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Neuroendokrine Neoplasien

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Pathologie

Part of the book series: Pathologie ((PATHOL))

Zusammenfassung

Das Kapitel beschäftigt sich mit den Tumoren des neuroendokrinen Zellsystems im Gastrointestinaltrakt. Einleitend werden die Definition des neuroendokrinen Systems und die neue WHO-Klassifikation dieser Neoplasien besprochen und erläutert. Es folgt eine detaillierte lokalisationsbezogene Darstellung der Tumorentitäten, wobei auch der Ösophagus berücksichtigt wird. Den Abschluss bildet eine differentialdiagnostische Zusammenfassung der wichtigsten immunhistologischen Charakteristika dieser Tumoren.

Unter Berücksichtigung von Manuskripten zu den ösophagealen, gastralen und intestinalen NEN von Frau Dr. Sigrid Rappel, Herrn Prof. Dr. Mario Sarbia und Herrn Prof. Dr. Georg Oberhuber

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Literatur

  1. Ahlman H, Dahlström A, Enerbäck L, Granérus G, Nilsson O, Persson S, Tisell LE (1988) Two cases of gastric carcinoids: diagnostic and therapeutic aspects. World J Surg 12:356–361

    Article  CAS  PubMed  Google Scholar 

  2. Alsaad KO, Serra S, Schmitt A, Perren A, Chetty R (2007) Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix. Endocr Pathol 18:16–22

    Article  CAS  PubMed  Google Scholar 

  3. Anlauf M, Enosawa T, Henopp T, Schmitt A, Gimm O, Brauckhoff M, Dralle H, Musil A, Hauptmann S, Perren A, Klöppel G (2008) Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor. Am J Surg Pathol 32:1101–1105

    Article  PubMed  Google Scholar 

  4. Anlauf M, Garbrecht N, Henopp T, Schmitt A, Schlenger R, Raffel A, Krausch M, Gimm O, Eisenberger CF, Knoefel WT, Dralle H, Komminoth P, Heitz PU, Perren A, Klöppel G (2006) Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features. World J Gastroenterol 12:5440–5446

    Article  PubMed  PubMed Central  Google Scholar 

  5. Anlauf M, Perren A, Meyer CL, Schmid S, Saremaslani P, Kruse ML, Weihe E, Komminoth P, Heitz PU, Klöppel G (2005) Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. Gastroenterology 128:1187–1198

    Article  CAS  PubMed  Google Scholar 

  6. Anlauf M, Gerlach P, Schott M, Raffel A, Krausch M, Knoefel WT, Pavel M, Klöppel G (2011) Pathologie neuroendokriner Neoplasien. Chirurg 82:567–573

    Article  CAS  PubMed  Google Scholar 

  7. Antonioli DA, Dayal Y, Dvorak AM, Banks PA (1987) Zollinger-Ellison syndrome. Cure by surgical resection of a jejunal gastrinoma containing growth hormone releasing factor. Gastroenterology 92:814–823

    Article  CAS  PubMed  Google Scholar 

  8. Assadi M, Kubiak R, Kaiser G (2002) Appendiceal carcinoid tumors in children: does size matter? Med Pediatr Oncol 38:65–66

    Article  PubMed  Google Scholar 

  9. Barbareschi M, Frigo B, Aldovini D, Leonardi E, Cristina S, Falleni M (1989) Duodenal gangliocytic paraganglioma. Report of a case and review of the literature. Virchows Arch [A] Pathol Anat 416:81–89

    Article  CAS  Google Scholar 

  10. Berardi RS (1972) Carcinoid tumors of the colon (exclusive of the rectum): review of the literature. Dis Colon Rectum 15:383–391

    Article  CAS  PubMed  Google Scholar 

  11. Bhagavan BS, Slavin RE, Goldberg J, Rao RN (1986) Ectopic gastrinoma and Zollinger-Ellison syndrome. Hum Pathol 17:584–592

    Article  CAS  PubMed  Google Scholar 

  12. Borch K, Ahren B, Ahlman H, Falkmer S, Granerus G, Grimelius L (2005) Gastric carcinoids: biologic behavior and prognosis after differentiated treatment in relation to type. Ann Surg 242:64–73

    Article  PubMed  PubMed Central  Google Scholar 

  13. Bordi C, Costa A, Missale G (1975) ECL cell proliferation and gastrin levels. Gastroenterology 68:205–206

    CAS  PubMed  Google Scholar 

  14. Bordi C, D'Adda T, Azzoni C, Ferraro G (1998) Pathogenesis of ECL cell tumors in humans. Yale J Biol Med 71:273–284

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Bordi C, Pilato FP, Bertelé A, D'Adda T, Missale G (1988) Expression of glycoprotein hormone alpha-subunit by endocrine cells of the oxyntic mucosa is associated with hypergastrinemia. Hum Pathol 19:580–585

    Article  CAS  PubMed  Google Scholar 

  16. Bordi C, Yu J-Y, Baggi MT, Davoli C, Pilato FP, Baruzzi G, Gardini G, Zamboni G, Franzin G, Papotti M, Bussolati G (1991) Gastric carcinoids and their precursor lesions. A histologic and immunohistochemical study of 23 cases. Cancer 67:663–672

    Article  CAS  PubMed  Google Scholar 

  17. Bosman FT, Carneiro F, Hruban RH, Theise N (2010) WHO classification of tumours of the digestive tract, liver, biliary tree and pancreas. IARC Press, Lyon

    Google Scholar 

  18. Brenner B, Tang LH, Klimstra DS, Kelsen DP (2004) Small-cell carcinomas of the gastrointestinal tract: a review. J Clin Oncol 22:2730–2739

    Article  PubMed  Google Scholar 

  19. Burke AP, Federspiel BH, Sobin LH, Shekitka KM, Helwig EB (1989) Carcinoids of the duodenum. A histologic and immunohistochemical study of 65 tumors. Am J Surg Pathol 13:828–837

    Article  CAS  PubMed  Google Scholar 

  20. Burke AP, Helwig EB (1989) Gangliocytic paraganglioma. Am J Clin Pathol 92:1–9

    Article  CAS  PubMed  Google Scholar 

  21. Burke AP, Sobin LH, Federspiel BH, Shekita KM, Helwig EB (1990) Goblet cell carcinoids and related tumors of the vermiform appendix. Am J Clin Pathol 94:27–35

    Article  CAS  PubMed  Google Scholar 

  22. Burke AP, Sobin LH, Federspiel BH, Shekitka KM, Helwig EB (1990) Carcinoid tumors of the duodenum. A clinicopathologic study of 99 cases. Arch Pathol Lab Med 114:700–704

    CAS  PubMed  Google Scholar 

  23. Burke AP, Thomas RM, Elsayed AM, Sobin LH (1997) Carcinoids of the jejunum and ileum. An immunohistochemical and clinicopathologic study of 167 cases. Cancer 79:1086–1093

    Article  CAS  PubMed  Google Scholar 

  24. Burkitt MD, Pritchard DM (2006) Review article: Pathogenesis and management of gastric carcinoid tumours. Aliment Pharmacol Ther 24:1305–1320

    Article  CAS  PubMed  Google Scholar 

  25. Capella C, Heitz PU, Höfler H, Solcia E, Klöppel G (1995) Revised classification of neuroendocrine tumours of the lung, pancreas and gut. Virchows Arch 425:547–560

    Article  CAS  PubMed  Google Scholar 

  26. Capella C, Riva C, Rindi G, Sessa F, Usellini L, Chiaravalli A, Carnevali L, Solcia E (1991) Histopathology, hormone products, and clinicopathological profile of endocrine tumors of the upper small intestine: a study of 44 cases. Endocr Pathol 2:92–110

    Article  Google Scholar 

  27. Capella C, Solcia E, Sobin LH, Arnold A (2000) Endocrine tumours of the colon and rectum. In: Hamilton SR, Aaltonen LA (Hrsg) Pathology and Genetics. Tumours of the Digestive System. WHO Classification of Tumours. IARC Press, Lyon, S 137–139

    Google Scholar 

  28. Capella C, Solcia E, Sobin LH, Arnold A (2000) Endocrine tumours of the small intestine. In: Hamilton SR, Aaltonen LA (Hrsg) Pathology and genetics. Tumours of the digestive system. WHO classification of tumours. IARC Press, Lyon, S 77–82

    Google Scholar 

  29. Capella C, Solcia E, Sobin LH, Arnold R (2000) Endocrine tumours of the oesophagus. In: Hamilton SR, Aaltonen LA (Hrsg) Pathology and genetics. Tumours of the digestive system. WHO classification of tumours. IARC Press, Lyon, S 26–27

    Google Scholar 

  30. Chejfec G, Kovarick P, Graham G, Eichorst M, Gould VE (1992) Neuroendocrine carcinoma of the stomach with extensive somatostatin immunoreactivity. Ultrastruct Pathol 16:537–545

    Article  CAS  PubMed  Google Scholar 

  31. Creutzfeldt W (1988) The achlorhydria-carcinoid sequence: Role of gastrin. Digestion 39:61–79

    Article  CAS  PubMed  Google Scholar 

  32. Dayal Y (1994) Hyperplastic proliferations of enteroendocrine cells. Endocr Pathol 5:4–26

    Article  Google Scholar 

  33. Dayal Y, Doos WG, O'Brien MJ, Nunnemacher G, DeLellis RA, Wolfe HJ (1983) Psammomatous somatostatinomas of the duodenum. Am J Surg Pathol 7:653–665

    Article  CAS  PubMed  Google Scholar 

  34. Dayal Y, Tallberg KA, Nunnemacher G, DeLellis RA, Wolfe HJ (1986) Duodenal carcinoids in patients with and without neurofibromatosis. A comparative study. Am J Surg Pathol 10:348–357

    Article  CAS  PubMed  Google Scholar 

  35. Deans GT, Spence RA (1995) Neoplastic lesions of the appendix. Br J Surg 82:299–306

    Article  CAS  PubMed  Google Scholar 

  36. Debelenko LV, Emmert-Buck MR, Zhuang Z, Epshteyn E, Moskaluk CA, Jensen RT, Liotta LA, Lubensky IA (1997) The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology 113:773–781

    Article  CAS  PubMed  Google Scholar 

  37. Delle Fave G, Capurso G, Milione M, Panzuto F (2005) Endocrine tumours of the stomach. Best Pract Res Clin Gastroenterol 19:659–673

    Article  CAS  PubMed  Google Scholar 

  38. Dobnig H, Stepan V, Leb G, Wolf G, Buchfelder M, Kreis GJ (1996) Recovery from severe osteoporosis following cure from ectopic ACTH syndrome caused by an appendix carcinoid. J Intern Med 239:365–369

    Article  CAS  PubMed  Google Scholar 

  39. Donow C, Pipeleers-Marichal M, Schröder S, Stamm B, Heitz PU, Klöppel G (1991) Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy. Cancer 68:1329–1334

    Article  CAS  PubMed  Google Scholar 

  40. Donow C, Pipeleers-Marichal M, Stamm B, Heitz PU, Klöppel G (1990) Pathologie des Insulinoms und Gastrinoms. Lokalisation, Größe, Multizentrizität, Assoziation mit der multiplen endokrinen Neoplasie Typ I und Malignität. Dtsch Med Wochenschr 115:1386–1391

