Skip to main content
SpringerLink
Log in
Book cover

Rare Tumors In Children and Adolescents pp 161–167Cite as

Esthesioneuroblastoma

  • Chapter
  • First Online:

  • 1211 Accesses

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Esthesioneuroblastoma, also often called olfactory neuroblastoma, is a rare tumor thought to arise from the olfactory neuroepithelium. It may occur at any age and accounts for 1–5% of intranasal tumors with an estimated incidence of 0.4/million population (Broich et al. 1997; Ferlito et al. 2003; Thompson 2009).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Argani P, Perez-Ordonez B et al (1998) Olfactory neuroblastoma is not related to the Ewing family of tumors: absence of EWS/FLI1 gene fusion and MIC2 expression. Am J Surg Pathol 22(4):391–398

    Article  PubMed  CAS  Google Scholar 

  • Argiris A, Dutra J et al (2003) Esthesioneuroblastoma: the Northwestern University experience. Laryngoscope 113(1):155–160

    Article  PubMed  Google Scholar 

  • Arnesen MA, Scheithauer BW et al (1994) Cushing’s syndrome secondary to olfactory neuroblastoma. Ultrastruct Pathol 18(1–2):61–68

    Article  PubMed  CAS  Google Scholar 

  • Bachar G, Goldstein DP et al (2008) Esthesioneuroblastoma: the Princess Margaret Hospital experience. Head Neck 30(12):1607–1614

    Article  PubMed  Google Scholar 

  • Banerjee AK, Sharma BS et al (1992) Intracranial olfactory neuroblastoma: evidence for olfactory epithelial origin. J Clin Pathol 45(4):299–302

    Article  PubMed  CAS  Google Scholar 

  • Benoit MM, Bhattacharyya N et al (2008) Cancer of the nasal cavity in the pediatric population. Pediatrics 121(1):e141–e145

    Article  PubMed  Google Scholar 

  • Bhattacharyya N, Thornton AF et al (1997) Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. Results in 9 cases. Arch Otolaryngol Head Neck Surg 123(1):34–40

    Article  PubMed  CAS  Google Scholar 

  • Biller HF, Lawson W et al (1990) Esthesioneuroblastoma: surgical treatment without radiation. Laryngoscope 100(11):1199–1201

    Article  PubMed  CAS  Google Scholar 

  • Bobele GB, Sexauer C et al (1994) Esthesioneuroblastoma presenting as an orbital mass in a young child. Med Pediatr Oncol 22(4):269–273

    Article  PubMed  CAS  Google Scholar 

  • Bradley PJ, Jones NS et al (2003) Diagnosis and management of esthesioneuroblastoma. Curr Opin Otolaryngol Head Neck Surg 11(2):112–118

    Article  PubMed  Google Scholar 

  • Broich G, Pagliari A et al (1997) Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924. Anticancer Res 17(4A):2683–2706

    PubMed  CAS  Google Scholar 

  • Chao KS, Kaplan C et al (2001) Esthesioneuroblastoma: the impact of treatment modality. Head Neck 23(9):749–757

    Article  PubMed  CAS  Google Scholar 

  • Cohen ZR, Marmor E et al (2002) Misdiagnosis of olfactory neuroblastoma. Neurosurg Focus 12(5):e3

    Article  PubMed  Google Scholar 

  • Devaiah AK, Andreoli MT (2009) Treatment of esthesioneuroblastoma: a 16-year meta-analysis of 361 patients. Laryngoscope 119(7):1412–1416

    Article  PubMed  Google Scholar 

  • Diaz EM Jr, Johnigan RH 3rd et al (2005) Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center. Head Neck 27(2):138–149

    Article  PubMed  Google Scholar 

  • Dulguerov P, Calcaterra T (1992) Esthesioneuroblastoma: the UCLA experience 1970–1990. Laryngoscope 102(8):843–849

    Article  PubMed  CAS  Google Scholar 

  • Dulguerov P, Allal AS et al (2001) Esthesioneuroblastoma: a meta-analysis and review. Lancet Oncol 2(11):683–690

    Article  PubMed  CAS  Google Scholar 

  • Eden BV, Debo RF et al (1994) Esthesioneuroblastoma. Long-term outcome and patterns of failure–the University of Virginia experience. Cancer 73(10):2556–2562

    Article  PubMed  CAS  Google Scholar 

  • Eich HT, Staar S et al (2001) Radiotherapy of esthesioneuroblastoma. Int J Radiat Oncol Biol Phys 49(1):155–160

    Article  PubMed  CAS  Google Scholar 

  • Eich HT, Hero B et al (2003) Multimodality therapy including radiotherapy and chemotherapy improves event-free survival in stage C esthesioneuroblastoma. Strahlenther Onkol 179(4):233–240

    Article  PubMed  Google Scholar 

  • Eich HT, Muller RP et al (2005) Esthesioneuroblastoma in childhood and adolescence. Better prognosis with multimodal treatment? Strahlenther Onkol 181(6):378–384

    Article  PubMed  Google Scholar 

  • Elkon D, Hightower SI et al (1979) Esthesioneuroblastoma. Cancer 44(3):1087–1094

    Article  PubMed  CAS  Google Scholar 

  • Faragalla H, Weinreb I (2009) Olfactory neuroblastoma: a review and update. Adv Anat Pathol 16(5):322–331

    Article  PubMed  CAS  Google Scholar 

  • Ferlito A, Rinaldo A et al (2003) Contemporary clinical commentary: esthesioneuroblastoma: an update on management of the neck. Laryngoscope 113(11):1935–1938

    Article  PubMed  Google Scholar 

  • Folbe A, Herzallah I et al (2009) Endoscopic endonasal resection of esthesioneuroblastoma: a multicenter study. Am J Rhinol Allergy 23(1):91–94

    Article  PubMed  Google Scholar 

  • Foote RL, Morita A et al (1993) Esthesioneuroblastoma: the role of adjuvant radiation therapy. Int J Radiat Oncol Biol Phys 27(4):835–842

    Article  PubMed  CAS  Google Scholar 

  • Franklin D, Miller RH et al (1987) Esthesioneuroblastoma metastatic to the trachea. Head Neck Surg 10(2):102–106

    Article  PubMed  CAS  Google Scholar 

  • Freeman SR, Mitra S et al (2005) Expression of somatostatin receptors in arginine vasopressin hormone-secreting olfactory neuroblastoma–report of two cases. Rhinology 43(1):61–65

    PubMed  CAS  Google Scholar 

  • Goldsweig HG, Sundaresan N (1990) Chemotherapy of recurrent esthesioneuroblastoma. Case report and review of the literature. Am J Clin Oncol 13(2):139–143

    Article  PubMed  CAS  Google Scholar 

  • Gore MR, Zanation AM (2009) Salvage treatment of late neck metastasis in esthesioneuroblastoma: a meta-analysis. Arch Otolaryngol Head Neck Surg 135(10):1030–1034

    Article  PubMed  Google Scholar 

  • Hirose T, Scheithauer BW et al (1995) Olfactory neuroblastoma. An immunohistochemical, ultrastructural, and flow cytometric study. Cancer 76(1):4–19

    Article  PubMed  CAS  Google Scholar 

  • Hyams V, Batsakis JG, Michaels L, Armed Forces Institute of Pathology Fascicles (1988) Tumors of the upper respiratory tract and ear, vol 2. American Registry of Pathology Press, Washington D.C

    Google Scholar 

  • Jethanamest D, Morris LG et al (2007) Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors. Arch Otolaryngol Head Neck Surg 133(3):276–280

    Article  PubMed  Google Scholar 

  • Jugie M, Marsot-Dupuch K et al (1992) Unusual localization of an olfactory esthesioneuroma. Ann Radiol (Paris) 35(6):477–482

    CAS  Google Scholar 

  • Kadish S, Goodman M et al (1976) Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 37(3):1571–1576

    Article  PubMed  CAS  Google Scholar 

  • Kairemo KJ, Jekunen AP et al (1998) Imaging of olfactory neuroblastoma–an analysis of 17 cases. Auris Nasus Larynx 25(2):173–179

    Article  PubMed  CAS  Google Scholar 

  • Kiyota N, Tahara M et al (2008) Nonplatinum-based chemotherapy with irinotecan plus docetaxel for advanced or metastatic olfactory neuroblastoma: a retrospective analysis of 12 cases. Cancer 112(4):885–891

    Article  PubMed  CAS  Google Scholar 

  • Koka VN, Julieron M et al (1998) Aesthesioneuroblastoma. J Laryngol Otol 112(7):628–633

    Article  PubMed  CAS  Google Scholar 

  • Kumar M, Fallon RJ et al (2002) Esthesioneuroblastoma in children. J Pediatr Hematol Oncol 24(6):482–487

    Article  PubMed  Google Scholar 

  • Lochrin C (1989) Esthesioneuroblastoma. Med Pediatr Oncol 17(5):433–438

    PubMed  CAS  Google Scholar 

  • Loy AH, Reibel JF et al (2006) Esthesioneuroblastoma: continued follow-up of a single institution’s experience. Arch Otolaryngol Head Neck Surg 132(2):134–138

    Article  PubMed  Google Scholar 

  • Lund VJ, Stammberger H, et al (2010) European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base. Rhinol Suppl (22):1–143

    Google Scholar 

  • Mariani L, Schaller B et al (2004) Esthesioneuroblastoma of the pituitary gland: a clinicopathological entity? Case report and review of the literature. J Neurosurg 101(6):1049–1052

    Article  PubMed  Google Scholar 

  • McElroy EA Jr, Buckner JC et al (1998) Chemotherapy for advanced esthesioneuroblastoma: the Mayo Clinic experience. Neurosurgery 42(5):1023–1027, discussion 1027–1028

    Article  PubMed  Google Scholar 

  • McLean JN, Nunley SR et al (2007) Combined modality therapy of esthesioneuroblastoma. Otolaryngol Head Neck Surg 136(6):998–1002

    Article  PubMed  Google Scholar 

  • Mezzelani A, Tornielli S et al (1999) Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing’s group. Br J Cancer 81(4):586–591

    Article  PubMed  CAS  Google Scholar 

  • Mills SE (2002) Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. Mod Pathol 15(3):264–278

    Article  PubMed  Google Scholar 

  • Morita A, Ebersold MJ et al (1993) Esthesioneuroblastoma: prognosis and management. Neurosurgery 32(5):706–714, discussion 714–705

    Article  PubMed  CAS  Google Scholar 

  • Myers SL, Hardy DA et al (1994) Olfactory neuroblastoma invading the oral cavity in a patient with inappropriate antidiuretic hormone secretion. Oral Surg Oral Med Oral Pathol 77(6):645–650

    Article  PubMed  CAS  Google Scholar 

  • Nelson RS, Perlman EJ et al (1995) Is esthesioneuroblastoma a peripheral neuroectodermal tumor? Hum Pathol 26(6):639–641

    Article  PubMed  CAS  Google Scholar 

  • Nguyen BD, Roarke MC et al (2006) F-18 FDG PET/CT staging and posttherapeutic assessment of esthesioneuroblastoma. Clin Nucl Med 31(3):172–174

    Article  PubMed  Google Scholar 

  • Nichols AC, Chan AW et al (2008) Esthesioneuroblastoma: the Massachusetts eye and ear infirmary and Massachusetts general hospital experience with craniofacial resection, proton beam radiation, and chemotherapy. Skull Base 18(5):327–337

    Article  PubMed  Google Scholar 

  • Oskouian RJ Jr, Jane JA Sr et al (2002) Esthesioneuroblastoma: clinical presentation, radiological, and pathological features, treatment, review of the literature, and the University of Virginia experience. Neurosurg Focus 12(5):e4

    Article  PubMed  Google Scholar 

  • Osterman J, Calhoun A et al (1986) Chronic syndrome of inappropriate antidiuretic hormone secretion and hypertension in a patient with olfactory neuroblastoma. Evidence of ectopic production of arginine vasopressin by the tumor. Arch Intern Med 146(9):1731–1735

    Article  PubMed  CAS  Google Scholar 

  • Ozsahin M, Gruber G et al (2010) Outcome and prognostic factors in olfactory neuroblastoma: a rare cancer network study. Int J Radiat Oncol Biol Phys 78(4):992–997

    Article  PubMed  Google Scholar 

  • Perkkio M, Majuri S et al (1991) A child with esthesioneuroblastoma with metastases to the spinal cord and the bone marrow. Med Pediatr Oncol 19(1):66–69

    Article  PubMed  CAS  Google Scholar 

  • Porter AB, Bernold DM et al (2008) Retrospective review of adjuvant chemotherapy for esthesioneuroblastoma. J Neurooncol 90(2):201–204

    Article  PubMed  Google Scholar 

  • Rakes SM, Yeatts RP et al (1985) Ophthalmic manifestations of esthesioneuroblastoma. Ophthalmology 92(12):1749–1753

    PubMed  CAS  Google Scholar 

  • Ramsay HA, Kairemo KJ et al (1996) Somatostatin receptor imaging of olfactory neuroblastoma. J Laryngol Otol 110(12):1161–1163

    Article  PubMed  CAS  Google Scholar 

  • Resto VA, Eisele DW et al (2000) Esthesioneuroblastoma: the Johns Hopkins experience. Head Neck 22(6):550–558

    Article  PubMed  CAS  Google Scholar 

  • Rinaldo A, Ferlito A et al (2002) Esthesioneuroblastoma and cervical lymph node metastases: clinical and therapeutic implications. Acta Otolaryngol 122(2):215–221

    Article  PubMed  Google Scholar 

  • Rostomily RC, Elias M et al (2006) Clinical utility of somatostatin receptor scintigraphic imaging (octreoscan) in esthesioneuroblastoma: a case study and survey of somatostatin receptor subtype expression. Head Neck 28(4):305–312

    Article  PubMed  Google Scholar 

  • Seccia V, Lenzi R et al (2010) Ectopic olfactory neuroblastoma arising in the pterygopalatine fossa. Otolaryngol Head Neck Surg 142(3):460–461

    Article  PubMed  Google Scholar 

  • Sharma SC, Reddy CE et al (2002) Isolated esthesioneuroblastoma of sphenoid sinus. Am J Otolaryngol 23(5):287–289

    Article  PubMed  Google Scholar 

  • Snyderman CH, Carrau RL et al (2008) Endoscopic skull base surgery: principles of endonasal oncological surgery. J Surg Oncol 97(8):658–664

    Article  PubMed  Google Scholar 

  • Sorensen PH, Wu JK et al (1996) Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma. Proc Natl Acad Sci USA 93(3):1038–1043

    Article  PubMed  CAS  Google Scholar 

  • Sterzing F, Stoiber EM et al (2009) Intensity Modulated Radiotherapy (IMRT) in the treatment of children and adolescents–a single institution’s experience and a review of the literature. Radiat Oncol 4:37

    Article  PubMed  Google Scholar 

  • Thompson LD (2009) Olfactory neuroblastoma. Head Neck Pathol 3(3):252–259

    Article  PubMed  Google Scholar 

  • Tselis N, Heyd R et al (2008) Interstitial high-dose-­rate-brachytherapy in advanced esthesioneuroblastoma. Laryngoscope 118(11):2006–2010

    Article  PubMed  Google Scholar 

  • Walch C, Stammberger H et al (2000) The minimally invasive approach to olfactory neuroblastoma: combined endoscopic and stereotactic treatment. Laryngoscope 110(4):635–640

    Article  PubMed  CAS  Google Scholar 

  • Woerner SJ, Lazerson J et al (1986) Olfactory neuroblastoma (esthesioneuroblastoma) in a 2-year-old boy. Pediatr Hematol Oncol 3(2):167–174

    Article  PubMed  CAS  Google Scholar 

  • Wormald R, Lennon P et al (2011) Ectopic olfactory neuroblastoma: report of four cases and a review of the literature. Eur Arch Otorhinolaryngol 268(4):555–560

    Article  PubMed  CAS  Google Scholar 

  • Zabel A, Thilmann C et al (2002a) The role of stereotactically guided conformal radiotherapy for local tumor control of esthesioneuroblastoma. Strahlenther Onkol 178(4):187–191

    Article  PubMed  Google Scholar 

  • Zabel A, Thilmann C et al (2002b) Comparison of forward planned conformal radiation therapy and inverse planned intensity modulated radiation therapy for esthesioneuroblastoma. Br J Radiol 75(892):356–361

    PubMed  CAS  Google Scholar 

  • Zanation AM, Ferlito A et al (2010) When, how and why to treat the neck in patients with esthesioneuroblastoma: a review. Eur Arch Otorhinolaryngol 267(11):1667–1671

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pediatric Oncology and Hematology, Children’s Hospital, University of Cologne, Cologne, Germany

    Barbara Hero

  2. Division of Hematology/Oncology, Department of Pediatrics, University-Hospital of Padova, Padova, Italy

    Gianni Bisogno

Authors
  1. Barbara Hero
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gianni Bisogno
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Barbara Hero .

Editor information

Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Klinikum Dortmund gGmbH, Beurhausstr. 40, Dortmund, 44137, Germany

    Dominik T. Schneider

  2. Klinik für Kinder und Jugendliche, Universitätsklinikum Erlangen-Nürnberg, Loschgestr. 15, Erlangen, 91054, Germany

    Ines B. Brecht

  3. at Egleston, Dept. Pediatric Hematology/Oncology, Children's Healthcare of Atlanta, Uppergate Drive NE., 2015, Atlanta, 30322, Georgia, USA

    Thomas A. Olson

  4. Unità di Oncologia Pediatrica, Istituto Nazionale Tumori, Via G. Venezian 1, Milano, 20133, Italy

    Andrea Ferrari

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hero, B., Bisogno, G. (2012). Esthesioneuroblastoma. In: Schneider, D., Brecht, I., Olson, T., Ferrari, A. (eds) Rare Tumors In Children and Adolescents. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04197-6_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-04197-6_18

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04196-9

  • Online ISBN: 978-3-642-04197-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation