Zusammenfassung
Das Kapitel behandelt, ausgehend von der WHO-Klassifikation, die ganze Pathologie der soliden und zystischen Tumoren des Pankreas mit Ausnahme der neuroendokrinen Neoplasien, die im Band zur Pathologie des Urogenitale, der endokrinen Organe, der Gelenke und der Knochen zur Sprache kommen. Bei den soliden Tumoren werden umfassend das sporadische und familiäre duktale Adenokarzinom (mitsamt seiner PanIN-Vorläuferläsionen), das Azinuszellkarzinom und die solide pseudopapilläre Neoplasie besprochen. Bei den zystischen Tumoren stehen die immer wichtiger und wegen ihrer verbesserten radiologischen Identifizierung immer häufiger werdenden intraduktalen Neoplasien an erster Stelle, gefolgt von den muzinös- und serös-zystischen Neoplasien. Den Abschluss bilden seltene und ungewöhnliche Neoplasien sowie tumorartige Läsionen wie die autoimmune Pankreatitis. Bei allen Tumoren wird auf die gegenwärtigen Therapieformen und Prognoseparameter sowie auf die molekulare Genetik im Hinblick auf die diagnostische Charakterisierung und mögliche therapeutische Bedeutung eingegangen.
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Literatur
Cancer Genome Atlas Research Network (2017) Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell 32:185–203
Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M, Cameron JL, Wu TT, Hruban RH (2002) Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol 160:1361–1369
Abraham SC, Wu TT, Hruban RH, Lee JH, Yeo CJ, Conlon K, Brennan M, Cameron JL, Klimstra DS (2002) Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol 160:953–962
Abraham SC, Wu TT, Klimstra DS, Finn LS, Lee JH, Yeo CJ, Cameron JL, Hruban RH (2001) Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas: frequent alterations in the APC/beta-catenin pathway and chromosome 11p. Am J Pathol 159:1619–1627
Adsay NV (2007) Cystic lesions of the pancreas. Mod Pathol 20(Suppl 1):S71–S93
Adsay NV, Adair CF, Heffess CS, Klimstra DS (1996) Intraductal oncocytic papillary neoplasms of the pancreas. Am J Surg Pathol 20:980–994
Adsay NV, Andea A, Basturk O, Kilinc N, Nassar H, Cheng JD (2004) Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature. Virchows Arch 444:527–535
Adsay NV, Hasteh F, Cheng JD, Klimstra DS (2000) Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts. Semin Diagn Pathol 17:56–65
Adsay NV, Klöppel G, Fukushima N, Offerhaus GJ, Furukawa N (2010) Intraductal neoplasms of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (Hrsg) WHO classification of tumors. WHO, Lyon, S 304–313
Adsay NV, Pierson C, Sarkar F, Abrams J, Weaver D, Conlon KC, Brennan MF, Klimstra DS (2001) Colloid (mucinous noncystic) carcinoma of the pancreas. Am J Surg Pathol 25:26–42
Adsay V, Logani S, Sarkar F, Crissman J, Vaitkevicius V (2000) Foamy gland pattern of pancreatic ductal adenocarcinoma. A deceptively benign-appearing variant. Am J Surg Pathol 24:493–504
Adsay V, Mino-Kenudson M, Furukawa T, Basturk O, Zamboni G, Marchegiani G, Bassi C, Salvia R, Malleo G, Paiella S, Wolfgang CL, Matthaei H, Offerhaus GJ, Adham M, Bruno MJ, Reid MD, Krasinskas A, Klöppel G, Ohike N, Tajiri T, Jang KT, Roa JC, Allen P, Fernandez-del Castillo C, Jang JY, Klimstra DS, Hruban RH (2016) Pathologic evaluation and reporting of intraductal papillary mucinous neoplasms of the pancreas and other tumoral intraepithelial neoplasms of pancreatobiliary tract: recommendations of Verona Consensus Meeting. Ann Surg 263:162–177
Agaimy A, Haller F, Frohnauer J, Schaefer IM, Strobel P, Hartmann A, Stoehr R, Klöppel G (2015) Pancreatic undifferentiated rhabdoid carcinoma: KRAS alterations and SMARCB1 expression status define two subtypes. Mod Pathol 28:248–260
Agaimy A, Kaiser A, Becker K, Brasen JH, Wunsch PH, Adsay NV, Klöppel G (2011) Pancreatic-type acinar cell carcinoma of the liver: a clinicopathologic study of four patients. Mod Pathol 24:1620–1626
Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Durr A, Höfler H, Klöppel G, Muller-Decker K, Brielmeier M, Esposito I (2012) Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol 226:723–734
Albores-Saavedra J, Simpson KW, Bilello SJ (2006) The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm. Am J Surg Pathol 30:1237–1242
Alguacil-Garcia A, Weiland LH (1977) The histologic spectrum, prognosis, and histogenesis of the sarcomatoid carcinoma of the pancreas. Cancer 39:1181–1189
Amato E, Molin MD, Mafficini A, Yu J, Malleo G, Rusev B, Fassan M, Antonello D, Sadakari Y, Castelli P, Zamboni G, Maitra A, Salvia R, Hruban RH, Bassi C, Capelli P, Lawlor RT, Goggins M, Scarpa A (2014) Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas. J Pathol 233:217–227
Anderloni A, Genco C, Ballare M, Carmagnola S, Battista S, Repici A (2015) A case of primary pancreatic non-Hodgkin B-cell lymphoma mimicking autoimmune pancreatitis. J Gastrointestin Liver Dis 24:245–248
Askan G, Deshpande V, Klimstra DS, Adsay V, Sigel C, Shia J, Basturk O (2016) Expression of markers of hepatocellular differentiation in pancreatic acinar cell neoplasms: a potential diagnostic pitfall. Am J Clin Pathol 146:163–169
Assifi MM, Nguyen PD, Agrawal N, Dedania N, Kennedy EP, Sauter PK, Prestipino A, Winter JM, Yeo CJ, Lavu H (2014) Non-neoplastic epithelial cysts of the pancreas: a rare, benign entity. J Gastrointest Surg 18:523–531
Atkinson BF, Ernst C, Herlyn M, Steplewski Z, Sears HF, Koprowski H (1982) Gastrointestinal cancer-associated antigen in immunoperoxidase assay. Cancer Res 42:4820–4823
Audard V, Cavard C, Richa H, Infante M, Couvelard A, Sauvanet A, Terris B, Paye F, Flejou JF (2008) Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas. Pancreas 36:80–83
Bagci P, Andea AA, Basturk O, Jang KT, Erbarut I, Adsay V (2012) Large duct type invasive adenocarcinoma of the pancreas with microcystic and papillary patterns: a potential microscopic mimic of non-invasive ductal neoplasia. Mod Pathol 25:439–448
Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, Miller DK, Christ AN, Bruxner TJ, Quinn MC, Nourse C, Murtaugh LC, Harliwong I, Idrisoglu S, Manning S, Nourbakhsh E, Wani S, Fink L, Holmes O, Chin V, Anderson MJ, Kazakoff S, Leonard C, Newell F, Waddell N, Wood S, Xu Q, Wilson PJ, Cloonan N, Kassahn KS, Taylor D, Quek K, Robertson A, Pantano L, Mincarelli L, Sanchez LN, Evers L, Wu J, Pinese M, Cowley MJ, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chantrill LA, Mawson A, Humphris J, Chou A, Pajic M, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Lovell JA, Merrett ND, Toon CW, Epari K, Nguyen NQ, Barbour A, Zeps N, Moran-Jones K, Jamieson NB, Graham JS, Duthie F, Oien K, Hair J, Grutzmann R, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Rusev B, Capelli P, Salvia R, Tortora G, Mukhopadhyay D, Petersen GM, Munzy DM, Fisher WE, Karim SA, Eshleman JR, Hruban RH, Pilarsky C, Morton JP, Sansom OJ, Scarpa A, Musgrove EA, Bailey UM, Hofmann O, Sutherland RL, Wheeler DA, Gill AJ, Gibbs RA, Pearson JV, Waddell N, Biankin AV, Grimmond SM (2016) Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 531:47–52
Baker ML, Seeley ES, Pai R, Suriawinata AA, Mino-Kenudson M, Zamboni G, Klöppel G, Longnecker DS (2012) Invasive mucinous cystic neoplasms of the pancreas. Exp Mol Pathol 93:345–349
Banville N, Geraghty R, Fox E, Leahy DT, Green A, Keegan D, Geoghegan J, O’Donoghue D, Hyland J, Sheahan K (2006) Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene. Hum Pathol 37:1498–1502
Bartsch DK, Dietzel K, Bargello M, Matthaei E, Klöppel G, Esposito I, Heverhagen JT, Gress TM, Slater EP, Langer P (2013) Multiple small “imaging” branch-duct type intraductal papillary mucinous neoplasms (IPMNs) in familial pancreatic cancer: indicator for concomitant high grade pancreatic intraepithelial neoplasia? Fam Cancer 12:89–96
Bartsch DK, Kress R, Sina-Frey M, Grutzmann R, Gerdes B, Pilarsky C, Heise JW, Schulte KM, Colombo-Benkmann M, Schleicher C, Witzigmann H, Pridohl O, Ghadimi MB, Horstmann O, von Bernstorff W, Jochimsen L, Schmidt J, Eisold S, Estevez-Schwarz L, Hahn SA, Schulmann K, Bock W, Gress TM, Zugel N, Breitschaft K, Prenzel K, Messmann H, Endlicher E, Schneider M, Ziegler A, Schmiegel W, Schafer H, Rothmund M, Rieder H (2004) Prevalence of familial pancreatic cancer in Germany. Int J Cancer 110:902–906
Basturk O, Adsay V, Askan G, Dhall D, Zamboni G, Shimizu M, Cymes K, Carneiro F, Balci S, Sigel C, Reid MD, Esposito I, Baldaia H, Allen P, Klöppel G, Klimstra DS (2017) Intraductal tubulopapillary neoplasm of the pancreas: a clinicopathologic and immunohistochemical analysis of 33 cases. Am J Surg Pathol 41:313–325
Basturk O, Chung SM, Hruban RH, Adsay NV, Askan G, Iacobuzio-Donahue C, Balci S, Zee SY, Memis B, Shia J, Klimstra DS (2016) Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas. Virchows Arch 469:523–532
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Kloppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T (2015) A revised classification system and recommendations from the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas. Am J Surg Pathol 39:1730–1741
Basturk O, Tan M, Bhanot U, Allen P, Adsay V, Scott SN, Shah R, Berger MF, Askan G, Dikoglu E, Jobanputra V, Wrzeszczynski KO, Sigel C, Iacobuzio-Donahue C, Klimstra DS (2016) The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. Mod Pathol 29:1058–1069
Basturk O, Zamboni G, Klimstra DS, Capelli P, Andea A, Kamel NS, Adsay NV (2007) Intraductal and papillary variants of acinar cell carcinomas – a new addition to the challenging differential diagnosis of intraductal neoplasms. Am J Surg Pathol 31:363–370
Bätge B, Bosslet K, Sedlacek HH, Kern HF, Klöppel G (1986) Monoclonal antibodies against CEA-related components discriminate between pancreatic duct type carcinomas and nonneoplastic duct lesions as well as nonduct type neoplasias. Virchows Arch A Pathol Anat Histol 408:361–374
Becker AE, Hernandez YG, Frucht H, Lucas AL (2014) Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection. World J Gastroenterol 20:11182–11198
Becker V, Doerr W, Seifert G, Uehlinger E (1973) Bauchspeicheldrüse (Inselapparat ausgenommen). Springer, Berlin
Benjamin E, Wright DH (1980) Adenocarcinoma of the pancreas of childhood: a report of two cases. Histopathology 4:87–104
Berg JW, Connelly RR (1979) Updating the epidemiologic data on pancreatic cancer. Semin Oncol 6:275–283
Bergmann F, Aulmann S, Sipos B, Kloor M, von Heydebreck A, Schweipert J, Harjung A, Mayer P, Hartwig W, Moldenhauer G, Capper D, Dyckhoff G, Freier K, Herpel E, Schleider A, Schirmacher P, Mechtersheimer G, Klöppel G, Bläker H (2014) Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases. Virchows Arch 465:661–672
Bergmann F, Esposito I, Michalski CW, Herpel E, Friess H, Schirmacher P (2007) Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution. Am J Surg Pathol 31:1919–1925
Bismar TA, Basturk O, Gerald WL, Schwarz K, Adsay NV (2004) Desmoplastic small cell tumor in the pancreas. Am J Surg Pathol 28:808–812
WHO classification of Tumours Editorial Board. Digestive system tumours. IARC 2019. http://publications.iarc.fr/579
Boyd CA, Benarroch-Gampel J, Sheffield KM, Cooksley CD, Riall TS (2012) 415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival. J Surg Res 174:12–19
Branchi V, Lingohr P, Willinek WA, Bolke E, Semaan A, Zhou H, Kristiansen G, Klöppel G, Kalff JC, Schafer N, Matthaei H (2015) Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified? Eur J Med Res 20:26
Brody JR, Costantino CL, Potoczek M, Cozzitorto J, McCue P, Yeo CJ, Hruban RH, Witkiewicz AK (2009) Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma. Mod Pathol 22:651–659
Brune K, Abe T, Canto M, O’Malley L, Klein AP, Maitra A, Adsay NV, Fishman EK, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH (2006) Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer. Am J Surg Pathol 30:1067–1076
Bubendorf L, Feichter GE, Obermann EC, Dalquen P (2011) Zytopathologie. In: Remmele W (Hrsg) Pathologie, 3. Aufl. Springer, Berlin, S 397 (Kapitel 18)
Buchino JJ, Castello FM, Nagaraj HS (1984) Pancreatoblastoma. A histochemical and ultrastructural analysis. Cancer 53:963–969
Burns WA, Matthews MJ, Hamosh M, Vander Weide G, Blum R, Johnson FB (1974) Lipase secreting acinar cell carcinoma of the pancreas with polyarthropathy – a light and electron microscopic, histochemical and biochemical study. Cancer 33:1002–1009
Cao W, Adley BP, Liao J, Lin X, Talamonti M, Bentrem DJ, Rao SM, Yang GY (2010) Mucinous nonneoplastic cyst of the pancreas: apomucin phenotype distinguishes this entity from intraductal papillary mucinous neoplasm. Hum Pathol 41:513–521
Chang X, Jiang Y, Li J, Chen J (2014) Intraductal tubular adenomas (pyloric gland-type) of the pancreas: clinicopathologic features are similar to gastric-type intraductal papillary mucinous neoplasms and different from intraductal tubulopapillary neoplasms. Diagn Pathol 9:172
Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D (2015) Early detection of sporadic pancreatic cancer: summative review. Pancreas 44:693–712
Chatterjee D, Katz MH, Rashid A, Varadhachary GR, Wolff RA, Wang H, Lee JE, Pisters PW, Vauthey JN, Crane C, Gomez HF, Abbruzzese JL, Fleming JB, Wang H (2012) Histologic grading of the extent of residual carcinoma following neoadjuvant chemoradiation in pancreatic ductal adenocarcinoma: a predictor for patient outcome. Cancer 118:3182–3190
Chatterjee D, Katz MH, Rashid A, Wang H, Iuga AC, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Crane CH, Gomez HF, Abbruzzese JL, Fleming JB, Wang H (2012) Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma. Am J Surg Pathol 36:409–417
Chen J, Baithun SI (1985) Morphological study of 391 cases of exocrine pancreatic tumours with special reference to the classification of exocrine pancreatic carcinoma. J Pathol 146:17–29
Chetty R, Serra S (2009) Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm. Histopathology 55:270–276
Cingolani N, Shaco-Levy R, Farruggio A, Klimstra DS, Rosai J (2000) Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: study of five cases, one arising in a mediastinal teratoma. Hum Pathol 31:938–944
Compagno J, Oertel JE (1978) Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol 69:289–298
Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Becouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardiere C, Bennouna J, Bachet JB, Khemissa-Akouz F, Pere-Verge D, Delbaldo C, Assenat E, Chauffert B, Michel P, Montoto-Grillot C, Ducreux M (2011) FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 364:1817–1825
Crippa S, Fernandez-Del Castillo C, Salvia R, Finkelstein D, Bassi C, Dominguez I, Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY, Partelli S, Pederzoli P, Warshaw AL (2010) Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol Hepatol 8:213–219
Cubilla AL, Fitzgerald PJ, Fortner JG (1978) Pancreas cancer – duct cell adenocarcinoma: survival in relation to site, size, stage and type of therapy. J Surg Oncol 10:465–482
Cubilla AL, Fitzgerald PJ, Hartmann WH, Sobin LH (1984) Tumors of the exocrine pancreas. AFIP Atlas of Tumor Pathology, second series, fascicle 19. Armed Forces Institute of Pathology, Washington
Cubilla AL, Fortner JG, Fitzgerald PJ (1978) Lymph node involvement in carcinoma of the head of the pancreas area. Cancer 41:880–887
Daum O, Klecka J, Ferda J, Treska V, Vanacek T, Sima R, Mukensnabl P, Michal M (2005) Gastrointestinal stromal tumor of the pancreas: case report with documentation of KIT gene mutation. Virchows Arch 446:470–472
de Alava E, Torramade J, Vazquez JJ (1993) Leiomyosarcoma of the pancreas. Virchows Arch A Pathol Anat Histol 422:419–422
de Mestier L, Danset JB, Neuzillet C, Rebours V, Cros J, Soufir N, Hammel P (2016) Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers. Endocr Relat Cancer 23:T57–T67
de Wilde RF, Ottenhof NA, Jansen M, Morsink FH, de Leng WW, Offerhaus GJ, Brosens LA (2011) Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma. Mod Pathol 24:1229–1236
Del Chiaro M, Verbeke C, Salvia R, Kloppel G, Werner J, McKay C, Friess H, Manfredi R, Van Cutsem E, Lohr M, Segersvard R, European Study Group on Cystic Tumours of the Pancreas (2013) European experts consensus statement on cystic tumours of the pancreas. Dig Liver Dis 45:703–711
Deshpande V, Oliva E, Young RH (2010) Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas. Am J Surg Pathol 34:1514–1520
Drut R, Jones MC (1988) Congenital pancreatoblastoma in Beckwith-Wiedemann syndrome: an emerging association. Pediatr Pathol 8:331–339
Dworak O, Wittekind C, Koerfgen HP, Gall FP (1993) Osteoclastic giant cell tumor of the pancreas. An immunohistological study and review of the literature. Pathol Res Pract 189:228–231
Egawa N, Maillet B, Schröder S, Foulis A, Mukai K, Klöppel G (1994) Serous oligocystic and ill-demarcated adenoma of the pancreas: a variant of serous cystic adenoma. Virchows Arch 424:13–17
Esposito I, Bauer A, Hoheisel JD, Kleeff J, Friess H, Bergmann F, Rieker RJ, Otto HF, Klöppel G, Penzel R (2004) Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity? Virchows Arch 444:447–453
Esposito I, Kleeff J, Bergmann F, Reiser C, Herpel E, Friess H, Schirmacher P, Buchler MW (2008) Most pancreatic cancer resections are R1 resections. Ann Surg Oncol 15:1651–1660
Esposito I, Konukiewitz B, Schlitter AM, Klöppel G (2014) Pathology of pancreatic ductal adenocarcinoma: facts, challenges and future developments. World J Gastroenterol 20:13833–13841
Esposito ISA, Steiger K, Klöppel G (2015) Pathology, genetics and precursors of human and experimental pancreatic neoplasms: an update. Pancreatology 15:598–610
Esposito I, Schlitter AM, Sipos B, Klöppel G (2015) Classification and malignant potential of pancreatic cystic tumors. Pathologe 36:99–112 (quiz 113–114)
Esposito I, Segler A, Steiger K, Klöppel G (2015) Pathology, genetics and precursors of human and experimental pancreatic neoplasms: an update. Pancreatology 15:598–610
Ettrich TJ, Perkhofer L, Seufferlein T (2015) Therapy in pancreatic cancer – and still it moves along! Dtsch Med Wochenschr 140:508–511
Evans DB, Rich TA, Byrd DR, Cleary KR, Connelly JH, Levin B, Charnsangavej C, Fenoglio CJ, Ames FC (1992) Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch Surg 127:1335–1339
Fallahzadeh MK, Zibari GB, Wellman G, Abdehou ST, Shokouh-Amiri H (2014) Mucinous cystic neoplasm of pancreas in a male patient: a case report and review of the literature. J State Med Soc 166:67–69
Fendrich V, Langer P, Bartsch DK (2014) Familial pancreatic cancer – status quo. Int J Colorectal Dis 29:139–145
Fischer HP, Altmannsberger M, Kracht J (1988) Osteoclast-type giant cell tumour of the pancreas. Virchows Arch A Pathol Anat Histol 412:247–253
Fischer LK, Katz MH, Lee SM, Liu L, Wang H, Varadhachary GR, Wolff RA, Lee JE, Maitra A, Roland CL, Fleming JB, Estrella J, Rashid A, Wang H (2016) The number and ratio of positive lymph nodes affect pancreatic cancer patient survival after neoadjuvant therapy and pancreaticoduodenectomy. Histopathology 68:210–220
Fitzgerald PJ, Cubilla A, Henson DE, Albores-Saavedra J (1986) Pancreas: the pathology of incipient neoplasia. Saunders, Philadelphia, S 217–231
Fukushima N, Zamboni G (2014) Mucinous cystic neoplasms of the pancreas: update on the surgical pathology and molecular genetics. Semin Diagn Pathol 31:467–474
Furlan D, Sahnane N, Bernasconi B, Frattini M, Tibiletti MG, Molinari F, Marando A, Zhang L, Vanoli A, Casnedi S, Adsay V, Notohara K, Albarello L, Asioli S, Sessa F, Capella C, La Rosa S (2014) APC alterations are frequently involved in the pathogenesis of acinar cell carcinoma of the pancreas, mainly through gene loss and promoter hypermethylation. Virchows Arch 464:553–564
Furukawa T, Klöppel G, Volkan AN, Albores-Saavedra J, Fukushima N, Horii A, Hruban RH, Kato Y, Klimstra DS, Longnecker DS, Lüttges J, Offerhaus GJ, Shimizu M, Sunamura M, Suriawinata A, Takaori K, Yonezawa S (2005) Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 447:794–799
Furukawa T, Sakamoto H, Takeuchi S, Ameri M, Kuboki Y, Yamamoto T, Hatori T, Yamamoto M, Sugiyama M, Ohike N, Yamaguchi H, Shimizu M, Shibata N, Shimizu K, Shiratori K (2015) Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas. Sci Rep 5:8829
Garcia-Carracedo D, Chen ZM, Qiu W, Huang AS, Tang SM, Hruban RH, Su GH (2014) PIK3CA mutations in mucinous cystic neoplasms of the pancreas. Pancreas 43:245–249
Gaujoux S, Brennan MF, Gonen M, D’Angelica MI, DeMatteo R, Fong Y, Schattner M, DiMaio C, Janakos M, Jarnagin WR, Allen PJ (2011) Cystic lesions of the pancreas: changes in the presentation and management of 1,424 patients at a single institution over a 15-year time period. J Am Coll Surg 212:590–600 (discussion 600–603)
Gaujoux S, Tang L, Klimstra D, Gonen M, Brennan MF, D’Angelica M, DeMatteo R, Fong Y, Jarnagin W, Allen PJ (2012) The outcome of resected cystic pancreatic endocrine neoplasms: a case-matched analysis. Surgery 151:518–525
George DH, Murphy F, Michalski R, Ulmer BG (1989) Serous cystadenocarcinoma of the pancreas: a new entity? Am J Surg Pathol 13:61–66
Goggins M, Offerhaus GJ, Hilgers W, Griffin CA, Shekher M, Tang D, Sohn TA, Yeo CJ, Kern SE, Hruban RH (1998) Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 152:1501–1507
Goldstein D, El-Maraghi RH, Hammel P, Heinemann V, Kunzmann V, Sastre J, Scheithauer W, Siena S, Tabernero J, Teixeira L, Tortora G, Van Laethem JL, Young R, Penenberg DN, Lu B, Romano A, Von Hoff DD (2015) </i>nab</i>-Paclitaxel plus gemcitabine for metastatic pancreatic cancer: long-term survival from a phase III trial. J Natl Cancer Inst 107:1–10
Hammel PR, Vilgrain V, Terris B, Penfornis A, Sauvanet A, Correas JM, Chauveau D, Balian A, Beigelman C, O’Toole D, Bernades P, Ruszniewski P, Richard S (2000) Pancreatic involvement in von Hippel-Lindau disease. Gastroenterology 119:1087–1095
Hoorens A, Gebhard F, Kraft K, Lemoine NR, Klöppel G (1994) Pancreatoblastoma in an adult: its separation from acinar cell carcinoma. Virchows Arch 424:485–490
Hoorens A, Lemoine NR, McLellan E, Morohoshi T, Kamisawa T, Heitz PU, Stamm B, Rüschoff J, Wiedenmann B, Klöppel G (1993) Pancreatic acinar cell carcinoma. An analysis of cell lineage markers, p53 expression, and Ki-ras mutation. Am J Pathol 143:685–698
Hoorens A, Prenzel K, Lemoine NR, Klöppel G (1998) Undifferentiated carcinoma of the pancreas: analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin. J Pathol 185:53–60
Horie A, Yano Y, Kotoo Y, Miwa A (1977) Morphogenesis of pancreatoblastoma, infantile carcinoma of the pancreas. Report of two cases. Cancer 39:247–254
Hosoda W, Sasaki E, Murakami Y, Yamao K, Shimizu Y, Yatabe Y (2015) GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas. Virchows Arch 466:665–674
Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, Kern SE, Klimstra DS, Klöppel G, Longnecker DS, Lüttges J, Offerhaus GJA (2001) Pancreatic intraepithelial neoplasia. A new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol 25:579–586
Hruban RH, Iacobuzio-Donahue C, Wilentz RE, Goggins M, Kern SE (2001) Molecular pathology of pancreatic cancer. Cancer J 7:251–258
Hruban RH, Klimstra DS (2014) Adenocarcinoma of the pancreas. Semin Diagn Pathol 31:443–451
Hruban RH, Klöppel G, Offerhaus GJ (2014) Pancreatic cancer. International Agency for Research on Cancer, Lyon
Hruban RH, Pitman MB, Klimstra DS (2007) Tumors of the pancreas. AFIP Atlas of Tumor Pathology, fourth series, fascicle 6. American Registry of Pathology, Washington
Ishii S, Kobayashi G, Fujita N, Noda Y, Ito K, Horaguchi J, Koshita S, Kanno Y, Ogawa T, Masu K, Hashimoto S, Sawai T, Uzuki M (2012) Undifferentiated carcinoma of the pancreas involving intraductal pedunculated polypoid growth. Intern Med 51:3373–3377
Ishikawa O, Ishiguro S, Ohhigashi H, Sasaki Y, Yasuda T, Imaoka S, Iwanaga T, Nakaizumi A, Fukita M, Wada A (1990) Solid and papillary neoplasm arising from an ectopic pancreas in the mesocolon. Am J Gastroenterol 85:597–601
Ishikawa O, Matsui Y, Aoki I, Iwanaga T, Terasawa T, Wada A (1980) Adenosquamous carcinoma of the pancreas: a clinicopathologic study and report of three cases. Cancer 46:1192–1196
Ishikawa O, Matsui Y, Aoki Y, Iwanaga T, Terasawa T, Wada A (1981) Leiomyosarcoma of the pancreas. Report of a case and review of the literature. Am J Surg Pathol 5:597–602
Jais B, Rebours V, Malleo G, Salvia R, Fontana M, Maggino L, Bassi C, Manfredi R, Moran R, Lennon AM, Zaheer A, Wolfgang C, Hruban R, Marchegiani G, Fernandez Del Castillo C, Brugge W, Ha Y, Kim MH, Oh D, Hirai I, Kimura W, Jang JY, Kim SW, Jung W, Kang H, Song SY, Kang CM, Lee WJ, Crippa S, Falconi M, Gomatos I, Neoptolemos J, Milanetto AC, Sperti C, Ricci C, Casadei R, Bissolati M, Balzano G, Frigerio I, Girelli R, Delhaye M, Bernier B, Wang H, Jang KT, Song DH, Huggett MT, Oppong KW, Pererva L, Kopchak KV, Del Chiaro M, Segersvard R, Lee LS, Conwell D, Osvaldt A, Campos V, Aguero Garcete G, Napoleon B, Matsumoto I, Shinzeki M, Bolado F, Fernandez JM, Keane MG, Pereira SP, Acuna IA, Vaquero EC, Angiolini MR, Zerbi A, Tang J, Leong RW, Faccinetto A, Morana G, Petrone MC, Arcidiacono PG, Moon JH, Choi HJ, Gill RS, Pavey D, Ouaissi M, Sastre B, Spandre M, De Angelis CG, Rios-Vives MA, Concepcion-Martin M, Ikeura T, Okazaki K, Frulloni L, Messina O, Levy P (2015) Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). Gut 65:305–312
Jang KT, Park SM, Basturk O, Bagci P, Bandyopadhyay S, Stelow EB, Walters DM, Choi DW, Choi SH, Heo JS, Sarmiento JM, Reid MD, Adsay V (2015) Clinicopathologic characteristics of 29 invasive carcinomas arising in 178 pancreatic mucinous cystic neoplasms with ovarian-type stroma: implications for management and prognosis. Am J Surg Pathol 39:179–187
Jiao Y, Yonescu R, Offerhaus GJ, Klimstra DS, Maitra A, Eshleman JR, Herman JG, Poh W, Pelosof L, Wolfgang CL, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N, Wood LD (2014) Whole-exome sequencing of pancreatic neoplasms with acinar differentiation. J Pathol 232:428–435
Kalimuthu SN, Serra S, Dhani N, Chetty R (2016) The spectrum of histopathological changes encountered in pancreatectomy specimens after neoadjuvant chemoradiation, including subtle and less-well-recognised changes. J Clin Pathol 69:463–471
Kamei K, Funabiki T, Ochiai M, Amano H, Kasahara M, Sakamoto T (1991) Multifocal pancreatic serous cystadenoma with atypical cells and focal perineural invasion. Int J Pancreatol 10:161–172
Kanda M, Matthaei H, Wu J, Hong SM, Yu J, Borges M, Hruban RH, Maitra A, Kinzler K, Vogelstein B, Goggins M (2012) Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology 142:730–733.e9
Kang CM, Choi SH, Kim SC, Lee WJ, Choi DW, Kim SW (2014) Predicting recurrence of pancreatic solid pseudopapillary tumors after surgical resection: a multicenter analysis in Korea. Ann Surg 260:348–355
Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, Masamune A, Asakura T, Shimosegawa T (2010) Prediction of invasive carcinoma in branch type intraductal papillary mucinous neoplasms of the pancreas. J Gastroenterol 45:952–959
Kardon DE, Thompson LD, Przygodzki RM, Heffess CS (2001) Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases. Mod Pathol 14:443–451
Kato O, Hattori K, Matsuyama M, Yoshizaki S (1982) Neurofibroma of the pancreas: differentiation from carcinoma. Am J Gastroenterol 77:630–632
Kekis PB, Murtin C, Künzli BM, Kappler A, Buchholz B, Büchler MW, Zimmermann A, Friess H (2004) Epstein-Barr virus-associated lymphoepithelial carcinoma in the pancreas. Pancreas 28:98–102
Kelly PJ, Shinagare S, Sainani N, Hong X, Ferrone C, Yilmaz O, Fernandez-del Castillo C, Lauwers GY, Deshpande V (2012) Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma. Am J Surg Pathol 36:696–701
Kern HF, Röher HD, von Bülow M, Klöppel G (1987) Fine structure of three major grades of malignancy of human pancreatic adenocarcinoma. Pancreas 2:2–13
Khayyata S, Basturk O, Adsay NV (2005) Invasive micropapillary carcinomas of the ampullo-pancreatobiliary region and their association with tumor-infiltrating neutrophils. Mod Pathol 18:1504–1511
Kim JY, Song JS, Park H, Byun JH, Song KB, Kim KP, Kim SC, Hong SM (2014) Primary mesenchymal tumors of the pancreas: single-center experience over 16 years. Pancreas 43:959–968
Kim SA, Kim MS, Kim MS, Kim SC, Choi J, Yu E, Hong SM (2014) Pleomorphic solid pseudopapillary neoplasm of the pancreas: degenerative change rather than high-grade malignant potential. Hum Pathol 45:166–174
Kim YS, Cho JH (2015) Rare nonneoplastic cysts of pancreas. Clin Endosc 48:31–38
Klibansky DA, Reid-Lombardo KM, Gordon SR, Gardner TB (2012) The clinical relevance of the increasing incidence of intraductal papillary mucinous neoplasm. Clin Gastroenterol Hepatol 10:555–558
Klimstra DS, Heffess CS, Oertel JE, Rosai J (1992) Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. Am J Surg Pathol 16:815–837
Klimstra DS, Lonardo F (1997) Microglandular carcinoma of the pancreas. Am J Clin Pathol 107:711–713
Klimstra DS, Rosai J, Heffess CS (1994) Mixed acinar-endocrine carcinomas of the pancreas. Am J Surg Pathol 18:765–778
Klimstra DS, Wenig BM, Adair CF, Heffess CS (1995) Pancreatoblastoma. A clinicopathologic study and review of the literature. Am J Surg Pathol 19:1371–1389
Klöppel G (1984) Pancreatic, non-endocrine tumours. Churchill Livingstone, Edinburgh
Klöppel G (1998) Clinicopathologic view of intraductal papillary-mucinous tumor of the pancreas. Hepatogastroenterology 45:1981–1985
Klöppel G (2000) Pseudocysts and other non-neoplastic cysts of the pancreas. Semin Diagn Pathol 17:7–15
Klöppel G, Adsay NV (2009) Chronic pancreatitis and the differential diagnosis versus pancreatic cancer. Arch Pathol Lab Med 133:382–387
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I (2014) Intraductal neoplasms of the pancreas. Semin Diagn Pathol 31:452–466
Klöppel G, Bommer G, Rückert K, Seifert G (1980) Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis. Virchows Arch A Pathol Anat Histol 387:221–233
Klöppel G, Lingenthal G, von Bülow M, Kern HF (1985) Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: studies in xenografted tumours and clinico-histopathologic correlation in a series of 75 cases. Histopathology 9:841–856
Klöppel G, Maurer R, Hofmann E, Luthold K, Oscarson J, Forsby N, Ihse I, Ljungberg O, Heitz PU (1991) Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: report of two patients. Virchows Arch A Pathol Anat Histopathol 418:179–183
Klöppel G, Morohoshi T, John HD, Oehmichen W, Opitz K, Angelkort A, Lietz H, Rückert K (1981) Solid and cystic acinar cell tumour of the pancreas. A tumour in young women with favourable prognosis. Virchows Arch A Pathol Anat Histol 392:171–183
Klöppel G, Sosnowski J, Eichfuß HP, Rückert K, Klapdor R (1979) Aktuelle Aspekte des Pankreaskarzinoms. Klinische und morphologische Analysen zur Diagnostic und Therapie. Dtsch Med Wochenschr 104:1801–1805
Robert-Koch-Institut (2013) Krebs in Deutschland. RKI, Berlin
Konigsrainer I, Glatzle J, Klöppel G, Konigsrainer A, Wehrmann M (2008) Intraductal and cystic tubulopapillary adenocarcinoma of the pancreas – a possible variant of intraductal tubular carcinoma. Pancreas 36:92–95
Konukiewitz B, Jesinghaus M, Steiger K, Schlitter AM, Kasajima A, Sipos B, Zamboni G, Weichert W, Pfarr N, Klöppel G (2018) Pancreatic neuroendocrine carcinomas reveal a closer relationship to ductal adenocarcinomas than to neuroendocrine tumors G3. Hum Pathol 77:70–79
Kosmahl M, Egawa N, Schröder S, Carneiro F, Lüttges J, Klöppel G (2002) Mucinous nonneoplastic cyst of the pancreas: a novel nonneoplastic cystic change? Mod Pathol 15:154–158
Kosmahl M, Pauser U, Anlauf M, Klöppel G (2005) Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform. Mod Pathol 18:1157–1164
Kosmahl M, Pauser U, Peters K, Sipos B, Luttges J, Kremer B, Kloppel G (2004) Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch 445:168–178
Kosmahl M, Seada LS, Jänig U, Harms D, Klöppel G (2000) Solid-pseudopapillary tumor of the pancreas: its origin revisited. Virchows Arch 436:473–480
Kosmahl M, Wagner J, Peters K, Sipos B, Klöppel G (2004) Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol 28:339–346
Krasinskas AM, Moser AJ, Saka B, Adsay NV, Chiosea SI (2013) KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas. Mod Pathol 26:1346–1354
Kroft SH, Stryker SJ, Winter JN, Ergun G, Rao MS (1995) Inflammatory pseudotumor of the pancreas. Int J Pancreatol 18:277–283
Kuerer H, Shim H, Pertsemlidis D, Unger P (1997) Functioning pancreatic acinar cell carcinoma: immunohistochemical and ultrastructural analyses. Am J Clin Oncol 20:101–107
La Rosa S, Adsay V, Albarello L, Asioli S, Casnedi S, Franzi F, Marando A, Notohara K, Sessa F, Vanoli A, Zhang L, Capella C (2012) Clinicopathologic study of 62 acinar cell carcinomas of the pancreas: insights into the morphology and immunophenotype and search for prognostic markers. Am J Surg Pathol 36:1782–1795
Laffan TA, Horton KM, Klein AP, Berlanstein B, Siegelman SS, Kawamoto S, Johnson PT, Fishman EK, Hruban RH (2008) Prevalence of unsuspected pancreatic cysts on MDCT. Am J Roentgenol 191:802–807
Lemaire J, Delaunoit T, Molle G (2014) Adenocarcinoma arising in gastric heterotopic pancreas. Case report and review of the literature. Acta Chir Belg 114:79–81
Lewandrowski K, Warshaw A, Compton C (1992) Macrocystic serous cystadenoma of the pancreas: a morphologic variant differing from microcystic adenoma. Hum Pathol 23:871–875
Lin MY, Stabile BE (2010) Solid pseudopapillary neoplasm of the pancreas: a rare and atypically aggressive disease among male patients. Am Surg 76:1075–1078
Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo WC, Zuo M, Valasek MA, Javle M, Wilkinson MF, Lu Y (2014) The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma. Nat Med 20:596–598
Longnecker DS (1983) Carcinogenesis in the pancreas. Arch Pathol Lab Med 107:54–58
Longnecker DS, Adler G, Hruban RH, Klöppel G (2000) Intraductal papillary-mucinous neoplasms of the pancreas. Tumors of the exocrine pancreas. In: Hamilton SR, Aaltonen LA (Hrsg) Pathology and genetics of tumours of the digestive system. IARC, Lyon, S 237–240
Lowenfels AB, Maisonneuve P, Büchler MW, Friess H, Uhl W, Malfertheiner P (2002) Epidemiology of chronic pancreatitis and the risk of cancer. Chronic pancreatitis. Novel concepts in biology and therapy. Blackwell Science, Oxford, S 29–36
Lüttges J, Feyerabend B, Buchelt T, Pacena M, Klöppel G (2002) The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 26:466–471
Lüttges J, Galehdari H, Brocker V, Schwarte-Waldhoff I, Henne-Bruns D, Klöppel G, Schmiegel W, Hahn SA (2001) Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis. Am J Pathol 158:1677–1683
Lüttges J, Mentzel T, Hübner G, Klöppel G (1999) Solitary fibrous tumour of the pancreas: a new member of the small group of mesenchymal pancreatic tumours. Virchows Arch 435:37–42
Lüttges J, Pierré E, Zamboni G, Weh G, Lietz H, Kussmann J, Klöppel G (1997) Maligne nicht-epitheliale Tumoren des Pankreas. Pathologe 18:233–237
Lüttges J, Reinecke-Lüthge A, Möllmann B, Menke MAOH, Clemens A, Klimpfinger M, Sipos B, Klöppel G (1999) Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution. Virchows Arch 435:461–468
Lüttges J, Stigge C, Pacena M, Klöppel G (2004) Rare ductal adenocarcinoma of the pancreas in patients younger than age 40 years. An analysis of its features and a literature review. Cancer 100:173–182
Lüttges J, Zamboni G, Klöppel G (1999) Recommendation for the examination of pancreaticoduodenectomy specimens removed from patients with carcinoma of the exocrine pancreas. A proposal for a standardized pathological staging of pancreaticoduodenectomy specimens including a checklist. Dig Surg 16:291–296
Macin G, Hekimoglu K, Uner H, Tarhan C (2014) Pancreatic cystic lymphangioma: diagnostic approach with MDCT and MR imaging. J Belg Radiol 97:97–99
Maisonneuve P, Lowenfels AB (2015) Risk factors for pancreatic cancer: a summary review of meta-analytical studies. Int J Epidemiol 44:186–198
Maisonneuve P, Lowenfels AB, Müllhaupt B, Cavallini G, Lankisch PG, Andersen JR, DiMagno EP, Andrén-Sandberg A, Domellöf L, Frulloni L, Ammann RW (2005) Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. Gut 54:510–514
Maitra A, Adsay NV, Argani P, Iacobuzio-Donahue C, De Marzo A, Cameron JL, Yeo CJ, Hruban RH (2003) Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol 16:902–912
Maragliano R, Vanoli A, Albarello L, Milione M, Basturk O, Klimstra DS, Wachtel A, Uccella S, Vicari E, Milesi M, Davi MV, Scarpa A, Sessa F, Capella C, La Rosa S (2015) ACTH-secreting pancreatic neoplasms associated with Cushing syndrome: clinicopathologic study of 11 cases and review of the literature. Am J Surg Pathol 39:374–382
Marchegiani G, Mino-Kenudson M, Ferrone CR, Warshaw AL, Lillemoe KD, Fernandez-del Castillo C (2015) Oncocytic-type intraductal papillary mucinous neoplasms: a unique malignant pancreatic tumor with good long-term prognosis. J Am Coll Surg 220:839–844
Marchegiani G, Mino-Kenudson M, Sahora K, Morales-Oyarvide V, Thayer S, Ferrone C, Warshaw AL, Lillemoe KD, Fernandez-Del Castillo C (2015) IPMN involving the main pancreatic duct: biology, epidemiology, and long-term outcomes following resection. Ann Surg 261:976–983
Marucci G, Betts CM, Liguori L, Eusebi V (2005) Basaloid carcinoma of the pancreas. Virchows Arch 446:322–324
Matthaei H, Hong SM, Mayo SC, dal Molin M, Olino K, Venkat R, Goggins M, Herman JM, Edil BH, Wolfgang CL, Cameron JL, Schulick RD, Maitra A, Hruban RH (2011) Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer. Ann Surg Oncol 18:3493–3499
Meckler KA, Brentnall TA, Haggitt RC, Crispin D, Byrd DR, Kimmey MB, Bronner MP (2001) Familial fibrocystic pancreatic atrophy with endocrine cell hyperplasia and pancreatic carcinoma. Am J Surg Pathol 25:1047–1053
Michalova K, Michal M, Sedivcova M, Kazakov DV, Bacchi C, Antic T, Miesbauerova M, Hes O, Michal M (2018) Solid pseudopapillary neoplasm (SPN) of the testis: comprehensive mutational analysis of 6 testicular and 8 pancreatic SPNs. Ann Diagn Pathol 35:42–47
Mino-Kenudson M, Fernandez-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M, Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP (2011) Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut 60:1712–1720
Moffitt RA, Marayati R, Flate EL, Volmar KE, Loeza SG, Hoadley KA, Rashid NU, Williams LA, Eaton SC, Chung AH, Smyla JK, Anderson JM, Kim HJ, Bentrem DJ, Talamonti MS, Iacobuzio-Donahue CA, Hollingsworth MA, Yeh JJ (2015) Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Gen 47:1168–1178
Morohoshi T, Held G, Klöppel G (1983) Exocrine pancreatic tumours and their histological classification. A study based on 167 autopsy and 97 surgical cases. Histopathology 7:645–661
Morohoshi T, Kanda M, Asanuma K, Klöppel G (1989) Intraductal papillary neoplasms of the pancreas. A clinicopathologic study of six patients. Cancer 64:1329–1335
Morohoshi T, Kanda M, Horie A, Chott A, Dreyer T, Klöppel G, Heitz PU (1987) Immunocytochemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor. Cancer 59:739–747
Muguerza R, Rodriguez A, Formigo E, Montero M, Vazquez JL, Paramo C, Campos C (2005) Pancreatoblastoma associated with incomplete Beckwith-Wiedemann syndrome: case report and review of the literature. J Pediatr Surg 40:1341–1344
Muraki T, Reid MD, Basturk O, Jang KT, Bedolla G, Bagci P, Mittal P, Memis B, Katabi N, Bandyopadhyay S, Sarmiento JM, Krasinskas A, Klimstra DS, Adsay V (2016) Undifferentiated carcinoma with osteoclastic giant cells of the pancreas: clinicopathologic analysis of 38 cases highlights a more protracted clinical course than currently appreciated. Am J Surg Pathol 40:1203–1216
Nagata K, Horinouchi M, Saitou M, Higashi M, Nomoto M, Goto M, Yonezawa S (2007) Mucin expression profile in pancreatic cancer and the precursor lesions. J Hepatobiliary Pancreat Surg 14:243–254
Nakashiro H, Tokunaga O, Watanabe T, Ishibashi K, Kuwaki T (1991) Localized lymphoid hyperplasia (pseudolymphoma) of the pancreas presenting with obstructive jaundice. Hum Pathol 22:724–726
Nakata K, Ohuchida K, Aishima S, Sadakari Y, Kayashima T, Miyasaka Y, Nagai E, Mizumoto K, Tanaka M, Tsuneyoshi M, Oda Y (2011) Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis. Pancreas 40:581–587
Nassar H, Pansare V, Zhang H, Che M, Sakr W, Ali-Fehmi R, Grignon D, Sarkar F, Cheng J, Adsay V (2004) Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. Mod Pathol 17:1045–1050
Neesse A, Hahnenkamp A, Griesmann H, Buchholz M, Hahn SA, Maghnouj A, Fendrich V, Ring J, Sipos B, Tuveson DA, Bremer C, Gress TM, Michl P (2013) Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions. Gut 62:1034–1043
Nitta T, Mitsuhashi T, Hatanaka Y, Hirano S, Matsuno Y (2013) Pancreatic ductal adenocarcinomas with multiple large cystic structures: a clinicopathologic and immunohistochemical study of seven cases. Pancreatology 13:401–408
Norris AL, Roberts NJ, Jones S, Wheelan SJ, Papadopoulos N, Vogelstein B, Kinzler KW, Hruban RH, Klein AP, Eshleman JR (2015) Familial and sporadic pancreatic cancer share the same molecular pathogenesis. Fam Cancer 14:95–103
Obara T, Saitoh Y, Maguchi H, Ura H, Kitazawa S, Koike Y, Okamura K, Namiki M (1992) Multicentric development of pancreatic intraductal carcinoma through atypical papillary hyperplasia. Hum Pathol 23:82–85
Oberhuber G (2013) Tumoren des Dünndarms. In: Stolte M, Rüschoff J, Klöppel G (Hrsg) Verdauungstrakt und Peritoneum, Pathologie, 3. Aufl. Springer, Berlin, S 429
Ohike N, Jürgensen A, Pipeleers-Marichal M, Klöppel G (2003) Mixed ductal-endocrine carcinomas of the pancreas and ductal adenocarcinomas with scattered endocrine cells: characterization of the endocrine cells. Virchows Arch 442:258–265
Ohike N, Kosmahl M, Klöppel G (2004) Mixed acinar-endocrine carcinoma of the pancreas. A clinicopathological study and comparison with acinar-cell carcinoma. Virchows Arch 445:231–235
Okamoto H, Fujishima F, Ishida K, Tsuchida K, Shimizu T, Goto H, Sato A, Satomi S, Sasano H (2014) Intraductal papillary mucinous neoplasm originating from a jejunal heterotopic pancreas: report of a case. Surg Today 44:349–353
Omiyale AO (2015) Clinicopathological review of pancreatoblastoma in adults. Gland Surg 4:322–328
Papavramidis T, Papavramidis S (2005) Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in english literature. J Am Coll Surg 200:965–972
Pauser U, Kosmahl M, Kruslin B, Klimstra DS, Klöppel G (2005) Pancreatic solid and cystic hamartoma in adults: characterization of a new tumorous lesion. Am J Surg Pathol 29:797–800
Perez-Ordonez B, Naseem A, Lieberman PH, Klimstra DS (1996) Solid serous adenoma of the pancreas. The solid variant of serous cystadenoma? Am J Surg Pathol 20:1401–1405
Permert J, Larsson J, Westermark GT, Herrington MK, Christmanson L, Pour PM, Westermark P, Adrian TE (1994) Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. N Engl J Med 330:313–318
Potjer TP, Schot I, Langer P, Heverhagen JT, Wasser MN, Slater EP, Kloppel G, Morreau HM, Bonsing BA, de Vos Tot Nederveen Cappel WH, Bargello M, Gress TM, Vasen HF, Bartsch DK (2013) Variation in precursor lesions of pancreatic cancer among high-risk groups. Clin Cancer Res 19:442–449
Ramuz O, Lelong B, Giovannini M, Delpero JR, Rochaix P, Xerri L, Hassoun J, Flejou JF, Monges G (2005) “Sugar” tumor of the pancreas: a rare entity that is diagnosable on preoperative fine-needle biopsies. Virchows Arch 446:555–559
Ray B, New NE, Wedgwood KR (2005) Clear cell carcinoma of exocrine pancreas: a rare tumor with an unusual presentation. Pancreas 30:184–185
Rebours V, Levy P, Mosnier JF, Scoazec JY, Soubeyrand MS, Flejou JF, Turlin B, Hammel P, Ruszniewski P, Bedossa P, Couvelard A (2010) Pathology analysis reveals that dysplastic pancreatic ductal lesions are frequent in patients with hereditary pancreatitis. Clin Gastroenterol Hepatol 8:206–212
Reid MD, Basturk O, Thirabanjasak D, Hruban RH, Klimstra DS, Bagci P, Altinel D, Adsay V (2011) Tumor-infiltrating neutrophils in pancreatic neoplasia. Mod Pathol 24:1612–1619
Reid MD, Choi HJ, Memis B, Krasinskas AM, Jang KT, Akkas G, Maithel SK, Sarmiento JM, Kooby DA, Basturk O, Adsay V (2015) Serous neoplasms of the pancreas: a clinicopathologic analysis of 193 cases and literature review with new insights on macrocystic and solid variants and critical reappraisal of so-called “serous cystadenocarcinoma”. Am J Surg Pathol 39:1597–1610
Reid MD, Saka B, Balci S, Goldblum AS, Adsay NV (2014) Molecular genetics of pancreatic neoplasms and their morphologic correlates: an update on recent advances and potential diagnostic applications. Am J Clin Pathol 141:168–180
Reilly C, Zenoni S, Hasan MK, Varadarajulu S, Tran TA, de la Fuente SG, Arnoletti JP (2013) Primary pancreatic Ewing’s sarcoma with portal vein tumor thrombosis. J Gastrointest Surg 17:1015–1019
Rickaert F, Cremer M, Devière J, Tavares L, Lambilliotte JP, Schröder S, Wurbs D, Klöppel G (1991) Intraductal mucin-hypersecreting neoplasms of the pancreas. A clinicopathologic study of eight patients. Gastroenterology 101:512–519
Rigaud G, Moore PS, Zamboni G, Orlandini S, Taruscio D, Paradisi S, Lemoine NR, Klöppel G, Scarpa A (2000) Allelotype of pancreatic acinar cell carcinoma. Int J Cancer 88:772–777
Roberts NJ, Norris AL, Petersen GM, Bondy ML, Brand R, Gallinger S, Kurtz RC, Olson SH, Rustgi AK, Schwartz AG, Stoffel E, Syngal S, Zogopoulos G, Ali SZ, Axilbund J, Chaffee KG, Chen YC, Cote ML, Childs EJ, Douville C, Goes FS, Herman JM, Iacobuzio-Donahue C, Kramer M, Makohon-Moore A, McCombie RW, McMahon KW, Niknafs N, Parla J, Pirooznia M, Potash JB, Rhim AD, Smith AL, Wang Y, Wolfgang CL, Wood LD, Zandi PP, Goggins M, Karchin R, Eshleman JR, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH, Klein AP (2016) Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer. Cancer Discov 6:166–175
Rosai J (1968) Carcinoma of pancreas simulating giant cell tumor of bone. Electron-microscopic evidence of its acinar cell origin. Cancer 22:333–344
Sadakari Y, Ohuchida K, Nakata K, Ohtsuka T, Aishima S, Takahata S, Nakamura M, Mizumoto K, Tanaka M (2010) Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type. Surgery 147:812–817
Saka B, Balci S, Basturk O, Bagci P, Postlewait LM, Maithel S, Knight J, El-Rayes B, Kooby D, Sarmiento J, Muraki T, Oliva I, Bandyopadhyay S, Akkas G, Goodman M, Reid MD, Krasinskas A, Everett R, Adsay V (2016) Pancreatic ductal adenocarcinoma is spread to the peripancreatic soft tissue in the majority of resected cases, rendering the AJCC T-stage protocol (7th edn). Inapplicable and insignificant: a size-based staging system (pT1: ≤2, pT2: >2-≤4, pT3: >4 cm) is more valid and clinically relevant. Ann Surg Oncol 23:2010–2018
Salvia R, Fernandez-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W, Pederzoli P, Warshaw AL (2004) Main-duct intraductal papillary mucinous neoplasms of the pancreas: clinical predictors of malignancy and long-term survival following resection. Ann Surg 239:678–685 (discussion 685–677)
Samdani RT, Hechtman JF, O’Reilly E, DeMatteo R, Sigel CS (2015) EBV-associated lymphoepithelioma-like carcinoma of the pancreas: case report with targeted sequencing analysis. Pancreatology 15:302–304
Schlitter AM, Born D, Bettstetter M, Specht K, Kim-Fuchs C, Riener MO, Jeliazkova P, Sipos B, Siveke JT, Terris B, Zen Y, Schuster T, Hofler H, Perren A, Klöppel G, Esposito I (2014) Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways. Mod Pathol 27:73–86
Schlitter AM, Jang KT, Klöppel G, Saka B, Hong SM, Choi H, Offerhaus GJ, Hruban RH, Zen Y, Konukiewitz B, Regel I, Allgauer M, Balci S, Basturk O, Reid MD, Esposito I, Adsay V (2015) Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases. Mod Pathol 28:1249–1264
Schlitter AM, Konukiewitz B, Kleeff J, Klöppel G, Esposito I (2013) Recurrent duodenal ulcer bleeding as the first manifestation of a solid pseudopapillary neoplasm of the pancreas with hepatic metastases. Dtsch Med Wochenschr 138:1050–1053
Schlitter AM, Segler A, Steiger K, Michalski CW, Jager C, Konukiewitz B, Pfarr N, Endris V, Bettstetter M, Kong B, Regel I, Kleeff J, Klöppel G, Esposito I (2017) Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDAcs): identification of prognostic subtypes. Sci Rep 7:41064
Schnelldorfer T, Sarr MG, Nagorney DM, Zhang L, Smyrk TC, Qin R, Chari ST, Farnell MB (2008) Experience with 208 resections for intraductal papillary mucinous neoplasm of the pancreas. Arch Surg 143:639–646 (discussion 646)
Schüssler MH, Skoudy A, Ramaekers F, Real FX (1992) Intermediate filaments as differentiation markers of normal pancreas and pancreas cancer. Am J Pathol 140:559–568
Seket B, Saurin JC, Scoazec JY, Partensky C (2003) Pancreatic acinar cell carcinoma in a patient with familial adenomatous polyposis. Gastroenterol Clin Biol 27:818–820
Sessa F, Bonato M, Frigerio B, Capella C, Solcia E, Prat M, Bara J, Samloff IM (1990) Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells. Gastroenterology 98:1655–1665
Sessa F, Solcia E, Capella C, Bonato M, Scarpa A, Zamboni G, Pellegata NS, Ranzani GN, Rickaert F, Klöppel G (1994) Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53, and c-erbB-2 abnormalities in 26 patients. Virchows Arch 425:357–367
Seufferlein T, Bachet JB, Van Cutsem E, Rougier P (2012) Pancreatic adenocarcinoma: ESMO-ESDO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23(Suppl 7):vii33–vii40
Shi C, Hruban RH, Klein AP (2009) Familial pancreatic cancer. Arch Pathol Lab Med 133:365–374
Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, Schulick R, Palmisano E, Hruban RH (2009) Increased prevalence of precursor lesions in familial pancreatic cancer patients. Clin Cancer Res 15:7737–7743
Shorten SD, Hart WR, Petras RE (1986) Microcystic adenomas (serous cystadenomas) of pancreas. A clinicopathologic investigation of eight cases with immunohistochemical and ultrastructural studies. Am J Surg Pathol 10:365–372
Shorter NA, Glick RD, Klimstra DS, Brennan MF, Laquaglia MP (2002) Malignant pancreatic tumors in childhood and adolescence: the memorial Sloan-Kettering experience, 1967 to present. J Pediatr Surg 37:887–892
Siegel R, Miller KD, Jemal A (2015) Cancer statistics, 2015. Cancer J Clin 65:5–29
Singh K, Patel N, Patil P, Paquette C, Mathews CA, Lawrence WD (2018) Primary ovarian solid pseudopapillary neoplasm with CTNNB1 c.98C>G (p.S33C) point mutation. Int J Gynecol Pathol 37:110–116
Singhi AD, Lilo M, Hruban RH, Cressman KL, Fuhrer K, Seethala RR (2014) Overexpression of lymphoid enhancer-binding factor 1 (LEF1) in solid-pseudopapillary neoplasms of the pancreas. Mod Pathol 27:1355–1363
Sipos B, Frank S, Gress T, Hahn S, Klöppel G (2009) Pancreatic intraepithelial neoplasia revisited and updated. Pancreatology 9:45–54
Sipos B, Möser S, Kalthoff H, Török V, Löhr M, Klöppel G (2003) A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. Virchows Arch 442:444–452
Sohn TA, Yeo CJ, Cameron JL, Hruban RH, Fukushima N, Campbell KA, Lillemoe KD (2004) Intraductal papillary mucinous neoplasms of the pancreas: an updated experience. Ann Surg 239:788–797
Solcia E, Capella C, Klöppel G (1997) Tumors of the pancreas. AFIP Atlas of Tumor Pathology, third series, fascicle 20. Armed Forces Institute of Pathology, Washington
Sommers SC, Murphy SA, Warren S (1954) Pancreatic duct hyperplasia and cancer. Gastroenterology 27:629–640
Springer S, Wang Y, Dal Molin M, Masica DL, Jiao Y, Kinde I, Blackford A, Raman SP, Wolfgang CL, Tomita T, Niknafs N, Douville C, Ptak J, Dobbyn L, Allen PJ, Klimstra DS, Schattner MA, Schmidt CM, Yip-Schneider M, Cummings OW, Brand RE, Zeh HJ, Singhi AD, Scarpa A, Salvia R, Malleo G, Zamboni G, Falconi M, Jang JY, Kim SW, Kwon W, Hong SM, Song KB, Kim SC, Swan N, Murphy J, Geoghegan J, Brugge W, Fernandez-Del Castillo C, Mino-Kenudson M, Schulick R, Edil BH, Adsay V, Paulino J, van Hooft J, Yachida S, Nara S, Hiraoka N, Yamao K, Hijioka S, van der Merwe S, Goggins M, Canto MI, Ahuja N, Hirose K, Makary M, Weiss MJ, Cameron J, Pittman M, Eshleman JR, Diaz LA Jr., Papadopoulos N, Kinzler KW, Karchin R, Hruban RH, Vogelstein B, Lennon AM (2015) A combination of molecular markers and clinical features improve the classification of pancreatic cysts. Gastroenterology 149:1501–1510
Stamm B, Burger H, Hollinger A (1987) Acinar cell cystadenocarcinoma of the pancreas. Cancer 60:2542–2547
Stelow EB, Shaco-Levy R, Bao F, Garcia J, Klimstra DS (2010) Pancreatic acinar cell carcinomas with prominent ductal differentiation: mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. Am J Surg Pathol 34:510–518
Suster S, Phillips M, Robinson MJ (1989) Malignant fibrous histiocytoma (giant cell type) of the pancreas. A distinctive variant of osteoclast-type giant cell tumor of the pancreas. Cancer 64:2302–2308
Szasz AM, Szirtes I, Tihanyi B, Barkaszi B, Baranyai Z, Tihanyi T, Harsanyi L, Timar J, Kulka J (2015) Basaloid carcinoma of the pancreas – clinicopathological presentation and oncogenetic snapshot of a rare entity. Virchows Arch 466:237–241
Tajiri T, Tate G, Inagaki T, Kunimura T, Inoue K, Mitsuya T, Yoshiba M, Morohoshi T (2005) Intraductal tubular neoplasms of the pancreas: histogenesis and differentiation. Pancreas 30:115–121
Tanaka M, Fernandez-del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K (2012) International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 12:183–197
Tanaka M, Sawai H, Okada Y, Yamamoto M, Funahashi H, Takeyama H, Manabe T (2006) Clinicopathologic study of intraductal papillary-mucinous tumors and mucinous cystic tumors of the pancreas. Hepatogastroenterology 53:783–787
Tanaka Y, Kato K, Notohara K, Hojo H, Ijiri R, Miyake T, Nagahara N, Sasaki F, Kitagawa N, Nakatani Y, Kobayashi Y (2001) Frequent á-catenin mutation and cytoplasmic/nuclear accumulation in pancreatic solid-pseudopapillary neoplasm. Cancer Res 61:8401–8404
Tang LH, Aydin H, Brennan MF, Klimstra DS (2005) Clinically aggressive solid pseudopapillary tumors of the pancreas: a report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol 29:512–519
Tanno S, Nakano Y, Nishikawa T, Nakamura K, Sasajima J, Minoguchi M, Mizukami Y, Yanagawa N, Fujii T, Obara T, Okumura T, Kohgo Y (2008) Natural history of branch duct intraductal papillary-mucinous neoplasms of the pancreas without mural nodules: long-term follow-up results. Gut 57:339–343
Temesgen WM, Wachtel M, Dissanaike S (2014) Osteoclastic giant cell tumor of the pancreas. Int J Surg Case Rep 5:175–179
Terris B, Cavard C (2014) Diagnosis and molecular aspects of solid-pseudopapillary neoplasms of the pancreas. Semin Diagn Pathol 31:484–490
Thompson LDR, Heffess CS (2000) Renal cell carcinoma to the pancreas in surgical pathology material. A clinicopathologic study of 21 cases with a review of the literature. Cancer 89:1076–1088
Tiemann K, Heitling U, Kosmahl M, Klöppel G (2007) Solid pseudopapillary neoplasms of the pancreas show an interruption of the Wnt-signaling pathway and express gene products of 11q. Mod Pathol 20:955–960
Tiemann K, Kosmahl M, Ohlendorf J, Krams M, Klöppel G (2006) Solid pseudopapillary neoplasms of the pancreas are associated with FLI-1 expression, but not with EWS/FLI-1 translocation. Mod Pathol 19:1409–1413
Toll AD, Mitchell D, Yeo CJ, Hruban RH, Witkiewicz AK (2011) Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature. Int J Surg Pathol 19:795–799
Tracey KJ, O’Brien MJ, Williams LF, Klibaner M, George PK, Saravis CA, Zamcheck N (1984) Signet ring carcinoma of the pancreas, a rare variant with very high CEA values. Immunohistologic comparison with adenocarcinoma. Dig Dis Sci 29:573–576
Trepeta RW, Mathur B, Lagin S, LiVolsi VA (1981) Giant cell tumor (“osteoclastoma”) of the pancreas: a tumor of epithelial origin. Cancer 48:2022–2028
Tschang TP, Garza-Garza R, Kissane JM (1977) Pleomorphic carcinoma of the pancreas: an analysis of 15 cases. Cancer 39:2114–2126
Tsujimura T, Kawano K, Taniguchi M, Yoshikawa K, Tsukaguchi I (1992) Malignant fibrous histiocytoma coexistent with mucinous cystadenoma of the pancreas. Cancer 70:2792–2796
Tunell WP (1976) Hemangioendothelioma of the pancreas obstructing the common bile duct and duodenum. J Pediatr Surg 11:827–830
Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernandez-del Castillo C (2012) 851 resected cystic tumors of the pancreas: a 33-year experience at the Massachusetts General Hospital. Surgery 152:S4–S12
van Heek NT, Meeker AK, Kern SE, Yeo CJ, Lillemoe KD, Cameron JL, Offerhaus GJA, Hicks JL, Wilentz RE, Goggins MG, De Marzo AM, Hruban RH, Maitra A (2002) Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia. Am J Pathol 161:1541–1547
van Klaveren RJ, de Mulder PH, Boerbooms AM, van de Kaa CA, van Haelst UJ, Wagener DJ, Hafkenscheid JC (1990) Pancreatic carcinoma with polyarthritis, fat necrosis, and high serum lipase and trypsin activity. Gut 31:953–955
Vanoli A, Argenti F, Vinci A, La Rosa S, Viglio A, Riboni R, Necchi V, Pugliese L, Sessa F, Pietrabissa A, Paulli M (2015) Hepatoid carcinoma of the pancreas with lymphoid stroma: first description of the clinical, morphological, immunohistochemical, and molecular characteristics of an unusual pancreatic carcinoma. Virchows Arch 467:237–245
Verbeke C, Lohr M, Karlsson JS, Del Chiaro M (2015) Pathology reporting of pancreatic cancer following neoadjuvant therapy: challenges and uncertainties. Cancer Treat Rev 41:17–26
Verbeke CS, Knapp J, Gladhaug IP (2011) Tumour growth is more dispersed in pancreatic head cancers than in rectal cancer: implications for resection margin assessment. Histopathology 59:1111–1121
Verbeke CS, Leitch D, Menon KV, McMahon MJ, Guillou PJ, Anthoney A (2007) Redefining the R1 resection in pancreatic cancer. Br J Surg 93:1232–1237
Volmar KE, Routbort MJ, Jones CK, Xie HB (2004) Primary pancreatic lymphoma evaluated by fine-needle aspiration: findings in 14 cases. Am J Clin Pathol 121:898–903
Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL, Miller D, Nones K, Quek K, Quinn MC, Robertson AJ, Fadlullah MZ, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Wani S, Wilson PJ, Markham E, Cloonan N, Anderson MJ, Fink JL, Holmes O, Kazakoff SH, Leonard C, Newell F, Poudel B, Song S, Taylor D, Waddell N, Wood S, Xu Q, Wu J, Pinese M, Cowley MJ, Lee HC, Jones MD, Nagrial AM, Humphris J, Chantrill LA, Chin V, Steinmann AM, Mawson A, Humphrey ES, Colvin EK, Chou A, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Pettitt JA, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N, Jamieson NB, Graham JS, Niclou SP, Bjerkvig R, Grützmann R, Aust D, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Falconi M, Zamboni G, Tortora G, Tempero MA, Australian Pancreatic Cancer Genome I, Gill AJ, Eshleman JR, Pilarsky C, Scarpa A, Musgrove EA, Pearson JV, Biankin AV, Grimmond SM (2015) Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518:495–501
Wasel BA, Keough V, Huang WY, Molinari M (2013) Histological percutaneous diagnosis of stage IV microcystic serous cystadenocarcinoma of the pancreas. BMJ Case Rep. https://doi.org/10.1136/bcr-2012-007924
Wilentz RE, Albores-Saavedra J, Hruban RH (2000) Mucinous cystic neoplasms of the pancreas. Semin Diagn Pathol 17:31–42
Woll S, Schlitter AM, Dhaene K, Roller M, Esposito I, Sahin U, Tureci O (2014) Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms. Int J Cancer 134:731–739
Wood LD, Klimstra DS (2014) Pathology and genetics of pancreatic neoplasms with acinar differentiation. Semin Diagn Pathol 31:491–497
Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, Eshleman JR, Goggins MG, Wolfgang CL, Canto MI, Schulick RD, Edil BH, Choti MA, Adsay V, Klimstra DS, Offerhaus GJ, Klein AP, Kopelovich L, Carter H, Karchin R, Allen PJ, Schmidt CM, Naito Y, Diaz LA Jr., Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B (2011) Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A 108:21188–21193
Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, Goggins M, Canto MI, Schulick RD, Edil BH, Wolfgang CL, Klein AP, Diaz LA Jr., Allen PJ, Schmidt CM, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B (2011) Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development. Sci Transl Med 3:92ra66
Xu J, Zhang T, Wang T, You L, Zhao Y (2013) Clinical characteristics and prognosis of primary leiomyosarcoma of the pancreas: a systematic review. World J Surg Oncol 11:290
Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shimizu K, Shiratori K, Shibata N, Shimizu M, Furukawa T (2013) The discrete nature and distinguishing molecular features of pancreatic intraductal tubulopapillary neoplasms and intraductal papillary mucinous neoplasms of the gastric type, pyloric gland variant. J Pathol 231:335–341
Yamaguchi H, Shimizu M, Ban S, Koyama I, Hatori T, Fujita I, Yamamoto M, Kawamura S, Kobayashi M, Ishida K, Morikawa T, Motoi F, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Ebihara Y, Koike N, Furukawa T (2009) Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 33:1164–1172
Yamaguchi K, Kanemitsu S, Hatori T, Maguchi H, Shimizu Y, Tada M, Nakagohri T, Hanada K, Osanai M, Noda Y, Nakaizumi A, Furukawa T, Ban S, Nobukawa B, Kato Y, Tanaka M (2011) Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. Pancreas 40:571–580
Yoshimi N, Sugie S, Tanaka T, Aijin W, Bunai Y, Tatematsu A, Okada T, Mori H (1992) A rare case of serous cystadenocarcinoma of the pancreas. Cancer 69:2449–2453
Zamboni G, Bonetti F, Castelli P, Balercia G, Pea M, Martignoni G, Iacono C, Fiore-Donati L (1994) Mucinous cystic tumor of the pancreas recurring after 11 years as cystadenocarcinoma with foci of choriocarcinoma and osteoclast-like giant cell tumor. Surg Pathol 5:253–262
Zamboni G, Bonetti F, Scarpa A, Pelosi G, Doglioni C, Iannucci A, Castelli P, Balercia G, Aldovini D, Bellomi A, Iacono C, Serio G, Mariuzzi GM (1993) Expression of progesterone receptors in solid-cystic tumour of the pancreas: a clinicopathological and immunohistochemical study of ten cases. Virchows Arch A Pathol Anat Histopathol 423:425–431
Zamboni G, Pea M, Martignoni G, Zancanaro C, Faccioli G, Gilioli E, Pederzoli P, Bonetti F (1996) Clear cell “sugar” tumor of the pancreas. A novel member of the family of lesions characterized by the presence of perivascular epithelioid cells. Am J Surg Pathol 20:722–730
Zamboni G, Scarpa A, Bogina G, Iacono C, Bassi C, Talamini G, Sessa F, Capella C, Solcia E, Rickaert F, Mariuzzi GM, Klöppel G (1999) Mucinous cystic tumors of the pancreas. Clinicopathological features, prognosis and relationship to other mucinous cystic tumors. Am J Surg Pathol 23:410–422
Zamboni G, Terris B, Scarpa A, Kosmahl M, Capelli P, Klimstra DS, Lam PW, Klöppel G (2002) Acinar cell cystadenoma of the pancreas: a new entity? Am J Surg Pathol 26:698–704
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Klöppel, G., Esposito, I., Kasajima, A., Konukiewitz, B., Lüttges, J., Sipos, B. (2020). Solide und zystische nichtendokrine Tumoren des Pankreas. In: Tannapfel, A., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04557-8_24
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