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Semi-supervised Outcome Prediction for a Type of Human Brain Tumour Using Partially Labeled MRS Information

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Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 5788))

Abstract

The diagnosis and prognosis of human brain tumours, especially when they are aggresive, are sensitive clinical tasks that usually require non-invasive measurement techniques. Outcome information for aggressive tumours, in particular, is usually scarce. In this paper, we aim to gauge the capability of a novel semi-supervised model, SS-Geo-GTM, to infer outcome stages from a very limited amount of available stage labels and Magnetic Resonance Spectroscopy (MRS) data corresponding to Glioblastoma, which is an aggressive tumor type. This model stems from a geodesic distance-based extension of Generative Topographic Mapping (Geo-GTM) that prioritizes neighbourhood relationships along a generated manifold embedded in the observed data space.

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References

  1. Zhu, X., Ghahramani, Z.: Learning from labeled and unlabeled data with label propagation. Technical report, CMU-CALD-02-107, Carnegie Mellon University (2002)

    Google Scholar 

  2. Belkin, M., Niyogi, P.: Using manifold structure for partially labelled classification. In: Procs. of NIPS, vol. 15. MIT Press, Cambridge (2003)

    Google Scholar 

  3. Herrmann, L., Ultsch, A.: Label propagation for semi-supervised learning in self-organizing maps. In: Proceedings of the 6th WSOM 2007 (2007)

    Google Scholar 

  4. Ultsch, A.: Maps for the visualization of high-dimensional data spaces. In: Proceedings of WSOM 2003, pp. 225–230 (2003)

    Google Scholar 

  5. Cruz-Barbosa, R., Vellido, A.: Geodesic Generative Topographic Mapping. In: Geffner, H., Prada, R., Machado Alexandre, I., David, N. (eds.) IBERAMIA 2008. LNCS (LNAI), vol. 5290, pp. 113–122. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  6. Bishop, C.M., Svensén, M., Williams, C.K.I.: The Generative Topographic Mapping. Neural Computation 10(1), 215–234 (1998)

    Article  MATH  Google Scholar 

  7. Bernstein, M., de Silva, V., Langford, J., Tenenbaum, J.: Graph approximations to geodesics on embedded manifolds. Technical report, Stanford U., CA (2000)

    Google Scholar 

  8. Cruz-Barbosa, R., Vellido, A.: On the improvement of the mapping trustworthiness and continuity of a manifold learning model. In: Fyfe, C., Kim, D., Lee, S.-Y., Yin, H. (eds.) IDEAL 2008. LNCS, vol. 5326, pp. 266–273. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  9. Dijkstra, E.W.: A note on two problems in connection with graphs. Numerische Mathematik 1, 269–271 (1959)

    Article  MathSciNet  MATH  Google Scholar 

  10. Archambeau, C., Verleysen, M.: Manifold constrained finite gaussian mixtures. In: Cabestany, J., Prieto, A.G., Sandoval, F. (eds.) IWANN 2005. LNCS, vol. 3512, pp. 820–828. Springer, Heidelberg (2005)

    Chapter  Google Scholar 

  11. Romero, E., Vellido, A., Julià-Sapé, M., Arús, C.: Discriminating glioblastomas from metastases in a SV 1H-MRS brain tumour database. In: European Soc. for MR in Biology and Medicine (ESMRMB) Congress 2009 (submitted, 2009)

    Google Scholar 

  12. Tate, A.R., Majós, C., Moreno, A., Howe, F.A., Griffiths, J.R., Arús, C.: Automated classification of short echo time in In Vivo 1 H brain tumor spectra: a multicenter study. Magnetic Resonance in Medicine 49, 29–36 (2003)

    Article  Google Scholar 

  13. Cruz-Barbosa, R., Vellido, A.: Comparative evaluation of semi-supervised geodesic GTM. In: Corchado, E., Wu, X., Oja, E., Herrero, Á., Barugue, B. (eds.) HAIS 2009. LNCS (LNAI), vol. 5572, pp. 344–351. Springer, Heidelberg (2009)

    Google Scholar 

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Cruz-Barbosa, R., Vellido, A. (2009). Semi-supervised Outcome Prediction for a Type of Human Brain Tumour Using Partially Labeled MRS Information. In: Corchado, E., Yin, H. (eds) Intelligent Data Engineering and Automated Learning - IDEAL 2009. IDEAL 2009. Lecture Notes in Computer Science, vol 5788. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04394-9_21

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  • DOI: https://doi.org/10.1007/978-3-642-04394-9_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04393-2

  • Online ISBN: 978-3-642-04394-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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