On Coupling Models Using Model-Checking: Effects of Irinotecan Injections on the Mammalian Cell Cycle

  • Elisabetta De Maria
  • François Fages
  • Sylvain Soliman
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5688)


In systems biology, the number of models of cellular processes increases rapidly, but re-using models in different contexts or for different questions remains a challenging issue. In this paper, we show how the validation of a coupled model and the optimization of its parameters with respect to biological properties formalized in temporal logics, can be done automatically by model-checking. More specifically, we illustrate this approach with the coupling of existing models of the mammalian cell cycle, the p53-based DNA-damage repair network, and irinotecan metabolism, with respect to the biological properties of this anticancer drug.


Model Check Temporal Logic Kripke Structure System Biology Markup Language Computation Tree Logic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Elisabetta De Maria
    • 1
  • François Fages
    • 1
  • Sylvain Soliman
    • 1
  1. 1.Project-team ContraintesINRIA Paris-RocquencourtFrance

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