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Karzinogenese der Mammakarzinome

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Pathologie

Part of the book series: Pathologie ((PATHOL))

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Zusammenfassung

Das Kapitel behandelt die Ätiologie und die heutzutage diskutierten multiplen molekulargenetischen Entwicklungswege des invasiven Mammakarzinoms, ausgehend von den intraepithelialen neoplastischen Vorläuferveränderungen. Speziell wird auf das Triple-negative Karzinom eingegangen.

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Literatur

  1. Andersen JA, Fechner RE, Lattes R, Rosen PP, Toker C (1980) Lobular carcinoma in situ: A Symposium. Pathol Annu 15:193–223

    PubMed  CAS  Google Scholar 

  2. Aubele M, Mattis A, Zitzelsberger H et al (2000) Extensive ductal carcinoma in situ with small foci of invasive ductal carcinoma: evidence of genetic resemblance by CGH. Int J Cancer 85:82–86

    Article  PubMed  CAS  Google Scholar 

  3. Aulmann S (2011) Ductal and lobular preneoplasia: Role in breast cancer development. Pathologe 32(2):316–320

    Article  PubMed  Google Scholar 

  4. Aulmann S, Elsawaf Z, Penzel R, Schirmacher P, Sinn HP (2008) Clonal association of flat epithelial atypia and tubular breast cancer. Pathologe 29(2):353–356

    Article  PubMed  Google Scholar 

  5. Aulmann S, Elsawaf Z, Penzel R, Schirmacher P, Sinn HP (2009) Invasive tubular carcinoma of the breast frequently is clonally related to flat epithelial atypia and low-grade ductal carcinoma in situ. Am J Surg Pathol 33:1646–1653

    Article  PubMed  Google Scholar 

  6. Aulmann S, Penzel R, Longerich T, Funke B, Schirmacher P, Sinn HP (2008) Clonality of lobular carcinoma in situ (LCIS) and metachronous invasive breast cancer. Breast Cancer Res Treat 107:331–335

    Article  PubMed  Google Scholar 

  7. Aulmann S, Penzel R, Schirmacher P, Sinn HP (2007) Lobular carcinoma in situ (LCIS): risk factor and precursor of invasive lobular breast cancer. Verh Dtsch Ges Pathol 91:208–213

    PubMed  CAS  Google Scholar 

  8. Azzopardi JG (1979) Study of minute ductal carcinomas. In: Problems in breast pathology. W.B. Saunders, London, pp 107–112

    Google Scholar 

  9. Bankfalvi A, Ludwig A, de Hesselle B, Buerger H, Buchwalow IB, Boecker W (2004) Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases. Mod Pathol 17:1051–1061

    Article  PubMed  Google Scholar 

  10. Bassett L, Winchester DP, Caplan RB et al (1997) Stereotactic core-needle biopsy of the breast: a report of the Joint Task Force of the American College of Radiology, American College of Surgeons, and College of American Pathologists. CA Cancer J Clin 47:171–190

    Article  PubMed  CAS  Google Scholar 

  11. Berx G, Cleton-Jansen AM, Nollet F, De Leeuw WJF, van de Vijver MJ, Cornelisse C, van Roy F (1995) E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 14:6107–6115

    PubMed  CAS  Google Scholar 

  12. Betsill Jr WL, Rosen PP, Lieberman PH, Robbins GF (1978) Intraductal carcinoma. Long-term follow-up after treatment by biopsy alone. JAMA 239:1863–1867

    Article  PubMed  Google Scholar 

  13. Bijker N, Peterse JL, Duchateau L et al (2001) Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: analysis of European Organization for Research and Treatment of Cancer Trial. J Clin Oncol 10853(19):2263–2271

    Google Scholar 

  14. Bijker N, Peterse JL, Duchateau L et al (2001) Histological type and marker expression of the primary tumour compared with its local recurrence after breast-conserving therapy for ductal carcinoma in situ. Br J Cancer 84:539–544

    Article  PubMed  CAS  Google Scholar 

  15. Boecker W (2006) Preneoplasia of the breast. A new conceptual approach to proliferative breast disease. Saunders Elsevier, München

