Skip to main content
SpringerLink
Log in

Neuroendokrines Pankreaskarzinom

  • Chapter
Book cover Praxis der Viszeralchirurgie Onkologische Chirurgie

  • 4350 Accesses

Zusammenfassung

In diesem Kapitel werden die seltenen neuroendokrine Pankreaskarzinome besprochen. Es handelt sich hierbei um maligne funktionelle neuroendokrine Pankreastumoren (NPT) wie Insulinome, Gastrinome, Glukagonome, VIPome und Somatostatinome, sowie um die immer häufiger diagnostizierten malignen nicht-funktionellen NPT. Ihre Abgrenzung gegenüber exokrinen Karzinomen, insbesondere dem duktalen Adenokarzinom oder dem Zystadenokarzinom, ist gelegentlich schwierig, aber klinisch wichtig, da sich ihre Therapie und ihre Prognose von denen exokriner Tumoren unterscheidet. Maligne NPT haben ein langsameres Wachstum, eine höhere Resektabilitätsrate und sprechen besser auf eine medikamentöse Therapie an als z. B. duktale Adenokarzinome des Pankreas. Somit ist ein aggressiver operativer Therapieansatz selbst bei metastasierten NPT meist gerechtfertigt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 269.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alessiani M, Tzakis A, Todo S et al. (1995) Assessment of five-year experience with abdominal organ cluster transplantation. J Am Coll Surg 180: 1–6

    CAS  PubMed  Google Scholar 

  • Ahlman H, Friman S, Cahlin C, et al. Liver transplantation of metastatic neuroendocrine tumors. Ann NY Acad Sci 2004; 1014:265–269

    Article  PubMed  Google Scholar 

  • Anlauf M, Enosawa T, Henopp T, Schmitt A, Gimm O, Brauckhoff M, Dralle H, Musil A, Hauptmann S, Perren A, Klöppel G (2008) Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor. Am J Surg Pathol 32:1101–1105

    Article  PubMed  Google Scholar 

  • Arnold R, Rinke A, Schmidt C et al. (2005) Chemotherapy. Best Pract Res Clin Gastroenterol 19:649–656

    Article  CAS  PubMed  Google Scholar 

  • Bartsch DK, Langer P, Wild A et al. (2000a) Pancreaticoduodenal endocrine tumors in multiple endocrine neoplasia type 1: surgery or surveillance? Surgery 128: 958–966

    Article  CAS  PubMed  Google Scholar 

  • Bartsch D, Schilling T, Ramaswamy A et al. (2000b) Management of non-functioning islet cell carcinomas. World J Surg 24: 1418–1424

    Article  CAS  PubMed  Google Scholar 

  • Bartsch DK, Fendrich V, Langer P, Celik I, Kann PH, Rothmund M (2005) Outcome of duodenopancreatic resections in patients with multiple endocrine neoplasia type 1. Ann Surg 242: 757–764, Discussion 764–766

    Article  PubMed  Google Scholar 

  • Chamberlain RS et al. (2000) Hepatic neuroendocrine metastases: does intervention alter outcomes? J Am Coll Surg 190: 432–435

    Article  CAS  PubMed  Google Scholar 

  • Delcore R, Friesen SR (1995) Role of pancreaticoduodenectomy in the management of primary duodenal wall gastrinomas in patients with Zollinger-Ellison syndrome. Surgery 112: 1016–1023

    Google Scholar 

  • El Rassi ZS, Ferdinand L, Mohsine RM, et al. (2002) Primary and second endocrine liver tumors: clinical presentation, surgical approach and outcome. Hepatogastroenterology 49: 1340–1346

    PubMed  Google Scholar 

  • Elvin A, Skogseid B, Hellman P (2005) Radiofrequency ablation of neuroendocrine liver metastases. Abdom Imaging 30: 427–434

    Article  CAS  PubMed  Google Scholar 

  • Evans DB, Skibber M, Lee JE (1993) Nonfunctioning islet cell carcinoma of the pancreas. Surgery 114: 1175–1182

    CAS  PubMed  Google Scholar 

  • Fendrich V, Langer P, Celik I, Bartsch DK, Zielke A, Ramaswamy A, Rothmund M (2006) An aggressive surgical approach leads to longterm survival in patients with pancreatic endocrine tumors. Ann Surg 244: 845–853

    Article  PubMed  Google Scholar 

  • Fendrich V, Langer P, Waldmann J, Bartsch DK, Rothmund M (2007a) Management of sporadic and MEN-1-gastrinomas. Br J Surg 94:1331–1341

    Article  CAS  PubMed  Google Scholar 

  • Fendrich V, Habbe N, Celik I, Langer P, Zielke A, Bartsch DK, Rothmund M (2007b) Operative Therapie und Langzeitüberleben bei neuroendokrinen Pankreastumoren — Erfahrungen bei 144 Patienten. Dtsch Med Wochenschr 2: 195–200

    Article  Google Scholar 

  • Fernandez JA, Robles R, Marin C, et al. (2003) Role of liver transplantation in the management of metastatic neuroendocrine tumors. Transplant Proc 35: 1832–1833

    Article  CAS  PubMed  Google Scholar 

  • Frank M, Klose K, Wied M et al. (1999) Combination therapy with octreotide and α-interferon. Am J Gastroenterol 94: 1381–1386

    CAS  PubMed  Google Scholar 

  • Gullo L et al. (2003) Nonfunctioning pancreatic endocrine tumors: a multicenter clinical study. American Journal of Gastroenterology 98: 2435–2439

    Article  PubMed  Google Scholar 

  • Imamura M, Komoto I, Doi R et al. (2005) New pancreas-preserving total duodenectomy technique. World J Surg 29:203–207

    Article  PubMed  Google Scholar 

  • Jensen RT (1999) Natural history of digestive endocrine tumors. In: Mignon M, Colombel JF (eds) Recent advances in the pathophysiology and management of inflammatory bowel diseases and digestive endocrine tumors. John Libbey Eurotext, Paris, pp 192–219

    Google Scholar 

  • Kalinowski M, Dressler M, König A, El-Sheik M, Rinke A, Höffken H, Gress TM, Arnold R, Klose KJ, Wagner HJ (2009) Selective Internal Radiotherapy with Yttrium-90 Microspheres for Hepatic Metastatic Neuroendocrine Tumors: A Prospective Single Center Study. Digestion 79:137–142

    Article  PubMed  Google Scholar 

  • Kouvaraki MA, Solorzano CC, Shapiro SE, Yao JC, Perrier ND, Lee JE, Evans DB (2005) Surgical treatment of non-functioning pancreatic islet cell tumors. J Surg Oncol 89:170–185

    Article  PubMed  Google Scholar 

  • Kress O, Wagner HJ, Wied M, Klose KJ, Arnold R, Alfke H (2003) Transarterial chemoembolization of advanced liver metastases of neuroendocrine tumors — a retrospective single-center analysis. Digestion 68: 94–101

    Article  CAS  PubMed  Google Scholar 

  • Lang H, Schlitt HJ, Schmidt H, et al. (1999) Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas — a single center experience with ten patients. Langenbeck’s Arch Surg 384:370–377

    Article  CAS  Google Scholar 

  • Lehnert T (1998) Liver transplantation for metastatic neuroendocrine carcinoma. Transplantation 66:1307

    Article  CAS  PubMed  Google Scholar 

  • Le Treut YP, Delpero JR, Dousset B, et al. (1997) Results of liver transplantation in the treatment of metastatic neuroendocrine tumors: a 31-case French multicentric report. Ann Surg 225:355–364

    Article  PubMed  Google Scholar 

  • Lo CY, van Heerden JA, Thompson B, Grant CS, Söreide JA, Harmsen WS (1996) Islet cell carcinoma of the pancreas. World J Surg 20: 878–884

    Article  CAS  PubMed  Google Scholar 

  • Mansour JC, Chen H (2004) Pancreatic endocrine tumors. J Surg Res 120:139–161

    Article  CAS  PubMed  Google Scholar 

  • Metz DC, Jensen RT (2008) Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. Gastroenterology 135:1469–1492

    Article  CAS  PubMed  Google Scholar 

  • Moertel CG, Lefkopoulo M, Lipsitz S, Hahn RG, Klaassen D (1992) Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet cell carcinoma. N Engl J Med 326: 519–523

    CAS  PubMed  Google Scholar 

  • Norton JA, Kivlen M, Li M, Schneider D, Chuter T, Jensen RT (2003) Morbidity and mortality of aggressive resection in patients with advanced neuroendocrine tumors. Arch Surg 138: 859–866

    Article  PubMed  Google Scholar 

  • Norton JA, Alexander HR, Fraker DL, et al. (2004) Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases, or survival in patients with Zollinger-Ellison syndrome? Ann Surg 239:617–625, discussion 626

    Article  PubMed  Google Scholar 

  • Norton JA, Fraker DL, Alexander HR, Gibril F, Liewehr DJ, Venzon DJ (2006) Surgery increases survival in patients with gastrinoma. Ann Surg 244: 410–419

    PubMed  Google Scholar 

  • Sarmiento JM et al. (2003) Surgical treatment of neuroendocrine metastases to the liver: a plea for resection to increase survival. J Am Coll Surg 197: 29–37

    Article  PubMed  Google Scholar 

  • Schrenck T von, Howard JM, Doppman JL et al. (1988) Prospective study of chemotherapy in patients with metastatic gastrinoma. Gastroenterology 94: 1326–1334

    Google Scholar 

  • Solorzano CC, Lee JE, Pisters PW et al. (2001) Nonfunctioning islet cell carcinoma of the pancreas: survival results in a contemporary series of 163 patients. Surgery 130: 1078–1085

    Article  CAS  PubMed  Google Scholar 

  • Thompson GB, van Heerden JA, Grant CS, Carney JA, Ilstrup DM (1988) Islet cell carcinoma of the pancreas: A twentyyear experience. Surgery 104: 1011–1017

    CAS  PubMed  Google Scholar 

  • Tonelli F, Fratini G, Nesi G, et al. (2006) Pancreatectomy in multiple endocrine neoplasia type 1-related gastrinomas and pancreatic endocrine neoplasias. Ann Surg 244:61–70

    Article  PubMed  Google Scholar 

  • Yu F, Venzon DJ, Serrano J et al. (1999) Prospective study of the clinical course, prognostic factors, causes of death, and survival in patients with long-standing Zollinger-Ellison syndrome. J Clin Oncol 17:615–630

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Viszeral-Thorax-und Gefäßchirurgie, Universitätsklinikum Marburg, Baldinger Straße, 35033, Marburg

    Dr. med. V. Fendrich

  2. Zentrum fßr Operative Medizin, Universitätsklinikum Marburg, Baldinger Straße, 35043, Marburg

    Univ.-Prof. Dr. med. D. Bartsch

Authors
  1. Dr. med. V. Fendrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Univ.-Prof. Dr. med. D. Bartsch
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Universitätsklinikum Heidelberg, Im Neuenheimer Feld 672, 69120, Heidelberg

    J. R. Siewert (Leitender Ärztlicher Direktor und Vorstandsvorsitzender) (Leitender Ärztlicher Direktor und Vorstandsvorsitzender)

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg

    Matthias Rothmund

  3. Universitätsklinik und Poliklinik, Medizinische Fakultät der RWTH, Pauwelsstraße 30, 52057, Aachen

    Volker Schumpelick

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Fendrich, V., Bartsch, D. (2010). Neuroendokrines Pankreaskarzinom. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie Onkologische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03808-2_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-03808-2_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03807-5

  • Online ISBN: 978-3-642-03808-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation