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Praxis der Viszeralchirurgie Onkologische Chirurgie pp 67–75Cite as

Genetische Aberration, Genexpressionprofile und Epigenetik

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Zusammenfassung

Die Behandlung von malignen Erkrankungen hat sich in den letzten Jahren zu einem interdisziplinären Konzept entwickelt. So ist nicht mehr allein die chirurgische Intervention maßgebend, sondern wird zusätzlich durch adjuvante und/ oder neoadjuvante radio-/chemotherapeutische Maßnahmen optimiert. Mit steigendem Verständnis über die Pathobiogenese von Krebserkrankungen werden in Zukunft weitere Therapieoptionen entwickelt werden können. Deshalb ist das grundlagentheoretische Wissen auch in der onkologischen Chirurgie nicht mehr wegzudenken. Im folgenden Kapitel sollen die wesentlichen Grundlagen maligner Tumoren vorgestellt werden.

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Literatur

  • Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, D Patterson S, Chang DD (2008) Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26(10): 1626–1634

    Article  CAS  PubMed  Google Scholar 

  • Burstein HJ (2005) The distinctive nature of HER2-positive breast cancers. N Engl J Med 353(16): 1652–1654

    Article  CAS  PubMed  Google Scholar 

  • Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296(5573): 1655–1657

    Article  CAS  PubMed  Google Scholar 

  • Debucquoy A, Haustermans K, Daemen A, Aydin S, Libbrecht L, Gevaert O, De Moor B, Tejpar S, McBride WH, Penninckx F, Scalliet P, Stroh C, Vlassak S, Sempoux C, Machiels JP (2009) Molecular response to cetuximab and efficacy of preoperative cetuximabbased chemoradiation in rectal cancer. J Clin Oncol 27(17): 2751–2757

    Article  CAS  PubMed  Google Scholar 

  • Fujimoto-Ouchi K, Sekiguchi F, Yasuno H, Moriya Y, Mori K, Y Tanaka (2007) Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models. Cancer Chemother Pharmacol 59(6): 795–805

    Article  CAS  PubMed  Google Scholar 

  • Ghadimi BM, Grade M, Difilippantonio MJ, Varma S, Simon R, Montagna C, Fuzesi L, Langer C, Becker H, Liersch T, Ried T (2005) Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol 23(9): 1826–1838

    Article  CAS  PubMed  Google Scholar 

  • Gravalos C, Jimeno A (2008) HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target. Ann Oncol 19(9): 1523–1529

    Article  CAS  PubMed  Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1): 57–70

    Article  CAS  PubMed  Google Scholar 

  • Hofmann M, Stoss O, Shi D, Buttner R, van de Vijver M, Kim W, Ochiai A, Ruschoff J, Henkel T (2008) Assessment of a HER2 scoring system for gastric cancer: results from a validation study. Histopathology 52(7): 797–805

    Article  CAS  PubMed  Google Scholar 

  • Hudis CA (2007) Trastuzumab—mechanism of action and use in clinical practice. N Engl J Med 357(1): 39–51

    Article  CAS  PubMed  Google Scholar 

  • Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 Suppl: 245–254

    Article  PubMed  Google Scholar 

  • Jhawer M, Goel S, Wilson AJ, Montagna C, Ling YH, Byun DS, Nasser S, Arango D, Shin J, Klampfer L, Augenlicht LH, Perez-Soler R, Mariadason JM (2008) PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 68(6): 1953–1961

    Article  CAS  PubMed  Google Scholar 

  • Jones PA, Baylin SB (2007) The epigenomics of cancer. Cell 128(4): 683–692

    Article  CAS  PubMed  Google Scholar 

  • Kinzler KW, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87(2): 159–170

    Article  CAS  PubMed  Google Scholar 

  • Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE (2002) Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. Mod Pathol 15(4): 441–447

    Article  PubMed  Google Scholar 

  • Laurent-Puig P, Lievre A, Blons H (2009) Mutations and response to epidermal growth factor receptor inhibitors. Clin Cancer Res 15(4): 1133–1139

    Article  CAS  PubMed  Google Scholar 

  • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275(5308): 1943–1947

    Article  CAS  PubMed  Google Scholar 

  • Lievre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Cote JF, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P (2006) KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 66(8): 3992–3995

    Article  CAS  PubMed  Google Scholar 

  • Mansour SJ, Matten WT, Hermann AS, Candia JM, S Rong, Fukasawa K, Vande Woude GF, Ahn NG (1994) Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265(5174): 966–970