    Google Scholar 

  16. Boecker W, Buerger H, Schmitz K et al (2001) Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridisation and high-molecular-weight cytokeratin expression patterns. J Pathol 195:415–421

    Article  PubMed  CAS  Google Scholar 

  17. Boecker W, Moll R, Dervan P et al (2002) Usual ductal hyperplasia of the breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. J Pathol 198:458–467

    Article  PubMed  Google Scholar 

  18. Boecker W, Moll R, Poremba C et al (2002) Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest 82:737–746

    Google Scholar 

  19. Boecker WJ, Bier B, Freytag G et al (1992) An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part I: normal breast and benign proliferative lesions. Virchows Arch A 421:315–322

    Article  Google Scholar 

  20. Boecker WJ, Bier B, Freytag G et al (1992) An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: Epitheliosis and ductal carcinoma in situ. Virchows Arch A 421:323–330

    Article  Google Scholar 

  21. Buerger H, Boecker W (2002) New insights into the pathogenesis of in situ carcinomas of the breast by means of comparative genomic hybridization. In: Silverstein M (ed) Ductal carcinoma of the breast. Lippincott Williams & Wilkins, New York, pp 67–76

    Google Scholar 

  22. Buerger H, Mommers EC, Littmann R et al (2000) Correlation of morphologic and cytogenetic parameters of genetic instability with chromosomal alterations in in situ carcinomas of the breast. Am J Clin Pathol 114:854–859

    Article  PubMed  CAS  Google Scholar 

  23. Buerger H, Mommers EC, Littmann R et al (2001) Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution. J Pathol 194:165–170

    Article  PubMed  CAS  Google Scholar 

  24. Buerger H, Otterbach F, Simon R et al (1999) Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways. J Pathol 187:396–402

    Article  PubMed  CAS  Google Scholar 

  25. Buerger H, Otterbach F, Simon R et al (1999) Different genetic pathways in the evolution of invasive breast cancer are associated with distinct morphological subtypes. J Pathol 189:521–526

    Article  PubMed  CAS  Google Scholar 

  26. Buerger H, Simon R, Schafer KL et al (2000) Genetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast. Mol Pathol 53:118–121

    Article  PubMed  CAS  Google Scholar 

  27. Chen CL, Weiss NS, Newcomb P, Barlow W, White E (2002) Hormone replacement therapy in relation to breast cancer. JAMA 287:734–741

    Article  PubMed  CAS  Google Scholar 

  28. Clemons M, Goss P (2001) Estrogen and the risk of breast cancer. N Engl J Med 344:276–285

    Article  PubMed  CAS  Google Scholar 

  29. Cleton-Jansen AM (2002) E-cadherin and loss of heterozygosity at chromosome 16 in breast carcinogenesis: different genetic pathways in ductal and lobular breast cancer. Breast Cancer Res 4:5–8

    Article  PubMed  CAS  Google Scholar 

  30. Cleton-Jansen AM, Buerger H, Haar N et al (2004) Different mechanisms of chromosome 16 loss of heterozygosity in well- versus poorly differentiated ductal breast cancer. Genes Chromosomes Cancer 41:109–116

    Article  PubMed  CAS  Google Scholar 

  31. Cleton-Jansen AM, Buerger H, Haar N et al (2004) Different mechanisms of chromosome 16 loss of heterozygosity in well- versus poorly differentiated ductal breast cancer. Genes Chromosomes Cancer 41:109–116

    Article  PubMed  CAS  Google Scholar 

  32. Dontu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS (2003) Stem cells in normal breast development and breast cancer. Cell Prolif 36(Suppl 1):59–72

    Article  PubMed  CAS  Google Scholar 

  33. Dupont WD, Page DL (1985) Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med 312:146–151

    Article  PubMed  CAS  Google Scholar 

  34. Dupont WD, Parl FF, Hartmann WH et al (1993) Breast cancer risk associated with proliferative breast disease and atypical hyperplasia [see comments]. Cancer 71:1258–1265

    Article  PubMed  CAS  Google Scholar 

  35. Eusebi V, Feudale E, Foschini MP et al (1994) Long-term follow-up of in situ carcinoma of the breast. Semin Diagn Pathol 11:223–235

    PubMed  CAS  Google Scholar 

  36. Farabegoli F, Champeme MH, Bieche I, Santini D, Ceccarelli C, Derenzini M, Lidereau R (2002) Genetic pathways in the evolution of breast ductal carcinoma in situ. J Pathol 196:280–286

    Article  PubMed  Google Scholar 

  37. Fechner RE (1970) Breast cancer during oral contraceptive therapy. Cancer 26:1204–1211

    Article  PubMed  CAS  Google Scholar 

  38. Fechner RE (1971) The surgical pathology of the reproductive system and breast during oral contraceptive therapy. Pathol Annu 6:299–319

    PubMed  CAS  Google Scholar 

  39. Fitzgibbons PL, Henson DE, Hutter RV (1998) Benign breast changes and the risk for subsequent breast cancer: an update of the 1985 consensus statement. Cancer Committee of the College of American Pathologists. Arch Pathol Lab Med 122:1053–1055

    PubMed  CAS  Google Scholar 

  40. Foschini MP, Krausz T (2010) Salivary gland-type tumors of the breast: a spectrum of benign and malignant tumors including "triple negative carcinomas" of low malignant potential. Semin Diagn Pathol 27:77–90

    Article  PubMed  Google Scholar 

  41. Fraser JL, Raza S, Chorny K, Connolly JL, Schnitt SJ (2000) Immunophenotype of columnar alteration with prominent apical snouts and secretions (CAPSS). Lab Invest 80:21A

    Google Scholar 

  42. Gomm JJ, Browne PJ, Coope RC et al (1997) A paracrine role for myoepithelial cell-derived FGF2 in the normal human breast. Exp Cell Res 234:165–173

    Article  PubMed  CAS  Google Scholar 

  43. Goss PE, Sierra S (1998) Current perspectives on radiation-induced breast cancer. J Clin Oncol 16:338–347

    PubMed  CAS  Google Scholar 

  44. Gusterson B (2009) Do 'basal-like' breast cancers really exist? Nat Rev Cancer 9:128–134

    Article  PubMed  CAS  Google Scholar 

  45. Gusterson BA, Warburton MJ, Mitchell D, Ellison M, Neville AM, Rudland PS (1982) Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. Cancer Res 42:4763–4770

    PubMed  CAS  Google Scholar 

  46. Haagensen CD (1986) Diseases of the breast. W.B. Saunders, Philadelphia

    Google Scholar 

  47. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70

    Article  PubMed  CAS  Google Scholar 

  48. Hildreth NG, Shore RE, Hempelmann LH (1983) Risk of breast cancer among women receiving radiation treatment in infancy for thymic enlargement. Lancet 2:273

    Article  PubMed  CAS  Google Scholar 

  49. Holland R, Faverley D, Silverstein MJ, Recht A, Lagios MD (2003) The local distribution of ductal carcinoma in situ of the breast: whole-organ studies. In: Ductal carcinoma in situ of the breast. Lippincott Williams & Wilkins, Philadelphia, pp 240–248

    Google Scholar 

  50. Holland R, Hendriks JH (1994) Microcalcifications associated with ductal carcinoma in situ: mammographic-pathologic correlation. Semin Diagn Pathol 11:181–192

    PubMed  CAS  Google Scholar 

  51. Holland R, Peterse JL, Millis RR, Eusebi V, Faverly D, van de Vijver MJ, Zafrani B (1994) Ductal carcinoma in situ: a proposal for a new classification. Semin Diagn Pathol 11:167–180

    PubMed  CAS  Google Scholar 

  52. Kelsey JL, Gammon MD (1991) The epidemiology of breast cancer. CA Cancer J Clin 41:146–165

    Article  PubMed  CAS  Google Scholar 

  53. Kim MJ, Ro JY, Ahn SH, Kim HH, Kim SB, Gong G (2006) Clinicopathologic significance of the basal-like subtype of breast cancer: a comparison with hormone receptor and Her2/neu-overexpressing phenotypes. Hum Pathol 37:1217–1226

    Article  PubMed  CAS  Google Scholar 

  54. Korsching E, Jeffrey SS, Meinerz W, Decker T, Boecker W, Buerger H (2008) Basal carcinoma of the breast revisited: an old entity with new interpretations. J Clin Pathol 61:553–560

    Article  PubMed  CAS  Google Scholar 

  55. Korsching E, Packeisen J, Agelopoulos K et al (2002) Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis. Lab Invest 82:1525–1533

    PubMed  CAS  Google Scholar 

  56. Korsching E, Packeisen J, Helms MW et al (2004) Deciphering a subgroup of breast carcinomas with putative progression of grade during carcinogenesis revealed by comparative genomic hybridisation (CGH) and immunohistochemistry. Br J Cancer 90:1422–1428

    Article  PubMed  CAS  Google Scholar 

  57. Korsching E, Packeisen J, Liedtke C et al (2005) The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? J Pathol 206:451–457

    Article  PubMed  CAS  Google Scholar 

  58. Laakso M, Tanner M, Nilsson J et al (2006) Basoluminal carcinoma: a new biologically and prognostically distinct entity between basal and luminal breast cancer. Clin Cancer Res 12:4185–4191

    Article  PubMed  CAS  Google Scholar 

  59. Lagios MD (1993) Heterogeneity of ductal carcinoma in situ of the breast. J Cell Biochem (Suppl 17G): 49–52

    Google Scholar 

  60. Lagios MD, Margolin FR, Westdahl PR, Rose MR (1989) Mammographically detected duct carcinoma in situ. Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence. Cancer 63:618–624

    Article  PubMed  CAS  Google Scholar 

  61. Lakhani SR (1998) The transition from hyperplasia to invasive carcinoma of the breast. J Pathol 187:272–278

    Article  Google Scholar 

  62. Lakhani SR, Collins N, Stratton MR (1995) Loss of heterozygosity in lobular carcinoma in situ of the breast. Clin Mol Pathol 48:M74–M78

    Article  PubMed  CAS  Google Scholar 

  63. Lakhani SR, O'Hare MJ (2001) The mammary myoepithelial cell – Cinderella or ugly sister. Breast Cancer Res 3:1–4

    Article  PubMed  CAS  Google Scholar 

  64. Lavasani MA, Moinfar F (2012) Molecular classification of breast carcinomas with particular emphasize on “basal-like” carcinoma: A critical review. J Biophotonics (Epub ahead of print)

    Google Scholar 

  65. London SJ, Connolly JL, Schnitt SJ, Colditz GA (1992) A prospective study of benign breast disease and the risk of breast cancer [published erratum appears in JAMA 1992; 267: 1780]. JAMA 267:941–944

    Article  PubMed  CAS  Google Scholar 

  66. Lopez-Garcia MA, Geyer FC, Lacroix-Triki M, Marchio C, Reis-Filho JS (2010) Breast cancer precursors revisited: molecular features and progression pathways. Histopathology 57:171–192

    Article  PubMed  Google Scholar 

  67. Lu YJ, Osin P, Lakhani SR, Di Palma S, Gusterson BA, Shipley JM (1998) Comparative genomic hybridization analysis of lobular carcinoma in situ and atypical lobular hyperplasia and potential roles for gains and losses of genetic material in breast neoplasia. Cancer Res 58:4721–4727

    PubMed  CAS  Google Scholar 

  68. Malzahn K, Mitze M, Thoenes M, Moll R (1998) Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating ductal breast carcinomas. Virchows Arch 433:119–129

    Article  PubMed  CAS  Google Scholar 

  69. Marchio C, Natrajan R, Shiu KK et al (2008) The genomic profile of HER2-amplified breast cancers: the influence of ER status. J Pathol 216:399–407

    Article  PubMed  CAS  Google Scholar 

  70. Marshall LM, Hunter DJ, Connolly JL, Schnitt SJ, Byrne C, London SJ, Colditz GA (1997) Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types. Cancer Epidemiol Biomarkers Prev 6:297–301

    PubMed  CAS  Google Scholar 

  71. Moinfar F (2008) Is 'basal-like' carcinoma of the breast a distinct clinicopathological entity? A critical review with cautionary notes. Pathobiology 75:119–131

    Article  PubMed  CAS  Google Scholar 

  72. Moinfar F, Man YG, Bratthauer GL, Ratschek M, Tavassoli FA (2000) Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ("clinging ductal carcinoma in situ"): a simulator of normal mammary epithelium. Cancer 88:2072–2081

    Article  PubMed  CAS  Google Scholar 

  73. Mommers EC, Leonhart AM, Falix F, Michalides R, Meijer CJ, Baak JP, Diest PJ (2001) Similarity in expression of cell cycle proteins between in situ and invasive ductal breast lesions of same differentiation grade. J Pathol 194:327–333

    Article  PubMed  CAS  Google Scholar 

  74. Nagle RB, Böcker W, Davis JR, Heid HW, Kaufmann M, Lucas DO, Jarasch ED (1986) Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. J Histochem Cytochem 34:869–881

    Article  PubMed  CAS  Google Scholar 

  75. Natrajan R, Lambros MB, Geyer FC et al (2009) Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype? Genes Chromosomes Cancer 48:351–365

    Article  PubMed  CAS  Google Scholar 

  76. Ottesen GL, Graversen HP, Blichert-Toft M, Zedeler K, Andersen JA (1992) Ductal carcinoma in situ of the female breast. short-term results of a prospective nationwide study. Am J Surg Pathol 16:1183–1196

    Article  PubMed  CAS  Google Scholar 

  77. Oyama T, Iijima K, Takei H, Horiguchi J, Iino Y, Nakajima T, Koerner F (2000) Atypical cystic lobule of the breast: an early stage of low-grade ductal carcinoma in-situ. Breast Cancer 7:326–331

    Article  PubMed  CAS  Google Scholar 

  78. Oyama T, Maluf H, Koerner F (1999) Atypical cystic lobules: an early stage in the formation of low-grade ductal carcinoma in situ. Virchows Arch 435:413–421

    Article  PubMed  CAS  Google Scholar 

  79. Page DL, Dupont WD, Rogers LW, Jensen RA, Schuyler PA (1995) Continued local recurrence of carcinoma 15-25 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy. Cancer 76:1197–1200

    Article  PubMed  CAS  Google Scholar 

  80. Page DL, Dupont WD, Rogers LW, Landenberger M (1982) Intraductal carcinoma of the breast: follow-up after biopsy only. Cancer 49:751–758

    Article  PubMed  CAS  Google Scholar 

  81. Page DL, Rogers LW, Schuyler PA et al (2002) The natural history of ductal carcinoma in situ of the breast. In Ductal carcinoma in situ of the breast. Lippincott Williams & Wilkins, Philadelphia, pp 17–21

    Google Scholar 

  82. Palli D, Rosselli-Del TM, Simoncini R, Bianchi S (1991) Benign breast disease and breast cancer: a case-control study in a cohort in Italy. Int J Cancer 47:703–706

    Article  PubMed  CAS  Google Scholar 

  83. Perou CM, Sorlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747–752

    Article  PubMed  CAS  Google Scholar 

  84. Poller DN, Silverstein MJ, Galea M, Locker AP, Elston CW, Blamey RW, Ellis IO (1994) Ductal carcinoma in situ of the breast: a proposal for a new simplified histological classification association between cellular proliferation and c-erbb-2 protein expression. Mod Pathol 7:257–262

    PubMed  CAS  Google Scholar 

  85. Potemski P, Kusinska R, Watala C, Pluciennik E, Bednarek AK, Kordek R (2005) Prognostic relevance of basal cytokeratin expression in operable breast cancer. Oncology 69:478–485

    Article  PubMed  CAS  Google Scholar 

  86. Rakha EA, Reis-Filho JS, Ellis IO (2008) Basal-like breast cancer: a critical review. J Clin Oncol 26:2568–2581

    Article  PubMed  Google Scholar 

  87. Reis-Filho JS, Milanezi F, Steele D et al (2006) Metaplastic breast carcinomas are basal-like tumours. Histopathology 49:10–21

    Article  PubMed  CAS  Google Scholar 

  88. Reis-Filho JS, Tutt AN (2008) Triple negative tumours: a critical review. Histopathology 52:108–118

    Article  PubMed  CAS  Google Scholar 

  89. Rennstam K, Ahlstedt-Soini M, Baldetorp B et al (2003) Patterns of chromosomal imbalances defines subgroups of breast cancer with distinct clinical features and prognosis. A study of 305 tumors by comparative genomic hybridization. Cancer Res 63:8861–8868

    PubMed  CAS  Google Scholar 

  90. Richard F, Pacyna-Gengelbach M, Schluns K et al (2000) Patterns of chromosomal imbalances in invasive breast cancer. Int J Cancer 89:305–310

    Article  PubMed  CAS  Google Scholar 

  91. Romieu I, Berlin JA, Colditz G (1990) Oral contraceptives and breast cancer. Review and meta-analysis. Cancer 66:2253–2263

    Article  PubMed  CAS  Google Scholar 

  92. Rosen PP (2001) Rosen's breast pathology. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  93. Ross RK, Paganini-Hill A, Gerkins VR, Mack TM, Pfeffer R, Arthur M, Henderson BE (1980) A case-control study of menopausal estrogen therapy and breast cancer. JAMA 243:1635–1639

    Article  PubMed  CAS  Google Scholar 

  94. Ross RK, Paganini-Hill A, Wan PC, Pike MC (2000) Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst 92:328–332

    Article  PubMed  CAS  Google Scholar 

  95. Rudland PS, Fernig DG, Smith JA (1995) Growth factors and their receptors in neoplastic mammary glands. Biomed Pharmacother 49:389–399

    Article  PubMed  CAS  Google Scholar 

  96. Schairer C, Lubin J, Troisi R, Sturgeon S, Brinton L, Hoover R (2000) Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk. JAMA 283:485–491

    Article  PubMed  CAS  Google Scholar 

  97. Schnitt SJ, Boecker W (2005) Flat epithelial atypia. In: Preneoplasia of the breast. Elsevier, München

    Google Scholar 

  98. Shao ZM, Nguyen M, Alpaugh ML, O'Connell JT, Barsky SH (1998) The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21WAF1/CIP1 induction, G2/M arrest, and apoptosis. Exp Cell Res 241:394–403

    Article  PubMed  CAS  Google Scholar 

  99. Shen CY, Yu JC, Lo YL et al (2000) Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis. Cancer Res 60:3884–3892

    PubMed  CAS  Google Scholar 

  100. Shore RE, Hempelmann LH, Kowaluk E, Mansur PS, Pasternack BS, Albert RE, Haughie GE (1977) Breast neoplasms in women treated with x-rays for acute postpartum mastitis. J Natl Cancer Inst 59:813–822

    PubMed  CAS  Google Scholar 

  101. Silverstein MJ, Lagios MD, Craig PH, Waisman JR, Lewinsky BS, Colburn WJ, Poller DN (1996) A prognostic index for ductal carcinoma in situ of the breast. Cancer 77:2267–2274

    Article  PubMed  CAS  Google Scholar 

  102. Silverstein MJ, Lagios MD, Groshen S, Waisman JR, Lewinsky BS, Martino S, Gamagami P, Colburn WJ (1999) The influence of margin width on local control of ductal carcinoma in situ of the breast. N Engl J Med 340:1455–1461

    Article  PubMed  CAS  Google Scholar 

  103. Simon N, Silverstone SM (1976) Radiation as a cause of breast cancer. Bull N Y Acad Med 52:741–751

    PubMed  CAS  Google Scholar 

  104. Simpson PT, Gale T, Reis-Filho JS et al (2005) Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis. Am J Surg Pathol 29:734–746

    Article  PubMed  Google Scholar 

  105. Slade MJ, Coope RC, Gomm JJ, Coombes RC (1999) The human mammary gland basement membrane is integral to the polarity of luminal epithelial cells. Exp Cell Res 247:267–278

    Article  PubMed  CAS  Google Scholar 

  106. Sloane JP, Lakhani SR, Stratton MR (1996) Terminology for carcinoma-in-situ of the breast. Lancet 347:1259–1260

    Article  PubMed  CAS  Google Scholar 

  107. Sloane JP, Sloane JP, Lakhani SR (2001) Atypical ductal hyperplasia. In: Biopsy pathology of the breast. Arnold, London, pp 105–109

    Google Scholar 

  108. Sorlie T, Perou CM, Tibshirani R et al (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98:10869–10874

    Article  PubMed  CAS  Google Scholar 

  109. Sternlicht MD, Kedeshian P, Shao ZM, Safarians S, Barsky SH (1997) The human myoepithelial cell is a natural tumor suppressor. Clin Cancer Res 3:1949–1958

    PubMed  CAS  Google Scholar 

  110. Tavassoli FA, Hoefler H, Rosai J et al. (2003) Intraductal proliferative lesions. In: Tumours of the breast and female genital organs. IARC-Press, Lyon, pp 63–73

    Google Scholar 

  111. van de Vijver MJ, Peterse H (2003) The diagnosis and management of pre-invasive breast disease: pathological diagnosis – problems with existing classifications. Breast Cancer Res 5:269

    Article  PubMed  Google Scholar 

  112. Vos CB, Cleton-Jansen AM, Berx G et al (1997) E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis. Br J Cancer 76:1131–1133

    Article  PubMed  CAS  Google Scholar 

  113. Vos CB, ter Haar NT, Rosenberg C, Peterse JL, Cleton-Jansen AM, Cornelisse CJ, van de Vijver MJ (1999) Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type. Br J Cancer 81:1410–1418

    Article  PubMed  CAS  Google Scholar 

  114. Vos CB, ter Haar NT, Rosenberg C, Peterse JL, Cleton-Jansen AM, Cornelisse CJ, van de Vijver MJ (1999) Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type. Br J Cancer 81:1410–1418

    Article  PubMed  CAS  Google Scholar 

  115. Waldman FM, DeVries S, Chew KL, Moore DH, Kerlikowske K, Ljung BM (2000) Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. J Natl Cancer Inst 92:313–320

    Article  PubMed  CAS  Google Scholar 

  116. White E, Malone KE, Weiss NS, Daling JR (1994) Breast cancer among young U.S. women in relation to oral contraceptive use. J Natl Cancer Inst 86:505–514

    Article  PubMed  CAS  Google Scholar 

  117. Wulfing P, Kersting C, Buerger H et al (2005) Expression patterns of angiogenic and lymphangiogenic factors in ductal breast carcinoma in situ. Br J Cancer 92:1720–1728

    Article  PubMed  CAS  Google Scholar 

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  1. Horst Bürger Prof. Dr. med.

    Present address: , Husener Straße 46a, 33098, Paderborn, Deutschland

  2. Werner Böcker Prof. em. Dr. med.

    Present address: Referenz- und Konsultationszentrum für Gynäko- und Mammapathologie, Fangdieckstr. 75a, 22547, Hamburg, Deutschland

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  1. Gerhard Domagk Institut für Pathologie der Universität Münster, Münster, Deutschland

    Werner Böcker Prof. em. Dr. med.

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  1. Horst Bürger Prof. Dr. med.
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  1. Institut für Pathologie, Konsultationszentrum für Pankreas- und, TU München, Ismaninger Str. 22, München, 81675, Germany

    Günter Klöppel

  2. Inst. Pathologie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, Hannover, 30623, Germany

    Hans Kreipe

  3. Kliniken der Landeshauptstadt, Institut für Pathologie, Ludwig-Erhard-Straße 100, Wiesbaden, 65199, Germany

    Wolfgang Remmele

  4. Charite - Universitätsmedizin Berlin, Campus Charité Mitte, Institut für Pathologie, Charitéplatz 1, Berlin, 10117, Berlin, Germany

    Manfred Dietel

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Bürger, H., Böcker, W. (2013). Karzinogenese der Mammakarzinome. In: Klöppel, G., Kreipe, H., Remmele, W., Dietel, M. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04564-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-04564-6_4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04563-9

  • Online ISBN: 978-3-642-04564-6

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