Abstract
Newly designed phosphatidylglyceroglycerolbased liposomes are shown to be a temperature sensitive contrast agent for MRI when MR-active manganese(II)ions are trapped inside. At the therapeutic temperature of hyperthermia of 42 − 43°C the encapsulated Mn2 + can be detected by T1 changes in a MRI-Hyperthermia hybrid-system. The physical properties of the liposomes are characterized by lipid composition, size, morphology and not least solvent composition. Dependent on the solvent two mechanisms for the T1 changes can be found, enhanced water exchange through the lipid membrane or release of Mn2 + .
Our results indicate that our new liposomal system has the potentiality to improve temperature monitoring of hyperthermia and thus the therapeutic outcome. Moreover, the liposomes may also be used for specific release of chemotherapeutics by moderate hyperthermia.
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© 2009 International Federation for Medical and Biological Engineering
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Reinl, H.M., Hossann, M., Lindner, L.H., Reiser, M. (2009). Thermosensitive Mn2 + - Liposomes for MR-Guided Hyperthermia - Solvent-Dependent Mn2 + Release. In: Dössel, O., Schlegel, W.C. (eds) World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, vol 25/13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03895-2_7
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DOI: https://doi.org/10.1007/978-3-642-03895-2_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03894-5
Online ISBN: 978-3-642-03895-2
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