    Article  CAS  PubMed  Google Scholar 

  41. Dookhan DB, Miettinen M, Finkel G, Gibas Z (1993) Recurrent duodenal gangliocytic paraganglioma with lymph node metastases. Histopathology 22:399–401

    Article  CAS  PubMed  Google Scholar 

  42. Edmonds P, Merino MJ, LiVolsi VA, Duray PH (1984) Adenocarcinoid (mucinous carcinoid) of the appendix. Gastroenterology 86:302–309

    CAS  PubMed  Google Scholar 

  43. Eissele R, Anlauf M, Schäfer MKH, Eiden LE, Arnold R, Weihe E (1999) Expression of vesicular monoamine transporters in endocrine hyperplasia and endocrine tumors of the oxyntic stomach. Digestion 60:428–439

    Article  CAS  PubMed  Google Scholar 

  44. Ekeblad S, Skogseid B, Dunder K, Oberg K, Eriksson B (2008) Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution. Clin Cancer Res 14:7798–7803

    Article  CAS  PubMed  Google Scholar 

  45. Feurle GE, Anlauf M, Hamscher G, Arnold R, Klöppel G, Weihe E (2002) Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin. Gastroenterology 123:1616–1626

    Article  PubMed  Google Scholar 

  46. Fischer L, Kleeff J, Esposito I, Hinz U, Zimmermann A, Friess H, Büchler MW (2008) Clinical outcome and long-term survival in 118 consecutive patients with neuroendocrine tumours of the pancreas. Br J Surg 95:627–635

    Article  CAS  PubMed  Google Scholar 

  47. Friesen SR, Tomita T (1981) Pseudo-Zollinger-Ellison syndrome: hypergastrinemia, hyperchlorhydria without tumor. Ann Surg 194:481–493

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Gaffey MJ, Mills SE, Lack EE (1990) Neuroendocrine carcinoma of the colon and rectum. A clinicopathologic, ultrastructural, and immunohistochemical study of 24 cases. Am J Surg Pathol 14:1010–1023

    Article  CAS  PubMed  Google Scholar 

  49. Garbrecht N, Anlauf M, Schmitt A, Henopp T, Sipos B, Raffel A, Eisenberger CF, Knoefel WT, Pavel M, Fottner C, Musholt TJ, Rinke A, Arnold R, Berndt U, Plöckinger U, Wiedenmann B, Moch H, Heitz PU, Komminoth P, Perren A, Klöppel G (2008) Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity. Endocr Relat Cancer 15:229–241

    Article  PubMed  Google Scholar 

  50. Gouzi JL, Laigneau P, Delalande JP, Flamant Y, Bloom E, Oberlin P, Fingerhut A (1993) Indications for right hemicolectomy in carcinoid tumors of the appendix. The French Associations for Surgical Research. Surg Gynecol Obstet 176:543–547

    CAS  PubMed  Google Scholar 

  51. Hamid QA, Bishop AE, Rode J, Dhillon AP, Rosenberg BF, Reed RJ, Sibley RK, Polak JM (1986) Duodenal gangliocytic paragangliomas: a study of 10 cases with immunocytochemical neuroendocrine markers. Hum Pathol 17:1151–1157

    Article  CAS  PubMed  Google Scholar 

  52. Håkanson R, Tielemans Y, Chen D, Andersson K, Ryberg B, Mattsson H, Sundler F (1992) The biology and pathobiology of the ECL cells. Yale J Biol Med 65:761–774

    PubMed  PubMed Central  Google Scholar 

  53. Harbeck B, Anlauf M, Klöppel G, Bröring D, Lehnert H, Möning H (2011) An unusual case of a retrorectal neuroendocrine tumor with high- and low-grade differentiation. Int J Colorectal Dis 27:1241–1242

    Article  PubMed  Google Scholar 

  54. Hermann G, Konukiewitz B, Schmitt A, Perren A, Klöppel G (2011) Hormonally defined pancreatic and duodenal neuroendocrine tumors differ in their transcription factor signatures: expression of ISL1, PDX1, NGN3, and CDX2. Virchows Arch 459:147–154

    Article  CAS  PubMed  Google Scholar 

  55. Hemminki K, Li X (2001) Incidence trends and risk factors of carcinoid tumors. A nationwide epidemiologic study from Sweden. Cancer 92:2204–2210

    Article  CAS  PubMed  Google Scholar 

  56. Hirschowitz BI, Griffith J, Pellegrin D, Cummings OW (1992) Rapid regression of enterochromaffinlike cell gastric carcinoids in pernicious anemia after antrectomy. Gastroenterology 102:1409–1418

    Article  CAS  PubMed  Google Scholar 

  57. Hoang MP, Hobbs CM, Sobin LH, Albores-Saavedra J (2002) Carcinoid tumor of the esophagus: a clinicopathologic study of four cases. Am J Surg Pathol 26:517–522

    Article  PubMed  Google Scholar 

  58. Hock YL, Scott KW, Grace RH (1993) Mixed adenocarcinoma/carcinoid tumour of large bowel in a patient with Crohn's disease. J Clin Pathol 46:183–185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Horenstein MG, Erlandson RA, Gonzalez-Cueto DM, Rosai J (1998) Presacral carcinoid tumors. Report of three cases and review of the literature. Am J Surg Pathol 22:251–255

    Article  CAS  PubMed  Google Scholar 

  60. Hou W, Schubert ML (2007) Treatment of gastric carcinoids. Curr Treat Options Gastroenterol 10:123–133

    Article  PubMed  Google Scholar 

  61. Huncharek M, Muscat J (1995) Small cell carcinoma of the esophagus. The Massachusetts General Hospital experience, 1978 to 1993. Chest 107:179–181

    Article  CAS  PubMed  Google Scholar 

  62. Isolauri J, Mattila J, Kallioniemi OP (1991) Primary undifferentiated small cell carcinoma of the esophagus: clinicopathological and flow cytometric evaluation of eight cases. J Surg Oncol 46:174–177

    Article  CAS  PubMed  Google Scholar 

  63. Jiang S-X, Mikami T, Umezawa A, Saegusa M, Kameya T, Okayasu I (2006) Gastric Large Cell Neuroendocrine Carcinomas: A Distinct Clinicopathologic Entity. Am J Surg Pathol 30:945–953

    Article  PubMed  Google Scholar 

  64. Keuppens F, Willems G, De Graef J, Woussen-Colle MC (1980) Antral gastrin cell hyperplasia in patients with peptic ulcer. Ann Surg 191:276–281

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Klöppel G, Dege K, Remmele W, Kapran Y, Tuzlali S, Modlin IM (2007) Siegfried Oberndorfer: a tribute to his work and life between Munich, Kiel, Geneva, and Istanbul. Virchows Arch 451(Suppl 1):S3–S7

    Article  PubMed  Google Scholar 

  66. Klöppel G, Anlauf M (2007) Gastrinoma – morphological aspects. Wien Klin Wochenschr 119:579–584

    Article  PubMed  Google Scholar 

  67. Klöppel G, Anlauf M, Perren A (2007) Endocrine precursor lesions of gastroenteropancreatic neuroendocrine tumors. Endocr Pathol 18:150–155

    Article  PubMed  Google Scholar 

  68. Klöppel G, Clemens A (1996) The biological relevance of gastric neuroendocrine tumors. Yale J Biol Med 69:69–74

    PubMed  PubMed Central  Google Scholar 

  69. Klöppel G, Couvelard A, Perren A, Komminoth P, McNicol AM, Nilsson O, Scarpa A, Scoazec JY, Wiedenmann B, Papotti M, Rindi G, Plöckinger U (2009) ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: towards a standardized approach to the diagnosis of gastroenteropancreatic neuroendocrine tumors and their prognostic stratification. Neuroendocrinology 90:162–166

    Article  PubMed  CAS  Google Scholar 

  70. Klöppel G, Heitz PU (1981) Die disseminierten (diffusen) endokrinen Zellen. In: Doerr W, Seifert G (Hrsg) Spezielle pathologische Anatomie. Bd 14. Springer, Berlin, S 1079–1135

    Google Scholar 

  71. Klöppel G, Heitz PU, Capella C, Solcia E (1996) Pathology and nomenclature of human gastrointestinal neuroendocrine (carcinoid) tumors and related lesions. World J Surg 20:132–141

    Article  PubMed  Google Scholar 

  72. Klöppel G, Rindi G, Anlauf M, Perren A, Komminoth P (2007) Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors. Virchows Arch 451(Suppl 1):S9–S27

    Article  PubMed  Google Scholar 

  73. Klöppel G, Rindi G, Perren A, Komminoth P, Klimstra DS (2010) The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement. Virchows Arch 456:595–597

    Article  PubMed  Google Scholar 

  74. Klöppel G, Scherübl H (2010) Neuroendokrine Tumoren des Magens, Risikostratifizierung und Therapie. Pathologe 31:182–187

    Article  PubMed  Google Scholar 

  75. Klöppel G (2011) Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocrine Related Cancer 18:S1–S7

    Article  PubMed  Google Scholar 

  76. Komminoth P, Heitz PU, Klöppel G (1998) Pathology of MEN-1: morphology, clinicopathologic correlations and tumour development. J Intern Med 243:455–464

    Article  CAS  PubMed  Google Scholar 

  77. La Rosa S, Klersy C, Uccella S, Dainese L, Albarello L, Sonzogni A, Doglioni C, Capella C, Solcia E (2009) Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors. Hum Pathol 40:30–40

    Article  PubMed  Google Scholar 

  78. La Rosa S, Rigoli E, Uccella S, Chiaravalli AM, Capella C (2004) CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors. Virchows Arch 445:248–254

    Article  CAS  PubMed  Google Scholar 

  79. La Rosa S, Finzi G, Puppa G, Capella C (2010) Lipid-rich variant of appendiceal well-differentiated endocrine tumor (carcinoid). Am J Clin Pathol 133:809–814

    Article  PubMed  Google Scholar 

  80. La Rosa S, Marando A, Sessa F, Capella C (2012) Mixed adenoneuroendocrine carcinomas (MANECs) of the gastrointestinal tract: An update. Cancers 4:11–30

    Article  PubMed  PubMed Central  Google Scholar 

  81. La Rosa S, Marando A, Furlan D, Sahnane N, Capella C (2012) Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers. Am J Surg Pathol 36:601–611

    Article  PubMed  Google Scholar 

  82. Lamberts R, Creutzfeldt W, Struber HG, Brunner G, Solcia E (1993) Long-term omeprazole therapy in peptic ulcer disease: gastrin, endocrine cell growth, and gastritis [see comments]. Gastroenterology 104:1356–1370

    Article  CAS  PubMed  Google Scholar 

  83. Landry CS, Brock G, Scoggins CR, McMasters KM, Martin RC (2008) A proposed staging system for gastric carcinoid tumors based on an analysis of 1,543 patients. Ann Surg Oncol 16:51–60

    Article  PubMed  Google Scholar 

  84. Larsson LI, Ljungberg O, Sundler F, Hakanson R, Svensson SO, Rehfeld J, Stadil R, Holst J (1973) Antro-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. Virchows Arch [A] Pathol Anat 360:305–314

    Article  CAS  Google Scholar 

  85. Lasson A, Alwmark A, Nobin A, Sundler F (1983) Endocrine tumors of the duodenum. Clinical characteristics and hormone content. Ann Surg 197:393–398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Law SY, Fok M, Lam KY, Loke SL, Ma LT, Wong J (1994) Small cell carcinoma of the esophagus. Cancer 73:2894–2899

    Article  CAS  PubMed  Google Scholar 

  87. Lee CM, Lee SM, Jeon CW, Ahn BK, Baek SU (2007) Carcinoid tumor arising within a tailgut cyst. A case report. J Korean Soc Coloprocto 123:65–67

    Article  Google Scholar 

  88. Levi F, Te VC, Randimbison L, Rindi G, La Vecchia C (2000) Epidemiology of carcinoid neoplasms in Vaud, Switzerland, 1974-97. Br J Cancer 83:952–955

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Lewin K (1987) Carcinoid tumors and the mixed (composite) glandular-endocrine cell carcinomas. Am J Surg Pathol 11(Suppl):71–86

    Article  PubMed  Google Scholar 

  90. Lewin KJ, Yang K, Ulich T, Elashoff JD, Walsh J (1984) Primary gastrin-cell hyperplasia. Report of five cases and a review of the literature. Am J Surg Pathol 8:821–832

    Article  CAS  PubMed  Google Scholar 

  91. Li Y, Yau A, Schaeffer D, Magliocco, Gui X, Urbanski S, Waghray R, Owen D, Gao Z (2011)  Colorectal glandular-neuroendocrine mixed tumor: pathologic spectrum and clinical implications. Am J Surg Pathol 35:413–425

    PubMed  Google Scholar 

  92. Luong TV, Salvagni S, Bordi C (2005) Presacral carcinoid tumor. Review of the literature and report of a clinically malignant case. Dig Liver Dis 37:278–281

    Article  CAS  PubMed  Google Scholar 

  93. MacGillivray DC, Heaton RB, Rushin JM, Cruess DF (1992) Distant metastasis from a carcinoid tumor of the appendix less than one centimeter in size. Surgery 111:466–471

    CAS  PubMed  Google Scholar 

  94. Maggard MA, O'Connell JB, Ko CY (2004) Updated population-based review of carcinoid tumors. Ann Surg 240:117–122

    Article  PubMed  PubMed Central  Google Scholar 

  95. Maru DP, Khurana H, Rashid A, Correa AM, Anandasabapathy S, Krishnan S, Komaki R, Ajani JA, Swisher SG, Hofstetter WL (2008) Retrospective study of clinicopathologic features and prognosis of high-grade neuroendocrine carcinoma of the esophagus. Am J Surg Pathol 32:1404–1411

    Article  PubMed  Google Scholar 

  96. Matsui K, Kitagawa M, Miwa A, Kuroda Y, Tsuji M (1991) Small cell carcinoma of the stomach: a clinicopathologic study of 17 cases. Am J Gastroenterol 86:1167–1175

    CAS  PubMed  Google Scholar 

  97. Matsumoto T, Jo Y, Mibu R, Hirahashi M, Yao T, Iida M (2003) Multiple microcarcinoids in a patient with long standing ulcerative colitis. J Clin Pathol 56:963–965

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. McCusker ME, Coté TR, Clegg LS, Sobin LH (2002) Primary malignant neoplasms of the appendix. A population-based study from the surveillance, epidemiology and end-results program. Cancer 94:3307–3312

    Article  PubMed  Google Scholar 

  99. McGory ML, Maggard MA, Kang H, O'Connell JB, Ko CY (2005) Malignancies of the appendix: beyond case series reports. Dis Colon Rectum 48:2264–2271

    Article  PubMed  Google Scholar 

  100. Merchant SH, VanderJagt T, Lathrop S, Amin MB (2006) Sporadic duodenal bulb gastrin-cell tumors: association with Helicobacter pylori gastritis and long-term use of proton pump inhibitors. Am J Surg Pathol 30:1581–1587

    Article  PubMed  Google Scholar 

  101. Mitschke H (1977) Funktionelle Pathomorphologie des gastrointestinalen endokrinen Zellsystems. In: Büngeler W, Eder M, Lennert K, Peters G, Sandritter W, Seifert G (Hrsg) Progress in pathology 104. Fischer, Stuttgart

    Google Scholar 

  102. Modlin IM, Champaneria MC, Chan AK, Kidd M (2007) A three-decade analysis of 3,911 small intestinal neuroendocrine tumors. The rapid pace of no progress. Am J Gastroenterol 102:1464–1473

    Article  PubMed  Google Scholar 

  103. Moyana TN (1989) Carcinoid tumors arising from Meckel's diverticulum. A clinical, morphologic, and immunohistochemical study. Am J Clin Pathol 91:52–56

    Article  CAS  PubMed  Google Scholar 

  104. Moyana TN (1995) Gastrointestinal endocrine cells and carcinoids. Histogenetic and pathogenetic considerations. Pathology Annual 30:227–246

    PubMed  Google Scholar 

  105. Moyana TN, Satkunam N (1992) A comparative immunohistochemical study of jejunoileal and appendiceal carcinoids. Cancer 70:1081–1088

    Article  CAS  PubMed  Google Scholar 

  106. Nascimbeni R, Villanacci V, Di Fabio F, Gavazzi E, Fellegara G, Rindi G (2005) Solitary microcarcinoid of the rectal stump in ulcerative colitis. Neuroendocrinology 81:400–404

    Article  CAS  PubMed  Google Scholar 

  107. Niederle MB, Hackl M, Kaserer K, Niederle B (2010) Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocrine-Related Cancer 17:909–918

    Article  PubMed  Google Scholar 

  108. Oberndorfer S (1907) Karzinoide Tumoren des Dünndarms. Frankf Z Pathol 1:425–432

    Google Scholar 

  109. Padberg B, Schröder S, Capella C, Frilling A, Klöppel G, Heitz PU (1995) Multiple endocrine neoplasia type 1 (MEN 1) revisited. Virchows Arch 426:541–548

    Article  CAS  PubMed  Google Scholar 

  110. Pape UF, Jann H, Muller-Nordhorn J, Bockelbrink A, Berndt U, Willich SN, Koch M, Rocken C, Rindi G, Wiedenmann B (2008) Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors. Cancer 113:256–265

    Article  PubMed  Google Scholar 

  111. Pape UF, Perren A, Niederle B, Gross D, Gress Th, Costa F, Arnold R, Denecke T, Plöckinger U, Salazar R, Grossman A, all other Barcelona Consensus Conference participants (2012)  Consensus guidelines for the management of patients with neuroendocrine neoplasms from the jejuno-ileum and the appendix, including goblet cell carcinomas. Neuroendocrinology 95:135–156

    Article  CAS  PubMed  Google Scholar 

  112. Parkes SE, Muir KR, al Sheyyab M, Cameron AH, Pincott JR, Raafat F, Mann JR (1993) Carcinoid tumours of the appendix in children 1957–1986: incidence, treatment and outcome. Br J Surg 80:502–504

    Article  CAS  PubMed  Google Scholar 

  113. Partensky C, Chayvialle JA, Berger F, Souquet JC, Moulinier B (1993) Five-year survival after transhiatal resection of esophageal carcinoid tumor with a lymph node metastasis. Cancer 72:2320–2322

    Article  CAS  PubMed  Google Scholar 

  114. Perkins PL, McLeod MK, Jin L, Fukuuchi A, Cho KJ, Thompson NW, Lloyd RV (1992) Analysis of gastrinomas by immunohistochemistry and in situ hybridization histochemistry. Diagn Mol Pathol 1:155–164

    Article  CAS  PubMed  Google Scholar 

  115. Perren A, Anlauf M, Komminoth P (2007) Molecular profiles of gastroenteropancreatic endocrine tumors. Virchows Arch 451(Suppl 1):S39–46

    Article  CAS  PubMed  Google Scholar 

  116. Perrone T, Sibley RK, Rosai J (1985) Duodenal gangliocytic paraganglioma. An immunohistochemical and ultrastructural study and a hypothesis concerning its origin. Am J Surg Pathol 9:31–41

    Article  CAS  PubMed  Google Scholar 

  117. Pipeleers-Marichal M, Donow C, Heitz PU, Klöppel G (1993) Pathologic aspects of gastrinomas in patients with Zollinger-Ellison syndrome with and without multiple endocrine neoplasia type I. World J Surg 17:481–488

    Article  CAS  PubMed  Google Scholar 

  118. Pipeleers-Marichal M, Somers G, Willems G, Foulis A, Imrie C, Bishop AE, Polak JM, Häcki WH, Stamm B, Heitz PU, Klöppel G (1990) Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. N Engl J Med 322:723–727

    Article  CAS  PubMed  Google Scholar 

  119. Plöckinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, de Herder WW, Gross D, Knapp WH, Knigge UP, Kulke MH, Pape UF, all other Frascati Consensus Conference participants (2008)  Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology 87:20–30

    Article  PubMed  CAS  Google Scholar 

  120. Polak JM (1993) Diagnostic histopathology of neuroendocrine tumours. Churchill Livingstone, Edinburgh

    Google Scholar 

  121. Posalaky Z, Mulholland M, Kasperson E, Posalaky IP (1987) Duodenal carcinoid in neurofibromatosis: a calcitonin- and amyloid-containing tumor. World J Surg 11:120–124

    Article  CAS  PubMed  Google Scholar 

  122. Pulitzer M, Xu R, Suriawinata AA, Waye JD, Harpaz N (2006) Microcarcinoids in large intestinal adenomas. Am J Surg Pathol 30:1531–1536

    Article  PubMed  Google Scholar 

  123. Ramnani DM, Wistuba II, Behrens C, Gazdar AF, Sobin LH, Albores-Saavedra J (1999) K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix. Cancer 86:14–21

    Article  CAS  PubMed  Google Scholar 

  124. Rappel S, Altendorf-Hofmann A, Stolte M (1995) Prognosis of gastric carcinoid tumours. Digestion 56:455–462

    Article  CAS  PubMed  Google Scholar 

  125. Ratzenhofer M (1977) Über enterale Hyperplasien und Geschwülste der disseminierten endokrinen (parakrinen) Hellen Zellen Feyrter's unter Berücksichtigung amphikriner Zellwucherungen. Verh Dtsch Ges Pathol 61:7–24

    CAS  PubMed  Google Scholar 

  126. Rindi G, Bordi C, Rappel S, La Rosa S, Stolte M, Solcia E (1996) Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World J Surg 20:168–172

    Article  CAS  PubMed  Google Scholar 

  127. Rindi G, Klöppel G, Ahlman H, Caplin M, Couvelard A, de Herder WW, Eriksson B, Falchetti A, Falconi M, Komminoth P, Körner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A, Scoazec JY, Wiedenmann B, all other Frascati Consensus Conference participants (2006) TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 449:395–401

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Rindi G, Klöppel G, Couvelard A, Komminoth P, Körner M, Lopes JM, McNicol AM, Nilsson O, Perren A, Scarpa A, Scoazec JY, Wiedenmann B (2007) TNM staging of midgut and hindgut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 451:757–762

    Article  CAS  PubMed  Google Scholar 

  129. Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E (1993) Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology 104:994–1006

    Article  CAS  PubMed  Google Scholar 

  130. Rindi G, Paolotti D, Fiocca R, Wiedenmann B, Henry JP, Solcia E (2000) Vesicular monoamine transporter 2 as a marker of gastric enterochromaffin-like cell tumors. Virchows Arch 436:217–223

    Article  CAS  PubMed  Google Scholar 

  131. Rinke A, Müller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, Mayer C, Aminossadati B, Pape UF, Bläker M, Harder J, Arnold C, Gress T, Arnold R, PROMID Study Group (2009) Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 27:4656–4663

    Article  CAS  PubMed  Google Scholar 

  132. Roberts LJII, Bloomgarden ZT, Marney Jr SR, Rabin D, Oates JA (1983) Histamine release from a gastric carcinoid: Provocation by pentagastrin and inhibition by somatostatin. Gastroenterology 84:272–275

    CAS  PubMed  Google Scholar 

  133. Rossi G, Bertolini F, Sartori G, Bigiani N, Cavazza A, Foroni M, Valli R, Rindi G, De Gaetani C, Luppi G (2004) Primary mixed adenocarcinoma and small cell carcinoma of the appendix. A clinicopathologic, immunohistochemical, and molecular study of a hitherto unreported tumor. Am J Surg Pathol 28:1233–1239

    Article  PubMed  Google Scholar 

  134. Rossi G, Valli R, Bertolini F, Sighinolfi P, Losi L, Cavazza A, Rivasi F, Luppi G (2003) Does mesoappendix infiltration predict a worse prognosis in incidental neuroendocrine tumors of the appendix? A clinicopathologic and immunohistochemical study of 15 cases. Am J Clin Pathol 120:706–711

    Article  PubMed  Google Scholar 

  135. Royston CMS, Brew DSJ, Garnham JR, Stagg BH, Polak J (1972) The Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach. Gut 13:638–642

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B, Kianmanesh R, Hochhauser D, Arnold R, Ahlman H, Pauwels S, Kwekkeboom DJ, Rindi G (2006) Well-differentiated gastric tumors/carcinomas. Neuroendocrinology 84:158–164

    Article  CAS  PubMed  Google Scholar 

  137. Scherübl H, Schwertner C, Steinberg J, Stölzel U, Pohl J, Dralle H, Klöppel G (2009) Neuroendokrine Tumoren des Dünndarms nehmen zu: frühe Tumoren und deren Management. Z Gastroenterol 47:1–8

    Article  Google Scholar 

  138. Scherübl H, Klöppel G (2009) Neuroendokrine Neoplasien des Rektums auf dem Vormarsch – ein Update. Z Gastroenterol 47:365–371

    Article  PubMed  Google Scholar 

  139. Shia J, Tang LH, Weiser MR, Brenner B, Adsay NV, Stelow EB, Saltz LB, Qin J, Landmann R, Leonard GD, Dhall D, Temple L, Guillem JG, Paty PB, Kelsen D, Wong YC, Klimstra DS (2008) Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity? Am J Surg Pathol 32:719–731

    Article  PubMed  Google Scholar 

  140. Sobin LH, Gospodarowicz MK, Wittekind C (2009) UICC: TNM classification of malignant tumours, 7. Aufl. Wiley-Blackwell, Oxford

    Google Scholar 

  141. Soga J (1997) Carcinoids of the rectum: an evaluation of 1271 reported cases. Surg Today 27:112–119

    Article  CAS  PubMed  Google Scholar 

  142. Soga J (1998) Carcinoids of the colon and ileocecal region: a statistical evaluation of 363 cases collected from the literature. J Exp Clin Cancer Res 17:139–148

    CAS  PubMed  Google Scholar 

  143. Soga J (2005) Early-stage carcinoids of the gastrointestinal tract: an analysis of 1914 reported cases. Cancer 103:1587–1595

    Article  PubMed  Google Scholar 

  144. Solcia E, Bordi C, Creutzfeldt W, Dayal Y, Dayan AD, Falkmer S, Grimelius L, Havu N (1988) Histopathological classification of nonantral gastric endocrine growths in man. Digestion 41:185–200

    Article  CAS  PubMed  Google Scholar 

  145. Solcia E, Capella C, Fiocca R, Rindi G, Rosai J (1990) Gastric argyrophil carcinoidosis in patients with Zollinger-Ellison syndrome due to type 1 multiple endocrine neoplasia. A newly recognized association. Am J Surg Pathol 14:503–513

    Article  CAS  PubMed  Google Scholar 

  146. Solcia E, Capella C, Fiocca R, Sessa F, La Rosa S, Rindi G (1998) Disorders of the endocrine system. In: Ming SC, Goldman H (Hrsg) Pathology of the gastrointestinal tract. Williams and Wilkins, Philadelphia, S 295–322

    Google Scholar 

  147. Solcia E, Fiocca R, Sessa F, Rindi G, Giannatti A, Cornaggia M, Capella C (1991) Morphology and natural history of gastric endocrine tumors. In: Hakanson R, Sundler F (Hrsg) The stomach as an endocrine organ. Elsevier, Amsterdam, S 473–498

    Google Scholar 

  148. Solcia E, Klöppel G, Sobin LH (2000) Histological typing of endocrine tumours, 2. Aufl. WHO international histological classification of tumours. Springer, Berlin (In collaboration with 9 pathologists from 4 countries)

    Book  Google Scholar 

  149. Stamm B, Hedinger CE, Saremaslani P (1986) Duodenal and ampullary carcinoid tumors. A report of 12 cases with pathological characteristics, polypeptide content and relation to the MEN 1 syndrome and von Recklingshausen's disease (neurofibromatosis). Virchows Arch [A] Pathol Anat 408:475–489

    Article  CAS  Google Scholar 

  150. Stephens M, Williams GT, Jasani B, Williams ED (1987) Synchronous duodenal neuroendocrine tumours in von Recklinghausen's disease – a case report of co-existing gangliocytic paraganglioma and somatostatin-rich glandular carcinoid. Histopathology 11:1331–1340

    Article  CAS  PubMed  Google Scholar 

  151. Stinner B, Kisker O, Zielke A, Rothmund M (1996) Surgical management for carcinoid tumors of small bowel, appendix, colon, and rectum. World J Surg 20:183–188

    Article  CAS  PubMed  Google Scholar 

  152. Subbuswamy SG, Gibbs NM, Ross CF, Morson BC (1974) Goblet cell carcinoid of the appendix. Cancer 34:338–344

    Article  CAS  PubMed  Google Scholar 

  153. Syracuse DC, Perzin KH, Price JB, Wiedel PD, Mesa-Tejada R (1979) Carcinoid tumors of the appendix. Mesoappendiceal extension and nodal metastases. Ann Surg 190:58–63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  154. Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS (2008) Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol 32:1429–1443

    Article  PubMed  Google Scholar 

  155. Tchana-Sato V, Detry O, Polus M et al (2006) Carcinoid tumor of the appendix: a consecutive series from 1,2237 appendectomies. World J Gastroenterol 12:6699–6701

    Article  PubMed  PubMed Central  Google Scholar 

  156. Theunissen P, Fickers M, Goei R (2001) Primary large cell neuroendocrine carcinoma of the presacral region. J Clin Pathol 54:880–882

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  157. Thompson NW, Bondeson AG, Bondeson L, Vinik A (1989) The surgical treatment of gastrinoma in MEN I syndrome patients. Surgery 106:1081–1085

    CAS  PubMed  Google Scholar 

  158. Thompson NW, Vinik AI, Eckhauser FE (1989) Microgastrinomas of the duodenum. A cause of failed operations for the Zollinger-Ellison syndrome. Ann Surg 209:396–404

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  159. Tsolakis AV, Stridsberg M, Grimelius L, Portela-Gomes GM, Falkmer SE, Waldum HL, Janson ET (2008) Ghrelin immunoreactive cells in gastric endocrine tumors and their relation to plasma ghrelin concentration. J Clin Gastroenterol 42:381–388

    Article  CAS  PubMed  Google Scholar 

  160. Van Eeden S, Offerhaus GJA, Peterse HL, Dingemann KP, Blaauwgeers HLG (2000) Gangliocytic paraganglioma of the appendix. Histopathology 36:47–49

    Article  PubMed  Google Scholar 

  161. van Eeden S, Offerhaus GJA, Hart AAM, Boerrigter L, Nederlof PM, Porter E, van Velthuysen MLF (2007) Goblet cell carcinoid of the appendix: a specific type of carcinoma. Histopathology 51:763–773

    Article  PubMed  Google Scholar 

  162. Warkel RL, Cooper PH, Helwig EG (1978) Adenocarcinoid, a mucin-producing carcinoid tumor of the appendix. A study of 39 cases. Cancer 42:2781–2793

    Article  CAS  PubMed  Google Scholar 

  163. Watson KJ, Shulkes A, Smallwood RA, Douglas MC, Hurley R, Kalnins R, Moran L (1985) Watery diarrhea-hypokalemia-achlorhydria syndrome and carcinoma of the esophagus. Gastroenterology 88:798–803

    Article  CAS  PubMed  Google Scholar 

  164. Weber HC, Venzon DJ, Lin JT, Fishbein VA, Orbuch M, Strader DB, Gibril F, Metz DC, Fraker DL, Norton JA, Jensen RT (1995) Determinants of metastatic rate and survival in patients with Zollinger-Ellison syndrome: A prospective long-term study. Gastroenterology 108:1637–1649

    Article  CAS  PubMed  Google Scholar 

  165. Wilander E, Grimelius L, Lundqvist G, Skoog V (1979) Polypeptide hormones in argentaffin and argyrophil gastroduodenal endocrine tumors. Am J Pathol 96:519–530

    CAS  PubMed  PubMed Central  Google Scholar 

  166. Wilander E, Sundstrom C, Grimelius L (1979) Pernicious anaemia in association with argyrophil (Sevier-Munger) gastric carcinoid. Scand J Haematol 23:415–420

    Article  CAS  PubMed  Google Scholar 

  167. Williams ED, Sandler M (1963)  The classification of carcinoid tumours. Lancet  1:238–239

    Article  PubMed  Google Scholar 

  168. Yantiss RK, Odze RD, Farraye FA, Rosenberg AE (2003) Solitary versus multiple carcinoid tumors of the ileum. A clinical and pathologic review of 68 cases. Am J Surg Pathol 27:811–817

    Article  PubMed  Google Scholar 

  169. Zamboni G, Franzin G, Bonetti F, Scarpa A, Chilosi M, Colombari R, Menestrina F, Pea M, Iacono C, Serio G (1990) Small-cell neuroendocrine carcinoma of the ampullary region. A clinicopathologic, immunohistochemical, and ultrastructural study of three cases. Am J Surg Pathol 14:703–713

    Article  CAS  PubMed  Google Scholar 

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  1. Günter Klöppel Prof. em. Dr. med.

    Present address: Klinikum rechts der Isar, Konsultationszentrum für Pankreas- und Endokrine Tumoren, Institut für Pathologie, Technische Universität München, Ismaninger Str. 22, 81675, München, Deutschland

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    1. Institut für Pathologie, Klinikum Kulmbach, Kulmbach, Germany

      Manfred Stolte

    2. Institut für Pathologie Nordhessen, Kassel, Germany

      Josef Rüschoff

    3. Konsultationszentrum für Pankreas- und, Technische Universität München Klinikum rechts der Isar, München, Germany

      Günter Klöppel

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    Klöppel, G. (2013). Neuroendokrine Neoplasien. In: Stolte, M., Rüschoff, J., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02322-4_35

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