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Inflammation and Gastrointestinal Cancers pp 185–199Cite as

Endoscopic Methods

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 185))

Abstract

Endoscopic methods to recognise and treat early gastrointestinal malignancies have increased in recent years. This has resulted in more lesions being diagnosed at an early stage and a shift away from invasive surgery towards endoscopic resection. However, it is necessary for the endoscopist to understand the key principles behind advanced endoscopic diagnosis and the new therapeutic options available. This chapter will review the advances in endoscopic techniques and methods which are changing the way we diagnose and treat these cancers. It will examine the general principles behind advanced endoscopy and then examine their application in Barrett’s neoplasia, gastric cancer and the dysplasia associated lesions or masses associated with ulcerative colitis. It will focus on the best techniques for each of the above pathology.

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References

  • Ackroyd R, Brown NJ, Davis MF et al (2000) Photodynamic therapy for dysplastic Barrett’s oesophagus: a prospective, bouble blind, randomised, placebo controlled trial. Gut 47:612–617

    Article  PubMed  CAS  Google Scholar 

  • Barr Hugh (2007) The case against oesophageal resection. Ann R Coll Surg Engl 89(6):586–588

    Article  PubMed  Google Scholar 

  • Bhandari P, Green S, Hamanaka H, Nakajima T, Matsuda T, Saito Y, Oda I, Gotoda T (2010) Use of Gascon and Pronase either as a pre-endoscopic drink or as targeted endoscopic flushes to improve visibility during gastroscopy: a prospective, randomized, controlled, blinded trial. Scand J Gastroenterol 45:357–361

    Article  PubMed  CAS  Google Scholar 

  • Birkmeyer JD, Siewers AE, Finlayson EV et al (2002) Hospital volume and surgical mortality in the United States. N End J Med 346:1128–1137

    Article  Google Scholar 

  • Blackstone MO, Riddell RH, Rodgers BHG, Levin B (1981) Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in longstanding colitis. An indication for colectomy. Gastroenterology 80:366–374

    PubMed  CAS  Google Scholar 

  • Blot WJ, Devesa SS, Kneller RW et al (1991) Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 265:1287–1289

    Article  PubMed  CAS  Google Scholar 

  • Canto MI, Selrakian S, Petras RE et al (1996) Methylene Blue selectively stains intestinal metaplasia in Barrett’s oesophagus. Gastrointest Endosc 44(1):1–7

    Article  PubMed  CAS  Google Scholar 

  • Canto MI, Selrakian S, Petras RE et al (2000) Methylene-blue directed biopsies improves detection of intestinal metaplasia and dysplasia in Barrett’s oesophagus. Gastrointest Endosc 51:560–568

    Article  PubMed  CAS  Google Scholar 

  • Canto MI, Setrakian S, Willis JE, Chak A, Petras RE, Sivak MV (2001) Methylene blue staining of dysplastic and nondysplastic Barrett’s esophagus: an in vivo and ex vivo study. Endoscopy 33:391–400

    Article  PubMed  CAS  Google Scholar 

  • Chang AC, Ji H, Birkmeyer NJ et al (2008) Outcomes after transhiatal and transthoracic esophagectomy for cancer. Ann Thorac Surg 85:424–429

    Article  PubMed  Google Scholar 

  • Choi IJ, Kim CG, Chang HJ, Kim SG, Kook MC, Bae JM (2005) The learning curve for EMR with circumferential mucosal incision in treating intramucosal gastric cancer. Gastrointest Endosc 62(6):860–865

    Article  PubMed  Google Scholar 

  • Curvers WL, Singh R, Song LM, Wolfsen HC, Ragunath K, Wang K, Wallace MB, Fockens P, Bergman JJ (2008) Endoscopic tri-modal imaging for detection of early neoplasia in Barrett’s oesophagus: a multi-centre feasibility study using high-resolution endoscopy, autofluorescence imaging and narrow band imaging incorporated in one endoscopy system. Gut 57:167–172

    Article  PubMed  CAS  Google Scholar 

  • Dacosta RS, Wilson BC, Marcon NE (2002) New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions. J Gastroenterol Hepatol 17:S85–S104

    Article  PubMed  Google Scholar 

  • Dekker E, van den Broek FJ, Reitsma JB, Hardwick JC, Offerhaus GJ, van Deventer SJ, Hommes DW, Fockens P (2007) Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis. Endoscopy 39(3):216–221

    Article  PubMed  CAS  Google Scholar 

  • Dunbar KB, Okolo P III, Montgomery E, Canto MI (2009) Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial. Gastrointest Endosc 70(4):645-654

    Article  PubMed  Google Scholar 

  • Eguchi T, Gotoda T, Oda I, Hamanaka H, Hasuike N, Saito D (2003) Is endoscopic one-piece mucosal resection essential for early gastric cancer? Dig Endosc 15:113–116

    Article  Google Scholar 

  • Ell C, May A, Gossner L, Pech O, Gunter E, Mayer G et al (2000) Endoscopic mucosal resection of early cancer and high-grade dysplasia in Barrett’s esophagus. Gastroenterology 118:670–677

    Article  PubMed  CAS  Google Scholar 

  • Engelsgjerd M, Farraye FA, Odze RD (1999) Polypectomy may be adequate treatment for adenoma-like dysplastic lesions in chronic ulcerative colitis. Gastroenterology 117(6):1288–1294

    Article  PubMed  CAS  Google Scholar 

  • Ernst P (1999) Review article: the role of inflammation in the pathogenesis of gastric cancer. Aliment Pharmacol Ther 13(suppl 1):13–18

    Article  PubMed  Google Scholar 

  • Fortun P, Anagnostopoulos G, Kaye P et al (2006) Acetic acid enhanced magnification endoscopy in the diagnosis of specialized intestinal metaplasia, dysplasia and early cancer in Barrett’s oesophagus. Aliment Pharmacol Ther 23:735–742

    Article  PubMed  CAS  Google Scholar 

  • Gossner L, Pech O, May A, Rabenstein T et al (2005) Inter- and intraobserver variability in high resolution chromoendoscopy with acetic acid for the detection of intestinal metaplasia and early neoplasia in Barrett’s esophagus (abstract). Gastrointest Endosc 61(5):AB132

    Google Scholar 

  • Gotoda Takuji (2007) Endoscopic resection of early gastric cancer. Gastric Cancer 10(1):1–11

    Article  PubMed  Google Scholar 

  • Guelrud M, Herrera L (1998) Acetic acid improves identification of remnant islands of Barrett’s epithelium after endoscopic therapy. Gastrointest Endosc 47:512–515

    Article  PubMed  CAS  Google Scholar 

  • Hellier MD, Sanderson JD, Morris AL, Elias E, De Caestecker J (2006) Care of patients with gastrointestinal disorders in the United Kingdom: a strategy for the future. British Society of Gastroenterology. Gut Online, p 24

    Google Scholar 

  • Hetil O (2002) Indigo carmine contrast staining in combination with high resolution electronic endoscopy. Gasztroenterológiai Osztály 143(1):25–29

    Google Scholar 

  • Hornick J, Odze RD, Farraye FA, Hecht JL, Jason L (2004) Long-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis. Clin Gastroenterol Hepatol 2(7): 534–541

    Article  PubMed  Google Scholar 

  • Hurlstone DP, Kiesslich R, Thomson M, Atkinson R, Cross SS (2008) Confocal chromoscopic endomicroscopy is superior to chromoscopy alone for the detection and characterisation of intraepithelial neoplasia in chronic ulcerative colitis. Gut 57(2):196–204

    Article  PubMed  CAS  Google Scholar 

  • Itzkowitz SH, Farraye FA , Odze RD, Eaden J (2010) AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease. Gastroenterology 38(2):738–745

    Google Scholar 

  • Kara MA, Peters FP, Ten Kate FJ, Van Deventer SJ, Fockens P, Bergman JJ (2005) Endoscopic video autofluorescence imaging may improve the detection of early neoplasia in patients with Barrett’s esophagus. Gastrointest Endosc 61(6):679–685