    Article  CAS  PubMed  Google Scholar 

  • Marx AH, Tharun L, Muth J, Dancau AM, Simon R, Yekebas E, Kaifi JT, Mirlacher M, Brummendorf TH, Bokemeyer C, R Izbicki J, Sauter G (2009) HER-2 amplification is highly homogenous in gastric cancer. Hum Pathol 40(6): 769–777

    Article  CAS  PubMed  Google Scholar 

  • Muto T, Bussey HJ, Morson BC (1975) The evolution of cancer of the colon and rectum. Cancer 36(6): 2251–2270

    CAS  PubMed  Google Scholar 

  • Nowell PC, Hungerford DA (1960) Chromosome studies on normal and leukemic human leukocytes. J Natl Cancer Inst 25: 85–109

    CAS  PubMed  Google Scholar 

  • Paik S, Kim C, Wolmark N (2008) HER2 status and benefit from adjuvant trastuzumab in breast cancer. N Engl J Med 358(13): 1409–1411

    Article  CAS  PubMed  Google Scholar 

  • Quackenbush J (2006) Microarray analysis and tumor classification. N Engl J Med 354(23): 2463–2472

    Article  CAS  PubMed  Google Scholar 

  • Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416(6880): 552–556

    Article  CAS  PubMed  Google Scholar 

  • Rudkin CT, Hungerford DA, Nowell PC (1964) DNA Contents of Chromosome Ph1 and Chromosome 21 in Human Chronic Granulocytic Leukemia. Science 144: 1229–1231

    Article  CAS  PubMed  Google Scholar 

  • Sauer, R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351(17): 1731–1740

    Article  CAS  PubMed  Google Scholar 

  • Schiffer CA (2007) BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukaemia. N Engl J Med 357(3): 258–265

    Article  CAS  PubMed  Google Scholar 

  • Sotiriou C, Pusztai L (2009) Gene-expression signatures in breast cancer N Engl J Med 360(8): 790–800

    Article  CAS  PubMed  Google Scholar 

  • Tarn C, Skorobogatko YV, Taguchi T, Eisenberg B, von Mehren M, Godwin AK (2006) Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer Res 66(10): 5477–5486

    Article  CAS  PubMed  Google Scholar 

  • Van Cutsem E, Kohne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, G D’Haens, Pinter T, Lim R, Bodoky G, Roh JK, Folprecht G, Ruff P, Stroh C, Tejpar S, Schlichting M, Nippgen J, Rougier P (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360(14): 1408–1417

    Article  PubMed  Google Scholar 

  • Van Cutsem E, Kang Y, Chung H, Sawaki A, Lordick F, Hill J, Lehle M, Feyereislova A, Bang Y (2009) Efficacy results from the ToGA trial: A phase III study of trastuzumab added to standard chemotherapy in first-line human epidermal growth factor recepor 2 (HER 2)-positive advanced gastric cancer. Journal of Clinical Oncology, 2009 ASCO Annual Meeting Proceedings (Postmeeting Edition) 27, No 15S

    Google Scholar 

  • Y Bang HC, Xu J, Lordick F, Sawaki A, Al-Sakaff N, Lipatov O, See C, Rueschoff J, Van Cutsem E (2009) Pathological features of advanced gastric cancer (GC): Relationship to human epidermal growth factor receptor 2 (HER2) positivity in the global screening programme of the ToGA trial. Journal of Clinical Oncology, ASCO Annual Meeting Abstracts 4556

    Google Scholar 

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Author information

Authors and Affiliations

  1. Klinik für Allgemein- und Viszeralchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37099, Göttingen

    Dr. med. R. Kemper

  2. Klinik u. Poliklinik für Allgemeinchirurgie, Universitätsmedizin Göttingen, Robert-Koch-Straße 40, 37099, Göttingen

    Prof. Dr. med. B. M. Ghadimi

Authors
  1. Dr. med. R. Kemper
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  2. Prof. Dr. med. B. M. Ghadimi
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Editor information

Editors and Affiliations

  1. Universitätsklinikum Heidelberg, Im Neuenheimer Feld 672, 69120, Heidelberg

    J. R. Siewert (Leitender Ärztlicher Direktor und Vorstandsvorsitzender) (Leitender Ärztlicher Direktor und Vorstandsvorsitzender)

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg

    Matthias Rothmund

  3. Universitätsklinik und Poliklinik, Medizinische Fakultät der RWTH, Pauwelsstraße 30, 52057, Aachen

    Volker Schumpelick

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Kemper, R., Ghadimi, B.M. (2010). Genetische Aberration, Genexpressionprofile und Epigenetik. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie Onkologische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03808-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-03808-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03807-5

  • Online ISBN: 978-3-642-03808-2

  • eBook Packages: Medicine (German Language)

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