Abstract
Rho GTPases play central roles in the regulation of essential cellular processes, such as directional expansion, motility, and division. RhoGEFs (Guanine Nucleotide Exchange Factors) have key functions in the stimulus-induced spatio-temporal control of Rho GTPase activity. RhoGAPs (GTPase activating proteins) and RhoGDIs (Guanine nucleotide dissociation inhibitors) have long been seen as less important regulators of Rho GTPase activity, with functions largely restricted to the constitutive attenuation of Rho signaling. Extended families of diverse RhoGAPs, as well as small families of structurally similar RhoGDIs, have been identified in yeast, animals, and plants. Recent research has established that members of these protein families play much more important and complex roles than previously anticipated in the regulation of Rho GTPase activity and cellular processes. Non-plant RhoGAPs and RhoGDIs were shown to be tightly regulated by upstream signaling, and the same is likely to be true for their plant homologs as well. The recent functional characterization of plant RhoGAPs and RhoGDIs has allowed exciting and universally important insights into the molecular mechanisms underlying the control of Rho GTPase activity by these proteins.
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BK thanks DFG, BBSRC, VR, and FORMAS for funding.
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Kost, B. (2010). Regulatory and Cellular Functions of Plant RhoGAPs and RhoGDIs. In: Yalovsky, S., Baluška, F., Jones, A. (eds) Integrated G Proteins Signaling in Plants. Signaling and Communication in Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03524-1_2
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