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Comparative Gene Expression Profiling of Senescent and Androgenetic Alopecia Using Microarray Analysis

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Aging Hair

Abstract

Androgenetic (AGA) and senescent alopecia (SA) are common nonscarring hair loss disorders. The histopathology of both disorders involves follicular downsizing, and yet, they differ in the age of onset, pattern of hair loss, and hormonal involvement. We compared gene expression profiles of scalp biopsies from age-matched men with AGA, SA, and normal controls. Our data suggest that follicular downsizing in AGA is associated with altered expression of genes required for hair follicle cycling. In stark contrast, the transcriptional profile of SA reveals mitochondrial dysfunction and oxidative stress response, which are characteristic of aging tissues. These marked differences between AGA and SA suggest that they are two distinct disorders that present diverse mechanisms for a final common phenotype of follicular downsizing.

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Acknowledgments

This work was funded by a pilot and feasibility grant to PK from the Skin Diseases Research Center (NIH-NIAMS; P30-AR-39750) at Case Western Reserve University. We would like to acknowledge the contribution of the Gene Expression Array Core Facility of the Comprehensive Cancer Center of Case Western Reserve University and University Case Medical Center (P30 CA43703).

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Authors and Affiliations

  1. Department of Dermatology, The Permanente Medical Group, 975 Sereno Drive, 2nd Floor, Hallway F, Vallejo, CA, 94589, USA

    Paradi Mirmirani

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  1. Paradi Mirmirani
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  2. Pratima Karnik
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Correspondence to Paradi Mirmirani .

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  1. Dermatologische Klinik, Universitätsspital Zürich, Gloriastr. 31, Zürich, 8091, Switzerland

    Ralph M. Trüeb

  2. Centre for Skin Sciences, University of Bradford, Bradford, W. Yorks., BD7 1DP, United Kingdom

    Desmond J. Tobin

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Mirmirani, P., Karnik, P. (2010). Comparative Gene Expression Profiling of Senescent and Androgenetic Alopecia Using Microarray Analysis. In: Trüeb, R., Tobin, D. (eds) Aging Hair. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02636-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-02636-2_8

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