Trabeculectomy, first described in the 1960s [1–3], was the surgical procedure of choice for glaucoma till recently. The original intention of trabeculectomy was to the bypass the resistance of the trabecular mesh-work by channeling aqueous humor directly to the Schlemm's canal. It soon became evident that successful reduction in IOP following trabeculectomy was clearly related to the presence of a subconjunctival fil-tering bleb [4]. Despite initial success, there was a progressive rate of failure of trabeculectomy due to subconjunctival fibrosis in the filtering bleb in most cases. Trabeculectomy was also associated with serious vision-threatening complications like postoperative choroidal effusions and hemorrhage, delayed bleb leaks, and bleb-related infections including endophthal-mitis. These complications were seen more frequently when wound-healing agents like 5-fluorouracil (5-FU) and MMC were used.
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Fine, I.H., Hoffman, R.S., Packer, M. (2010). New Minimally Invasive, Sclerothalamotomy Ab Interno Surgical Technique. In: Fine, I.H., Mojon, D.S. (eds) Minimally Invasive Ophthalmic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02602-7_12
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