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Coherent Raman Scattering Microscopy

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Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

A series of advances over the past decade have made the combination of coherent Raman scattering (CRS) with optical microscopy a highly sensitive and chemically selective tool for the label-free and noninvasive analysis of chemical species or biological components inside a sub-femtoliter probe volume. By exploiting the coherent driving and detection of Raman modes in coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS), CRS imaging allows the point-by-point chemical mapping of living cells and tissues in three dimensions and in real time, which is often difficult to attain by fluorescence and incoherent vibrational microscopy techniques. Beyond imaging, CRS microspectroscopy in the frequencyand time-domain provides fast access to the full wealth of the sample’s spontaneous Raman response. In this review, we give an overview of the common fundamental aspects of CARS and SRS microscopy, their distinct image contrast mechanisms and microspectroscopy implementations, together with emerging biomedical applications.

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References

  1. T. Wilson, C. Sheppard, Theory and Practice of Scanning Optical Microscopy (Academic Press, Orlando, 1984)

    Google Scholar 

  2. W. Denk, J.H. Strickler, W.W. Webb, Science 248, 73 (1990)

    ADS  Google Scholar 

  3. Handbook of Biological Confocal Microscopy, ed. by J.B. Pawley (Plenum, New York, 1995)

    Google Scholar 

  4. R.P. Haugland, Handbook of Fluorescent Probes and Research Chemicals, 6th edn. (Molecular Probes, Eugene, 1996)

    Google Scholar 

  5. R.Y. Tsien, A. Miyawaki, Science 280, 1954 (1998)

    Google Scholar 

  6. J. Hoyland, in Fluorescent and Luminescent Probes for Biological Activity, ed. by W.T. Mason (Academic Press, San Diego, 1999), p. 108

    Google Scholar 

  7. H.J. Humecki, in Practical Spectroscopy, vol. 19, ed. by J.E.G. Brame (Marcel Dekker, New York, 1995)

    Google Scholar 

  8. G. Turrell, J. Corset, Raman Microscopy Development and Applications (Academic Press, San Diego, 1996)

    Google Scholar 

  9. S. Nie, S.R. Emory, Science 275, 1102–1106 (1997)

    Google Scholar 

  10. K. Kneipp, Y. Wang, H. Kneipp, L.T. Perelman, I. Itzkan, R.R. Dasari, M.S. Feld, Phys. Rev. Lett. 78, 1667–1670 (1997)

    ADS  Google Scholar 

  11. A. Zumbusch, G.R. Holtom, X.S. Xie, Phys. Rev. Lett. 82, 4142 (1999)

    ADS  Google Scholar 

  12. C.W. Freudiger, W. Min, B.G. Saar, S. Lu, G.R. Holtom, C. He, J.C. Tsai, J.X. Kang, X.S. Xie, Science 322, 1857–1861 (2008)

    ADS  Google Scholar 

  13. P. Nandakumar, A. Kovalev, A. Volkmer, New J. Phys. 11, 033026 (2009)

    ADS  Google Scholar 

  14. M.D. Duncan, J. Reintjes, T.J. Manuccia, Opt. Lett. 7, 350 (1982)

    ADS  Google Scholar 

  15. J.X. Cheng, X.S. Xie, J. Phys. Chem. B 108, 827–840 (2004)

    Google Scholar 

  16. A. Volkmer, J. Phys. D: Appl. Phys. 38, R59–R81 (2005)

    ADS  Google Scholar 

  17. J.X. Cheng, Appl. Spectrosc. 61, 197A–208A (2007)

    ADS  Google Scholar 

  18. M. Müller, A. Zumbusch, ChemPhysChem 8, 2156–2170 (2007)

    Google Scholar 

  19. C.L. Evans, X.S. Xie, Annu. Rev. Anal. Chem. 1, 883–909 (2008)

    Google Scholar 

  20. P. Nandakumar, A. Kovalev, A. Volkmer. Paper presented at the 17th international conference on laser spectroscopy (ICOLS’05), T54, Aviemore, 19–24 June 2005, and the 8th European/French Israeli symposium on nonlinear and quantum optics (FRISNO-8), Ein Bokek, 20–25 February 2005 (http://www.weizmann.ac.il/conferences/frisno8/program.html)

  21. Y. Ozeki, F. Dake, S. Kajiyama, K. Fukui, K. Itoh, Opt. Express 17, 3651–3658 (2009)

    ADS  Google Scholar 

  22. J.N. Gannaway, C.J.R. Sheppard, Opt. Quantum Electron. 10, 435–439 (1978)

    Google Scholar 

  23. M. Florsheimer, C. Brillert, H. Fuchs, Langmuir 15, 5437–5439 (1999)

    Google Scholar 

  24. Y. Barad, H. Eisenberg, M. Horowitz, Y. Silberberg, Appl. Phys. Lett. 70, 922–924 (1997)

    ADS  Google Scholar 

  25. M. Müller, J. Squier, K.R. Wilson, G.J. Brakenhoff, J. Microsc. 191, 266–274 (1998)

    Google Scholar 

  26. C.L. Evans, E.O. Potma, M. Puoris’haag, D. Côté, C.P. Lin, X.S. Xie, Proc. Natl. Acad. Sci. U S A 102, 16807–16812 (2005)

    ADS  Google Scholar 

  27. G.L. Eesley, Coherent Raman spectroscopy (Pergamon Press, Oxford, 1981)

    Google Scholar 

  28. Y.R. Shen, The Principles of Nonlinear Optics (Wiley, New York, 1984)

    Google Scholar 

  29. M.D. Levenson, S.S. Kano, Introduction to Nonlinear Laser Spectroscopy (Academic Press, San Diego, 1988)

    Google Scholar 

  30. S. Maeda, T. Kamisuki, Y. Adachi, in Advances in Non-linear Spectroscopy, ed. by R.J.H. Clark, R.E. Hester (Wiley, New York, 1988), p. 253

    Google Scholar 

  31. P.N. Butcher, D. Cotter, The Elements of Nonlinear Optics (Cambridge University Press, Cambridge, 1990)

    Google Scholar 

  32. S.A. Akhmanov, N.I. Koroteev, Sov. Phys. Usp. 20, 899 (1977)

    ADS  Google Scholar 

  33. M.A. Yuratich, D.C. Hanna, Mol. Phys. 33, 671–682 (1977)

    ADS  Google Scholar 

  34. R. Igarashi, Y. Adachi, S. Maeda, J. Chem. Phys. 72, 4308–4314 (1980)

    ADS  Google Scholar 

  35. D. Lee, A.C. Albrecht, in Advances in Infrared and Raman Spectroscopy, vol. 12, ed. by R.J.H. Clark, R.E. Hester (Wiley Heyden, London, 1985), pp. 179–213

    Google Scholar 

  36. D.A. Kleinman, Phys. Rev. 126, 1977–1979 (1962)

    ADS  Google Scholar 

  37. J.X. Cheng, A. Volkmer, L.D. Book, X.S. Xie, J. Phys. Chem. B 105, 1277–1280 (2001)

    Google Scholar 

  38. B. Broers, L.D. Noordam, H.B.v.L.v.d. Heuvell, Phys. Rev. A 46, 2749–2756 (1992)

    ADS  Google Scholar 

  39. E.T.J. Nibbering, D.A. Wiersma, K. Duppen, Phys. Rev. Lett. 68, 514–517 (1992)

    ADS  Google Scholar 

  40. A.M. Zheltikov, A.N. Naumov, Quantum Electron. 30, 606–610 (2000)

    ADS  Google Scholar 

  41. T. Hellerer, A.M.K. Enejder, A. Zumbusch, Appl. Phys. Lett. 85, 25–27 (2004)

    ADS  Google Scholar 

  42. I. Rocha-Mendoza, W. Langbein, P. Borri, Appl. Phys. Lett. 93, 201103 (2008)

    ADS  Google Scholar 

  43. A.F. Pegoraro, A. Ridsdale, D.J. Moffatt, Y. Jia, J.P. Pezacki, A. Stolow, Opt. Express 17, 2984–2996 (2009)

    ADS  Google Scholar 

  44. N. Dudovich, D. Oron, Y. Silberberg, Nature 418, 512–514 (2002)

    ADS  Google Scholar 

  45. D. Oron, N. Dudovich, Y. Silberberg, Phys. Rev. Lett. 89, 273001 (2002)

    ADS  Google Scholar 

  46. D. Oron, N. Dudovich, Y. Silberberg, Phys. Rev. Lett. 90, 213902 (2003)

    ADS  Google Scholar 

  47. N. Dudovich, D. Oron, Y. Silberberg, J. Chem. Phys. 118, 9208–9215 (2003)

    ADS  Google Scholar 

  48. S.A. Akhmanov, N.I. Koroteev, A.I. Kholodnykh, J. Raman Spectrosc. 2, 239–248 (1974)

    ADS  Google Scholar 

  49. D.W. McCamant, P. Kukura, R.A. Mathies, Appl. Spectrosc. 57, 1317–1323 (2003)

    ADS  Google Scholar 

  50. P.D. Maker, R.W. Terhune, Phys. Rev. 137, A801 (1965)

    ADS  Google Scholar 

  51. M.D. Duncan, Opt. Commun. 50, 307–312 (1984)

    ADS  Google Scholar 

  52. M. Müller, J. Squier, C.A.d. Lange, G.J. Brakenhoff, J. Microsc. 197, 150–158 (2000)

    Google Scholar 

  53. C. Heinrich, S. Bernet, M. Ritsch-Marte, Appl. Phys. Lett. 84, 816–818 (2004)

    ADS  Google Scholar 

  54. I. Toytman, K. Cohn, T. Smith, D. Simanovskii, D. Palanker, Opt. Lett. 32, 1941–1943 (2007)

    ADS  Google Scholar 

  55. C. Heinrich, A. Hofer, S. Bernet, M. Ritsch-Marte, New J. Phys. 10, 023029 (2008)

    ADS  Google Scholar 

  56. R.D. Schaller, J.C. Johnson, K.R. Wilson, L.F. Lee, L.H. Haber, R.J. Saykally, J. Chem. Phys. B 106, 5143–5154 (2002)

    Google Scholar 

  57. T. Ichimura, N. Hayazawa, M. Hashimoto, Y. Inouye, S. Kawata, Phys. Rev. Lett. 92, 220801 (2004)

    ADS  Google Scholar 

  58. F. Legare, C.L. Evans, F. Ganikhanov, X.S. Xie, Opt. Express 14, 4427–4432 (2006)

    ADS  Google Scholar 

  59. S. Mukamel, Principles of Nonlinear Optical Spectroscopy (Oxford University Press, Oxford, 1995).

    Google Scholar 

  60. A. Volkmer, J.X. Cheng, X.S. Xie, Phys. Rev. Lett. 87, 023901 (2001)

    ADS  Google Scholar 

  61. J.X. Cheng, A. Volkmer, X.S. Xie, J. Opt. Soc. Am. B 19, 1363–1375 (2002)

    ADS  Google Scholar 

  62. P. Hall, B. Selinger, Z. Phys. Chem.-Int. J. Res. Phys. Chem. Chem. Phys. 141, 77–89 (1984)

    Google Scholar 

  63. J.X. Cheng, L.D. Book, X.S. Xie, Opt. Lett. 26, 1341–1343 (2001)

    ADS  Google Scholar 

  64. A. Volkmer, L.D. Book, X.S. Xie, Appl. Phys. Lett. 80, 1505–1507 (2002)

    ADS  Google Scholar 

  65. D.L. Marks, S.A. Boppart, Phys Rev. Lett. 92, 123905 (2004)

    ADS  Google Scholar 

  66. E.O. Potma, C.L. Evans, X.S. Xie, Opt. Lett. 31, 241–243 (2006)

    ADS  Google Scholar 

  67. M. Jurna, J.P. Korterik, C. Otto, H.L. Offerhaus, Opt. Express 15, 15207–15213 (2007)

    ADS  Google Scholar 

  68. J.L. Oudar, R.W. Smith, Y.R. Shen, Appl. Phys. Lett. 34, 758–760 (1979)

    ADS  Google Scholar 

  69. E.O. Potma, X.S. Xie, J. Raman Spectrosc. 34, 642–650 (2003)

    ADS  Google Scholar 

  70. G.W.H. Wurpel, J.M. Schins, M. Müller, J. Phys. Chem. B 108, 3400–3403 (2004)

    Google Scholar 

  71. R.K. Chang, J. Ducuing, N. Bloembergen, Phys. Rev. Lett. 15, 6–8 (1965)

    ADS  Google Scholar 

  72. Y. Yacoby, R. Fitzgibbon, B. Lax, J. Appl. Phys. 51, 3072–3077 (1980)

    ADS  Google Scholar 

  73. G. Marowsky, G. Luepke, Appl. Phys. B 51, 49–51 (1990)

    ADS  Google Scholar 

  74. C. Vinegoni, J.S. Bredfeldt, D.L. Marks, S.A. Boppart, Opt. Express 12, 331–341 (2004)

    ADS  Google Scholar 

  75. C.L. Evans, E.O. Potma, X.S. Xie, Opt. Lett. 29, 2923–2925 (2004)

    ADS  Google Scholar 

  76. E.O. Potma, W.P.d. Boeij, D.A. Wiersma, J. Opt. Soc. Am. B 17, 1678–1684 (2000)

    ADS  Google Scholar 

  77. M. Hashimoto, T. Araki, J. Opt. Soc. Am. A 18, 771–776 (2001)

    MathSciNet  ADS  Google Scholar 

  78. D. Gachet, N. Sandeau, H. Rigneault, J. Eur. Opt. Soc. 1, 06013 (2006)

    Google Scholar 

  79. D. Gachet, F. Billard, H. Rigneault, J. Opt. Soc. Am. B 25, 1655–1666 (2008)

    ADS  Google Scholar 

  80. M. Marrocco, J. Phys. Chem. A 112, 13458–13462 (2008)

    Google Scholar 

  81. J.X. Cheng, S. Pautot, D.A. Weitz, S.X. Xie, Proc. Natl. Acad. Sci. 100, 9826–9830 (2003)

    ADS  Google Scholar 

  82. E.O. Potma, X.S. Xie, ChemPhysChem. 6, 77–79 (2005)

    Google Scholar 

  83. L. Li, H. Wang, J.X. Cheng, Biophys. J. 89, 3480–3490 (2005)

    Google Scholar 

  84. L. Li, J.X. Cheng, Biochemistry 45, 11819–11826 (2006)

    Google Scholar 

  85. J.X. Cheng, Y.K. Jia, G. Zheng, X.S. Xie, Biophys. J. 83, 502–509 (2002)

    ADS  Google Scholar 

  86. X. Nan, J.X. Cheng, X.S. Xie, J. Lipid Res. 44, 2202–2208 (2003)

    Google Scholar 

  87. Y. Fu, H. Wang, R. Shi, J.X. Cheng, Opt. Express 14, 3942–3951 (2006)

    ADS  Google Scholar 

  88. X. Nan, A.M. Tonary, A. Stolow, X.S. Xie, J.P. Pezacki, ChemBioChem. 7, 1895–1897 (2006)

    Google Scholar 

  89. X. Nan, E.O. Potma, X.S. Xie, Biophys. J. 91, 728–735 (2006)

    ADS  Google Scholar 

  90. X.S. Xie, J. Yu, W.Y. Yang, Science 312, 228–230 (2006)

    ADS  Google Scholar 

  91. B. Rakic, S.M. Sagan, M. Noestheden, S. Belanger, X. Nan, C.L. Evans, X.S. Xie, J.P. Pezacki, Chem. Biol. 13, 1–8 (2006)

    Google Scholar 

  92. L. Tong, Y. Lu, R.J. Lee, J.X. Cheng, J. Phys. Chem. B 111, 9980–9985 (2007)

    Google Scholar 

  93. S.O. Konorov, C.H. Glover, J.M. Piret, J. Bryan, H.G. Schulze, M.W. Blades, R.B. Turner, Anal. Chem. 79, 7221–7225 (2007)

    Google Scholar 

  94. H. Wang, N. Bao, T.T. Le, C. Lu, J.X. Cheng, Opt. Express 16, 5782–5789 (2008)

    ADS  Google Scholar 

  95. S. Murugkar, C.L. Evans, X.S. Xie, H. Anis, J. Microsc. 233, 244–250 (2009)

    MathSciNet  Google Scholar 

  96. H. Wang, Y. Fu, P. Zickmund, R. Shi, J.X. Cheng, Biophys. J. 89, 581–591 (2005)

    Google Scholar 

  97. T.B. Huff, J.X. Cheng, J. Microsc. 225, 175–182 (2006)

    MathSciNet  Google Scholar 

  98. T. Hellerer, C. Axäng, C. Brackmann, P. Hillertz, M. Pilon, A.M.K. Enejder, Proc. Natl. Acad. Sci. U S A 104, 14658–14663 (2007)

    ADS  Google Scholar 

  99. C.L. Evans, X. Xu, S. Kesari, X.S. Xie, S.T.C. Wong, G.S. Young, Opt. Express 15, 12076–12087 (2007)

    ADS  Google Scholar 

  100. S. Ly, G. McNerney, S. Fore, J. Chan, T. Huser, Opt. Express 15, 16839–16851 (2007)

    ADS  Google Scholar 

  101. I. Veilleux, J.A. Spencer, D.P. Biss, D. Cote, C.P. Lin, IEEE J. Sel. Top. Quantum Electron. 14, 10–18 (2008)

    Google Scholar 

  102. C.P. Pfeffer, B.R. Olsen, F. Ganikhanov, F. Légaré, J. Struct. Biol. 164, 140–145 (2008)

    Google Scholar 

  103. Y.M. Wu, H.C. Chen, W.T. Chang, J.W. Jhan, H.L. Lin, I. Liau, Anal. Chem. 81, 1496–1504 (2009)

    Google Scholar 

  104. E.R. Dufresne, E.I. Corwin, N.A. Greenblatt, J. Ashmore, D.Y. Wang, A.D. Dinsmore, J.X. Cheng, X.S. Xie, J.W. Hutchinson, D.A. Weitz, Phys. Rev. Lett. 91, 224501 (2003)

    ADS  Google Scholar 

  105. E.O. Potma, X.S. Xie, L. Muntean, J. Preusser, D. Jones, J. Ye, S.R. Leone, W.D. Hinsberg, W. Schade, J. Phys. Chem. B. 108, 1296–1301 (2004)

    Google Scholar 

  106. E. Kang, H. Wang, K. Kwon, J. Robinson, K. Park, J.X. Cheng, Anal. Chem. 78, 8036–8043 (2006)

    Google Scholar 

  107. A.V. Kachynski, A.N. Kuzmin, P.N. Prasad, Appl. Phys. Lett. 91, 151905 (2007)

    ADS  Google Scholar 

  108. B.G. Saar, H.S. Park, X.S. Xie, O.D. Lavrentovich, Opt. Express 15, 13585–13596 (2007)

    ADS  Google Scholar 

  109. E.O. Potma, D.J. Jones, J.X. Cheng, X.S. Xie, J. Ye, Opt. Lett. 27, 1168–1170 (2002)

    ADS  Google Scholar 

  110. F. Ganikhanov, S. Carrasco, X.S. Xie, M. Katz, W. Seitz, D. Kopf, Opt. Lett. 31, 1292–1294 (2006)

    ADS  Google Scholar 

  111. M. Jurna, J.P. Korterik, H.L. Offerhaus, C. Otto, Appl. Phys. Lett. 89, 251116 (2006)

    ADS  Google Scholar 

  112. G.R. Holtom, B.D. Thrall, B.Y. Chin, H.S. Wiley, S.D. Colson, Traffic 2, 781–788 (2001)

    Google Scholar 

  113. I.W. Schie, T. Weeks, G.P. McNerney, S. Fore, J.K. Sampson, S. Wachsmann-Hogiu, J.C. Rutledge, T. Huser, Opt. Express 16, 2168–2175 (2008)

    ADS  Google Scholar 

  114. C. Heinrich, A. Hofer, A. Ritsch, C. Ciardi, S. Bernet, M. Ritsch-Marte, Opt. Express 16, 2699–2708 (2008)

    ADS  Google Scholar 

  115. J. Moger, B.D. Johnston, C.R. Tyler, Opt. Express 16, 3408–3419 (2008)

    ADS  Google Scholar 

  116. Y. Fu, H. Wang, T.B. Huff, R. Shi, J.X. Cheng, J. Neurosci. Res. 85, 2870–2881 (2007)

    Google Scholar 

  117. T.B. Huff, H. Wang, J.X. Cheng, IEEE J. Sel. Top. Quantum Electron. 14, 4–9 (2008)

    Google Scholar 

  118. T.T. Le, I.M. Langohr, M.J. Locker, M. Sturek, J.X. Cheng, J. Biomed. Opt. 12, 054007 (2007)

    ADS  Google Scholar 

  119. C. Otto, A. Voroshilov, S.G. Kruglik, J. Greve, J. Raman Spectrosc. 32, 495–501 (2001)

    ADS  Google Scholar 

  120. M. Müller, J.M. Schins, J. Phys. Chem. B 106, 3715–3723 (2002)

    Google Scholar 

  121. J.X. Cheng, A. Volkmer, L.D. Book, X.S. Xie, J. Phys. Chem. B 106, 8493–8498 (2002)

    Google Scholar 

  122. H.N. Paulsen, K.M. Hilligsoe, J. Thogersen, S.R. Keiding, J.J. Larsen, Opt. Lett. 28, 1123–1125 (2003)

    ADS  Google Scholar 

  123. T.W. Kee, M.T. Cicerone, Opt. Lett. 29, 2701–2703 (2004)

    ADS  Google Scholar 

  124. H. Kano, H. Hamaguchi, Appl. Phys. Lett. 86, 121113 (2005)

    ADS  Google Scholar 

  125. G.I. Petrov, V.V. Yakovlev, Opt. Express 13, 1299–1306 (2005)

    ADS  Google Scholar 

  126. B. von Vacano, W. Wohlleben, M. Motzkus, Opt. Lett. 31, 413–415 (2006)

    ADS  Google Scholar 

  127. H. Kano, H. Hamaguchi, Opt. Express 14, 2798–2804 (2006)

    ADS  Google Scholar 

  128. T.W. Kee, H. Zhao, M.T. Cicerone, Opt. Express 14, 3631–3640 (2006)

    ADS  Google Scholar 

  129. E.R. Andresen, S.R. Keiding, E.O. Potma, Opt. Express 14, 7246–7251 (2006)

    ADS  Google Scholar 

  130. V.P. Mitrokhin, A.B. Fedotov, A.A. Ivanov, M.V. Alfimov, A.M. Zheltikov, Opt. Lett. 32, 3471–3473 (2007)

    ADS  Google Scholar 

  131. K.P. Knutsen, J.C. Johnson, A.E. Miller, P.B. Petersen, R.J. Saykally, Chem. Phys. Lett. 387, 436–441 (2004)

    ADS  Google Scholar 

  132. S.H. Lim, A.G. Caster, S.R. Leone, Phys. Rev. A 72, 041803(R) (2005)

    ADS  Google Scholar 

  133. B. von Vacano, T. Buckup, M. Motzkus, Opt. Lett. 31, 2495–2497 (2006)

    ADS  Google Scholar 

  134. B.C. Chen, S.H. Lim, J. Phys. Chem. B 112, 3653–3661 (2008)

    Google Scholar 

  135. B. von Vacano, L. Meyer, M. Motzkus, J. Raman Spectrosc. 38, 916–926 (2007)

    ADS  Google Scholar 

  136. H.A. Rinia, M. Bonn, M. Müller, J. Phys. Chem. B 110, 4472–4479 (2006)

    Google Scholar 

  137. E.M. Vartiainen, J. Opt. Soc. Am. B 9, 1209–1214 (1992)

    ADS  Google Scholar 

  138. E.M. Vartiainen, H.A. Rinia, M. Müller, M. Bonn, Opt. Express 14, 3622–3630 (2006)

    ADS  Google Scholar 

  139. H.A. Rinia, M. Bonn, M. Müller, E.M. Vartiainen, ChemPhysChem. 8, 279–287 (2007)

    Google Scholar 

  140. G.I. Petrov, R. Arora, V.V. Yakovlev, X. Wang, A.V. Sokolov, M.O. Scully, Proc. Natl. Acad. Sci. U S A 104, 7776–7779 (2007)

    ADS  Google Scholar 

  141. H.A. Rinia, K.N.J. Burger, M. Bonn, M. Müller, Biophys. J. 95, 4908–4914 (2008)

    ADS  Google Scholar 

  142. G.W.H. Wurpel, J.M. Schins, M. Müller, Opt. Lett. 27, 1093–1095 (2002)

    ADS  Google Scholar 

  143. G.W.H. Wurpel, M. Müller, Chem. Phys. Lett. 425, 336–341 (2006)

    ADS  Google Scholar 

  144. H. Kano, H. Hamaguchi, Opt. Express 13, 1322–1327 (2005)

    ADS  Google Scholar 

  145. H. Kano, H. Hamaguchi, Jpn. J. Appl. Phys. 46, 6875–6877 (2007)

    ADS  Google Scholar 

  146. H. Kano, H. Hamaguchi, Anal. Chem. 79, 8967–8973 (2007)

    Google Scholar 

  147. H. Kano, J. Raman Spectrosc. 39, 1649–1652 (2008)

    MathSciNet  ADS  Google Scholar 

  148. H. Kano, H. Hamaguchi, Chem. Lett. 35, 1124–1125 (2006)

    Google Scholar 

  149. H. Kano, H. Hamaguchi, Vibr. Spectrosc. 42, 135–139 (2006)

    Google Scholar 

  150. D. Schafer, J.A. Squier, J. van Maarseveen, D. Bonn, M. Bonn, M. Müller, J. Am. Chem. Soc. 130, 11592–11593 (2008)

    Google Scholar 

  151. F.M. Kamga, M.G. Sceats, Opt. Lett. 5, 126–128 (1980)

    ADS  Google Scholar 

  152. J.P. Ogilvie, E. Beaurepaire, A. Alexandrou, M. Joffre, Opt. Lett. 31, 480–482 (2006)

    ADS  Google Scholar 

  153. K. Shi, P. Li, Z. Liua, Appl. Phys. Lett. 90, 141116 (2007)

    ADS  Google Scholar 

  154. Y.Y. Lee, M.T. Cicerone, Appl. Phys. Lett. 92, 041108 (2008)

    ADS  Google Scholar 

  155. B.J. Berne, R. Pecora, Dynamic Light Scattering (Wiley, New York, 1976)

    Google Scholar 

  156. D. Magde, E.L. Elson, W.W. Webb, Phys. Rev. Lett. 29, 705–708 (1972)

    ADS  Google Scholar 

  157. D. Magde, E.L. Elson, W.W. Webb, Biopolymers 13, 29–61 (1974)

    Google Scholar 

  158. M. Ehrenberg, R. Rigler, Chem. Phys. 4, 390–401 (1974)

    ADS  Google Scholar 

  159. J. Widengren, U. Mets, R. Rigler, J. Phys. Chem. 99, 13368–13379 (1995)

    Google Scholar 

  160. W. Schrof, J.F. Klingler, S. Rozouvan, D. Horn, Phys. Rev. E 57, R2523–R2526 (1998)

    ADS  Google Scholar 

  161. C. Eggeling, J. Schaffer, C.A.M. Seidel, J. Korte, G. Brehm, S. Schneider, W. Schrof, J. Phys. Chem. A 105, 3673–3679 (2001)

    Google Scholar 

  162. T. Hellerer, A. Schiller, G. Jung, A. Zumbusch, ChemPhysChem. 7, 630–633 (2002)

    Google Scholar 

  163. J.X. Cheng, E.O. Potma, S.X. Xie, J. Phys. Chem. A. 106, 8561–8568 (2002)

    Google Scholar 

  164. A.G. Palmer, N.L. Thompson, Biophys. J. 51, 339–343 (1987)

    Google Scholar 

  165. A.G. Palmer, N.L. Thompson, Biophys. J. 52, 257–270 (1987)

    Google Scholar 

  166. P. Schwille, U. Haupts, S. Maiti, W.W. Webb, Biophys. J. 77, 2251–2265 (1999)

    Google Scholar 

  167. S.R. Arag/cn, R. Pecora, J. Chem. Phys. 64, 1791–1803 (1976)

    ADS  Google Scholar 

  168. R. Rigler, J. Widengren, in Bioscience, ed. by B. Klinge, C. Owman (Lund University Press, Lund, 1990), pp. 180–183

    Google Scholar 

  169. M. Eigen, R. Rigler, Proc. Natl. Acad. Sci. U S A 91, 5740–5747 (1994)

    ADS  Google Scholar 

  170. E.J. Woodbury, W.K. Ng, Proc. Inst. Radio Eng. 50, 2367 (1962)

    Google Scholar 

  171. W.J. Jones, B.P. Stoicheff, Phys. Rev. Lett. 13, 657 (1964)

    ADS  Google Scholar 

  172. A. Owyoung, E.D. Jones, Opt. Lett. 1, 152–154 (1977)

    ADS  Google Scholar 

  173. B.F. Levine, C.G. Bethea, Appl. Phys. Lett. 36, 245–247 (1980)

    ADS  Google Scholar 

  174. P. Kukura, D.W. McCamant, R.A. Mathies, Annu. Rev. Phys. Chem. 58, 461–488 (2007)

    ADS  Google Scholar 

  175. J.P. Heritage, D.L. Allara, Chem. Phys. Lett. 74, 507–509 (1980)

    ADS  Google Scholar 

  176. E. Ploetz, S. Laimgruber, S. Berner, W. Zinth, P. Gilch, Appl. Phys. B 87, 389–393 (2007)

    ADS  Google Scholar 

  177. A.J. Wright, S.P. Poland, J.M. Girkin, C.W. Freudiger, C.L. Evans, X.S. Xie, Opt. Express 15, 18209–18219 (2007)

    ADS  Google Scholar 

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Acknowledgments

I would like to extent a special thanks to my former colleagues X. Sunney Xie, Gary R. Holtom, Ji-Xin Cheng, and Lewis D. Book at Harvard University where the work on CARS microscopy described in this review had its origin. In equal measure, I wish to acknowledge my former and past group members Nandakumar Patincharath, Alexander Kovalev, Adam Muschielok, Stephan Busch, and Gregor Hehl at the University of Stuttgart for their essential contributions to the depicted work on in vivo CARS microspectroscopy and SRS imaging. Financial and infrastructural support from the Emmy-Noether program of the Deutsche Forschungsgemeinschaft (DFG: VO 825/1-2, 1-3, 1-4), the 3. Physikalisches Institut, and the University of Stuttgart is gratefully acknowledged.

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  1. Physikalisches Institut, Universität Stuttgart, Pfaffenwaldring 57, Stuttgart, 70550, Germany

    Andreas Volkmer

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  1. Science & Technology Facilities Council, Central Laser Facility, Didcot, Oxon., OX11 0QX, United Kingdom

    Pavel Matousek

  2. Dept. Chemistry, University of Michigan, Ann Arbor, 48109-1055, U.S.A.

    Michael D. Morris

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Volkmer, A. (2010). Coherent Raman Scattering Microscopy. In: Matousek, P., Morris, M. (eds) Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02649-2_6

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