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Emerging Dental Applications of Raman Spectroscopy

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Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Until recently, the application of Raman spectroscopy to investigate dental tissues has primarily focused on using microspectroscopy to characterize dentin and enamel structures as well as to understand the adhesive interface of various resin and bonding agents used in restorative procedures. With the advent of improved laser, imaging/mapping and fibre optic technologies, the applications have expanded to investigate various biomedical problems ranging from oral cancer, bacterial identification and early dental caries detection. The overall aim of these applications is to develop Raman spectroscopy into a tool for use in the dental clinic. This chapter presents the recent dental applications of Raman spectroscopy as well as discusses the potential, strengths and limitations of the technology in comparison with alternative techniques. In addition, a discussion and rationale about combining Raman spectroscopy with other optical techniques will be included.

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Abbreviations

PRS:

polarized Raman spectroscopy

OCT:

optical coherence tomography

:

Symbols:

ρ :

Raman depolarization ratio

r :

correlation coefficient

References

  1. P.J. Caspers, G.W. Lucassen, E.A. Carter, H.A. Bruining, G.J. Puppels, J. Invest. Dermatol. 116, 434 (2001)

    Article  Google Scholar 

  2. M.A. Short, S. Lam, A. McWilliams, J.H. Zhao, H. Lui, H.S. Zeng, Opt. Lett. 33, 711 (2008)

    Article  ADS  Google Scholar 

  3. A.H. Chau, J.T. Motz, J.A. Gardecki, S. Waxman, B.E. Bouma, G.J. Tearney, J. Biomed. Opt. 13, 040501 (2008)

    Article  ADS  Google Scholar 

  4. G.J. Puppels, T.C. Bakker Schut, P.J. Caspers, R. Wolthuis, M. van Aken, A. van der Laarse, H.A. Bruining, H.P.J. Buschman, M.G. Shim, B.C. Wilson, Handbook of Raman Spectroscopy (Marcel Dekker, New York, 2001), p. 549.

    Google Scholar 

  5. X. Li, K.M. Kolltveit, L. Tronstad, I. Olsen, Clin. Microbiol. Rev. 13, 547 (2000)

    Article  Google Scholar 

  6. R. Rautemaa, A. Lauhio, M.P. Cullinan, G.J. Seymour, Clin. Microbiol. Infect. 13, 1041 (2007)

    Article  Google Scholar 

  7. A.M. Iacopino, J. Can. Dent. Assoc. 74, 418 (2008)

    Google Scholar 

  8. R.M. Lemor, M.B. Kruger, D.M. Wieliczka, J.R. Swafford, P. Spencer, J. Biomed. Opt. 4, 22 (1999)

    Article  ADS  Google Scholar 

  9. H. Tsuda, J. Arends, Adv. Dent. Res. 11, 539 (1997)

    Article  Google Scholar 

  10. Y. Wang, P. Spencer, J. Biomed. Mater. Res. 59, 46 (2002)

    Article  Google Scholar 

  11. R. Malini, K. Venkatakrishna, J. Kurien, K.M. Pai, L. Rao, V.B. Kartha, C.M. Krishna, Biopolymers 81, 179 (2006)

    Article  Google Scholar 

  12. A.P. Oliveira, R.A. Bitar, L. Silveira, R.A. Zangaro, A.A. Martin, Photomed. Laser Surg. 24, 348 (2006)

    Article  Google Scholar 

  13. D.C.G. de Veld, T.C. Bakker Schut, M. Skurichina, M.J.H. Witjes, J.E. Van der Wal, J.L.N. Roodenburg, H. Sterenborg, Lasers Med. Sci. 19, 203 (2005)

    Article  Google Scholar 

  14. K. Venkatakrishna, J. Kurien, K.M. Pai, M. Valiathan, N.N. Kumar, C.M. Krishna, G. Ullas, V.B. Kartha, Curr. Sci. 80, 665 (2001)

    Google Scholar 

  15. C.M. Krishna, G.D. Sockalingum, J. Kurien, L. Rao, L. Venteo, M. Pluot, M. Manfait, V.B. Kartha, Appl. Spectrosc. 58, 1128 (2004)

    Article  ADS  Google Scholar 

  16. T.C. Bakker Schut, M.J.H. Witjes, H. Sterenborg, O.C. Speelman, J.L.N. Roodenburg, E.T. Marple, H.A. Bruining, G.J. Puppels, Anal. Chem. 72, 6010 (2000)

    Article  Google Scholar 

  17. A.J. Berger, Q.Y. Zhu, J. Mod. Opt. 50, 2375 (2003)

    ADS  Google Scholar 

  18. Q.Y. Zhu, R.G. Quivey, A.J. Berger, J. Biomed. Opt. 9, 1182 (2004)

    Article  ADS  Google Scholar 

  19. Q.Y. Zhu, R.G. Quivey, A.J. Berger, Appl. Spectrosc. 61, 1233 (2007)

    Article  ADS  Google Scholar 

  20. T. Jiang, X. Ma, Y.N. Wang, H. Tong, X.Y. Shen, Y.G. Hu, J.M. Hu, J. Biomed. Opt. 13, 014019 (2008)

    Article  ADS  Google Scholar 

  21. L.E.S. Soares, P.C.S. Liporoni, A.A. Martin, Oper. Dent. 32, 160 (2007)

    Google Scholar 

  22. R. Parthasarathy, G. Thiagarajan, X. Yao, Y.P. Wang, P. Spencer, Y. Wang, J. Biomed. Opt. 13, 014020 (2008)

    Article  ADS  Google Scholar 

  23. M.A. Latta, J. Adhes. Dent. 9(S2), 245 (2007)

    Google Scholar 

  24. L.E.S. Soares, A.A. Martin, A.L.B. Pinheiro, M.T.T. Pacheco, J. Biomed. Opt. 9, 601 (2004)

    Article  ADS  Google Scholar 

  25. J.L. Katz, A. Misra, P. Spencer, Y. Wang, S. Bumrerraj, T. Nomura, S.J. Eppell, M. Tabib Azar, Mater. Sci. Eng. C Biomim. Supramol. Syst. 27(S3), 450 (2007)

    Article  Google Scholar 

  26. M.A. Lopez Heredia, J. Sohier, C. Gaillard, S. Quillard, M. Dorget, P. Layrolle, Biomaterials 29, 2608 (2008)

    Article  Google Scholar 

  27. Y. Wang, P. Spencer, M.P. Walker, J. Biomed. Mater. Res. A 81A, 279 (2007)

    Article  Google Scholar 

  28. K.A. Schulze, M. Balooch, G. Balooch, G.W. Marshall, S.J. Marshall, J. Biomed. Mater. Res. A 69A, 286 (2004)

    Article  Google Scholar 

  29. C. Robinson, R.C. Shore, S.J. Brookes, S. Strafford, S.R. Wood, J. Kirkham, Crit. Rev. Oral. Biol. Med. 11, 481 (2000)

    Article  Google Scholar 

  30. T.M. Roberson, H. Heymann, E.J. Swift, C.M. Sturdevant, Sturdevant’s Art & Science of Operative Dentistry (Mosby, St. Louis, 2002), p. 947

    Google Scholar 

  31. H. Tsuda, J. Arends, J. Dent. Res. 73, 1703 (1994)

    Google Scholar 

  32. G. Penel, G. Leroy, C. Rey, E. Bres, Calcif. Tissue Int. 63, 475 (1998)

    Article  Google Scholar 

  33. National Institutes of Health Consensus Development Conference Statement, J. Dent. Educ. 65, 1162 (2001)

    Google Scholar 

  34. S.C. White, M.J. Pharoah, Oral Radiology: Principles and Interpretation (Mosby, Toronto, 2004), p. 297

    Google Scholar 

  35. D.J. White, Adv. Dent. Res. 9, 175 (1995)

    ADS  Google Scholar 

  36. W. Hill, V. Petrou, Appl. Spectrosc. 51, 1265 (1997)

    Article  ADS  Google Scholar 

  37. W. Hill, V. Petrou, Appl. Spectrosc. 54, 795 (2000)

    Article  ADS  Google Scholar 

  38. T. Izawa, M. Wakaki, Prog. Biomed. Opt. Imaging Proc. SPIE 5687, 1 (2005)

    Article  ADS  Google Scholar 

  39. M. Mukhin, A. Sklyarov, V.B. Dhuru, V.V. Yakovlev, Prog. Biomed. Opt. Imaging Proc. SPIE 5687, 9 (2005)

    Article  ADS  Google Scholar 

  40. H. Kinoshita, N. Miyoshi, Y. Fukunaga, T. Ogawa, T. Ogasawara, K. Sano, J. Raman Spectrosc. 39, 655 (2008)

    Article  ADS  Google Scholar 

  41. V. Bulatov, L. Feller, Y. Yasman, I. Schechter, Instr. Sci. Tech. 36, 235 (2008)

    Article  Google Scholar 

  42. A.C.-T. Ko, L.-P. Choo-Smith, M. Hewko, L. Leonardi, M.G. Sowa, C.C.S. Dong, P. Williams, B. Cleghorn, J. Biomed. Opt. 10, 031118 (2005)

    Article  ADS  Google Scholar 

  43. L.-P. Choo-Smith, A.C.-T. Ko, M.D. Hewko, C.C.S. Dong, B.M. Cleghorn, M.G. Sowa, Lasers Dent. XII Proc. SPIE 6137, 613706 (2006)

    Google Scholar 

  44. A.C.-T. Ko, L.-P. Choo-Smith, M. Hewko, M.G. Sowa, C.C.S. Dong, B. Cleghorn, Opt. Express 14, 203 (2006)

    Article  ADS  Google Scholar 

  45. S. Frisk, R.M. Ikeda, D.B. Chase, J.F. Rabolt, Appl. Spectrosc. 58, 279 (2004)

    Article  ADS  Google Scholar 

  46. M. Tsuboi, J.M. Benevides, P. Bondre, G.J. Thomas, Biochemistry 44, 4861 (2005)

    Article  Google Scholar 

  47. G. Leroy, G. Penel, N. Leroy, E. Bres, Appl. Spectrosc. 56, 1030 (2002)

    Article  ADS  Google Scholar 

  48. A.C.-T. Ko, M. Hewko, M.G. Sowa, C.C.S. Dong, B. Cleghorn, L.-P. Choo-Smith, Opt. Express 16, 6274 (2008)

    Article  ADS  Google Scholar 

  49. L.-P. Choo-Smith, C.C.S. Dong, B. Cleghorn, M. Hewko, J. Can. Dent. Assoc. 74, 913 (2008)

    Google Scholar 

  50. L.-P. Choo-Smith, K. Gibrayel, C.C.S. Dong, D. Popescu, M.G. Sowa, B. Cleghorn, Caries Res. 41, 326 (2007)

    Google Scholar 

  51. A. Huminicki, C.C.S. Dong, B. Cleghorn, L.-P. Choo-Smith, J. Dent. Res. 87(Spec. Iss. B), 521 (2008)

    Google Scholar 

  52. C.C.S. Dong, A. Huminicki, M.G. Sowa, B. Cleghorn, L.-P. Choo-Smith, Caries Res. 42, 213 (2008)

    Google Scholar 

  53. L.-P. Choo-Smith, A. Huminicki, C.C.S. Dong, M. Hewko, B. Cleghorn, M.G. Sowa, Caries Res. 42, 214 (2008)

    Google Scholar 

  54. A. Hall, J.M. Girkin, J. Dent. Res. 83(Spec. Iss. C), 89 (2004)

    Google Scholar 

  55. I.A. Pretty, J. Dent. 34, 727 (2006)

    Article  Google Scholar 

  56. A.F. Zandona, D.T. Zero, J. Am. Dent. Assoc. 137, 1675 (2006)

    Google Scholar 

  57. C.A. Murdoch-Kinch, J. Calif. Dent. Assoc. 27, 773 (1999)

    Google Scholar 

  58. X.Q. Shi, U. Welander, B. Angmar-Mansson, Caries Res. 34, 151 (2000)

    Article  Google Scholar 

  59. A. Lussi, S. Imwinkelried, N. Pitts, C. Longbottom, E. Reich, Caries Res. 33, 261 (1999)

    Article  Google Scholar 

  60. J.D. Bader, D.A. Shugars, A.J. Bonito, J. Public Health Dent. 62, 201 (2002)

    Article  Google Scholar 

  61. F.I. Feldchtein, G.V. Gelikonov, V.M. Gelikonov, R.R. Iksanov, R.V. Kuranov, A.M. Sergeev, N.D. Gladkova, M.N. Ourutina, J.A. Warren Jr., D.H. Reitze, Opt. Express 3, 239 (1998)

    Article  ADS  Google Scholar 

  62. X.J. Wang, T.E. Milner, J.F. de Boer, Y. Zhang, D.H. Pashley, J.S. Nelson, Appl. Opt. 38, 2092 (1999)

    Article  ADS  Google Scholar 

  63. W. Drexler, C.K. Hitzenberger, H. Sattmann, A.F. Fercher, Opt. Eng. 34, 701 (1995)

    Article  ADS  Google Scholar 

  64. J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, E.A. Swanson, Curr. Opin. Ophthalmol. 6, 89 (1995)

    Google Scholar 

  65. X.D. Li, S.A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M.L. Krinsky, M.E. Brezinski, J.G. Fujimoto, Endoscopy 32, 921 (2000)

    Article  Google Scholar 

  66. M. Tsuboi, A. Hayashi, N. Ikeda, H. Honda, Y. Kato, S. Ichinose, H. Kato, Lung Cancer 49, 387 (2005)

    Article  Google Scholar 

  67. I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, B.E. Bouma, Circulation 111, 1551 (2005)

    Article  Google Scholar 

  68. D.C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, J.G. Fujimoto, Nat. Photonics 1, 709 (2007)

    Article  ADS  Google Scholar 

  69. L.-P. Choo-Smith, P. Qiu, D. Popescu, M. Hewko, C.C.S. Dong, B.M. Cleghorn, M.G. Sowa, J. Dent. Res. 87(Spec. Iss. B), 2838 (2008)

    Google Scholar 

  70. D.P. Popescu, M.G. Sowa, M.D. Hewko, L.-P. Choo-Smith, J. Biomed. Opt. 13, 054053 (2008)

    Article  ADS  Google Scholar 

  71. M.G. Sowa, D.P. Popescu, J. Werner, M. Hewko, A.C.-T. Ko, J. Payette, C.C.S. Dong, B. Cleghorn, L.-P. Choo-Smith, Anal. Bioanal. Chem. 387, 1613 (2007)

    Article  Google Scholar 

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Acknowledgments

Research funding has been derived in part from past and current grants from the Manitoba Medical Service Foundation, Canadian Institutes of Health – Institute of Musculoskeletal Health and Arthritis, and the US National Institutes of Health – National Institute for Dental and Craniofacial Research (#R01DE017889).We thank our clinical collaborators, Dr. Cecilia Dong (Faculty of Dentistry, U. Manitoba) and Dr. Blaine Cleghorn (Faculty of Dentistry, Dalhousie U.) for insightful discussions and clinical assessments. We also thank the staff and students of the Dental Clinics at U. Manitoba and at Dalhousie U. for assistance with tooth collection.

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Authors and Affiliations

  1. National Research Council Canada, Institute for Biodiagnostics, 435 Ellice Ave., Winnipeg, Manitoba, Canada, R3B 1Y6

    Lin-P’ing Choo-Smith, Mark Hewko & Michael G. Sowa

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  1. Lin-P’ing Choo-Smith
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  2. Mark Hewko
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  3. Michael G. Sowa
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Correspondence to Lin-P’ing Choo-Smith .

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Editors and Affiliations

  1. Science & Technology Facilities Council, Central Laser Facility, Didcot, Oxon., OX11 0QX, United Kingdom

    Pavel Matousek

  2. Dept. Chemistry, University of Michigan, Ann Arbor, 48109-1055, U.S.A.

    Michael D. Morris

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Choo-Smith, LP., Hewko, M., Sowa, M.G. (2010). Emerging Dental Applications of Raman Spectroscopy. In: Matousek, P., Morris, M. (eds) Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02649-2_11

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  • DOI: https://doi.org/10.1007/978-3-642-02649-2_11

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