Towards DNA Comparator: The Machine That Compares DNA Concentrations

  • Fumiaki Tanaka
  • Takashi Tsuda
  • Masami Hagiya
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5347)


A DNA comparator, which compares the concentration of target strand with that of reference strand, was developed. To extend the potentiality of autonomous machines consisting of DNA, the DNA comparator was designed by utilizing a difference of kinetics between hybridizations and branch migrations. The performance was evaluated through a fluorescence quenching experiment. As a result, the DNA comparator can detect at least four times higher concentration of target strand compared with that of reference strand. Furthermore, the limitation of this DNA comparator is discussed based on the rate constants and the ratio of branch migration.


Logic Gate Time High Concentration Target Strand Branch Migration Bulge Loop 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Fumiaki Tanaka
    • 1
  • Takashi Tsuda
    • 1
  • Masami Hagiya
    • 1
  1. 1.Graduate School of Information Science and TechnologyUniversity of TokyoTokyoJapan

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