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Protein–Lipid Modifications and Targeting of ROP/RAC and Heterotrimeric G Proteins

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Integrated G Proteins Signaling in Plants

Part of the book series: Signaling and Communication in Plants ((SIGCOMM))

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Abstract

ROP/RAC GTPases and heterotrimeric G protein are soluble proteins that function at cellular membranes, primarily the plasma membranes. Attachment to the membrane takes place by virtue of the posttranslational lipid modifications: prenylation, S-acylation, and N-myristoylation, as well as by lysine and arginine-rich positively charged domain, referred to as polybasic region. The lipid modifications and the polybasic regions have important regulatory roles in G protein signaling. In this chapter, we first describe the characteristic of each of the three lipid modifications. We then discuss their regulatory roles and how they synergistically modulate signaling by ROP/RAC GTPases and heterotrimeric G proteins.

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  1. Department of Plant Sciences, Tel Aviv University, 603 Britannia Building, Ramat Aviv, 69978, Tel Aviv, Israel

    Nadav Sorek & Shaul Yalovsky

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  1. Nadav Sorek
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  2. Shaul Yalovsky
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Correspondence to Shaul Yalovsky .

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  1. Dept. Plant Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel

    Shaul Yalovsky

  2. Inst. Zelluläre und Molekulare, Universität Bonn, Kirschallee 1, Bonn, 53115, Germany

    František Baluška

  3. Dept. Biology & Pharmacology, University of North Carolina, Coker Hall 317, Chapel Hill, 27599, U.S.A.

    Alan Jones

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Sorek, N., Yalovsky, S. (2010). Protein–Lipid Modifications and Targeting of ROP/RAC and Heterotrimeric G Proteins. In: Yalovsky, S., Baluška, F., Jones, A. (eds) Integrated G Proteins Signaling in Plants. Signaling and Communication in Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03524-1_4

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