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Helicobacter pylori and Gastric Cancer

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Inflammation and Gastrointestinal Cancers

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 185))

Abstract

Gastric cancer remains a major cause of cancer death worldwide. The discovery of Helicobacter pylori Helicobacter pylori and its association with gastric cancer has opened up new insights into its pathogenesis. Gastric cancer pathogenesis is the result of a complex interplay between bacterial, host and environmental factors resulting in a step wise histological progression to neoplasia. H. pylori is a major factor in the early stages of cancer development and the mechanism of action of its virulence factors are being steadily unravelled. It is also now recognised that host genetic polymorphisms also play a complex role interacting synergistically with the bacterial virulence factors. The role of H. pylori in the causation of gastric cancer also raises the possibility of cancer prevention through screening and eradication, actions which may improve outcomes in high risk populations but which may not be cost-effective in areas of low risk. Ultimately, despite the vast improvements in knowledge, as yet there has not been a corresponding improvement in terms of gastric cancer survival rates.

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Authors and Affiliations

  1. St George’s, University of London, London, UK

    Michael Rathbone

  2. University Hospitals of Leicester, Leicester, UK

    Barrie Rathbone

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  1. Michael Rathbone
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Correspondence to Barrie Rathbone .

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  1. Leicester Royal Infirmary, Dept. Cancer Studies and, University of Leicester, Windsor Building, Level 4, Leicester, LE1 5WW, United Kingdom

    Janusz A. Z. Jankowski

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Rathbone, M., Rathbone, B. (2011). Helicobacter pylori and Gastric Cancer. In: Jankowski, J. (eds) Inflammation and Gastrointestinal Cancers. Recent Results in Cancer Research, vol 185. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03503-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-03503-6_5

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