Skip to main content
SpringerLink
Log in

Rare Tumors of the Urinary Tract

  • Chapter
  • First Online:
Rare Tumors In Children and Adolescents

Part of the book series: Pediatric Oncology ((PEDIATRICO))

  • 1193 Accesses

Abstract

Malignant renal tumors cover 6% of all childhood cancers (Pastore et al. 2006). Wilms tumor or nephroblastoma is largely the most common type of cancer in the kidney of children, accounting for more than 90% of primary renal tumors. Other tumors, like clear cell sarcoma of the kidney (CCSK), rhabdoid tumor of the kidney (RTK), renal cell carcinoma (RCC), renal medullary carcinoma, congenital mesoblastic nephroma (CMN), primitive neuroectodermal tumor of the kidney, adenoma of the kidney, oncocytoma, and others, are much rarer. As their treatment and prognosis is quite different from Wilms tumor, an early timely diagnosis is crucial to deliver the best treatment to patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahmed HU, Arya M, Levitt G et al (2007) Part I: primary malignant non-Wilms’ renal tumors in children. Lancet Oncol 8:730–737

    Article  PubMed  Google Scholar 

  • Alanee S, Shukla AR (2009) Bladder malignancies in children aged  <  18 years: results from the Surveillance, Epidemiology and End results database. BJU Int 106:557–560

    Article  PubMed  Google Scholar 

  • Ammerlaan AC, Ararou A, Houben MP, Baas F, Tijssen CC, Teepen JL, Wesseling P, Hulsebos TJ (2007) Long-term survival and transmission of INI1-mutation via nonpenetrant males in a family with rhabdoid tumour predisposition syndrome. Br J Cancer 18:18

    Google Scholar 

  • Argani P, Ladanyi M (2003) Recent advances in paediatric renal neoplasia. Adv Anat Pathol 10:243–260

    Article  PubMed  Google Scholar 

  • Argani P, Ladanyi M (2005) Translocation carcinomas of the kidney. Clin Lab Med 25:363–378

    Article  PubMed  Google Scholar 

  • Argani P, Ladanyi M (2006) The evolving story of renal translocation carcinomas. Am J Clin Pathol 126:332–334

    Article  PubMed  Google Scholar 

  • Argani P, Perlman EJ, Breslow NE, Browning NG, Green DM, D’Angio GJ, Beckwith JB (2000) Clear cell sarcoma of the kidney: a review of 351 cases from the National Wilms Tumor Study Group Pathology Center. Am J Surg Pathol 24:4–18

    Article  PubMed  CAS  Google Scholar 

  • Argani P, Antonescu CR, Illei PB et al (2001a) Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinct tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol 159:179–192

    Article  PubMed  CAS  Google Scholar 

  • Argani P, Hawkins A, Griffin CA et al (2001b) A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome trans location. Am J Pathol 158:2089–2096

    Article  PubMed  CAS  Google Scholar 

  • Argani P, Lui MY, Couturier J et al (2003) A novel CLTC-TFE3 gene fusion in pediatric renal cell adenocarcinoma with t(X;17)(p11.2;q23). Oncogene 22:5374–5378

    Article  PubMed  CAS  Google Scholar 

  • Argani P, Laé M, Hutchinson B et al (2005) Renal carcinoma with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol 29:230–240

    Article  PubMed  Google Scholar 

  • Argani P, Laé M, Ballard ET, Amin M et al (2006) Translocation carcinomas of the kidney after chemotherapy in childhood. J Clin Oncol 24:1530–1534

    Article  CAS  Google Scholar 

  • Argani P, Olgac S, Tickoo SK et al (2007) Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrum. Am J Surg Pathol 31:1149–1160

    Article  PubMed  Google Scholar 

  • Arroyo MR, Green DM, Perman EJ et al (2001) The spectrum of metanephric adenofibroma and related lesions. Am J Surg Pathol 25:433–444

    Article  PubMed  CAS  Google Scholar 

  • Athale UH, Duckworth J, Odame I, Barr R (2009) Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies. J Pediatr Hematol Oncol 31:651–663

    Article  PubMed  Google Scholar 

  • Baek M, Jung JY, Kim JJ, Park KH, Ryu DS (2010) Characteristics and clinical outcomes of renal cell carcinoma in children: a single center experience. Int J Urol 17(8):737–740

    Article  PubMed  Google Scholar 

  • Barroca H (2008) Fine needle biopsy and genetics, two allied weapons in the diagnosis, prognosis, and target therapeutics of solid pediatric tumors. Diagn Cytopathol 36:678–684

    Article  PubMed  Google Scholar 

  • Bellmunt J, Guix M (2009) The medical management of metastatic renal cell carcinoma: integrating new guidelines and recommendations. BJU Int 103:572–577

    Article  PubMed  CAS  Google Scholar 

  • Berger A, Kim C, Hagstrom N, Ferrer F (2007) Succesful preoperative treatment of pediatric bladder inflammatory myofibroblastic tumor with anti-inflammatory therapy. Urology 70(372):e13–e15

    PubMed  Google Scholar 

  • Biegel JA (2006) Molecular genetics of atypical teratoid/rhabdoid tumor. Neurosurg Focus 20:E11

    Article  PubMed  Google Scholar 

  • Biegel JA, Allen CS, Kawasaki K, Shimizu N, Budarf ML, Bell CJ (1996) Narrowing the critical region for a rhabdoid tumor locus in 22q11. Genes Chromosomes Cancer 16:94–105

    Article  PubMed  CAS  Google Scholar 

  • Biegel JA, Kalpana G, Knudsen ES, Packer RJ, Roberts CW, Thiele CJ, Weissman B, Smith M (2002a) The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors. Cancer Res 62:323–328

    PubMed  CAS  Google Scholar 

  • Biegel JA, Tan L, Zhang F, Wainwright L, Russo P, Rorke LB (2002b) Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clin Cancer Res 8:3461–3467

    PubMed  CAS  Google Scholar 

  • Blom JH, van Poppel H, Maréchal JM et al (2008) Radical nephrectomy with and without lymph-node dissection: final results of the European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881. Eur Urol 55:28–34

    Article  PubMed  Google Scholar 

  • Brownlee NA, Perkins LA, Stewart W, Jackle B, Pettenati MJ, Koty PP, Iskandar SS, Garvin AJ (2007) Recurring translocation (10;17) and deletion (14q) in clear cell sarcoma of the kidney. Arch Pathol Lab Med 131:446–451

    PubMed  Google Scholar 

  • Bruder E, Passera O, Harms D et al (2004) Morphologic and molecular characterization of renal cell carcinoma in children and young adults. Am J Surg Pathol 28:1117–1132

    Article  PubMed  Google Scholar 

  • Brugarolas J (2007) Renal-cell carcinoma – molecular pathways and therapies. N Engl J Med 356:185–187

    Article  PubMed  CAS  Google Scholar 

  • Bukowski RM (2010) Pazopanib: amultikinase inhibitor with activity in advanced renal cell carcinoma. Expert Rev Anticancer Ther 10:635–645

    Article  PubMed  CAS  Google Scholar 

  • Camparo P, Vasiliu V, Molinie V et al (2008) Renal translocation carcinomas: clinicopathologic, immunohistochemical, and gene expression profiling analysis of 31 cases with a review of the literature. Am J Surg Pathol 35:656–670

    Google Scholar 

  • Carcao MD, Taylor GP, Greenberg ML et al (1998) Renal-cell carcinoma in children: a different disorder from its adult counterpart? Med Pediatr Oncol 31:153–158

    Article  PubMed  CAS  Google Scholar 

  • Chi SN, Zimmerman MA, Yao X, Cohen KJ, Burger P, Biegel JA, Rorke-Adams LB, Fisher MJ, Janss A, Mazewski C, Goldman S, Manley PE, Bowers DC, Bendel A, Rubin J, Turner CD, Marcus KJ, Goumnerova L, Ullrich NJ, Kieran MW (2008) Intensive multimodality treatment for children with newly diagnosed CNS atypical teratoid rhabdoid tumor. J Clin Oncol 8:8–14

    Google Scholar 

  • Ciftci AO, Talim B, Senocak ME et al (2000) Renal oncocytoma: diagnostic and therapeutic aspects. J Pediatr Surg 35:1396–1398

    Article  PubMed  CAS  Google Scholar 

  • Cook A, Lorenzo AJ, Salle JL et al (2006) Pediatric renal cell carcinoma: single institution 25-year case series and initial experience with partial nephrectomy. J Urol 175:1456–1460

    Article  PubMed  Google Scholar 

  • Corey SJ, Andersen JW, Vawter GF, Lack EE, Sallan SE (1991) Improved survival for children with anaplastic Wilms’ tumors. Cancer 68:970–974

    Article  PubMed  CAS  Google Scholar 

  • Cutcliffe C, Kersey D, Huang CC, Zeng Y, Walterhouse D, Perlman EJ, Renal Tumor Committee of the Children’s Oncology Group (2005) Clear cell sarcoma of the kidney: up-regulation of neural markers with activation of the sonic hedgehog and Akt pathways. Clin Cancer Res 11:7986–7994

    Article  PubMed  CAS  Google Scholar 

  • D’Angio GJ, Breslow N, Beckwith JB, Evans A, Baum H, deLorimier A, Fernbach D, Hrabovsky E, Jones B, Kelalis P et al (1989) Treatment of Wilms’ tumor. Results of the Third National Wilms’ Tumor Study. Cancer 64:349–360

    Article  PubMed  Google Scholar 

  • Davis CJ Jr, Mostofi FK, Sesterhenn IA (1995) Renal medullary carcinoma. The seventh sickle cell nephropathy. Am J Surg Pathol 19:1–11

    Article  PubMed  Google Scholar 

  • Eble JN, Sauter G, Epstein JI, Sesterhenn IA (2004) Pathology and genetics of tumours of the urinary system and male genital organs. In: Kleihue P, Sobin L (eds) World Health Orgnization classification of tumors. IARC Press, Lyon, pp 89–123

    Google Scholar 

  • Escudier B (2010a) Chemo-immunotherapy in RCC: the end of a story. Lancet 375:613–614

    Article  PubMed  Google Scholar 

  • Escudier B (2010b) Sunitinib for the management of advanced renal cell carcinoma. Expert Rev Anticancer Ther 10:305–317

    Article  PubMed  CAS  Google Scholar 

  • Escudier B, Kataja V (2010) Renal cell carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 21(suppl 5):v137–v139

    Article  PubMed  Google Scholar 

  • Escudier B, Eisen T, Stadler WM et al (2007a) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356:125–134

    Article  PubMed  CAS  Google Scholar 

  • Escudier B, Pluzanska A, Koralewski P et al (2007b) Bevacizumab plus interferon alfa-2a fro treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 370:2103–2111

    Article  PubMed  Google Scholar 

  • Escudier B, Eisen T, Stadler WM et al (2009) Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 27:3312–3318

    Article  PubMed  CAS  Google Scholar 

  • Escudier B, Bellmunt J, Négrier S et al (2010) Phase III trial of bevacizumab plus interferon alfta-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 28:2144–2150

    Article  PubMed  CAS  Google Scholar 

  • Estrada CR, Suthar AM, Eaton SH et al (2005) Renal cell carcinoma: Children’s Hospital Boston experience. Urology 66:1296–1300

    Article  PubMed  Google Scholar 

  • Ficarra V (2007) Open radical nephrectomy versus open partial nephrectomy: is it still an issue? Eur Urol 51:593–595

    Article  PubMed  Google Scholar 

  • Fine SW, Humphrey PA, Dehner LP et al (2005) Urothelial neoplasms in patients 20 years or younger: a clinicopathological analysis using the World Health Organization 2004 bladder consensus classification. J Urol 174:1976–1980

    Article  PubMed  Google Scholar 

  • Frühwald MC, Hasselblatt M, Wirth S, Köhler G, Schneppenheim R, Subero JI, Siebert R, Kordes U, Jürgens H, Vormoor J (2006) Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome. Pediatr Blood Cancer 47:273–278

    Article  PubMed  Google Scholar 

  • Geller JI, Dome JS (2004) Local lymph node involvement does not predict poor outcome in pediatric renal cell carcinoma. Cancer 101:1575–1583

    Article  PubMed  Google Scholar 

  • Geller JI, Argani P, Adeniran A et al (2008) Translocation renal cell carcinoma: lack of negative impact due to lymph node spread. Cancer 112:1607–1616

    Article  PubMed  Google Scholar 

  • Giedl J, Wild PJ, Stoehr R et al (2006) Urothelial neoplasms in individuals younger than 20 years show very few genetic alterations and have a favourable clinical outcome. Verh Dtsch Ges Pathol 90:253–263

    PubMed  CAS  Google Scholar 

  • Gill IS, Aron M, Gervais DA, Jewett MAS (2010) Small renal masses. N Engl J Med 362:624–634

    Article  PubMed  CAS  Google Scholar 

  • Graf N, Reinhard H, Aliani S et al (2003) Wilms tumour with or without tumour related symptoms at diagnosis. Med Pediatr Oncol 41:266, O036 (Abstract)

    Google Scholar 

  • Gripp KW, Lin AE (2005) Tumor predisposition in Costello syndrome. Am J Med Genet C Semin Med Genet 137C(1):72–77

    Article  PubMed  Google Scholar 

  • Grundy RG, Hutton C, Middleton H, Imeson J, Pritchard J, Kelsey A, Marsden HB, Vujanic GM, Taylor RE, United Kingdom Children’s Cancer Study Group (2004) Outcome of patients with stage III or inoperable WT treated on the second United Kingdom WT protocol (UKWT2); a United Kingdom Children’s Cancer Study Group (UKCCSG) study. Pediatr Blood Cancer 42:311–319

    Article  PubMed  CAS  Google Scholar 

  • Gururangan S, Bowman LC, Parham DM, Wilimas JA, Rao B, Pratt CB, Douglass EC (1993) Primary extracranial rhabdoid tumors: clinicopathologic features and response to ifosfamide. Cancer 71:2653–2659

    Article  PubMed  CAS  Google Scholar 

  • Gutjahr P, Kaatsch P, Spaar HJ et al (1990) Klinik, Therapie und Prognose bei 373 Kindern mit Wilms-Tumoren – Ergebnisse der bundesweiten Studie 1980–1988. Akt Uro 121:132–141

    Article  Google Scholar 

  • Haas JE, Palmer NF, Weinberg AG, Beckwith JB (1981) Ultrastructure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol 12:646–657

    Article  PubMed  CAS  Google Scholar 

  • Hirose M, Yamada T, Toyosaka A, Hirose T, Kagami S, Abe T, Kuroda Y (1996) Rhabdoid tumor of the kidney: a report of two cases with respective tumor markers and a specific chromosomal abnormality, del(11p13). Med Pediatr Oncol 27:174–178

    Article  PubMed  CAS  Google Scholar 

  • Hoenig DM, McRae S et al (1996) Transitional cell carcinoma of the bladder in the pediatric patient. J Urol 156:203

    Article  PubMed  CAS  Google Scholar 

  • Houben CH, Chan A, Lee KH et al (2007) Inflammatory myofibroblastic tumor of the bladder in children: what can be expected? Pediatr Surg Int 23:815–819

    Article  PubMed  CAS  Google Scholar 

  • Huang CC, Cutcliffe C, Coffin C, Sorensen PH, Beckwith JB, Perlman EJ, Renal Tumor Committee of the Children’s Oncology Group (2006) Classification of malignant pediatric renal tumors by gene expression. Pediatr Blood Cancer 46:728–738

    Article  PubMed  Google Scholar 

  • Hudes G, Carducci M, Tomczak P et al (2007) Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356:2271–2281

    Article  PubMed  CAS  Google Scholar 

  • Indolfi P, Terenziani M, Casale F et al (2003) Renal cell carcinoma in children: a clinicopathologic study. J Clin Oncol 21:530–535

    Article  PubMed  Google Scholar 

  • Jackson EM, Sievert AJ, Gai X, Hakonarson H, Judkins AR, Tooke L, Perin JC, Xie H, Shaikh TH, Biegel JA (2009) Genomic analysis using high-density single nucleotide ­polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors. Clin Cancer Res 15:1923–1930

    Article  PubMed  CAS  Google Scholar 

  • Janson K, Nedzi LA, David O, Schorin M, Walsh JW, Bhattacharjee M, Pridjian G, Tan L, Judkins AR, Biegel JA (2006) Predisposition to atypical teratoid/rhabdoid tumor due to an inherited INI1 mutation. Pediatr Blood Cancer 47:279–284

    Article  PubMed  Google Scholar 

  • Joshi DD, Banerjee T (2008) Vascular endothelial growth factor (VEGF) receptor antibody bevacizumab (avastin) induces regression of renal cell carcinoma in an adolescent resulting in residual tumorectomy. Pediatr Blood Cancer 50:903–904

    Article  PubMed  Google Scholar 

  • Judkins AR (2007) Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology. Adv Anat Pathol 14:335–339

    Article  PubMed  CAS  Google Scholar 

  • Kidd JM (1970) Exclusion of certain renal neoplasms from the category of Wilms tumor [abstract]. Am J Pathol 58:16a

