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Characterisation of Deep Layers of Tissue and Powders: Spatially Offset Raman and Transmission Raman Spectroscopy

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Book cover Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

This chapter reviews emerging techniques for deep, non-invasive Raman spectroscopy of diffusely scattering media. As generic analytical tools, these methods pave the way for a host of new applications including non-invasive disease diagnosis, chemical identification and characterisation of pharmaceutical products.

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References

  1. M.J. Pelletier, Analytical Applications of Raman Spectroscopy (Blackwell Science, Oxford, 1999)

    Google Scholar 

  2. B.B. Das, F. Liu, R.R. Alfano, Rep. Prog. Phys. 60, 227 (1997)

    Article  ADS  Google Scholar 

  3. J.C. Hebden, A. Gibson, R. Yusof, N. Everdell, E.M.C. Hillman, D.T. Delpy, S.R. Arridge, T. Austin, J.H. Meek, J.S. Wyatt, Phys. Med. Biol. 47, 4155 (2002)

    Article  Google Scholar 

  4. H. Koizumi, Y. Yamashita, A. Maki, T. Yamamoto, Y. Ito, H. Itagaki, R. Kennan, J. Biomed. Opt. 4, 403 (1999)

    Article  ADS  Google Scholar 

  5. T.J. Pfefer, K.T. Schomacker, M.N. Ediger, N.S. Nishioka, Appl. Opt. 41, 4712 (2002)

    Article  ADS  Google Scholar 

  6. N. Ghosh, S.K. Majumder, H.S. Patel, P.K. Gupta, Opt. Lett. 30, 162 (2005)

    Article  ADS  Google Scholar 

  7. L. Quan, N. Ramanujam, Opt. Lett. 27, 104 (2002)

    Article  ADS  Google Scholar 

  8. S.C. Gebhart, S.K. Majumder, A. Mahadevan-Jansen, Appl. Opt. 46, 1343 (2007)

    Article  ADS  Google Scholar 

  9. J. Wu, Y. Wang, L. Perelman, I. Itzkan, R. Dasari, M.S. Feld, Appl. Opt. 34, 3425 (1995)

    Article  ADS  Google Scholar 

  10. N. Everall, T. Hahn, P. Matousek, A.W. Parker, M. Towrie, Appl. Spectrosc. 55, 1701 (2001)

    Article  ADS  Google Scholar 

  11. N. Everall, T. Hahn, P. Matousek, A.W. Parker, M. Towrie, Appl. Spectrosc. 58, 591 (2004)

    Article  ADS  Google Scholar 

  12. P. Matousek, N. Everall, M. Towrie, A.W. Parker, Appl. Spectrosc. 59, 200 (2005)

    Article  ADS  Google Scholar 

  13. M.D. Morris, P. Matousek, M. Towrie, A.W. Parker, A.E. Goodship, E.R.C. Draper, J. Biomed. Opt. 10, 014014 (2005)

    Article  ADS  Google Scholar 

  14. P. Matousek, M. Towrie, A. Stanley, A.W. Parker, Appl. Spectrosc. 53, 1485 (1999)

    Article  ADS  Google Scholar 

  15. P. Matousek, M. Towrie, C. Ma, W.M. Kwok, D. Phillips, W.T. Toner, A.W. Parker, J. Raman Spectrosc. 32, 983 (2001)

    Article  ADS  Google Scholar 

  16. P. Matousek, M. Towrie, A.W. Parker, J. Raman Spectrosc. 33, 238 (2002)

    Article  ADS  Google Scholar 

  17. P. Matousek, Chem. Soc. Rev. 36, 1292 (2007)

    Article  Google Scholar 

  18. P. Matousek, I.P. Clark, E.R.C. Draper, M.D. Morris, A.E. Goodship, N. Everall, M. Towrie, W.F. Finney, A.W. Parker, Appl. Spectrosc. 59, 393 (2005)

    Article  ADS  Google Scholar 

  19. P. Matousek, M.D. Morris, N. Everall, I.P. Clark, M. Towrie, E. Draper, A. Goodship, A.W. Parker, Appl. Spectrosc. 59, 1485 (2005)

    Article  ADS  Google Scholar 

  20. M.V. Schulmerich, K.A. Dooley, T.M. Vanasse, S.A. Goldstein, M.D. Morris, Appl. Spectrosc. 61, 671 (2007)

    Article  ADS  Google Scholar 

  21. E. Widjaja, C.Z. Li, M. Garland, Organometallics 21, 1991 (2002)

    Article  Google Scholar 

  22. W. Chew, E. Widjaja, M. Garland, Organometallics 21, 1982 (2002)

    Article  Google Scholar 

  23. C.Z. Li, E. Widjaja, M. Garland, J. Catal. 213, 126 (2003)

    Article  Google Scholar 

  24. E. Widjaja, C.Z. Li, W. Chew, M. Garland, Anal. Chem. 75, 4499 (2003)

    Article  Google Scholar 

  25. E. Widjaja, N.J. Crane, T.C. Chen, M.D. Morris, M.A. Ignelzi, B.R. McCreadie, Appl. Spectrosc. 57, 1353 (2003)

    Article  ADS  Google Scholar 

  26. C. Eliasson, P. Matousek, Anal. Chem. 79, 1696 (2007)

    Article  Google Scholar 

  27. C. Eliasson, N.A. Macleod, P. Matousek, Anal. Chem. 79, 8185 (2007)

    Article  Google Scholar 

  28. C. Eliasson, M. Claybourn, P. Matousek, Appl. Spectrosc. 61, 1123 (2007)

    Article  ADS  Google Scholar 

  29. J.Y. Ma, D. Ben-Amotz, Appl. Spectrosc. 51, 1845 (1997)

    Article  ADS  Google Scholar 

  30. M.V. Schulmerich, W.F. Finney, V. Popescu, M.D. Morris, T.M. Vanasse, S.A. Goldstein, Transcutaneous Raman spectroscopy of bone tissue using a non-confocal fiber optic array probe, in Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, ed. by A. Mahadevan-Jansen, W.H. Petrich. Proceedings of SPIE, vol. 6093 (2006), article number 60930O

    Google Scholar 

  31. M.V. Schulmerich, W.F. Finney, R.A. Fredricks, M.D. Morris, Appl. Spectrosc. 60, 109 (2006)

    Article  ADS  Google Scholar 

  32. P. Matousek, E.R.C. Draper, A.E. Goodship, I.P. Clark, K.L. Ronayne, A.W. Parker, Appl. Spectrosc. 60, 758 (2006)

    Article  ADS  Google Scholar 

  33. B. Depret, P. Verkerk, D. Hennequin, Opt. Commun. 211, 31 (2002)

    Article  ADS  Google Scholar 

  34. P. Matousek, Appl. Spectrosc. 60, 1341 (2006)

    Article  ADS  Google Scholar 

  35. M.V. Schulmerich, K.A. Dooley, M.D. Morris, T.M. Vanasse, S.A. Goldstein, J. Biomed. Opt. 11, 060502 (2006)

    Article  ADS  Google Scholar 

  36. M.V. Schulmerich, M.D. Morris, T.M. Vanasse, S.A. Goldstein, Transcutaneous Raman spectroscopy of bone global sampling and ring/disk fiber optic probes, in Advanced Biomedical and Clinical Diagnostic Systems V, ed. by T. Vo-Dinh, W.S. Grundfest, D.A. Benaron, G.E. Cohn, R. Raghavachari. Proceedings of SPIE, vol. 6430 (2007), article number 643009

    Google Scholar 

  37. A.H. Hielscher, Curr. Opin. Biotech. 16, 79 (2005)

    Article  Google Scholar 

  38. M.V. Schulmerich, J.H. Cole, K.A. Dooley, M.D. Morris, J.M. Kreider, S.A. Goldstein, S. Srinivasan, B.W. Pogue, J. Biomed. Opt. 13, 020506 (2008)

    Article  ADS  Google Scholar 

  39. M.V. Schulmerich, S. Srinivasan, J. Kreider, J.H. Cole, K.A. Dooley, S.A. Goldstein, B.W. Pogue, M.D. Morris, Raman tomography of tissue phantoms and bone tissue. Paper presented at Biomedical Optical Spectroscopy, San Jose, CA, USA, SPIE, 2008

    Google Scholar 

  40. C.M. Carpenter, B.W. Pogue, S. Jiang, H. Dehghani, X. Wang, K.D. Paulsen, W.A. Wells, J. Forero, C. Kogel, J.B. Weaver, S.P. Poplack, P.A. Kaufman, Opt. Lett. 32, 933 (2007)

    Article  ADS  Google Scholar 

  41. S. Srinivasan, M. Schulmerich, J.H. Cole, K.A. Dooley, J.M. Kreider, B.W. Pogue, M.D. Morris, S.A. Goldstein, Opt. Express 16, 12190 (2008)

    Article  ADS  Google Scholar 

  42. B. Schrader, G. Bergmann, Z. Anal. Chem. 225, 230 (1967)

    Article  Google Scholar 

  43. P. Matousek, A.W. Parker, Appl. Spectrosc. 60, 1353 (2006)

    Article  ADS  Google Scholar 

  44. J. Johansson, S. Pettersson, S. Folestad, J. Pharm. Biomed. Anal. 39, 510 (2005)

    Article  Google Scholar 

  45. P. Matousek, A.W. Parker, J. Raman Spectrosc. 38, 563 (2007)

    Article  ADS  Google Scholar 

  46. P. Matousek, Appl. Spectrosc. 61, 845 (2007)

    Article  ADS  Google Scholar 

  47. K. Buckley, A. Goodship, N.A. Macleod, A.W. Parker, P. Matousek, Anal. Chem. 80, 6006 (2008)

    Article  Google Scholar 

  48. D.A. Long, Raman Spectroscopy (McGraw-Hill, New York, 1977)

    Google Scholar 

  49. J.C. Henderson, Q. Su, R. Grobe, Laser Phys. 14, 515 (2004)

    Google Scholar 

  50. A. Carden and M.D. Morris, J. Biomed. Opt. 5, 259 (2000)

    Article  ADS  Google Scholar 

  51. E.R.C. Draper, M.D. Morris, N.P. Camacho, P. Matousek, M. Towrie, A.W. Parker, A.E. Goodship, J. Bone Miner. Res. 20, 1968 (2005) and references therein

    Article  Google Scholar 

  52. B.R. McCreadie, M.D. Morris, T. Chen, D.S. Rao, W.F. Finney, E. Widjaja, S.A. Goldstein, Bone 39, 1190 (2006)

    Article  Google Scholar 

  53. M.V. Schulmerich, J.H. Cole, J.M. Kreider, F. Esmonde-White, K.A. Dooley, S.A. Goldstein, M.D. Morris, Appl. Spectrosc. 63, 286 (2009)

    Article  ADS  Google Scholar 

  54. R. Baker, P. Matousek, K.L. Ronayne, A.W. Parker, K.Rogers, N. Stone, Analyst 132, 48 (2007)

    Article  ADS  Google Scholar 

  55. N. Stone, R. Baker, K. Rogers, A.W. Parker, P. Matousek, Analyst 132, 899 (2007)

    Article  ADS  Google Scholar 

  56. P. Matousek, N. Stone, J. Biomed. Opt. 12, (2007) 024008

    Article  ADS  Google Scholar 

  57. S. Haka, K.E. Shafer-Peltier, M. Fitzmaurice, J. Crowe, R.R. Dasari, M.S. Feld, Cancer Res. 62, 5375 (2002)

    Google Scholar 

  58. R. Cockburn, P.N. Newton, E.K. Agyarko, D. Akunyili, N.J. White, PLoS Med. 4, 1553 (2007)

    Article  Google Scholar 

  59. P. Aldhous, Nature 434, 132 (2005)

    Article  ADS  Google Scholar 

  60. P.N. Newton, M.D. Green, F.M. Fernández, N.P.J. Day, N.J. White, Lancet Infect. Dis. 6, 602 (2006)

    Article  Google Scholar 

  61. M.R. Witkowski, Am. Pharm. Rev. 8, 56 (2005)

    Google Scholar 

  62. C. Eliasson, P. Matousek, Laser Focus World 43, 123 (2007)

    Google Scholar 

  63. C. Ricci, C. Eliasson, N.A. Macleod, P. Newton, P. Matousek, S.G. Kazarian, Anal. Bioanal. Chem. 389, 1525 (2007)

    Article  Google Scholar 

  64. J. Johansson, A. Sparen, O. Svensson, S. Folestad, M. Claybourn, Appl. Spectrosc. 61, 1211 (2007)

    Article  ADS  Google Scholar 

  65. C. Eliasson, N.A. Macleod, L. Jayes, F.C. Clarke, S. Hammond, M.R. Smith, P. Matousek, J. Pharm. Biomed. Anal. 47, 221 (2008)

    Article  Google Scholar 

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Acknowledgments

The authors wish to thank Dr Darren Andrews and Dr Tim Bestwick of CLIK Knowledge Transfer and Dr Charlotte Eliasson, Professor Anthony Parker and Professor Mike Dunne of the Science and Technology Facilities Council for their support of this work. The EPSRC is also gratefully acknowledged for their support (grant EP/D037662/1).

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Macleod, N., Morris, M., Matousek, P. (2010). Characterisation of Deep Layers of Tissue and Powders: Spatially Offset Raman and Transmission Raman Spectroscopy. In: Matousek, P., Morris, M. (eds) Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02649-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-02649-2_3

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