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Tumorangiogenese

  • Chapter
Praxis der Viszeralchirurgie Onkologische Chirurgie

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Zusammenfassung

Solide Tumoren entstehen durch die Anhäufung von genetischen Mutationen oder Verlusten bestimmter Allele in Körper- oder Keimzellen und den dadurch bedingten Ausfall zellinterner Kontrollmechanismen mit konsekutiv ungehemmtem Zellwachstum. Dieser Umstand ist unter anderem in der Adenom-Karzinom-Sequenz von kolorektalen Karzinomen beschrieben und stellt sich meist als schrittweiser Prozess ausgehend von der mutierten Zelle über einen nichtinvasiven Tumor bis hin zum invasiven, metastasierenden Karzinom dar (Hanahan u. Weinberg 2000). Die verschiedenen genetischen Veränderungen bewirken einen Überlebens- und Wachstumsvorteil der mutierten Zellen und begünstigen die Entstehung von Tumoren mikroskopischer und im weiteren Verlauf auch makroskopischer Größe. Um den Prozess des Tumorwachstums und dem Zuwachs seiner Malignität zu verstehen, muss neben den genetischen Veränderungen in der Tumorzelle auch die Interaktion des Tumors mit dem umliegenden Mikromilieu, insbesondere mit dem Gefäßssystem betrachtet werden.

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Author information

Authors and Affiliations

  1. Chirurgische Klinik und Poliklinik G5, Klinikum Großhadern der LMU München, Marchioninistraße 15, 81337, München

    Dr. med. H. Nieß

  2. Chirurgische Klinik und Poliklinik, Klinikum Großhadern der LMU München, Marchioninistraße 15, 81337, München

    Dr. med. C. Conrad & Prof. Dr. med. C. J. Bruns

  3. Chirurgische Klinik und Poliklinik H 21, Klinikum Großhadern der LMU München, Marchioninistraße 15, 81337, München

    Dr. med. H. Seeliger

  4. Chirurgische Klinik und Poliklinik H6, Klinikum Großhadern der LMU München, Marchioninistraße 15, 81337, München

    Priv.-Doz. Dr. med. M. K. Angele & Prof. Dr. med. K.-W. Jauch

  5. Chirurgische Klinik und Poliklinik, Klinikum der Universität München, Marchioninistraße 15, 81337, München

    Dr. med. M. Eichhorn

Authors
  1. Dr. med. H. Nieß
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  2. Dr. med. C. Conrad
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  3. Dr. med. H. Seeliger
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  4. Priv.-Doz. Dr. med. M. K. Angele
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  5. Dr. med. M. Eichhorn
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  6. Prof. Dr. med. K.-W. Jauch
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  7. Prof. Dr. med. C. J. Bruns
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Editor information

Editors and Affiliations

  1. Universitätsklinikum Heidelberg, Im Neuenheimer Feld 672, 69120, Heidelberg

    J. R. Siewert (Leitender Ärztlicher Direktor und Vorstandsvorsitzender) (Leitender Ärztlicher Direktor und Vorstandsvorsitzender)

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg

    Matthias Rothmund

  3. Universitätsklinik und Poliklinik, Medizinische Fakultät der RWTH, Pauwelsstraße 30, 52057, Aachen

    Volker Schumpelick

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Nieß, H. et al. (2010). Tumorangiogenese. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie Onkologische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03808-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-03808-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03807-5

  • Online ISBN: 978-3-642-03808-2

  • eBook Packages: Medicine (German Language)

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