    Google Scholar 

  • Kordes U, Gesk S, Frühwald MC, Graf N, Leuschner I, Hasselblatt M, Jeibmann A, Oyen F, Peters O, Pietsch T, Siebert R, Schneppenheim R (2010) Clinical and molecular features in patients with rhabdoid tumor predisposition syndrome. Genes Chromosomes Cancer 49:176–181

    PubMed  CAS  Google Scholar 

  • Kumar D, Sharma P, Agarwala S et al (2010) Pediatric renal non Hodgkin lymphoma with inferior cava thrombosis. J Pediatr Hematol Oncol 32:147–149

    Article  PubMed  Google Scholar 

  • Kusumakumary P, Chellam VG, Rojymon J, Hariharan S, Krishnan NM (1997) Late recurrence of clear cell sarcoma of the kidney. Med Pediatr Oncol 28:355–357

    Article  PubMed  CAS  Google Scholar 

  • Lerena J, Krauel L, Garcia-Aparicio L et al (2010) Transitional cell carcinoma of the bladder in children and adolescents: six-cases series and review of the literature. J Pediatr Urol 6:481–485

    Article  PubMed  Google Scholar 

  • Lopez-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z, Montironi R (2009) 2009 update on the classification of renal epithelial tumors in adults. Int J Urol 16:432–443

    Article  PubMed  Google Scholar 

  • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109

    Article  PubMed  Google Scholar 

  • Magnani C, Gatta G, Corazziari I et al (2001) Childhood malignancies in the EUROCARE study: the database and the methods of survival analysis. Eur J Cancer 37:678–686

    Article  PubMed  CAS  Google Scholar 

  • Malouf GG, Camparo P, Oudard S et al (2010) Targeted agents in metastatic Xp11 translocation/TFE3 gene fusion renal cell carcinoma (RCC): a report from the Juvenile RCC Network. Ann Oncol 21(9):1834–1838

    Article  PubMed  CAS  Google Scholar 

  • Margulis V, Wood CG (2008) The role of lymph node dissection in renal cell carcinoma: the pendulum swings back. Cancer J 14:308–314

    Article  PubMed  Google Scholar 

  • Marsden HB, Lawler W (1980) Bone metastasizing renal tumor of childhood. Histopathological and clinical review of 38 cases. Virchows Arch A Pathol Anat Histol 387:341–351

    Article  PubMed  CAS  Google Scholar 

  • Miniati D, Gay AN, Parks KV et al (2008) Imaging accuracy and incidence of Wilms’ and non-Wilms’ renal tumors in children. J Pediatr Surg 43:1301–1307

    Article  PubMed  Google Scholar 

  • Mitchell C, Pritchard-Jones K, Shannon R, Hutton C, Stevens S, Machin D, Imeson J, Kelsey A, Vujanic GM, Gornall P, Walker J, Walker J, Taylor R, Sartori P, Hale J, Levitt G, Messahel B, Middleton H, Grundy R, Pritchard J, United Kingdom Cancer Study Group (2006) Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms’ tumour: results of a randomised trial (UKW3) by the UK Children’s Cancer Study Group. Eur J Cancer 42:2554–2562

    Article  PubMed  CAS  Google Scholar 

  • Motzer RJ, Hutson TE, Tomczak P et al (2007) Sunitinib versus inteferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115–124

    Article  PubMed  CAS  Google Scholar 

  • Motzer RJ, Hutson TE, Tomczak P et al (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 27:3584–3590

    Article  PubMed  CAS  Google Scholar 

  • Mou JW, Lee KH, Tam YH et al (2008) Urinary bladder pheochromocytoma, an extremely rare tumor in children: case report and review of the literature. Pediatr Surg Int 24:479–480

    Article  PubMed  CAS  Google Scholar 

  • Niu ZB, Yang Y, Hou Y et al (2010) Lymphangioma of bladder. Urology 76(4):955–957

    Article  PubMed  Google Scholar 

  • Parham DM, Weeks DA, Beckwith JB (1994) The clinicopathologic spectrum of putative extrarenal rhabdoid tumors. An analysis of 42 cases studied with immunohistochemistry or electron microscopy. Am J Surg Pathol 18:1010–1029

    Article  PubMed  CAS  Google Scholar 

  • Pastore G, Znaor A, Spreafico F, Graf N et al (2006) Malignant renal tumours incidence and survival in European children (1978–1997): report from the automated childhood cancer information system project. Eur J Cancer 42:2103–2114

    Article  PubMed  Google Scholar 

  • Patel R, Tery T, Ninan GK (2008) Transitional cell carcinoma of the bladder in first decade of life. Pediatr Surg Int 24:1265–1268

    Article  PubMed  Google Scholar 

  • Proust F, Laquerriere A, Constantin B, Ruchoux MM, Vannier JP, Freger P (1999) Simultaneous presentation of atypical teratoid/rhabdoid tumor in siblings. J Neurooncol 43:63–70

    Article  PubMed  CAS  Google Scholar 

  • Radulescu VC, Gerrard M, Moertel C et al (2008) Treatment of recurrent clear cell sarcoma of the kidney with brain metastasis. Pediatr Blood Cancer 50:246–249

    Article  PubMed  Google Scholar 

  • Ramphal R, Pappo A, Zielenska M et al (2006) Pediatric renal cell carcinoma: clinical, pathologic, and molecular abnormalities associated with the members of the MiT Transcription factor family. Am J Clin Pathol 126:349–364

    Article  PubMed  CAS  Google Scholar 

  • Rao Q, Chen JY, Wang JD et al (2009) Renal cell carcinoma in children and young adults: clinicopathological, immunohistochemical, and VHL gene analysis of 46 cases with follow-up. Int J Surg Pathol 19(2):170–179

    PubMed  Google Scholar 

  • Reinhard H, Reinert J, Beier R, Furtwängler R, Alkasser M, Rutkowski S, Frühwald M, Koscielniak E, Leuschner I, Kaatsch P, Graf N (2008) Rhabdoid tumors in children: prognostic factors in 70 patients diagnosed in Germany. Oncol Rep 19:819–823

    PubMed  Google Scholar 

  • Renshaw MD (2005) Local lymph node involvement does not predict poor out come in pediatric renal cell carcinoma. Cancer 103:1317–1318

    Article  PubMed  Google Scholar 

  • Rickert CH, Paulus W (2004) Chromosomal imbalances detected by comparative genomic hybridisation in atypical teratoid/rhabdoid tumours. Childs Nerv Syst 20:221–224, Epub 2004 Feb 4

    Article  PubMed  Google Scholar 

  • Ries LAG, Melbert D, Krapcho M et al (eds) (2008) SEER cancer statistics review, 1975–2005. National Cancer Institute. National Cancer Institute, Bethesda

    Google Scholar 

  • Rini BI, Campbell SC, Escudier B (2009) Renal cell carcinoma. Lancet 373:1119–1132

    Article  PubMed  CAS  Google Scholar 

  • Roberts CW, Galusha SA, McMenamin ME, Fletcher CD, Orkin SH (2000) Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci USA 97:13796–13800

    Article  PubMed  CAS  Google Scholar 

  • Roberts CW, Leroux MM, Fleming MD, Orkin SH (2002) Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell 2:415–425

    Article  PubMed  CAS  Google Scholar 

  • Sausville JE, Hernandez DJ, Argani P et al (2009) Pediatric renal cell carcinoma. J Pediatr Urol 5:308–314

    Article  PubMed  Google Scholar 

  • Schafernak KT, Yang XJ, Hsueh W, Leestma JL, Stagl J, Goldman S (2007) Pediatric renal cell carcinoma as second malignancy: reports of two cases and review of the literature. Can J Urol 14:3739–3744

    PubMed  Google Scholar 

  • Schenk JP, Engelmann D, Rohrschneider W et al (2004) Rhabdoid tumors of the kidney in childhood. Röfo 176:965–971

    PubMed  CAS  Google Scholar 

  • Schenk JP, Engelmann D, Zieger B et al (2005) [Radiologic differentiation of rhabdoid tumor from Wilms’ tumor and mesoblastic nephroma]. Urologe A 44:155–161

    Article  PubMed  CAS  Google Scholar 

  • Schuster AE, Schneider DT, Fritsch MK, Grundy P, Perlman EJ (2003) Genetic and genetic expression analyses of clear cell sarcoma of the kidney. Lab Invest 83:1293–1299

    Article  PubMed  CAS  Google Scholar 

  • Scott RH, Walker L, Olsen ØE et al (2006) Surveillance for Wilms tumour in at-risk children: pragmatic recommendations for best practice. Arch Dis Child 91:995–999

    Article  PubMed  CAS  Google Scholar 

  • Sebire NJ, Vujanic GM (2009) Paediatric renal tumours: recent developments, new entities and pathological features. Histopathology 54:516–528

    Article  PubMed  Google Scholar 

  • Seibel NL, Li S, Breslow NE et al (2004) Effect of duration of treatment on treatment outcome for patients with clear-cell sarcoma of the kidney: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 22:468–473

    Article  PubMed  Google Scholar 

  • Seibel NL, Sun J, Anderson JR, et al (2006) Outcome of clear cell sarcoma of the kidney (CCSK) treated on the National Wilms Tumor Study-5 (NWTS) [Abstract]. J Clin Oncol 24(suppl 18): A-9000, 502s

    Google Scholar 

  • Selle B, Furtwängler R, Graf N, Kaatsch P, Bruder E, Leuschner I (2006) Population-based study of renal cell carcinoma in children in Germany, 1980-2005: more frequently localized tumors and underlying disorders compared with adult counterparts. Cancer 107:2906–2914

    Article  PubMed  Google Scholar 

  • Sevenet N, Sheridan E, Amram D, Schneider P, Handgretinger R, Delattre O (1999) Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers. Am J Hum Genet 65:1342–1348

    Article  PubMed  CAS  Google Scholar 

  • Shet T, Viswanathan S (2009) The cytological diagnosis of paediatric renal tumours. J Clin Pathol 62:961–969

    Article  PubMed  CAS  Google Scholar 

  • Silberstein J, Grabowski J, Saltzstein SL, Kane CJ (2009) Renal cell carcinoma in the pediatric population: results from the California cancer registry. Pediatr Blood Cancer 52:237–241

    Article  PubMed  Google Scholar 

  • Smets AM, de Kraker J (2010) Malignant tumours of the kidney: imaging strategy. Pediatr Radiol 40:1010–1018

    Article  PubMed  Google Scholar 

  • Sotelo-Avila C, Gonzalez-Crussi F, deMello D, Vogler C, Gooch WM III, Gale G, Pena R (1986) Renal and extrarenal rhabdoid tumors in children: a clinicopathologic study of 14 patients. Semin Diagn Pathol 3:151–163

    PubMed  CAS  Google Scholar 

  • Soulières D (2009) Review of guidelines on the treatment of metastatic renal cell carcinoma. Curr Oncol 16(suppl 1):67–70

    Google Scholar 

  • Squire SE, Chan MD, Marcus KJ (2007) Atypical teratoid/rhabdoid tumor: the controversy behind radiation therapy. J Neurooncol 81:97–111, Epub 2006 Jul 20

    Article  PubMed  Google Scholar 

  • Sun M, Lughezzani G, Perrotte P, Karakiewicz PI (2010) Treatment of metastatic renal cell carcinoma. Nat Rev Urol 7:327–338

    Article  PubMed  CAS  Google Scholar 

  • Swartz MA, Karth J, Schneider DT et al (2002) Renal medullary carcinoma: clinical, pathological, immunohistochemical, and genetic analysis with pathogenetic implications. Urology 60:1083–1089

    Article  PubMed  Google Scholar 

  • Taylor MD, Gokgoz N, Andrulis IL, Mainprize TG, Drake JM, Rutka JT (2000) Familial posterior fossa brain tumors of infancy secondary to germline mutation of the hSNF5 gene. Am J Hum Genet 66:1403–1406, Epub 2000 Mar 14

    Article  PubMed  CAS  Google Scholar 

  • Tomlinson GE, Breslow NE, Dome J, Guthrie KA, Norkool P, Li S, Thomas PR, Perlman E, Beckwith JB, D’Angio GJ, Green DM (2005) Rhabdoid tumor of the kidney in the National Wilms’ tumor study: age at diagnosis as a prognostic factor. J Clin Oncol 23:7641–76415

    Article  PubMed  Google Scholar 

  • Touijer K, Jacqmin D, Kavoussi LR et al (2010) The expanding role of partial nephrectomy: a critical analysis of indications, results, and complications. Eur Urol 57:214–222

    Article  PubMed  Google Scholar 

  • van den Heuvel-Eibrink MM, Grundy P, Graf N, Pritchard-Jones K, Bergeron C, Patte C, van Tinteren H, Rey A, Langford C, Anderson JR, de Kraker J (2008) Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: a collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups. Pediatr Blood Cancer 50:1130–1134

    Article  PubMed  Google Scholar 

  • Versteege I, Sevenet N, Lange J, Rousseau-Merck MF, Ambros P, Handgretinger R, Aurias A, Delattre O (1998) Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 394:203–206

    Article  PubMed  CAS  Google Scholar 

  • Vujanic GM, Sandstedt B, Harms D, Boccon-Gibod L, Delemarre JF (1996) Rhabdoid tumour of the kidney: a ­clinicopathological study of 22 patients from the International Society of Paediatric Oncology (SIOP) nephroblastoma file. Histopathology 28:333–340

    Article  PubMed  CAS  Google Scholar 

  • Vujanic GM, Sandstedt B, Kelsey A, Sebire NJ (2009) Central pathology review in multicenter trials and studies: lessons from the nephroblastoma trials. Cancer 115:1977–1983

    Article  PubMed  Google Scholar 

  • Wagner L, Hill DA, Fuller C, Pedrosa M, Bhakta M, Perry A, Dome JS (2002) Treatment of metastatic rhabdoid tumor of the kidney. J Pediatr Hematol Oncol 24:385–388

    Article  PubMed  Google Scholar 

  • Waldron PE, Rodgers BM, Kelly MD, Womer RB (1999) Successful treatment of a patient with stage IV rhabdoid tumor of the kidney: case report and review. J Pediatr Hematol Oncol 21:53–57

    Article  PubMed  CAS  Google Scholar 

  • Weeks DA, Beckwith JB, Mierau GW (1989) Rhabdoid tumor. An entity or a phenotype? Arch Pathol Lab Med 113:113–114

    PubMed  CAS  Google Scholar 

  • Wick MR, Ritter JH, Dehner LP (1995) Malignant rhabdoid tumors: a clinicopathologic review and conceptual discussion. Semin Diagn Pathol 12:233–248

    PubMed  CAS  Google Scholar 

  • Wiesbauer P (2008) Nephrogene Tumoren. Radiologe 48:932–939

    Article  PubMed  CAS  Google Scholar 

  • Wiygul JB, Palmer L (2010) Isolated hemangioma causing gross painless hematuria in an adolescent male. Urology 76:463–464

    Article  PubMed  Google Scholar 

  • Wu A, Kunju LP, Cheng L, Shah RB (2008) Renal cell carcinoma in children and young adults: analysis of clinicopathological, immunohistochemical and molecular characteristics with an emphasis on the spectrum of Xp11.2 translocation-associated and unusual clear cell subtype. Histopathology 53:533–544

    Article  PubMed  CAS  Google Scholar 

  • Yossepowitch O, Dalbagni G (2002) Transitional cell carcinoma of the bladder in young adults: presentation, natural history and outcome. J Urol 168:61

    Article  PubMed  Google Scholar 

  • Zhang F, Tan L, Wainwright LM, Bartolomei MS, Biegel JA (2002) No evidence for hypermethylation of the hSNF5/INI1 promoter in pediatric rhabdoid tumors. Genes Chromosomes Cancer 34:398–405

    Article  PubMed  CAS  Google Scholar 

  • Zhuge Y, Cheung MC, Yang R et al (2010) Pediatric non-Wilms tumors: subtypes, survival, and prognostic indicators. J Surg Res 163:257–263

    Article  PubMed  Google Scholar 

  • Zimmerman MA, Goumnerova LC, Proctor M, Scott RM, Marcus K, Pomeroy SL, Turner CD, Chi SN, Chordas C, Kieran MW (2005) Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor. J Neurooncol 72:77–84

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133, Milano, Italy

    Filippo Spreafico & Norbert Graf

Authors
  1. Filippo Spreafico
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Norbert Graf
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Filippo Spreafico .

Editor information

Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Klinikum Dortmund gGmbH, Beurhausstr. 40, Dortmund, 44137, Germany

    Dominik T. Schneider

  2. Klinik für Kinder und Jugendliche, Universitätsklinikum Erlangen-Nürnberg, Loschgestr. 15, Erlangen, 91054, Germany

    Ines B. Brecht

  3. at Egleston, Dept. Pediatric Hematology/Oncology, Children's Healthcare of Atlanta, Uppergate Drive NE., 2015, Atlanta, 30322, Georgia, USA

    Thomas A. Olson

  4. Unità di Oncologia Pediatrica, Istituto Nazionale Tumori, Via G. Venezian 1, Milano, 20133, Italy

    Andrea Ferrari

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Spreafico, F., Graf, N. (2012). Rare Tumors of the Urinary Tract. In: Schneider, D., Brecht, I., Olson, T., Ferrari, A. (eds) Rare Tumors In Children and Adolescents. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04197-6_40

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-04197-6_40

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04196-9

  • Online ISBN: 978-3-642-04197-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation