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Pediatric Pleural Mesothelioma

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Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Malignant mesothelioma is an aggressive tumor that originates from the lining cells (mesothelium) that cover the serosal surfaces of the pleural and peritoneal cavities, or more rarely the tunica vaginalis testis and the pericardium (Moore et al. 2008). Based on the stage of the disease at the time of diagnosis, mesothelioma may present as discrete multifocal nodules or as a diffuse confluent mass encasing the adjacent organs and/or obliterating the serosal cavity from which the tumor has originated.

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References

  • Anderson KA, Hurley WC, Hurley BT et al (1985) Malignant pleural mesothelioma following radiotherapy in a 16-year-old boy. Cancer 56:273–276

    Article  PubMed  CAS  Google Scholar 

  • André N, Ratsimandresy R, Réguerre Y et al (2009) Paediatric malignant mesothelioma: the SFCE experience. Pediatr Blood Cancer 53:823

    Article  Google Scholar 

  • Antman KH, Ruxer RL Jr, Aisner J et al (1984) Mesothelioma following Wilms’ tumor in childhood. Cancer 54:367–369

    Article  PubMed  CAS  Google Scholar 

  • Brenner J, Sordillo PP, Magill GB (1981) Malignant mesothelioma in children: report of seven cases and review of the literature. Med Pediatr Oncol 9:367–373

    Article  PubMed  CAS  Google Scholar 

  • Falchero L, Coiffier B, Guibert B et al (1996) Malignant mesothelioma of the pleura following radiotherapy for Hodgkin disease. Bull Cancer 83:964–968

    PubMed  CAS  Google Scholar 

  • Flores RM, Su W, Lal D, Rusch VW, La Quaglia MP (2006) Extrapleural pneumonectomy in children. J Pediatr Surg 41:1738–1742

    Article  PubMed  Google Scholar 

  • Fraire AE, Cooper S, Greenberg SD et al (1988) Mesothelioma of childhood. Cancer 62:838–847

    Article  PubMed  CAS  Google Scholar 

  • Gordon PL, Wilroy RS, Lasater OE et al (1995) Neoplasms in Proteus syndrome. Am J Med Genet 57:74–78

    Article  PubMed  CAS  Google Scholar 

  • Grundy GW, Miller RW (1972) Malignant mesothelioma in childhood. Cancer 5:1216–1218

    Article  Google Scholar 

  • Haber DA, Buckler AJ (1992) WT1: a novel tumor suppressor gene inactivated in Wilms’ tumor. New Biol 4:97–106

    PubMed  CAS  Google Scholar 

  • Kashanskiy SV, André N (2010) Paediatric mésothelioma: is there the such a disease? Bull Cancer 97:571–576

    PubMed  CAS  Google Scholar 

  • Kauffman SL, Stout AP (1964) Mesothelioma in children. Cancer 17:539–544

    Article  PubMed  CAS  Google Scholar 

  • Kung FH, Desai SJ, Dickerman JD et al (1995) Ifosfamide/carboplatin/etoposide (ICE) for recurrent malignant solid tumors of childhood: a pediatric oncology group phase I/II study. J Pediatr Hematol Oncol 17:265–269

    Article  PubMed  CAS  Google Scholar 

  • Malamitsi-Puchner A, Dimitriadis D, Bartsocas C et al (1990) Proteus syndrome: course of a severe case. Am J Med Genet 35:283–285

    Article  PubMed  CAS  Google Scholar 

  • Margery J, Ruffié P (2008) Environmental cancer: malignant pleural mesothelioma. Bull Cancer 95:77–86

    PubMed  CAS  Google Scholar 

  • Milano E, Pourroy B, Rome A, Delarue A et al (2006) Efficacy of a combination of pemetrexed and multiple redo-surgery in an 11-year-old girl with a recurrent multifocal abdominal mesothelioma. Anticancer Drugs 17:1231–1234

    Article  PubMed  CAS  Google Scholar 

  • Moore AJ, Parker RJ, Wiggins J (2008) Malignant mesothelioma. Orphanet J Rare Dis 3:34

    Article  PubMed  Google Scholar 

  • Moran CA, Albores-Saavedral J, Suster S (2008) Primary peritoneal mesotheliomas in children: a clinicopathological and immunohistochemical study of eight cases. Histopathology 52:824–830

    Article  PubMed  CAS  Google Scholar 

  • Mutafoğlu-Uysal K, Kargi A, Sarialioğlu F, et al. (2002) Malignant pleural mesothelioma in a child: long-term survival with ICE-WAC chemotherapy regimen. Turk J Pediatr. 44(3):244–247

    Google Scholar 

  • Park S, Schalling M, Bernard A et al (1993) The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Nat Genet 4:415–420

    Article  PubMed  CAS  Google Scholar 

  • Pilling J, Dartnell JA (2010) Lang-lazdunski L integrated positron emission tomography-computed tomography does not accurately stage intrathoracic disease of patients undergoing trimodality therapy for malignant pleural mesothelioma. Thorac Cardiovasc Surg 58:215–219

    Article  PubMed  CAS  Google Scholar 

  • Scherpereel A, Astoul P, Baas P et al (2010) Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J 35:479–495

    Article  PubMed  CAS  Google Scholar 

  • Ugolini D, Neri M, Ceppi M et al (2008) Genetic susceptibility to malignant mesothelioma and exposure to asbestos: the influence of the familial factor. Mutat Res 658:162–167

    Article  PubMed  CAS  Google Scholar 

  • Vogelzang NJ, Rusthoven JJ, Symanowski J et al (2003) Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 21:2636–2644

    Article  PubMed  CAS  Google Scholar 

  • Wang ZJ, Reddy GP, Gotway MB, Higgins CB, Jablons DM, Ramaswamy M, Hawkins RA, Webb WR (2004) Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET. Radiographics 24:105–119

    Article  PubMed  Google Scholar 

  • You B, Blandin S, Gérinière L et al (2007) Mésothéliomes familiaux: une composante génétique associée aux risques environnementaux? Bull Cancer 7:705–710

    Google Scholar 

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Correspondence to Nicolas André .

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© 2012 Springer-Verlag Berlin Heidelberg

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André, N., Kashanskiy, S.K.V.V., Agaimy, A. (2012). Pediatric Pleural Mesothelioma. In: Schneider, D., Brecht, I., Olson, T., Ferrari, A. (eds) Rare Tumors In Children and Adolescents. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04197-6_27

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  • DOI: https://doi.org/10.1007/978-3-642-04197-6_27

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04196-9

  • Online ISBN: 978-3-642-04197-6

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