Skip to main content

Zytologische Tumorkriterien

  • Chapter
Pathologie

Zusammenfassung

Die zytologischen Tumorkriterien entsprechen grundsätzlich Veränderungen, die auch im histologischen Präparat nachweisbar sind. Doch im Unterschied zur Histologie kommt es in der Zytologie fast ausschließlich auf das Erscheinungsbild der Einzelzelle an. Die strukturelle Beziehung der einzelnen Zellen zu ihren Nachbarzellen lässt sich zytologisch nur sehr eingeschränkt beurteilen. Diese Einschränkung des Kriterienspektrums bedingt denn auch eine Einengung der diagnostischen Möglichkeiten. So lassen sich, wie bereits im vorigen Kapitel erwähnt, an einzelnen, aus dem Gewebsverband herausgelösten Zellen zytologisch hauptsächlich neoplastische und weniger nichtneoplastische Krankheiten diagnostizieren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 269.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 349.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aiello A, Delia D, Giardini R et al. (1997) PCR analysis of IgH and BCL2 gene rearrangement in the diagnosis of follicular lymphoma in lymph node fine-needle aspiration. A critical appraisal. Diagn Mol Pathol 6: 154–160

    Article  CAS  PubMed  Google Scholar 

  2. Bullerdiek J, Rogalla P (1999) Molekulare Zytologie. Ver Dtsch Ges Zyt 21 Tagung: 16–24

    Google Scholar 

  3. Cajulis RS, Haines GK 3rd, Frias-Hidvegi D et al. (1995) Cytology, flow cytometry, image analysis, and interphase cytogenetics by fluorescence in situ hybridization in the diagnosis of transitional cell carcinoma in bladder washes: a comparative study. Diagn Cytopathol 13: 214–223; discussion 224

    Article  CAS  PubMed  Google Scholar 

  4. Cibas ES (1995) Applications of flow cytometric DNA analysis to diagnostic cytology. Diagn Cytopathol 13: 166–171

    Article  CAS  PubMed  Google Scholar 

  5. Cohen C (1996) Image cytometric analysis in pathology. Hum Pathol 27: 482–493

    Article  CAS  PubMed  Google Scholar 

  6. Cremer C, Munkel C, Granzow M et al. (1996) Nuclear architecture and the induction of chromosomal aberrations. Mutat Res 366: 97–116

    CAS  PubMed  Google Scholar 

  7. Dalquen P, Baschiera B, Chaffard R et al. (1997) MIB-1 (Ki-67) immunostaining of breast cancer cells in cytologic smears. Acta Cytol 41: 229–237

    CAS  PubMed  Google Scholar 

  8. Dey P (2005) Chromatin pattern alteration in malignant cells: an enigma. Diagn Cytopathol 32: 25–30

    Article  PubMed  Google Scholar 

  9. Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19: 403–410

    Article  CAS  PubMed  Google Scholar 

  10. Fischer JR, Lahm H (2004) Validation of molecular and immunological factors with predictive importance in lung cancer. Lung Cancer 45 [Suppl 2]: S151–161

    Article  PubMed  Google Scholar 

  11. Holst F, Stahl PR, Ruiz C et al. (2007) Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nat Genet 39: 655–660

    Article  CAS  PubMed  Google Scholar 

  12. Jeffers MD, McCorriston J, Farquharson MA et al. (1997) Analysis of clonality in cytologic material using the polymerase chain reaction (PCR) Cytopathology 8: 114–121

    CAS  PubMed  Google Scholar 

  13. Johnson TM, Kuffel DG, Dewald GW (1996) Detection of hyperdiploid malignant cells in pleural effusions with chromosome-specific probes and fluorescence in situ hybridization. Mayo Clin Proc 71: 643–648

    Article  CAS  PubMed  Google Scholar 

  14. Lovchik J, Lane MA, Clark DP (1997) Polymerase chain reaction-based detection of B-cell clonality in the fine needle aspiration biopsy of a thyroid mucosa-associated lymphoid tissue (MALT) lymphoma. Hum Pathol 28: 989–992

    Article  CAS  PubMed  Google Scholar 

  15. Motherby H, Nadjari B, Remmerbach T et al. (1998) Static DNA cytometry as a diagnostic aid in effusion cytology: II DNA aneuploidy for identification of neoplastic cells in equivocal effusions. Anal Quant Cytol Histol 20: 162–168

    CAS  PubMed  Google Scholar 

  16. Motherby H, Ross B, Kube M et al. (1998) Pleural carcinosis confirmed by adjuvant cytological methods: a case report. Diagn Cytopathol 19: 370–374

    Article  CAS  PubMed  Google Scholar 

  17. Oberholzer M, Ettlin R, Christen H et al. (1991) The significanceofmorphometricmethodsincytologicdiagnostics: differentiation between mesothelial cells, mesothelioma cells and metastatic adenocarcinoma cells in pleural effusions with special emphasis on chromatin texture. Anal Cell Pathol 3: 25–42

    CAS  PubMed  Google Scholar 

  18. Press MF, Sauter G, Bernstein L et al. (2005) Diagnostic evaluation of HER-2 as a molecular target: an assessment of accuracy and reproducibility of laboratory testing in large, prospective, randomized clinical trials. Clin Cancer Res 11: 6598–6607

    Article  CAS  PubMed  Google Scholar 

  19. Riley RS, Mahin EL, Ross W (1993) Clinical application of flow cytometry. Igaku-Shoin, New York Tokyo, pp 251–322

    Google Scholar 

  20. Sauter G, Feichter G, Torhorst J et al. (1996) Fluorescence in situ hybridization for detecting erbB-2 amplification in breast tumor fine needle aspiration biopsies. Acta Cytol 40: 164–173

    CAS  PubMed  Google Scholar 

  21. Sauter G, Lee J, Bartlett JM et al. (2009) Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations. J Clin Oncol 27: 1323– 1333

    Article  CAS  PubMed  Google Scholar 

  22. Seufferlein T, Ahn J, Krndija D et al. (2009) Tumor biology and cancer therapy – an evolving relationship. Cell Commun Signal 7: 19

    Google Scholar 

  23. Vianello F, Tison T, Radossi P et al. (1998) Detection of B-cell monoclonality in fine needle aspiration by PCR analysis. Leuk Lymphoma 29: 179–185

    Article  CAS  PubMed  Google Scholar 

  24. Visser AE, Eils R, Jauch A et al. (1998) Spatial distributions of early and late replicating chromatin in interphase chromosome territories. Exp Cell Res 243: 398–407

    Article  CAS  PubMed  Google Scholar 

  25. Zink D, Bornfleth H, Visser A et al. (1999) Organization of early and late replicating DNA in human chromosome territories. Exp Cell Res 247: 176–188

    Article  CAS  PubMed  Google Scholar 

  26. Zink D, Cremer T, Saffrich R et al. (1998) Structure and dynamics of human interphase chromosome territories in vivo. Hum Genet 102: 241–251

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bubendorf, L., Feichter, G., Obermann, E., Dalquen, P. (2011). Zytologische Tumorkriterien. In: Klöppel, G., Kreipe, H., Remmele, W. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04562-2_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-04562-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04561-5

  • Online ISBN: 978-3-642-04562-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics