Abstract
There is paucity of convincing scientific evidence to support practice of complementary and alternative medicine (CAM) therapies in pediatric cancer patients even though their use is well documented. However, certain CAM therapies have been proven effective for symptoms that conventional therapies fail to treat, such as nausea, pain, and psychosocial well-being. Rigorous research methods in pediatric oncology need to be followed to build the evidence base in CAM and bridge these effectiveness gaps. A strategy that combines qualitative and quantitative studies to assess CAM therapies in the context they are being used in, with awareness of the unique challenges in pediatric oncology research, will guide future clinical practice. Finally, national and international collaborations among researchers, policy makers, and clinicians will facilitate the regulated use of effective CAM therapies in pediatric oncology.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Birdee GS et al (2010) Factors associated with pediatric use of complementary and alternative medicine. Pediatrics (Evanston) 125(2):249–256
Bishop FL, Prescott P, Chan YK, Saville J, von Elm E, Lewith GT (2010) Prevalence of complementary medicine use in pediatric cancer: a systematic review. Pediatrics 125(4):768–776. doi:10.1542/peds.2009-1775
Buttle SG, McMurtry M, Marshall S (2011) Massage for pain relief in pediatric palliative care: potential benefits and challenges. Pediatr Pain Lett 13(3):24–29
Chan E (2008) Quality of efficacy research in complementary and alternative medicine. JAMA 299(22):2685–2686. doi:10.1001/jama.299.22.2685
Deng GE et al (2009) Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. J Soc Integr Oncol 7(3):85
Dhillon HM (2011) Researching complementary and alternative therapies: frameworks for evaluation. Cancer Forum 35(1):23–26
Dupuis LL et al (2010) Symptom assessment in children receiving cancer therapy: the parents’ perspective. Support Care Cancer 18(3):281–299
Ernst E, Snyder J, Dunlop RA et al (2012) National center for complementary and alternative medicine-funded randomised controlled trials of acupuncture: a systematic review. Focus Altern Complement Ther 17(1):15–21
Fisher P et al (2004) Effectiveness gaps: a new concept for evaluating health service and research needs applied to complementary and alternative medicine. J Altern Complement Med (NY) 10(4):627–632
Fonnebo V, Grimsgaard S, Walach H, Ritenbaugh C, Norheim AJ, MacPherson H, Lewith G, Launso L, Koithan M, Falkenberg T, Boon H, Aickin M (2007) Researching complementary and alternative treatments–the gatekeepers are not at home. BMC Med Res Methodol 7:7. doi:10.1186/1471-2288-7-7
Holdsworth MT et al (2006) Acute and delayed nausea and emesis control in pediatric oncology patients. Cancer 106(4):931–940
Hughes D, Ladas E, Rooney D, Kelly K (2008) Massage therapy as a supportive care intervention for children with cancer. Oncol Nurs Forum 35(3):431–442. doi:10.1188/08.ONF.431-442
Jindal V et al (2008) Safety and efficacy of acupuncture in children a review of the evidence. J Pediatr Hematol Oncol 30(6):431–442
Kelly KM (2004) Complementary and alternative medical therapies for children with cancer. Eur J Cancer 40(14):2041–2046. doi:10.1016/j.ejca.2004.05.012
Kemper KJ et al (2008) The use of complementary and alternative medicine in pediatrics. Pediatrics (Evanston) 122(6):1374–1386
Klassen TP, Pham B, Lawson ML, Moher D (2005) For randomized controlled trials, the quality of reports of complementary and alternative medicine was as good as reports of conventional medicine. J Clin Epidemiol 58(8):763–768. doi:10.1016/j.jclinepi.2004.08.020
Ladas EJ, Post-White J, Hawks R, Taromina K (2006) Evidence for symptom management in the child with cancer. J Pediatr Hematol Oncol 28(9):601–615
Landier W, Tse A (2010) Use of complementary and alternative medical interventions for the management of procedure-related pain, anxiety, and distress in pediatric oncology: an integrative review. J Pediatr Nurs 25(6):566–579
Lawenda BD et al (2008) Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 100(11):773–783
Lawson ML, Pham B, Klassen TP, Moher D (2005) Systematic reviews involving complementary and alternative medicine interventions had higher quality of reporting than conventional medicine reviews. J Clin Epidemiol 58(8):777–784. doi:10.1016/j.jclinepi.2004.08.022
Linde K, Jonas WB, Melchart D, Willich S (2001) The methodological quality of randomized controlled trials of homeopathy, herbal medicines and acupuncture. Int J Epidemiol 30(3):526–531
Maizes V (2009) Integrative medicine and patient-centered care. Explore (NY) 5(5):277–289
Melnick SJ (2006) Developmental therapeutics: review of biologically based complementary and alternative medicine (CAM) therapies for potential application in children with cancer-part II. J Pediatr Hematol Oncol 28(5):271–285
Moffet HH (2006) How might acupuncture work? a systematic review of physiologic rationales from clinical trials. BMC Complement Altern Med 6(1):25
Myers C et al (2005) Complementary therapies and childhood cancer. Cancer Control 12(3):172–180
Perrone G et al (2009) Ascorbic acid inhibits antitumor activity of bortezomib in vivo. Leukemia 23(9):1679–1686
Post-White J, Hawks R (2005) Complementary and alternative medicine in pediatric oncology. Semin Oncol Nurs 21(2):107–114
Rheingans JI (2007) A systematic review of nonpharmacologic adjunctive therapies for symptom management in children with cancer. J Pediatr Oncol Nurs 24(2):81–94
Rooney D, Le TK, Hughes D et al (2006) A retrospective review investigating the feasibility of acupuncture as a supportive care agent in a pediatric oncology service. In: Annual meeting of the Society of Integrative Oncology, Boston, 2006
Sagar SM (2006) Integrative oncology in North America. J Soc Integr Oncol 4(1):27–39
Sencer SF, Kelly KM (2007) Complementary and alternative therapies in pediatric oncology. Pediatr Clin North Am 54:1043–1060
Sencer SF et al (2012) Traumeel S in preventing and treating mucositis in young patients undergoing SCT: a report of the Children’s Oncology Group. Bone Marrow Transplant. doi:10.1038/bmt.2012.30.
Sharpe D, Rossiter L (2002) Siblings of children with a chronic illness: a meta-analysis. J Pediatr Psychol 27(8):699–710
Sox HC, Greenfield S (2009) Comparative effectiveness research: a report from the institute of medicine. Ann Intern Med 151(3):203
Verhoef MJ et al (2002) Assessing efficacy of complementary medicine: adding qualitative research methods to the “gold standard”. J Altern Complement Med (NY) 8(3):275–281
Walach H et al (2003) The role of outcomes research in evaluating complementary and alternative medicine. Altern Ther Health Med 8(3):88
Wayne JB (2005) Building an evidence house: challenges and solutions to research in complementary and alternative medicine. Forsch Komplementarmed Klass Naturheilkd 12:159–167
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Chokshi, S., Kelly, K. (2012). Potential Role of Complementary and Alternative Medicine in Pediatric Oncology: The Future of CAM Research – Addressing the “Effectiveness Gaps”. In: Längler, A., Mansky, P., Seifert, G. (eds) Integrative Pediatric Oncology. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04201-0_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-04201-0_11
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-04200-3
Online ISBN: 978-3-642-04201-0
eBook Packages: MedicineMedicine (R0)