Abstract
Human umbilical veins (HUV) have recently been suggested as a starting material for vascular tissue engineering. HUV possess a functional smooth muscle layer and could be turned into an immunologically inert graft with contractile properties by creating a neoendothelium from the recipient’s own cells. This study investigated methods to remove the native endothelium without impairing the contractile function of the smooth muscle layer. These denuded HUV were then seeded with endothelial cells in a perfusion bioreactor, demonstrating the creation of a confluent, shear-resistant neoendothelium.
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© 2009 Springer-Verlag Berlin Heidelberg
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Hoenicka, M., Schrammel, S., Jacobs, V.R., Huber, G., Schmid, C., Birnbaum, D.E. (2009). Tissue Engineering of Small Caliber Vessel Grafts from Human Umbilical Veins. In: Dössel, O., Schlegel, W.C. (eds) World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, vol 25/10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03900-3_12
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DOI: https://doi.org/10.1007/978-3-642-03900-3_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03899-0
Online ISBN: 978-3-642-03900-3
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