Skip to main content
SpringerLink
Log in

Psychiatrische Erkrankungen

  • Chapter
Pathologie

  • 5405 Accesses

Zusammenfassung

Für Schizophrenie, bipolare Erkrankung, Depression und Autismus werden die in der Literatur erhobenen Befund hinsichtlich Bildgebung, Makroskopie, Mikroskopie, Signaltransduktion, Proteomik und Genetik sowie der daraus resultierenden pathogenetischen Hypothesen beschrieben, wobei die Heterogenität und Problematik publizierter Befund deutlich wird.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 359.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Abrahams BS, Geschwind DH (2008) Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 9: 341–355

    Article  PubMed  CAS  Google Scholar 

  2. Adler CM, DelBello MP, Strakowski SM (2006) Brain network dysfunction in bipolar disorder. CNS Spectr 11: 312–320

    PubMed  Google Scholar 

  3. Allan CL, Cardno AG, McGuffin P (2008) Schizophrenia: from genes to phenes to disease. Curr Psychiatry Rep 10: 339–343

    Article  PubMed  Google Scholar 

  4. Amaral DG, Schumann CM, Nordahl CW (2008) Neuroanatomy of autism. Trends Neurosci 31: 137–145

    Article  PubMed  CAS  Google Scholar 

  5. Anisman H, Merali Z, Hayley S (2008) Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders. Prog Neurobiol 85: 1–74

    Article  PubMed  CAS  Google Scholar 

  6. Bauman ML, Kemper TL (2005) Neuroanatomic observations of the brain in autism: a review and future directions. Int J Dev Neurosci 23: 183–187

    Article  PubMed  Google Scholar 

  7. Baumann ML, Kemper TL (eds.) (2008) The neurobiology of autism, 2nd edn. Johns Hopkins University Press, Baltimore

    Google Scholar 

  8. Blatt GJ (2005) GABAergic cerebellar system in autism: a neuropathological and developmental perspective. Int Rev Neurobiol 71: 167–178

    Article  PubMed  CAS  Google Scholar 

  9. Bray NJ (2008) Gene expression in the etiology of schizophrenia. Schizophr Bull 34: 412–418

    Article  PubMed  Google Scholar 

  10. Brunoni AR, Lopes M, Fregni F (2008) A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11: 1169–1180

    Article  PubMed  CAS  Google Scholar 

  11. Burmeister M, McInnis MG, Zöllner S (2008): Psychiatric genetics: progress amid controversy. Nature Reviews Genetics 9: 527–540

    Article  PubMed  CAS  Google Scholar 

  12. Casanova MF (2006) Neuropathological and genetic findings in autism: the significance of a putative minicolumnopathy. Neuroscientist 12: 435–441

    Article  PubMed  Google Scholar 

  13. Casanova MF (2007) The neuropathology of autism. Brain Pathol 17: 422–433

    Article  PubMed  Google Scholar 

  14. Charney DS, Nestler EJ (eds) (2009) Neurobiology of mental illness, 3rd edn. Oxford University Press, Oxford

    Google Scholar 

  15. Courchesne E (2004) Brain development in autism: early overgrowth followed by premature arrest of growth. Ment Retard Dev Disabil Res Rev 10: 106–111

    Article  PubMed  Google Scholar 

  16. Cowen PJ (2008) Serotonin and depression: pathophysiological mechanism or marketing myth? Trends Pharmacol Sci 29: 433–436

    Article  PubMed  CAS  Google Scholar 

  17. Danese A (2008) Genetic opportunities for psychiatric epidemiology: on life stress and depression. Epidemiol Psichiatr Soc 17: 201–210

    PubMed  Google Scholar 

  18. DiCicco-Bloom E, Lord C, Zwaigenbaum L, Courchesne E, Dager SR, Schmitz C, Schultz RT, Crawley J, Young LJ (2006) The developmental neurobiology of autism spectrum disorder. J Neurosci 26: 6897–6906

    Article  PubMed  CAS  Google Scholar 

  19. Drevets WC, Price JL, Furey ML (2008) Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct 213: 93–118

    Article  PubMed  Google Scholar 

  20. Escamilla MA, Zavala JM (2008) Genetics of bipolar disorder. Dialogues Clin Neurosci 10: 141–152

    PubMed  Google Scholar 

  21. Fanous AH, Kendler KS (2008) Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature. Curr Psychiatry Rep 10: 164–170

    Article  PubMed  Google Scholar 

  22. Förstl H, Hautzinger M, Roth G (Hrsg) (2006) Neurobiologie psychischer Störungen. Springer, Berlin Heidelberg New York

    Google Scholar 

  23. Golden SH (2007) A review of the evidence for a neuroendocrine link between stress, depression and diabetes mellitus. Curr Diabetes Rev 3: 252–259

    Article  PubMed  Google Scholar 

  24. Gonzalez-Burgos G, Lewis DA (2008) GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia. Schizophr Bull 34: 944–961

    Article  PubMed  Google Scholar 

  25. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psych 160: 636–645

    Article  Google Scholar 

  26. Grippo AJ, Johnson AK (2009) Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress 12: 1–21

    Article  PubMed  CAS  Google Scholar 

  27. Hancock JT (2005) Cell signalling, 2nd edn. Oxford University Press, Oxford

    Google Scholar 

  28. Harrison PJ, Roberts GW (eds) (2000) The neuropathology of schizophrenia. Progress and interpretation. Oxford University Press, Oxford

    Google Scholar 

  29. Harrison PJ (2007) Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1. Novartis Found Symp 288: 246–255

    Article  PubMed  Google Scholar 

  30. Hirsch SR, Weinberger D (eds) (2003) Schizophrenia, 2nd edn. Blackwell, Boston

    Google Scholar 

  31. Hrdlicka M (2008) Structural neuroimaging in autism. Neuro Endocrinol Lett 29: 281–286

    PubMed  Google Scholar 

  32. Kaplan GB, Hammer RP (2002) Brain circuitry and signalling in psychiatry. American Psychiatry Publishing Inc., Arlington

    Google Scholar 

  33. Keener MT, Phillips ML (2007) Neuroimaging in bipolar disorder: a critical review of current findings. Curr Psychiatry Rep 9: 512–520

    Article  PubMed  Google Scholar 

  34. Keshavan M, Kennedy, Murray R (2004) Neurodevelopment and Schizophrenia. Cambridge University Press, Cambridge

    Book  Google Scholar 

  35. Koros E, Dorner-Ciossek C (2007) The role of glycogen synthase kinase-3beta in schizophrenia. Drug News Perspect 20: 437–445

    Article  PubMed  CAS  Google Scholar 

  36. Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455: 894–902

    Article  PubMed  CAS  Google Scholar 

  37. Krivoy A, Fischel T, Weizman A (2008) The possible involvement of metabotropic glutamate receptors in schizophrenia. Eur Neuropsychopharmacol 18: 395–405

    Article  PubMed  CAS  Google Scholar 

  38. Lang UE, Puls I, Muller DJ, Strutz-Seebohm N, Gallinat J (2007) Molecular mechanisms of schizophrenia. Cell Physiol Biochem 20: 687–702

    Article  PubMed  CAS  Google Scholar 

  39. Lieberman JA (1999) Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biol Psych 46: 729–739

    Article  CAS  Google Scholar 

  40. Mesulam MM (2000) Principles of behavioral and cognitive neurology, 2nd edn. Oxford University Press, Oxford

    Google Scholar 

  41. Minshew NJ, Williams DL (2007) The new neurobiology of autism. Cortex, connectivity, and neuronal organization. Arch Neurol 64: 945–950

    Article  PubMed  Google Scholar 

  42. Mitterauer B (2005) Nonfunctional glial proteins in tripartite synapses: a pathophysiological model of schizophrenia. Neuroscientist 1: 192–198

    Article  Google Scholar 

  43. Möller HJ, Laux G, Kapfhammer HP (2008) Psychiatrie und Psychotherapie, 3. Aufl. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

  44. Müller RA (2008) From loci to networks and back again: anomalies in the study of autism. Ann N Y Acad Sci 1145: 300–315

    Article  PubMed  Google Scholar 

  45. Mulle JG (2008) Genomic structural variation and schizophrenia. Curr Psychiatry Rep 10: 171–177

    Article  PubMed  Google Scholar 

  46. Murray RM, Lappin J, Di Forti M (2008) Schizophrenia: from developmental deviance to dopamine dysregulation. Eur Neuropsychopharmacol 18 (Suppl 3): S129–134

    Article  PubMed  CAS  Google Scholar 

  47. Nelson J (2008) Structure and function in cell signalling. John Wiley, San Francisco

    Google Scholar 

  48. Newberg AR, Catapano LA, Zarate CA, Manji HK (2008) Neurobiology of bipolar disorder. Expert Rev Neurother 8: 93–110

    Article  PubMed  CAS  Google Scholar 

  49. Ochoa EL, Lasalde-Dominicci J (2007) Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking. Cell Mol Neurobiol 27: 609–639

    Article  PubMed  CAS  Google Scholar 

  50. Parpura V, Haydon PG (2009) Astrocytes in (Patho) Physiology of the Nervous system. Springer, Berlin Heidelberg New York

    Google Scholar 

  51. Paz RD, Tardito S, Atzori M, Tseng KY (2008) Glutamatergic dysfunction in schizophrenia: from basic neuroscience to clinical psychopharmacology. Eur Neuropsychopharmacol 18: 773–786

    Article  PubMed  CAS  Google Scholar 

  52. Pennington K, Beasley CL, Dicker P, Fagan A, English J, Pariante CM, Wait R, Dunn MJ, Cotter DR (2008) Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry 13: 1102–1117

    Article  PubMed  CAS  Google Scholar 

  53. Rajkowska G, Halaris A, Selemon LD (2001) Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol Psychiatry 49: 741–752

    Article  PubMed  CAS  Google Scholar 

  54. Remington G (2008) Alterations of dopamine and serotonin transmission in schizophrenia. Prog Brain Res 172: 117–140

    Article  PubMed  CAS  Google Scholar 

  55. Rietkerk T, Boks MP, Sommer IE, Liddle PF, Ophoff RA, Kahn RS (2008) The genetics of symptom dimensions of schizophrenia: review and meta-analysis. Schizophr Res 102: 97–205

    Article  Google Scholar 

  56. Schloesser RJ, Huang J, Klein PS, Manji HK (2008) Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33: 110–133

    Article  PubMed  CAS  Google Scholar 

  57. Selemon LD (2003) Regional specificity in the neuropathology of schizophrenia: A morphometric analysis of Broca’s area 44 and area 9. Arch Gen Psychiatry 60: 69–77

    Article  PubMed  Google Scholar 

  58. Serretti A, Mandelli L (2008) The genetics of bipolar disorder: genome ‘hot region’, genes, new potential candidates and future directions. Molecular Psychiatry 13: 742–771

    Article  PubMed  CAS  Google Scholar 

  59. Siegel GJ, Albers RW, Brady ST, Price DL (2007) Basic neurochemistry, 7th edn. Academic Press, New York

    Google Scholar 

  60. Soares JC, Gershon S (eds) (2000) Bipolar disorders. Basic mechanisms and therapeutic implications. Marcel Dekker, New York

    Google Scholar 

  61. Stanfield AC, McIntosh AM, Spencer MD, Philip R, Gaur S, Lawrie SM (2008) Towards a neuroanatomy of autism: a systematic review and meta-analysis of structural magnetic resonance imaging studies. Eur Psychiatry 23: 289–299

    Article  PubMed  Google Scholar 

  62. Stahl SM (2008) Stahl’s essential psychopharmacology. Neuroscientific basis and practical applications, 3rd edn. Cambridge University Press, Cambridge

    Google Scholar 

  63. Strakowski SM, Delbello MP, Adler CM (2005) The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry 10: 105–116

    Article  PubMed  CAS  Google Scholar 

  64. Tandon R, Keshavan MS, Nasrallah HA (2008) Schizophrenia, „Just the Facts“: what we know in 2008 part 1: overview. Schizophr Res 100: 4–19

    Article  PubMed  Google Scholar 

  65. Tandon R, Keshavan MS, Nasrallah HA (2008) Schizophrenia, „just the facts“ what we know in 2008. 2. Epidemiology and etiology. Schizophr Res 102: 1–18

    Article  PubMed  Google Scholar 

  66. Torrey EF, Barci BM, Webster MJ, Bartko JJ, Meador-Woodruff JH, Knable MB (2005) Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psych 57: 252–260

    Article  CAS  Google Scholar 

  67. van Haren NE, Bakker SC, Kahn RS (2008) Genes and structural brain imaging in schizophrenia. Curr Opin Psychiatry 21: 161–167

    Article  PubMed  Google Scholar 

  68. Verkhratsky A, Butt A (2007) Glial neurobiology. John Wiley, San Francisco

    Book  Google Scholar 

  69. Watis L, Chen SH, Chua HC, Chong SA, Sim K (2008) Glutamatergic abnormalities of the thalamus in schizophrenia: a systematic review. J Neural Transm 115: 493–511

    Article  PubMed  CAS  Google Scholar 

  70. Weinberger DR (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psych 44: 660–669

    CAS  Google Scholar 

  71. Williams LM (2008) Voxel-based morphometry in schizophrenia: implications for neurodevelopmental connectivity models, cognition and affect. Expert Rev Neurother 8: 1049–1065

    Article  PubMed  Google Scholar 

  72. Yadid G, Friedman A (2008) Dynamics of the dopaminergic system as a key component to the understanding of depression. Prog Brain Res 172: 265–286

    Article  PubMed  CAS  Google Scholar 

  73. Yang MS, Gill M (2007) A review of gene linkage, association and expression studies in autism and an assessment of convergent evidence. Int J Dev Neurosci 25: 69–85

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Labor für Neuropathologie, Institut für Klinische Pathologie und Neuropathologie, Landesnervenklinik Wagner-Jauregg, Wagner-Jauregg-Weg 15, 4020, Linz, Österreich

    Serge Weis

Authors
  1. Serge Weis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Pathologie Konsultationszentrum für Pankreas- und Endokrine Tumore, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    Günter Klöppel (Werkherausgeber) (Werkherausgeber)

  2. Zentrum Pathologie und Rechtsmedizin, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Hans H. Kreipe (Werkherausgeber) (Werkherausgeber)

  3. Institut für Pathologie, Kliniken der Landeshauptstadt, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland

    Wolfgang Remmele (Werkherausgeber) (Werkherausgeber)

  4. Institut für Neuropathologie, Universitätsklinikum Münster, Domagkstraße 19, 48149, Münster, Deutschland

    Werner Paulus (Bandherausgeber) (Bandherausgeber)

  5. Institut für Neuropathologie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    J. Michael Schröder (Bandherausgeber) (Bandherausgeber)

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Weis, S. (2012). Psychiatrische Erkrankungen. In: Klöppel, G., Kreipe, H., Remmele, W., Paulus, W., Schröder, J. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02324-8_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-02324-8_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02323-1

  • Online ISBN: 978-3-642-02324-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation