Skip to main content
SpringerLink
Log in

Zentralnervensystem

  • Chapter
Pathologie

  • 4741 Accesses

Zusammenfassung

Im Bereich des Zentralnervensystems steht die Liquorzytologie ganz im Vordergrund. Sie spielt vor allem eine Rolle in der Diagnose nichtneoplastischer Erkrankungen (Infekte!) von ZNS und Meningen. Darüber hinaus ist sie die Methode der Wahl, um eine meningeale Beteiligung bei Hämoblastosen und anderen malignen Tumoren zu erkennen und den Erfolg der zytostatischen Therapie zu kontrollieren [37, 58].

Im Unterschied zu Hämoblastosen, Lymphomen und metastasierenden Karzinomen manifestieren sich primäre Hirntumoren mit Ausnahme der hochmalignen Glioblastome und Medulloblatome nur selten im Liquor [11]. Einen nicht zu unterschätzenden Beitrag vermag die Zytologie aber in der intraoperativen Diagnostik der Hirntumoren zu leisten.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 269.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 349.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Akhtar M, Ali MA, Bakry M et al. (1992) Fine-needle aspiration biopsy diagnosis of rhabdomyosarcoma: cytologic, histologic, and ultrastructural correlations. Diagn Cytopathol 8: 465–474

    Article  CAS  PubMed  Google Scholar 

  2. Bahrain H, Laureno R, Krishnan J et al. (2007) Lyme disease mimicking central nervous system lymphoma. Cancer Invest 25: 336–339

    Article  PubMed  Google Scholar 

  3. Bell JE (1994) Update on central nervous system cytopathology I Cerebrospinal fluid J Clin Pathol 47: 573–578

    Article  CAS  PubMed  Google Scholar 

  4. Bigner SH, Johnston WW (1981) The cytopathology of cerebrospinal fluid. II. Metastatic cancer, meningeal carcinomatosis and primary central nervous system neoplasms. Acta Cytol 25: 461–479

    CAS  PubMed  Google Scholar 

  5. Bigner SH, Jonston WW (1981) The cytopathology of cerebrospinal fluid. I. Nonneoplastic conditions, lymphoma and leukemia. Acta Cytol 25: 345–353

    CAS  PubMed  Google Scholar 

  6. Bleggi-Torres LF, de Noronha L, Schneider Gugelmin E et al. (2001) Accuracy of the smear technique in the cytological diagnosis of 650 lesions of the central nervous system. Diagn Cytopathol 24: 293–295

    Article  CAS  PubMed  Google Scholar 

  7. Bleggi-Torres LF, Gasparetto EL, Faoro LN et al. (2001) Pleomorphic xanthoastrocytoma: report of a case diagnosed by intraoperative cytopathological examination. Diagn Cytopathol 24: 120–122

    Article  CAS  PubMed  Google Scholar 

  8. Bleggi-Torres LF, Netto MR, Gasparetto EL et al. (2002) Dysembrioplastic neuroepithelial tumor: cytological diagnosis by intraoperative smear preparation. Diagn Cytopathol 26: 92–94

    Article  PubMed  Google Scholar 

  9. Challa VR, Kilpatrick SE, Ricci P et al. (1998) Solitary fibrous tumor of the meninges. Clin Neuropathol 17: 73–78

    CAS  PubMed  Google Scholar 

  10. Chen KT (2005) Crush cytology of pituicytoma. Diagn Cytopathol 33: 255–257

    Article  PubMed  Google Scholar 

  11. Chhieng DC, Elgert P, Cohen JM et al. (2002) Cytology of primary central nervous system neoplasms in cerebrospinal fluid specimens. Diagn Cytopathol 26: 209–212

    Article  PubMed  Google Scholar 

  12. Conrad KA, Groß JL, Trojanowski JQ (1986) Leptomeningeal carcinomatosis presenting as eosinophilic meningitis. Acta Cytol 30: 29–31

    CAS  PubMed  Google Scholar 

  13. Dal Maso L, Franceschi S (2003) Epidemiology of non-Hodgkin lymphomas and other haemolymphopoietic neoplasms in people with AIDS Lancet Oncol 4: 110–119

    Article  Google Scholar 

  14. Dvoracek MA, Kirby PA (2001) Intraoperative diagnosis of tanycytic ependymoma: pitfalls and differential diagnosis. Diagn Cytopathol 24: 289–292

    Article  CAS  PubMed  Google Scholar 

  15. Fagan MF, Rone R (1985) Esthesioneuroblastoma: cytologic features with differential diagnostic considerations. Diagn Cytopathol 1: 322–326

    Article  CAS  PubMed  Google Scholar 

  16. Feiden W, Bise K, Steude U et al. (1993) The stereotactic biopsy diagnosis of focal intracerebral lesions in AIDS patients. Acta Neurol Scand 87: 228–233

    Article  CAS  PubMed  Google Scholar 

  17. Feiden W, Steudel WI (1997) Schnellschnittuntersuchungen bei neurochirurgischen Operationen. Pathologe 18: 107–110

    CAS  PubMed  Google Scholar 

  18. Fukuoka K, Hirokawa M, Kanahara T et al. (2000) Cytology of microcystic meningioma in crush preparation. Diagn Cytopathol 23: 275–278

    Article  CAS  PubMed  Google Scholar 

  19. Gaudin PB, Sherman ME, Brat DJ et al. (1997) Accuracy of grading gliomas on CT-guided stereotactic biopsies: a survival analysis. Diagn Cytopathol 17: 461–466

    Article  CAS  PubMed  Google Scholar 

  20. Glantz MJ, Cole BF, Glantz LK et al. (1998) Cerebrospinal fluid cytology in patients with cancer: minimizing falsenegative results. Cancer 82: 733–739

    Article  CAS  PubMed  Google Scholar 

  21. Glass JP, Melamed M, Chernik NL et al. (1979) Malignant cells in cerebrospinal fluid (CSF): the meaning of a positive CSF cytology. Neurology 29: 1369–1375

    CAS  PubMed  Google Scholar 

  22. Goh SG, Chuah KL (2003) Role of intraoperative smear cytology in the diagnosis of anaplastic oligodendroglioma. A case report. Acta Cytol 47: 293–298

    PubMed  Google Scholar 

  23. Gupta M, Djalilvand A, Brat DJ (2005) Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma. Am J Clin Pathol 124: 755–768

    Article  CAS  PubMed  Google Scholar 

  24. Hajdu SI (2004) Pilocytic astrocytoma. Acta Cytol 48: ‚1–2

    Google Scholar 

  25. Hartmann C, Sieberns J, Gehlhaar C et al. (2006) NF2 mutations in secretory and other rare variants of meningiomas. Brain Pathol 16: 15–19

    Article  CAS  PubMed  Google Scholar 

  26. Hasegawa Y, Hayabuchi Y, Namba I et al. (2001) Cytologic features of desmoplastic infantile ganglioglioma: a report of two cases. Acta Cytol 45: 1037–1042

    CAS  PubMed  Google Scholar 

  27. Hernandez O, Zagzag D, Kelly P et al. (2004) Cytological diagnosis of cystic brain tumors: a retrospective study of 88 cases. Diagn Cytopathol 31: 221–228

    Article  PubMed  Google Scholar 

  28. Herrlinger U (1999) Primary CNS lymphoma: findings outside the brain J Neurooncol 43: 227–230

    Article  CAS  PubMed  Google Scholar 

  29. Hinton DR, Kovacs K, Chandrasoma PT (1999) Cytologic features of secretory meningioma. Acta Cytol 43: 121–125

    CAS  PubMed  Google Scholar 

  30. Imlay SP, Snider TE, Raab SS (1998) Clear-cell meningioma: diagnosis by fine-needle aspiration biopsy. Diagn Cytopathol 18: 131–136

    Article  CAS  PubMed  Google Scholar 

  31. Inagawa H, Ishizawa K, Shimada S et al. (2004) Cytologic features of chordoid meningioma. A case report. Acta Cytol 48: 397–401

    PubMed  Google Scholar 

  32. Jeibmann A, Hasselblatt M, Gerss J et al. (2006) Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol 65: 1069–1073

    Article  PubMed  Google Scholar 

  33. Karamitopoulou E, Perentes E, Tolnay M et al. (1998) Prognostic significance of MIB-1, p53, and bcl-2 immunoreactivity in meningiomas. Hum Pathol 29: 140–145

    Article  CAS  PubMed  Google Scholar 

  34. Katz RL, Alappattu C, Glass JP et al. (1989) Cerebrospinal fluid manifestations of the neurologic complications of human immunodeficiency virus infection. Acta Cytol 33: 233–244

    CAS  PubMed  Google Scholar 

  35. Kleihus P, Cavenee WK (2000) Pathology and genetics of tumours of the nervous system. International Agency for Research on Cancer (IARC Press), Lyon

    Google Scholar 

  36. Kobayashi S, Hirakawa E, Haba R (1999) Squash cytology of pleomorphic xanthoastrocytoma mimicking glioblastoma. A case report. Acta Cytol 43: 652–658

    CAS  PubMed  Google Scholar 

  37. Kolmel HW (1998) Cytology of neoplastic meningosis J Neurooncol 38: 121–125

    Article  CAS  PubMed  Google Scholar 

  38. Kulesza P, Tihan T, Ali SZ (2002) Myxopapillary ependymoma: cytomorphologic characteristics and differential diagnosis. Diagn Cytopathol 26: 247–250

    Article  PubMed  Google Scholar 

  39. Kumar PV, Hosseinzadeh M, Bedayat GR (2001) Cytologic findings of medulloblastoma in crush smears. Acta Cytol 45: 542–546

    CAS  PubMed  Google Scholar 

  40. Lee CC, Jiang JS, Chen ET et al. (2006) Cytologic diagnosis of a metastatic oligodendroglioma in a pleural effusion. A case report. Acta Cytol 50: 542–544

    PubMed  Google Scholar 

  41. Logrono R, Futoran RM, Hartig G et al. (1997) Olfactory neuroblastoma (esthesioneuroblastoma): appearance on fine-needle aspiration: report of a case. Diagn Cytopathol 17: 205–208

    Article  CAS  PubMed  Google Scholar 

  42. Lopez-Rios F, Alberti N, Ballestin C et al. (2000) Extracranial metastasis of a glioma: diagnosis by fine-needle aspiration and immunocytochemistry. Diagn Cytopathol 23: 43–45

    Article  CAS  PubMed  Google Scholar 

  43. Louis DN, Ohgaki H, Wiestler OD et al. (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114: 97–109

    Article  PubMed  Google Scholar 

  44. MacKenzie JM (1996) Malignant meningitis: a rational approach to cerebrospinal fluid cytology. J Clin Pathol 49: 497–499

    Article  CAS  PubMed  Google Scholar 

  45. Madhavan M, Abdullah Jafri J et al. (2005) Intraventricular squamous papillary craniopharyngioma: report of a case with intraoperative imprint cytology. Acta Cytol 49: 431–434

    PubMed  Google Scholar 

  46. McGahey BE, Moriarty AT, Nelson WA et al. (1992) Fineneedle aspiration biopsy of small round blue cell tumors of childhood. Cancer 69: 1067–1073

    Article  CAS  PubMed  Google Scholar 

  47. Mitsuhashi T, Shimizu Y, Ban S et al. (2007) Anaplastic oligodendroglioma: a case report with characteristic cytologic features, including minigemistocytes. Acta Cytol 51: 657–660

    PubMed  Google Scholar 

  48. New KC, Bulsara KR, Dodd LG et al. (2001) Fine-needle aspiration diagnosis of medulloblastoma metastatic to the pelvis. Diagn Cytopathol 24: 361–363

    Article  CAS  PubMed  Google Scholar 

  49. Odom LF, Wilson H, Cullen J et al. (1990) Significance of blasts in low-cell-count cerebrospinal fluid specimens from children with acute lymphoblastic leukemia. Cancer 66: 1748–1754

    Article  CAS  PubMed  Google Scholar 

  50. Pai RR, Kini H, Rao VS et al. (2001) Choroid plexus papilloma diagnosed by crush cytology. Diagn Cytopathol 25: 165–167

    Article  CAS  PubMed  Google Scholar 

  51. Palombini L, Vetrani A (1976) Letter: Cytologic diagnosis of ganglioneuroblastoma. Acta Cytol 20: 286–289

    CAS  PubMed  Google Scholar 

  52. Palombini L, Vetrani A, Vecchione R et al. (1982) The cytology of ganglioneuroma of fine needle aspiration smear. Acta Cytol 26: 259–260

    CAS  PubMed  Google Scholar 

  53. Park JY, Suh YL, Han J (2003) Dysembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. Acta Cytol 47: 624–629

    PubMed  Google Scholar 

  54. Parwani AV, Berman D, Burger PC et al. (2004) Gliosarcoma: cytopathologic characteristics on fine-needle aspiration (FNA) and intraoperative touch imprint. Diagn Cytopathol 30: 77–81

    Article  PubMed  Google Scholar 

  55. Parwani AV, Taylor DC, Burger PC et al. (2003) Keratinized squamous cells in fine needle aspiration of the brain. Cytopathologic correlates and differential diagnosis. Acta Cytol 47: 325–331

    PubMed  Google Scholar 

  56. Pedersen AG, Olsen J, Nasiell M (1986) Cerebrospinal fluid cytology diagnosis of meningeal carcinomatosis in patients with small-cell carcinoma of the lung. A study of interobserver and intraobserver variability. Acta Cytol 30: 648–652

    CAS  PubMed  Google Scholar 

  57. Perry A, Gutmann DH, Reifenberger G (2004) Molecular pathogenesis of meningiomas J Neurooncol 70: 183–202

    Article  PubMed  Google Scholar 

  58. Prayson RA, Fischler DF (1998) Cerebrospinal fluid cytology: an 11-year experience with 5951 specimens. Arch Pathol Lab Med 122: 47–51

    CAS  PubMed  Google Scholar 

  59. Roessler K, Dietrich W, Kitz K (2002) High diagnostic accuracy of cytologic smears of central nervous system tumors. A 15-year experience based on 4,172 patients. Acta Cytol 46: 667–674

    PubMed  Google Scholar 

  60. Salinero E, Beltran L, Costa JR (2004) Intraoperative cytologic diagnosis of chordoid meningioma. A case report. Acta Cytol 48: 259–263

    PubMed  Google Scholar 

  61. Savargaonkar P, Bhuiya T, Valderrama E et al. (2001) Scrape cytology of meningioangiomatosis: a report of two cases with diagnostic cytologic features. Acta Cytol 45: 1069–1072

    CAS  PubMed  Google Scholar 

  62. Schmidt P, Neuen-Jacob E, Blanke M et al. (1988) Primary malignant melanoblastosis of the meninges. Clinical, cytologic and neuropathologic findings in a case. Acta Cytol 32: 713–718

    CAS  PubMed  Google Scholar 

  63. Schwartz JH, Canellos GP, Young RC et al. (1975) Meningeal leukemia in the blastic phase of chronic granulocytic leukemia. Am J Med 59: 819–828

    Article  CAS  PubMed  Google Scholar 

  64. Scroggs MW, Johnston WW, Klintworth GK (1990) Intraocular tumors. A cytopathologic study. Acta Cytol 34: 401–408

    CAS  PubMed  Google Scholar 

  65. Serrano R, Rodriguez-Peralto JL, De Orbe GG et al. (2002) Intrarenal neuroblastoma diagnosed by fine-needle aspiration: a report of two cases. Diagn Cytopathol 27: 294–297

    Article  PubMed  Google Scholar 

  66. Shakoor KA (1989) Fine needle aspiration cytology in advanced pediatric tumors. Pediatr Pathol 9: 713–718

    Article  CAS  PubMed  Google Scholar 

  67. Sidawy MK, Jannotta FS (1997) Intraoperative cytologic diagnosis of lesions of the central nervous system. Am J Clin Pathol 108: S56–66

    CAS  PubMed  Google Scholar 

  68. Silverman JF, Berns LA, Holbrook CT et al. (1992) Fine needle aspiration cytology of primitive neuroectodermal tumors. A report of these cases. Acta Cytol 36: 541–550

    CAS  PubMed  Google Scholar 

  69. Smith AR, Elsheikh TM, Silverman JF (1999) Intraoperative cytologic diagnosis of suprasellar and sellar cystic lesions. Diagn Cytopathol 20: 137–147

    Article  CAS  PubMed  Google Scholar 

  70. Sugita Y, Tokunaga O, Morimatsu M et al. (2004) Cytodiagnosis of central neurocytoma in intraoperative preparations. Acta Cytol 48: 194–198

    PubMed  Google Scholar 

  71. Takei H, Bhattacharjee MB, Adesina AM (2006) Chordoid glioma of the third ventricle: Report of a case with cytologic features and utility during intraoperative consultation. Acta Cytol 50: 691–696

    PubMed  Google Scholar 

  72. Takei H, Dauser RC, Adesina AM (2007) Cytomorphologic characteristics, differential diagnosis and utility during intraoperative consultation for medulloblastoma. Acta Cytol 51: 183–192

    PubMed  Google Scholar 

  73. Taylor SR, Nunez C (1984) Fine-needle aspiration biopsy in a pediatric population. Report of 64 consecutive cases. Cancer 54: 1449–1453

    Article  CAS  PubMed  Google Scholar 

  74. Tihan T, Vohra P, Berger MS et al. (2006) Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspective J Neurooncol 76: 175–183

    Article  PubMed  Google Scholar 

  75. Vick WW, Wikstrand CJ, Bullard DE et al. (1987) The use of a panel of monoclonal antibodies in the evaluation of cytologic specimens from the central nervous system. Acta Cytol 31: 815–824

    CAS  PubMed  Google Scholar 

  76. Wieczorek V, Greger J (1965) Erfahrungen mit der Liquorzelldiagnostik. Eine Analyse von etwa 5000 liquorzytologischen Untersuchungen. Psychiatr Neurol (Basel) 150: 104–117

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Pathologie, Universitätsspital Basel, Schönbeinstrasse 40, 4031, Basel, Schweiz

    Lukas Bubendorf, Georg E. Feichter, Ellen C. Obermann & Peter Dalquen

Authors
  1. Lukas Bubendorf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Georg E. Feichter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ellen C. Obermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peter Dalquen
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Pathologie, Konsultationszentrum für Pankreas- und Endokrine Tumore, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    Günter Klöppel

  2. Zentrum Pathologie und Rechtsmedizin, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Hans H. Kreipe

  3. Institut für Pathologie, Kliniken der Landeshauptstadt, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland

    Wolfgang Remmele

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bubendorf, L., Feichter, G., Obermann, E., Dalquen, P. (2011). Zentralnervensystem. In: Klöppel, G., Kreipe, H., Remmele, W. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04562-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-04562-2_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04561-5

  • Online ISBN: 978-3-642-04562-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation