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Partikeltherapie

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Praxis der Viszeralchirurgie Onkologische Chirurgie

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Zusammenfassung

Die Strahlentherapie mit Protonen und Schwerionen bietet sicher viele Vorteile hinsichtlich der physikalischen Dosisverteilung und, im Falle der Schwerionen auch hinsichtlich der biologischen Wirksamkeit. Mittlerweile wurde eine Vielzahl von Studien darunter einige prospektive Studien zur Partikeltherapie publiziert. Diese Therapieform konnte aufgrund der oben dargestellten Datenlage für die Behandlung von Uveamelanomen, Chordomen/Chondrosarkomen, adenoidzystischen Karzinomen, Lungentumoren, HCC und Prostatakarzinomen etabliert werden.

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Literatur

  • Akakura K, Tsujii H, et al. (2004) Phase I/II clinical trials of carbon ion therapy for prostate cancer. Prostate 58(3): 252–258

    Article  CAS  PubMed  Google Scholar 

  • Bittner N, W J Koh, et al. (2008) Treatment of locally advanced adenoid cystic carcinoma of the trachea with neutron radiotherapy. Int J Radiat Oncol Biol Phys 72(2): 410–414

    PubMed  Google Scholar 

  • Blomgren H, Lax I, et al. (1995) Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator Clinical experience of the first thirty-one patients. Acta Oncol 34(6): 861–870

    Article  CAS  PubMed  Google Scholar 

  • Bush DA, Hillebrand DJ, et al. (2004) High-dose proton beam radiotherapy of hepatocellular carcinoma: preliminary results of a phase II trial. Gastroenterology 127(5 Suppl 1): S189–S193

    Article  PubMed  Google Scholar 

  • Bush DA, Slater JD, et al. (2004) Hypofractionated proton beam radiotherapy for stage I lung cancer. Chest 126(4): 1198–1203

    Article  PubMed  Google Scholar 

  • Castro JR, Char DH, et al. (1997) 15 years experience with helium ion radiotherapy for uveal melanoma Int J Radiat Oncol Biol Phys 39(5): 989–996

    CAS  PubMed  Google Scholar 

  • Castro JR, Linstadt DE, et al. (1994) Experience in charged particle irradiation of tumors of the skull base: 1977–1992. Int J Radiat Oncol Biol Phys 29(4): 647–655

    CAS  PubMed  Google Scholar 

  • Char DH, Quivey JM, et al. (1993) Helium ions versus iodine 125 brachytherapy in the management of uveal melanoma A prospective, randomized, dynamically balanced trial. Ophthalmology 100(10): 1547–1554

    CAS  PubMed  Google Scholar 

  • Chen AM, Bucci MK, et al. (2006) Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: prognostic features of recurrence. Int J Radiat Oncol Biol Phys 66(1): 152–159

    PubMed  Google Scholar 

  • Chiba T, Tokuuye K, et al. (2005) Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162 patients. Clin Cancer Res 11(10): 3799–3805

    Article  PubMed  Google Scholar 

  • Courd, A, Caujolle JP, et al. (1999) Results of proton therapy of uveal melanomas treated in Nice. Int J Radiat Oncol Biol Phys 45(1): 5–11

    Google Scholar 

  • Damato B, Kacperek A, et al. (2005) Proton beam radiotherapy of iris melanoma. Int J Radiat Oncol Biol Phys 63(1): 109–115

    PubMed  Google Scholar 

  • Debus J, Schulz-Ertner D, et al. (2000) Stereotactic fractionated radiotherapy for chordomas and chondrosarcomas of the skull base. Int J Radiat Oncol Biol Phys 47(3): 591–596

    Article  CAS  PubMed  Google Scholar 

  • DeLaney TF, Park L, et al. (2005) Radiotherapy for local control of osteosarcoma. Int J Radiat Oncol Biol Phys 61(2): 492–498

    PubMed  Google Scholar 

  • Dendale R, Lumbroso-Le Rouic L, et al. (2006) Proton beam radiotherapy for uveal melanoma: results of Curie Institut-Orsay proton therapy center (ICPO). Int J Radiat Oncol Biol Phys 65(3): 780–787

    PubMed  Google Scholar 

  • Desjardins L, Lumbroso L, et al. (2003) Treatment of uveal melanoma with iodine 125 plaques or proton beam therapy: indications and comparison of local recurrence rates. J Fr Ophthalmol 26(3): 269–276

    CAS  Google Scholar 

  • Douglas JG, Koh WJ, et al. (2003) Treatment of salivary gland neoplasms with fast neutron radiotherapy. Arch Otolaryngol.+ Head Neck Surg 129(9): 944–948

    Article  PubMed  Google Scholar 

  • Dunst J, Kuhnt T, et al. (2003) Anemia in cervical cancers: impact on survival, patterns of relapse, and association with hypoxia and angiogenesis. Int J Radiat Oncol Biol Phys 56(3): 778–787

    PubMed  Google Scholar 

  • Egger E, Zografos L, et al. (2003) Eye retention after proton beam radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys 55(4): 867–880

    PubMed  Google Scholar 

  • Fuss M, Loredo LN, et al. (2001) Proton radiation therapy for medium and large choroidal melanoma: preservation of the eye and its functionality. Int J Radiat Oncol Biol Phys 49(4): 1053–1059

    Article  CAS  PubMed  Google Scholar 

  • Garden A S, R S Weber, et al. (1994) Postoperative radiation therapy for malignant tumors of minor salivary glands Outcome and patterns of failure. Cancer 73(10): 2563–2569

    Article  CAS  PubMed  Google Scholar 

  • Gragoudas ES, Lane AM, et al. (2000) A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. Arch Ophthalmol 118(6): 773–778

    CAS  PubMed  Google Scholar 

  • Gurne TA, Eisele DW, et al. (2005) Adenoid cystic carcinoma of the major salivary glands treated with surgery and radiation. Laryngoscope 115(7): 1278–1282

    Article  Google Scholar 

  • Haddad RI, MR Posner, et al. (2006) Chemoradiotherapy for adenoid cystic carcinoma: preliminary results of an organ sparing approach. Am J Clin Oncol 29(2): 153–157

    Article  PubMed  Google Scholar 

  • Hashimoto T, Tokuuye K, et al. (2006) Repeated proton beam therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 65(1): 196–202

    PubMed  Google Scholar 

  • Hata M, Tokuuye K, et al. (2007) Hypofractionated high-dose proton beam therapy for stage I non-small-cell lung cancer: preliminary results of a phase I/II clinical study. Int J Radiat Oncol Biol Phys 68(3): 786–793

    PubMed  Google Scholar 

  • Hata M, Tokuuye K, et al. (2007) Proton irradiation in a single fraction for hepatocellular carcinoma patients with uncontrollable ascites Technical considerations and results. Strahlenther Onkol 183(8): 411–416

    Article  PubMed  Google Scholar 

  • Hocht, S, Bechrakis NE, et al. (2004) Proton therapy of uveal melanomas in Berlin 5 years of experience at the Hahn-Meitner Institute. Strahlenther Onkol 180(7): 419–424

    Article  PubMed  Google Scholar 

  • Huber PE, Debus J, et al. (2001) Radiotherapy for advanced adenoid cystic carcinoma: neutrons, photons or mixed beam? Radiother Oncol 59(2): 161–167

    Article  CAS  PubMed  Google Scholar 

  • Imai R, Kamada T, et al. (2004) Carbon ion radiotherapy for unresectable sacral chordomas. Clin Cancer Res 10(17): 5741–5746

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa H, Tsuji H, et al. (2008) Adverse effects of androgen deprivation therapy on persistent genitourinary complications after carbon ion radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 72(1): 78–84

    CAS  PubMed  Google Scholar 

  • Kadono K, Homma T, et al. (2002) Effect of heavy-ion radiotherapy on pulmonary function in stage I non-small cell lung cancer patients. Chest 122(6): 1925–1932

    Article  CAS  PubMed  Google Scholar 

  • Kagei K, Tokuuye K, et al. (2003) Long-term results of proton beam therapy for carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 55(5): 1265–1271

    PubMed  Google Scholar 

  • Kato H, Tsujii H, et al. (2004) Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis. Int J Radiat Oncol Biol Phys 59(5): 1468–1476

    PubMed  Google Scholar 

  • Kato S, Ohno T, et al. (2006) Dose escalation study of carbon ion radiotherapy for locally advanced carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 65(2): 388–397

    PubMed  Google Scholar 

  • Kawashima M, Furuse J, et al. (2005) Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma. J Clin Oncol 23(9): 1839–1846

    Article  PubMed  Google Scholar 

  • Koto M, Miyamoto T, et al. (2004) Local control and recurrence of stage I non-small cell lung cancer after carbon ion radiotherapy. Radiother Oncol 71(2): 147–156

    Article  PubMed  Google Scholar 

  • Linstadt D, Quivey JM, et al. (1988) Comparison of helium-ion radiation therapy and split-course megavoltage irradiation for unresectable adenocarcinoma of the pancreas Final report of a Northern California Oncology Group randomized prospective clinical trial. Radiology 168(1): 261–264

    CAS  PubMed  Google Scholar 

  • Matsushita K, Ochiai T, et al. (2006) The effects of carbon ion irradiation revealed by excised perforated intestines as a late morbidity for uterine cancer treatment. Surg Today 36(8): 692–700

    Article  PubMed  Google Scholar 

  • Mayahara H, Murakami M, et al. (2007) Acute morbidity of proton therapy for prostate cancer: the Hyogo Ion Beam Medical Center experience. Int J Radiat Oncol Biol Phys 69(2): 434–443

    PubMed  Google Scholar 

  • Mendenhall WM, Morris CG, et al. (2004) Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck. Head Neck 26(2): 154–162

    Article  PubMed  Google Scholar 

  • Minsky BD, Pajak TF, et al. (2002) INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol 20(5): 1167–1174

    Article  CAS  PubMed  Google Scholar 

  • Miyamoto T, Baba M, et al. (2007) Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week. J Thorac Oncol 2(10): 916–926

    Article  PubMed  Google Scholar 

  • Miyamoto T, Baba M, et al. (2007) Curative treatment of Stage I nonsmall-cell lung cancer with carbon ion beams using a hypofractionated regimen. Int J Radiat Oncol Biol Phys 67(3): 750–758

    CAS  PubMed  Google Scholar 

  • Miyamoto T, Yamamoto N, et al. (2003) Carbon ion radiotherapy for stage I non-small cell lung cancer. Radiother Oncol 66(2): 127–140

    Article  PubMed  Google Scholar 

  • Mizoe JE, Tsujii H, et al. (2004) Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 60(2): 358–364

    PubMed  Google Scholar 

  • Mizumoto, M, K Tokuuye, et al. (2007) Proton beam therapy for hepatocellular carcinoma with inferior vena cava tumor thrombus: report of three cases. Jpn J Clin Oncol 37(6): 459–462

    Article  PubMed  Google Scholar 

  • Munzenrider JE, Liebsch NJ (1999) Proton therapy for tumors of the skull base. Strahlenther Onkol 175Suppl 2: 57–63

    Article  PubMed  Google Scholar 

  • Nihei K, Ogino T, et al. (2005) Phase II feasibility study of high-dose radiotherapy for prostate cancer using proton boost therapy: first clinical trial of proton beam therapy for prostate cancer in Japan. Jpn J Clin Oncol 35(12): 745–752

    Article  PubMed  Google Scholar 

  • Nihei K, Ogino T, et al. (2006) High-dose proton beam therapy for Stage I non-small-cell lung cancer Int J Radiat Oncol Biol Phys 65(1): 107–111

    PubMed  Google Scholar 

  • Nishimura H, Miyamoto T, et al. (2003) Radiographic pulmonary and pleural changes after carbon ion irradiation. Int J Radiat Oncol Biol Phys 55(4): 861–866

    PubMed  Google Scholar 

  • Noel G, Habrand JL, et al. (2001) Combination of photon and proton radiation therapy for chordomas and chondrosarcomas of the skull base: the Centre de Protontherapie D’Orsay experience.e Int J Radiat Oncol Biol Phys 51(2): 392–398

    CAS  PubMed  Google Scholar 

  • Ohara K, Okumura T, et al. (1997) Radiation tolerance of cirrhotic livers in relation to the preserved functional capacity: analysis of patients with hepatocellular carcinoma treated by focused proton beam radiotherapy. Int J Radiat Oncol Biol Phys 38(2): 367–372

    CAS  PubMed  Google Scholar 

  • Park L, Delaney TF, et al. (2006) Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys 65(5): 1514–1521

    PubMed  Google Scholar 

  • Pieters RS, Niemierko A, et al. (2006) Cauda equina tolerance to high-dose fractionated irradiation. Int J Radiat Oncol Biol Phys 64(1): 251–257

    PubMed  Google Scholar 

  • Pommier P, Liebsch NJ, et al. (2006) Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 132(11): 1242–1249

    Article  PubMed  Google Scholar 

  • Robertson JM, Lawrence TS, et al. (1993) Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy. J Clin Oncol 11(7): 1286–1293

    CAS  PubMed  Google Scholar 

  • Romero J, Cardenes H, et al. (1993) Chordoma: results of radiation therapy in eighteen patients. Radiother Oncol 29(1): 27–32

    Article  CAS  PubMed  Google Scholar 

  • Rossi CJ, Jr, Slater JD, et al. (2004) Influence of patient age on biochemical freedom from disease in patients undergoing conformal proton radiotherapy of organ-confined prostate cancer. Urology 64(4): 729–732

    Article  PubMed  Google Scholar 

  • Rutz, H P, D C Weber, et al. (2007) Extracranial chordoma: Outcome in patients treated with function-preserving surgery followed by spot-scanning proton beam irradiation. Int J Radiat Oncol Biol Phys 67(2): 512–520

    PubMed  Google Scholar 

  • Saunders W, Castro JR, et al. (1985) Helium-ion radiation therapy at the Lawrence Berkeley Laboratory: recent results of a Northern California Oncology Group. Clinical Trial Radiat Res Suppl 8: S227–S234

    Article  CAS  Google Scholar 

  • Schlegel W, Mahr A (2007) 3D conformal radiation therapy, 2nd ed. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Scholz M, Jakob B, et al. (2001) Direct evidence for the spatial correlation between individual particle traversals and localized CDKN1A (p21) response induced by high-LET radiation. Radiat Res 156(5 Pt 1): 558–563

    Article  CAS  PubMed  Google Scholar 

  • Schulz-Ertner D, Karger CP, et al. (2007) Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas Int J Radiat Oncol Biol Phys 68(2): 449–457

    PubMed  Google Scholar 

  • Schulz-Ertner D, Nikoghosyan A, et al. (2007) Carbon ion radiotherapy of skull base chondrosarcomas. Int J Radiat Oncol Biol Phys 67(1): 171–177

    PubMed  Google Scholar 

  • Schulz-Ertner D, Tsujii H (2007) Particle radiation therapy using proton and heavier ion beams. J Clin Oncol 25(8): 953–964

    Article  PubMed  Google Scholar 

  • Schulz-Ertner D, Nikoghosyan A, et al. (2005) Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques. Cancer 104(2): 338–344

    Article  PubMed  Google Scholar 

  • Shioyama Y, Tokuuye K, et al. (2003) Clinical evaluation of proton radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 56(1): 7–13

    PubMed  Google Scholar 

  • Slater, J D, C J Rossi, Jr, et al. (2004) Proton therapy for prostate cancer: the initial Loma Linda University experience Int J Radiat Oncol Biol Phys 59(2): 348–352

    PubMed  Google Scholar 

  • Spiro RH (1986) Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg 8(3): 177–184

    Article  CAS  PubMed  Google Scholar 

  • Sugahara S, Tokuuye K, et al. (2005) Clinical results of proton beam therapy for cancer of the esophagus Int J Radiat Oncol Biol Phys 61(1): 76–84

    PubMed  Google Scholar 

  • Terahara A, Niemierko A, et al. (1999) Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. Int J Radiat Oncol Biol Phys 45(2): 351–358

    CAS  PubMed  Google Scholar 

  • Terhaard CH, Lubsen H, et al. (2004) Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group. Head Neck 26(8): 681–692; discussion 692-3

    Article  PubMed  Google Scholar 

  • Tsuji H, Ishikawa H, et al. (2007) Carbon-ion radiotherapy for locally advanced or unfavorably located choroidal melanoma: a Phase I/II dose-escalation study Int J Radiat Oncol Biol Phys 67(3): 857–862

    PubMed  Google Scholar 

  • Tsuji H, Yanagi T, et al. (2005) Hypofractionated radiotherapy with carbon ion beams for prostate cancer. Int J Radiat Oncol Biol Phys 63(4): 1153–1160

    PubMed  Google Scholar 

  • Urie M, Goitein M, M Wagner (1984) Compensating for heterogeneities in proton radiation therapy. Phys Med Biol 29(5): 553–566

    Article  CAS  PubMed  Google Scholar 

  • Weber DC, Rutz HP, et al. (2005) Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of the skull base: the Paul Scherrer Institut experience. Int J Radiat Oncol Biol Phys 63(2): 401–409

    PubMed  Google Scholar 

  • Yamada S, Kato H, et al. (2005) Carbon ion therapy for patients with localized, resectable adenocarcinoma of the pancreas. Proc ASCO GI Abstr #130

    Google Scholar 

  • Yamada, S, Hara R, et al. (2008) Carbon Ion radiotherapy for pancreas cancer. Proc NIRS-MD Anderson Symposium on Clinical Issues for particle therapy

    Google Scholar 

  • Yonemoto LT, Slater JD, et al. (1997) Combined proton and photon conformal radiation therapy for locally advanced carcinoma of the prostate: preliminary results of a phase I/II study. Int J Radiat Oncol Biol Phys 37(1): 21–29

    CAS  PubMed  Google Scholar 

  • Zietman AL, DeSilvio ML, et al. (2005) Comparison of conventionaldose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA 294(10): 1233–1239

    Article  CAS  PubMed  Google Scholar 

  • Zietman AL (2008) Correction: Inaccurate analysis and results in a study of radiation therapy in adenocarcinoma of the prostate. JAMA 299(8): 898–899

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Radiologische Universitätsklinik Radioonkologie, Universität Heidelberg, In Neuenheimer Feld 400, 69120, Heidelberg

    Dr. med. A. Jensen & Univ.-Prof. Dr. med. J. Debus

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  1. Dr. med. A. Jensen
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  2. M. Münter
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  3. Univ.-Prof. Dr. med. J. Debus
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Editors and Affiliations

  1. Universitätsklinikum Heidelberg, Im Neuenheimer Feld 672, 69120, Heidelberg

    J. R. Siewert (Leitender Ärztlicher Direktor und Vorstandsvorsitzender) (Leitender Ärztlicher Direktor und Vorstandsvorsitzender)

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg

    Matthias Rothmund

  3. Universitätsklinik und Poliklinik, Medizinische Fakultät der RWTH, Pauwelsstraße 30, 52057, Aachen

    Volker Schumpelick

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Jensen, A., Münter, M., Debus, J. (2010). Partikeltherapie. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie Onkologische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03808-2_27

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  • DOI: https://doi.org/10.1007/978-3-642-03808-2_27

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