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Lipids and Bariatric Surgery

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Principles of Metabolic Surgery
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Abstract

Lipids are either resorbed with food or produced by the body itself. All animal cells are able to produce cholesterol, but cholesterol cannot be degraded by the human body. A considerable characteristic of lipids is their poor water solubility. In aqueous solution free fatty acids are transported by binding to albumin, while all other lipids are bound to lipid-protein complexes, the so-called lipoproteins. Depending on their function, lipoproteins are of variable composition: Water-insoluble triglycerides and cholesterol esters are located in the core, whereas better water-soluble apolipoproteins, phospholipids, and free cholesterol are transported in the outer shell. Lipoproteins are defined by their density, depending on their triglyceride content:

  • Lipoproteins of very low density have a high content of triglycerides, chylomicrons, and very low density lipoproteins ( VLDL).

  • Low-density lipoproteins ( LDL)

  • Intermediate-density lipoproteins ( IDL)

  • High-density lipoproteins ( HDL) hold an increasingly lower fraction of triglycerides and therefore have an increased density.

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Literatur

  1. Shachter NS (2001) Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. Curr Opin Lipidol 12:297–304

    Article  PubMed  CAS  Google Scholar 

  2. Evans K, Burdge GC, et al (2002) Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes 51:2684–2690

    Article  PubMed  CAS  Google Scholar 

  3. Friedewald WT, Levy RI, et al (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502

    PubMed  CAS  Google Scholar 

  4. Phillips NR, Waters D, Havel RJ (1993) Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events. Circulation 88:2762–2770

    PubMed  CAS  Google Scholar 

  5. Gardne, CD, Fortmann SP, et al (1996) Association of small lowdensity lipoprotein particles with the incidence of coronary artery disease in men and women. JAMA 276:875–881

    Article  Google Scholar 

  6. Stampfer MJ, Krauss RM, et al (1996) A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA 276:882–888

    Article  PubMed  CAS  Google Scholar 

  7. St-Pierre AC, Cantin B, et al (2005) Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Quebec Cardiovascular Study. Arterioscler Thromb Vasc Biol 25:553–559

    Article  PubMed  CAS  Google Scholar 

  8. Mora S (2009) Advanced lipoprotein testing and subfractionation are not (yet) ready for routine clinical use. Circulation 119:2396–2404

    Article  PubMed  Google Scholar 

  9. Lindgren FT, Jensen LT, Hatch FT (1972) The isolation and quantitative analysis of serum lipoproteins. In: Nelson GJ (ed) Blood lipids and lipoproteins: quantitation, composition and metabolism.

    Google Scholar 

  10. Sich D, Saidi Y, et al (1998) Hyperalphalipoproteinemia: characterization of a cardioprotective profile associating increased highdensity lipoprotein 2 levels and decreased hepatic lipase activity. Metabolism 47:965–973

    Article  PubMed  CAS  Google Scholar 

  11. Miller NE, Hammett F, et al (1981) Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins. Br Med J (Clin Res Ed) 282:1741–1744

    Article  CAS  Google Scholar 

  12. Grundy SM, Cleeman JI, et al (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110:227–239

    Article  PubMed  Google Scholar 

  13. Goff DC jr, D'Agostino RB jr, et al (2005) Insulin resistance and adiposity influence lipoprotein size and subclass concentrations. Results from the Insulin Resistance Atherosclerosis Study. Metabolism 54: 264–270

    Article  PubMed  CAS  Google Scholar 

  14. Garvey WT, Kwon S, et al (2003) Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes 52:453–462

    Article  PubMed  CAS  Google Scholar 

  15. Kathiresan S, Otvos JD, et al (2006) Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study. Circulation 113:20–29

    Article  PubMed  CAS  Google Scholar 

  16. Burstein R, Epstein Y, et al (1995) Glucose utilization in morbidly obese subjects before and after weight loss by gastric bypass operation. Int J Obes Relat Metab Disord 19:558–561

    PubMed  CAS  Google Scholar 

  17. Kersten S (2001. Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep 2:282–286

    Article  PubMed  CAS  Google Scholar 

  18. Anthonsen MW, Ronnstrand L, et al (1998) Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem 273:215–221

    Article  PubMed  CAS  Google Scholar 

  19. Kissebah AH, Alfarsi S, et al (1976) The metabolic fate of plasma lipoproteins in normal subjects and in patients with insulin resistance and endogenous hypertriglyceridaemia. Diabetologia 12:501–509

    Article  PubMed  CAS  Google Scholar 

  20. Kissebah AH, Alfarsi S, et al (1976) Transport kinetics of plasma free fatty acid, very low density lipoprotein triglycerides and apoprotein in patients with endogenous hypertriglyceridaemia: effects of 2,2-dimethyl, 5(2, 5-xylyoxy) valeric acid therapy. Atherosclerosis 24:199–218

    Article  PubMed  CAS  Google Scholar 

  21. Lewis GF (1997) Fatty acid regulation of very low density lipoprotein production. Curr Opin Lipidol 8:146–153

    Article  PubMed  CAS  Google Scholar 

  22. Gholam PM, Kotler DP, et al (2002) Liver pathology in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery. Obes Surg 12:49–51

    Article  PubMed  Google Scholar 

  23. Silverman JF, O'Brien KF, et al (1990) Liver pathology in morbidly obese patients with and without diabetes. Am J Gastroenterol 85:1349–1355

    PubMed  CAS  Google Scholar 

  24. Sjöström L, Lindroos AK, et al (2004) Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 351:2683–2693

    Article  PubMed  Google Scholar 

  25. Zambon S, Romanato G, et al (2009) Bariatric surgery improves atherogenic LDL profile by triglyceride reduction. Obes Surg 19:190–195

    Article  PubMed  Google Scholar 

  26. Wolf AM, Beisiegel U, et al (1998) Does gastric restriction surgery reduce the risks of metabolic diseases? Obes Surg 8:9–13

    Article  PubMed  CAS  Google Scholar 

  27. Busetto L, Pisent C, et al (2000) Variation in lipid levels in morbidly obese patients operated with the LAP-BAND adjustable gastric banding system: effects of different levels of weight loss. Obes Surg 10:569–577

    Article  PubMed  CAS  Google Scholar 

  28. Buchwald, H., S. E. Williams, et al. (2002). "Overall mortality in the program on the surgical control of the hyperlipidemias." J Am Coll Surg 195:327–331

    Article  PubMed  Google Scholar 

  29. Vila M, Ruiz O, et al (2009) Changes in lipid profile and insulin resistance in obese patients after Scopinaro biliopancreatic diversion. Obes Surg 19:299–306.

    Article  PubMed  Google Scholar 

  30. Lubrano C, Cornoldi A, et al (2004) Reduction of risk factors for cardiovascular diseases in morbid-obese patients following biliary-intestinal bypass: 3 years' follow-up. Int J Obes Relat Metab Disord 28:1600–1606

    Article  PubMed  CAS  Google Scholar 

  31. Brizzi P, Angius MF, et al (2003) Plasma lipids and lipoprotein changes after biliopancreatic diversion for morbid obesity. Dig Surg 20:18–23

    Article  PubMed  CAS  Google Scholar 

  32. Garcia-Diaz J, Lozano DO, et al (2003) Changes in lipid profile after biliopancreatic diversion. Obes Surg 13:756–760

    Article  Google Scholar 

  33. Nguyen NT, Varela E, et al (2006) Resolution of hyperlipidemia after laparoscopic Roux-en-Y gastric bypass. J Am Coll Surg 203:24–29

    Article  PubMed  Google Scholar 

  34. Corradini SG, Eramo A, Lubrano C, Spera G, Cornoldi A, Grossi A, Liguori F, Siciliano M, Pisanelli MC, Salen G, Batta AK, Attili AF, Badiali M (2005) Obes Surg 15:367–377

    Google Scholar 

  35. Buchwald H, Avidor Y, et al (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724–1737

    Article  PubMed  CAS  Google Scholar 

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Schewe, T., Winkler, K. (2012). Lipids and Bariatric Surgery. In: Karcz, W.K., Thomusch, O. (eds) Principles of Metabolic Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02411-5_8

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  • DOI: https://doi.org/10.1007/978-3-642-02411-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02410-8

  • Online ISBN: 978-3-642-02411-5

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