Simulation of Controlled Drug Release from Non-Swellable Micro-Hydrogel Particle



In this chapter, a transient model is presented for simulation of drug delivery from non-swellable micro-hydrogel particle, where the nifedipine controlled release from the spherical chitosan microgel is investigated numerically. The model developed mathematically takes into account both the drug dissolution and drug diffusion through the continuous matrix of spherical microgel. The influences of several important microgel and drug parameters on drug release are evaluated, which include the microsphere mean radius, equivalent drug saturation concentration, drug dissolution rate and drug diffusion coefficient.


Drug Release Control Drug Release Drug Release Rate Drug Dissolution Drug Diffusion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Hua Li
    • 1
  1. 1.College of Engineering School of Mechanical & Aerospace EngineeringNanyang Technological UniversitySingaporeSingapore

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