    Article  PubMed  Google Scholar 

  • Kiesslich R, Goetz M, Lammersdorf K, Schneider C, Burg J, Stolte M, Vieth M, Nafe B, Galle PR, Neurath MF (2007) Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology 132:874–882

    Article  PubMed  Google Scholar 

  • Lambert R, Rey JF, Sankaranarayanan R (2003) Magnification and chromoscopy with the acetic acid test. Endoscopy 35:437–445

    Article  PubMed  CAS  Google Scholar 

  • Loftus EV (2004) Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126(6):1504–1517

    Article  PubMed  Google Scholar 

  • Longcroft-Wheaton G, Duku M, Mead R, Poller D, Bhandari P (2010) Acetic acid spray is an effective tool for the endoscopic detection of neoplasia in patients with Barrett’s esophagus. Clin Gastroenterol Hepatol 8(10):843-847

    Article  PubMed  Google Scholar 

  • Marion JF, Waye JD, Present DH, Israel Y, Bodian C, Harpaz N, Chapman M, Itzkowitz S, Steinlauf AF, Abreu MT, Ullman TA, Aisenberg J, Mayer L (2008) Chromoendoscopy-targeted biopsies are superior to standard colonoscopic surveillance for detecting dysplasia in inflammatory bowel disease patients: a prospective endoscopic trial. Am J Gastroenterol 103(9):2342–2349

    Article  PubMed  Google Scholar 

  • May A, Gossner L, Pech O, Müller H, Vieth M, Stolte M, Ell C (2002a) Intraepithelial high-grade neoplasia and early adenocarcinoma in short-segment Barrett’s esophagus (SSBE): curative treatment using local endoscopic treatment techniques. Endoscopy 34:604–610

    Article  PubMed  CAS  Google Scholar 

  • May A, Gossner L, Pech O, Fritz A, Günter E, Mayer G, Müller H, Seitz G, Vieth M, Stolte M, Ell C (2002b) Local endoscopic therapy for intraepithelial high-grade neoplasia and early adenocarcinoma in Barrett’s oesophagus: acute-phase and intermediate results of a new treatment approach. Eur J Gastroenterol Hepatol 14:1085–1091

    Article  PubMed  Google Scholar 

  • McNamara D, El-Omar E (2008) Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions. Dig Liver disease 40(7):504–509

    Article  CAS  Google Scholar 

  • Nakajima T (2002) Gastric cancer treatment guidelines in Japan. Gastric Cancer 5(1):1–5

    Article  PubMed  Google Scholar 

  • Oda I, Gotoda T, Hamanaka H, Eguchi T, Saito Y, Takahisa M, Bhandari P, Emura F, Saito D, Hiroyuki O (2005) Endoscopic submucosal dissection for early gastric cancer: technical feasibility, operation time and complications from a large consecutive series. Dig Endosc 17:54–58

    Article  Google Scholar 

  • Oda I, Saito D, Tada M, Iishi H, Tanabe S, Oyama T, Doi T, Otani Y, Fujisaki J, Ajioka Y, Hamada T, Inoue H, Gotoda T, Yoshida S (2006) A multicenter retrospective study of endoscopic resection for early gastric cancer. Gastric Cancer 9(4):262–270

    Article  PubMed  Google Scholar 

  • Odze RD (2008) What are the guidelines for treating adenoma-like DALMs in UC? Inflamm Bowel Dis 14(52):s243–s244

    Article  PubMed  Google Scholar 

  • Overholt BF, Panjehpour M, Haydek JM (1999) Photodynamic therapy for Barrett’s esophagus: follow up in 100 patients. Gastrointest Endosc 49(1):1–7

    Article  Google Scholar 

  • Overholt BF, Lightdale CJ, Wang KK et al (2005) Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett’s esophagus: international, partially blinded, randomised phase III trial. Gastrointest Endosc 62(4):488–498

    Article  Google Scholar 

  • Panjehpour M, Coppola D, Overholt BF, Vo-Dinh T, Overholt S (2008) Photodynamic therapy of Barrett’s esophagus: ablation of Barrett’s mucosa and reduction in p53 protein expression after treatment. Anticancer Res 28(1B):485–489

    PubMed  Google Scholar 

  • Parsonnett J, Harris RA, Hack HM, Owens DK (1996) Modelling cost effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials. Lancet 348(9021):150–154

    Article  Google Scholar 

  • Pech O, Behrens A, May A, Nachbar L, Gossner L, Rabenstein T, Manner H, Guenter E, Huijsmans J, Vieth M, Stolte M, Ell C (2008) Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut 57:1200–1206

    Article  PubMed  CAS  Google Scholar 

  • Pera M, Cameron AJ, Trastek VF et al (1993) Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gut 104:510–513

    CAS  Google Scholar 

  • Playford RJ (2006) New British Society of Gastroenterology (BSG) guidelines for the diagnosis and management of Barrett’s oesophagus. Gut 55(4):442

    Article  PubMed  CAS  Google Scholar 

  • Pohl J, May A, Rabenstein T, Pech O, Nguyen-Tat M, Fissler-Eckhoff A, Ell C (2007) Comparison of computed virtual chromoendoscopy and conventional chromoendoscopy with acetic acid for detection of neoplasia in Barrett’s esophagus. Endoscopy 39(7):594–598

    Article  PubMed  CAS  Google Scholar 

  • Riddell RH (1990) Screening strategies in gastrointestinal cancer. Scand J Gastroenterol Suppl 175:177–184

    Article  PubMed  CAS  Google Scholar 

  • Roderick P, Davies R, Raftery J, Crabbe D, Pearce R, Patel P, Bhandari P (2003) Cost-effectiveness of population screening for Helicobacter pylori in preventing gastric cancer and peptic ulcer disease, using simulation. J Med Screen 10(3):148–156

    Article  PubMed  CAS  Google Scholar 

  • Ronkainen J, Aro P, Storskrubb T, Johansson SE, Lind T, Bolling-Sternevald E, Vieth M, Stolte M, Talley NJ, Agréus L (2005) Prevalence of Barrett’s esophagus in the general population: an endoscopic study. Gastroenterology 129(6):1825–1831

    Article  PubMed  Google Scholar 

  • Rubin PH, Friedman S, Harpaz N et al (1999) Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps. Gastroenterology 117(6):1295–3000

    Article  PubMed  CAS  Google Scholar 

  • Rutter MD, Saunders BP, Schofield G, Forbes A, Price AB, Talbot IC (2004) Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis. Gut 53(2):256–260

    Article  PubMed  CAS  Google Scholar 

  • Shaheen NJ, Sharma P, Overholt BF et al (2008) A randomised, multicenter, sham-controlled trial of radiofrequency ablation (RFA) for subjects with Barrett’s esophagus (BE) containing dysplasia: interim results of the AIM dysplasia trial. Gastroenterology 134:A37

    Article  Google Scholar 

  • Shaheen NJ, Sharma P, Overholt BF, Wolfsen HC, Sampliner RE, Wang KK, Galanko JA, Bronner MP, Goldblum JR, Bennett AE, Jobe BA, Eisen GM, Fennerty MB, Hunter JG, Fleischer DE, Sharma VK, Hawes RH, Hoffman BJ, Rothstein RI, Gordon SR, Mashimo H, Chang KJ (2009) Radiofrequency ablation in Barrett’s esophagus with dysplasia. New Engl J Med 360(22):2277–2288

    Article  PubMed  CAS  Google Scholar 

  • Sharma P, Weston AP, Topalovski M, Cherian R, Bhattacharyya A, Sampliner RE (2003) Magnification chromoendoscopy for the detection of intestinal metaplasia and dysplasia in Barrett’s oesophagus. Gut 52(1):24–27

    Article  PubMed  CAS  Google Scholar 

  • Sharma P, Marcon N, Wani S, Bansal A, Mathur S, Sampliner R, Lightdale C (2006) Non-biopsy detection of intestinal metaplasia and dysplasia in Barrett’s esophagus: a prospective multicenter study. Endoscopy 38:1206–1212

    Article  PubMed  CAS  Google Scholar 

  • Tanabe S, Koizumi W, Mitomi H, Nakai H, Murakami S, Nagaba S et al (2002) Clinical outcome of endoscopic aspiration mucosectomy for early stage gastric cancer. Gastro intestinal Endosc 56(5):708–713

    Article  Google Scholar 

  • Trovato C, Sonzogni A, Fiori G, Ravizza D et al (2008) Confocal Laser Endomicroscopy for in vivo diagnosis of Barrett’s oesophagus and associated neoplasia: an ongoing prospective study. Gastrointest Endosc 67(5):AB 97

    Article  Google Scholar 

  • Tsujitani S, Oka S, Saito H, Kondo A, Ikeguchi M, Maeta M et al (1999) Less invasive surgery for early gastric cancer based on the low probability of lymph node metastasis. Surgery 125(2):148–154

    Article  PubMed  CAS  Google Scholar 

  • Van Le L, Broekhuizen FF, Janzer-Steele R et al (1993) Acetic acid visualization of the cervix to detect cervical dysplasia. Obstet Gynecol 81:293–295

    PubMed  CAS  Google Scholar 

  • Vázquez-Iglesias JL, Alonso-Aguirre P, Diz-Lois MT, Vázquez-Millán MA, Alvarez A, Lorenzo MJ (2007) Acetic acid allows effective selection of areas for obtaining biopsy samples in Barrett’s esophagus. Eur J Gastroenterol Hepatol 19(3):187–193

    Article  PubMed  Google Scholar 

  • Watson A, Heading RC, Shepherd NA (2005) Guidelines for the diagnosis and management of Barrett’s Columnar-lined oesophagus (CLO). A report of the working party of the British Society of Gastroenterology, Q3 Print Project Management Limited, Loughborough, Leicestershire

    Google Scholar 

  • Whiting JL, Sigurdsson A, Rowlands DC, Hallissey MT, Fielding JW (2002) The long term results of endoscopic surveillance of premalignant gastric lesions. Gut 50(3):378–381

    Article  PubMed  CAS  Google Scholar 

  • Wolfsen HC, Crook JE, Krishna M, Achem SR, Devault KR, Bouras EP, Loeb DS, Stark ME, Woodward TA, Hemminger LL, Cayer FK, Wallace MB (2008) Prospective, controlled tandem endoscopy study of narrow band imaging for dysplasia detection in Barrett’s Esophagus. Gastroenterology 135(1):24–31

    Article  PubMed  Google Scholar 

  • Yeoh KG, Salto-Tellez M, Khor CJL et al (2005) Confocal laser endoscopy is useful for in vivo rapid diagnosis of gastric neoplasia and pre-neoplasia. Gastroenterology 128(4):A27 Suppl

    Google Scholar 

  • Yin JX, Oda I, Suzuki H, Gotoda T, Shimoda T, Saito D (2009) Endoscopic diagnosis of gastric cancer invasion depth. Nippon Shokakibyo Gakkai Zasshi 106(11):1603–1609

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, Queen Alexandra Hospital, Cosham, Portsmouth, PO6 3LY, UK

    Gaius Longcroft-Wheaton & Pradeep Bhandari

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  1. Gaius Longcroft-Wheaton
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  2. Pradeep Bhandari
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Correspondence to Pradeep Bhandari .

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  1. Leicester Royal Infirmary, Dept. Cancer Studies and, University of Leicester, Windsor Building, Level 4, Leicester, LE1 5WW, United Kingdom

    Janusz A. Z. Jankowski

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Longcroft-Wheaton, G., Bhandari, P. (2011). Endoscopic Methods. In: Jankowski, J. (eds) Inflammation and Gastrointestinal Cancers. Recent Results in Cancer Research, vol 185. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03503-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-03503-6_12

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