-Beltran A, MacLennan GT, Eble JN, Montironi R, Sung MT, Tan PH, Zheng S, Zhou H, Cheng L (2007) Telomere shortening and chromosomal abnormalities in intestinal metaplasia of the urinary bladder. Clin Cancer Res 13:6232–6236
Murphy WM, Grignon DJ, Perlman EJ (2004) Tumors of the Urinary Bladder. In: Atlas of tumor pathology, 4th series, Fascicle 1: Tumors of the kidney, bladder, and related urinary structures. Armed Forces Institute of Pathology, Washington, DC, S 241–343
Nickel JC (2000) Interstitial cystitis. Etiology, diagnosis, and treatment. Can Fam Physician 46:2430–2440
Oberpenning F, van Ophoven A, Herwig R, Piechota HJ (2000) Diagnostik der interstitiellen Zystitis. Urologe A 39:530–534
Paduch DA (2007) Viral lower urinary tract infections. Curr Urol Rep 8:324–335
Paner GP, Brown JG, Lapetino S, Nese N, Gupta R, Shen SS, Hansel DE, Amin MB (2010) Diagnostic use of antibody to smoothelin in the recognition of muscularis propria in transurethral resection of urinary bladder tumor (TURBT) specimens. Am J Surg Pathol 34:792–799
Pang X, Marchand J, Sant GR, Kream RM, Theoharides TC (1995) Increased number of substance P positive nerve fibres in interstitial cystitis. Br J Urol 75:744–750
Parsons JK, Kurth K, Sant GR (2007) Epidemiologic issues in interstitial cystitis. Urology 69:5–8
Peeker R, Enerback L, Fall M, Aldenborg F (2000) Recruitment, distribution and phenotypes of mast cells in interstitial cystitis. J Urol 163:1009–1015
Peterson NE (1985) Eosinophilic cystitis. Urology 26:167–169
Piper W (2013) Krankheiten der Nieren und ableitenden Harnwege. In: Piper W (Hrsg) Innere Medizin, 2. Aufl. Springer, Berlin, S 317–321
Popov Z, Gil-Diez-De-Medina S, Ravery V, Hoznek A, Bastuji-Garin S, Lefrere-Belda MA, Abbou CC, Chopin DK (2004) Prognostic value of EGF receptor and tumor cell proliferation in bladder cancer: therapeutic implications. Urol Oncol 22:93–101
Quint HJ, Drach GW, Rappaport WD, Hoffmann CJ (1992) Emphysematous cystitis: a review of the spectrum of disease. J Urol 147:134–137
Rausch S, Lotan Y, Youssef RF (2014) Squamous cell carcinogenesis and squamous cell carcinoma of the urinary bladder: A contemporary review with focus on nonbilharzial squamous cell carcinoma. Urol Oncol 32:e11–16
Ronald A (2002) The etiology of urinary tract infection: traditional and emerging pathogens. Am J Med 113(Suppl 1A):14S–19S
Rubin L, Pincus MB (1974) Eosinophilic cystitis: the relationship of allergy in the urinary tract to eosinophilic cystitis and the pathophysiology of eosinophilia. J Urol 112:457–460
Saito K, Kawakami S, Okada Y, Takazawa R, Koga F, Kageyama Y, Kihara K (2006) Spatial and isoform specific p63 expression in the male human urogenital tract. J Urol 176:2268–2273
Samaratunga H, Martignoni G, Egevad L, Delahunt B (2013) Premalignant lesions of the urinary bladder. Pathology 45:243–250
Sant GR, Kempuraj D, Marchand JE, Theoharides TC (2007) The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology 69:34–40
Sarma KP (1970) On the nature of cystitis follicularis. J Urol 104:709–714
Seftel AD, Matthews LA, Smith MC, Willis J (1996) Polyomavirus mimicking high grade transitional cell carcinoma. J Urol 156:1764
Sheinfeld J, Reuter VE, Sarkis AS, Cordon-Cardo C (1992) Blood group antigens in normal and neoplastic urothelium. J Cell Biochem Suppl 16I:50–55
Shewakramani S, Reed KC (2011) Genitourinary trauma. Emerg Med Clin North Am 29:501–518
Shortliffe LM, McCue JD (2002) Urinary tract infection at the age extremes: pediatrics and geriatrics. Am J Med 113(Suppl 1A):55S–66S
Siddiqui A, Melamed MR, Abbi R, Ahmed T (1996) Mucinous (colloid) carcinoma of urinary bladder following long-term cyclophosphamide therapy for Waldenstrom’s macroglobulinemia. Am J Surg Pathol 20:500–504
Siener R, Glatz S, Nicolay C, Hesse A (2003) Prospective study on the efficacy of a selective treatment and risk factors for relapse in recurrent calcium oxalate stone patients. Eur Urol 44:467–474
Sigal SH, Tomaszewski JE, Brooks JJ, Wein A, LiVolsi VA (1991) Carcinosarcoma of bladder following long-term cyclophosphamide therapy. Arch Pathol Lab Med 115:1049–1051
Smith AK, Hansel DE, Jones JS (2008) Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma. Urology 71:915–918
Spagnolo DV, Waring PM (1986) Bladder granulomata after bladder surgery. Am J Clin Pathol 86:430–437
Stein JP, Skinner EC, Boyd SD, Skinner DG (1993) Squamous cell carcinoma of the bladder associated with cyclophosphamide therapy for Wegener’s granulomatosis: a report of 2 cases. J Urol 149:588–589
Stevens S, McClure J (1982) The histochemical features of the Michaelis-Gutmann body and a consideration of the pathophysiological mechanisms of its formation. J Pathol 137:119–127
Stillwell TJ, Benson RC Jr. (1988) Cyclophosphamide-induced hemorrhagic cystitis. A review of 100 patients. Cancer 61:451–457
Sung MT, Lopez-Beltran A, Eble JN, MacLennan GT, Tan PH, Montironi R, Jones TD, Ulbright TM, Blair JE, Cheng L (2006) Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder. Mod Pathol 19:1395–1401
Tanguay C, Harvey I, Houde M, Srigley JR, Tetu B (2003) Leiomyosarcoma of urinary bladder following cyclophosphamide therapy: report of two cases. Mod Pathol 16:512–514
Teo JK, Poh BK, Ng FC (2010) Ureteral diverticulosis. Singapore Med J 51:e161–e162
Tezval H, Tezval M, von Klot C, Herrmann TR, Dresing K, Jonas U, Burchardt M (2007) Urinary tract injuries in patients with multiple trauma. World J Urol 25:177–184
Theoharides TC, Kempuraj D, Sant GR (2001) Mast cell involvement in interstitial cystitis: a review of human and experimental evidence. Urology 57:47–55
Thomas AA, Lane BR, Thomas AZ, Remer EM, Campbell SC, Shoskes DA (2007) Emphysematous cystitis: a review of 135 cases. BJU Int 100:17–20
Trottmann M, Tritschler S, Graser A, Strittmatter F, Becker A, Haseke N, Stief CG (2007) Injuries of the renal pelvis and ureter. Diagnosis and management. Urologe A 46:927–934
van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, Elneil S, Fall M, Hohlbrugger G, Irwin P, Mortensen S, van Ophoven A, Osborne JL, Peeker R, Richter B, Riedl C, Sairanen J, Tinzl M, Wyndaele JJ (2008) Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol 53:60–67
Volmar KE, Chan TY, De Marzo AM, Epstein JI (2003) Florid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma. Am J Surg Pathol 27:1243–1252
Walb D (2008) Nephrolithiasis und Nephrokalzinose, obstruktive Nephropathie. In: Kuhlmann U, Walb D, Böhler J, Luft FC (Hrsg) Nephrologie. Thieme, Stuttgart, S 461–486
Wall RL, Clausen KP (1975) Carcinoma of the urinary bladder in patients receiving cyclophosphamide. N Engl J Med 293:271–273
Walsh PC, Gittes RF, Perlmutter AD, Stamey TA (1986) Campbell’s Urology, 5. Aufl. Saunders, Philadelphia
Warne SA, Hiorns MP, Curry J, Mushtaq I (2011) Understanding cloacal anomalies. Arch Dis Child 96:1072–1076
Warren JW, Horne LM, Hebel JR, Marvel RP, Keay SK, Chai TC (2000) Pilot study of sequential oral antibiotics for the treatment of interstitial cystitis. J Urol 163:1685–1688
Warren JW, Keay SK (2002) Interstitial cystitis. Curr Opin Urol 12:69–74
Weaver MG, Abdul-Karim FW (1990) The prevalence and character of the muscularis mucosae of the human urinary bladder. Histopathology 17:563–566
Wiener DP, Koss LG, Sablay B, Freed SZ (1979) The prevalence and significance of Brunn’s nests, cystitis cystica and squamous metaplasia in normal bladders. J Urol 122:317–321
Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT (2009) Uroplakins in urothelial biology, function, and disease. Kidney Int 75:1153–1165
Yamada T, Murayama T, Mita H, Akiyama K (2000) Subtypes of bladder mast cells in interstitial cystitis. Int J Urol 7:292–297
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Grobholz, R., Schubert, G.E. (2016). Nichtneoplastische Erkrankungen der ableitenden Harnwege. In: Amann, K., Kain, R., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04566-0_15
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