Skip to main content

Potential Role of Complementary and Alternative Medicine in Pediatric Oncology: The Future of CAM Research – Addressing the “Effectiveness Gaps”

  • Chapter
  • First Online:
Integrative Pediatric Oncology

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

There is paucity of convincing scientific evidence to support practice of complementary and alternative medicine (CAM) therapies in pediatric cancer patients even though their use is well documented. However, certain CAM therapies have been proven effective for symptoms that conventional therapies fail to treat, such as nausea, pain, and psychosocial well-being. Rigorous research methods in pediatric oncology need to be followed to build the evidence base in CAM and bridge these effectiveness gaps. A strategy that combines qualitative and quantitative studies to assess CAM therapies in the context they are being used in, with awareness of the unique challenges in pediatric oncology research, will guide future clinical practice. Finally, national and international collaborations among researchers, policy makers, and clinicians will facilitate the regulated use of effective CAM therapies in pediatric oncology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Birdee GS et al (2010) Factors associated with pediatric use of complementary and alternative medicine. Pediatrics (Evanston) 125(2):249–256

    Article  Google Scholar 

  • Bishop FL, Prescott P, Chan YK, Saville J, von Elm E, Lewith GT (2010) Prevalence of complementary medicine use in pediatric cancer: a systematic review. Pediatrics 125(4):768–776. doi:10.1542/peds.2009-1775

    Article  PubMed  Google Scholar 

  • Buttle SG, McMurtry M, Marshall S (2011) Massage for pain relief in pediatric palliative care: potential benefits and challenges. Pediatr Pain Lett 13(3):24–29

    Google Scholar 

  • Chan E (2008) Quality of efficacy research in complementary and alternative medicine. JAMA 299(22):2685–2686. doi:10.1001/jama.299.22.2685

    Article  PubMed  CAS  Google Scholar 

  • Deng GE et al (2009) Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. J Soc Integr Oncol 7(3):85

    PubMed  Google Scholar 

  • Dhillon HM (2011) Researching complementary and alternative therapies: frameworks for evaluation. Cancer Forum 35(1):23–26

    Google Scholar 

  • Dupuis LL et al (2010) Symptom assessment in children receiving cancer therapy: the parents’ perspective. Support Care Cancer 18(3):281–299

    Article  PubMed  Google Scholar 

  • Ernst E, Snyder J, Dunlop RA et al (2012) National center for complementary and alternative medicine-funded randomised controlled trials of acupuncture: a systematic review. Focus Altern Complement Ther 17(1):15–21

    Article  Google Scholar 

  • Fisher P et al (2004) Effectiveness gaps: a new concept for evaluating health service and research needs applied to complementary and alternative medicine. J Altern Complement Med (NY) 10(4):627–632

    Google Scholar 

  • Fonnebo V, Grimsgaard S, Walach H, Ritenbaugh C, Norheim AJ, MacPherson H, Lewith G, Launso L, Koithan M, Falkenberg T, Boon H, Aickin M (2007) Researching complementary and alternative treatments–the gatekeepers are not at home. BMC Med Res Methodol 7:7. doi:10.1186/1471-2288-7-7

    Article  PubMed  Google Scholar 

  • Holdsworth MT et al (2006) Acute and delayed nausea and emesis control in pediatric oncology patients. Cancer 106(4):931–940

    Article  PubMed  Google Scholar 

  • Hughes D, Ladas E, Rooney D, Kelly K (2008) Massage therapy as a supportive care intervention for children with cancer. Oncol Nurs Forum 35(3):431–442. doi:10.1188/08.ONF.431-442

    Article  PubMed  Google Scholar 

  • Jindal V et al (2008) Safety and efficacy of acupuncture in children a review of the evidence. J Pediatr Hematol Oncol 30(6):431–442

    Article  PubMed  Google Scholar 

  • Kelly KM (2004) Complementary and alternative medical therapies for children with cancer. Eur J Cancer 40(14):2041–2046. doi:10.1016/j.ejca.2004.05.012

    Article  PubMed  Google Scholar 

  • Kemper KJ et al (2008) The use of complementary and alternative medicine in pediatrics. Pediatrics (Evanston) 122(6):1374–1386

    Article  Google Scholar 

  • Klassen TP, Pham B, Lawson ML, Moher D (2005) For randomized controlled trials, the quality of reports of complementary and alternative medicine was as good as reports of conventional medicine. J Clin Epidemiol 58(8):763–768. doi:10.1016/j.jclinepi.2004.08.020

    Article  PubMed  Google Scholar 

  • Ladas EJ, Post-White J, Hawks R, Taromina K (2006) Evidence for symptom management in the child with cancer. J Pediatr Hematol Oncol 28(9):601–615

    Article  PubMed  Google Scholar 

  • Landier W, Tse A (2010) Use of complementary and alternative medical interventions for the management of procedure-related pain, anxiety, and distress in pediatric oncology: an integrative review. J Pediatr Nurs 25(6):566–579

    Article  PubMed  Google Scholar 

  • Lawenda BD et al (2008) Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 100(11):773–783

    Article  PubMed  CAS  Google Scholar 

  • Lawson ML, Pham B, Klassen TP, Moher D (2005) Systematic reviews involving complementary and alternative medicine interventions had higher quality of reporting than conventional medicine reviews. J Clin Epidemiol 58(8):777–784. doi:10.1016/j.jclinepi.2004.08.022

    Article  PubMed  Google Scholar 

  • Linde K, Jonas WB, Melchart D, Willich S (2001) The methodological quality of randomized controlled trials of homeopathy, herbal medicines and acupuncture. Int J Epidemiol 30(3):526–531

    Article  PubMed  CAS  Google Scholar 

  • Maizes V (2009) Integrative medicine and patient-centered care. Explore (NY) 5(5):277–289

    Article  Google Scholar 

  • Melnick SJ (2006) Developmental therapeutics: review of biologically based complementary and alternative medicine (CAM) therapies for potential application in children with cancer-part II. J Pediatr Hematol Oncol 28(5):271–285

    Article  PubMed  CAS  Google Scholar 

  • Moffet HH (2006) How might acupuncture work? a systematic review of physiologic rationales from clinical trials. BMC Complement Altern Med 6(1):25

    Article  PubMed  Google Scholar 

  • Myers C et al (2005) Complementary therapies and childhood cancer. Cancer Control 12(3):172–180

    PubMed  Google Scholar 

  • Perrone G et al (2009) Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia 23(9):1679–1686

    Article  PubMed  CAS  Google Scholar 

  • Post-White J, Hawks R (2005) Complementary and alternative medicine in pediatric oncology. Semin Oncol Nurs 21(2):107–114

    Article  PubMed  Google Scholar 

  • Rheingans JI (2007) A systematic review of nonpharmacologic adjunctive therapies for symptom management in children with cancer. J Pediatr Oncol Nurs 24(2):81–94

    Article  PubMed  Google Scholar 

  • Rooney D, Le TK, Hughes D et al (2006) A retrospective review investigating the feasibility of acupuncture as a supportive care agent in a pediatric oncology service. In: Annual meeting of the Society of Integrative Oncology, Boston, 2006

    Google Scholar 

  • Sagar SM (2006) Integrative oncology in North America. J Soc Integr Oncol 4(1):27–39

    PubMed  Google Scholar 

  • Sencer SF, Kelly KM (2007) Complementary and alternative therapies in pediatric oncology. Pediatr Clin North Am 54:1043–1060

    Article  PubMed  Google Scholar 

  • Sencer SF et al (2012) Traumeel S in preventing and treating mucositis in young patients undergoing SCT: a report of the Children’s Oncology Group. Bone Marrow Transplant. doi:10.1038/bmt.2012.30.

  • Sharpe D, Rossiter L (2002) Siblings of children with a chronic illness: a meta-analysis. J Pediatr Psychol 27(8):699–710

    Article  PubMed  Google Scholar 

  • Sox HC, Greenfield S (2009) Comparative effectiveness research: a report from the institute of medicine. Ann Intern Med 151(3):203

    PubMed  Google Scholar 

  • Verhoef MJ et al (2002) Assessing efficacy of complementary medicine: adding qualitative research methods to the “gold standard”. J Altern Complement Med (NY) 8(3):275–281

    Article  Google Scholar 

  • Walach H et al (2003) The role of outcomes research in evaluating complementary and alternative medicine. Altern Ther Health Med 8(3):88

    Google Scholar 

  • Wayne JB (2005) Building an evidence house: challenges and solutions to research in complementary and alternative medicine. Forsch Komplementarmed Klass Naturheilkd 12:159–167

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kara Kelly M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Chokshi, S., Kelly, K. (2012). Potential Role of Complementary and Alternative Medicine in Pediatric Oncology: The Future of CAM Research – Addressing the “Effectiveness Gaps”. In: Längler, A., Mansky, P., Seifert, G. (eds) Integrative Pediatric Oncology. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04201-0_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-04201-0_11

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04200-3

  • Online ISBN: 978-3-642-04201-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics