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Pathologie pp 491–510Cite as

Innervationsstörungen des Kolorektums

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Zusammenfassung

Nach einer kurzen Einführung in die embryologische Entwicklung, Funktion und normale Histologie des enterischen Nervensystems, werden in diesem Kapitel die Klassifikation und die einzelnen konnatalen Störungen des kolorektalen Nervensystems behandelt. Die verschiedenen Formen der Aganglionose, die Reifungsstörungen und die hypo- bzw. hyperplastischen Anomalien des kolorektalen Nervensystems werden in klinischer und pathologisch-anatomischer Hinsicht beschrieben und die für die feingewebliche Diagnostik notwendigen Methoden dargestellt. Der Text ist begleitet von zahlreichen Abbildungen, die die für jede Störung typischen lichtmikroskopischen, histochemischen und immunhistochemischen Befunde präsentieren.

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Literatur

  1. Aldridge RT, Campbell PE (1986) Ganglion cell distribution in the normal rectum and anal canal. A basis for the diagnosis of Hirschsprung’s disease by anorectal biopsy. J Pediatr Surg 3:475–490

    Article  Google Scholar 

  2. Amman K, Stoss F, Meier-Ruge W (1999) Intestinal neuronal dysplasia in adults as cause of chronic constipation: morphometric characterization of colon innervation. Chirurg 70:771–776

    Article  Google Scholar 

  3. Anderson VM, Greco MA, Recalde AL et al (1990) Intestinal cytomegalovirus ganglioneuritis in children with human immundeficiency virus infektion. Pediatr Pathol 10:167–174

    Article  CAS  PubMed  Google Scholar 

  4. Attie T, Pelet A, Edery P (1995) Diversity of RET-protooncogene mutations in familial and sporadic Hirschsprung’s disease. Hum Molecular Genet 4:1381

    Article  CAS  Google Scholar 

  5. Baumgarten HG, Holstein AF, Stelzner F (1973) Nervous elements in the human colon of Hirschsprung’s disease. Virschows Arch 358:113–136

    Article  CAS  Google Scholar 

  6. Benailly HK, Lapierre JM, Laudier B et al (2003) PMX2B, a new candidate gene for Hirschsprung’s disease. Clin Genet 64:204–209

    Article  CAS  PubMed  Google Scholar 

  7. Berry CL (1993) Intestinal neuronal dysplasia: does it exist or has it been invented? Virchows Arch 422:183–184

    Article  CAS  Google Scholar 

  8. Blisard KS, Kleinman R (1986) Hirschsprung’s disease: A clinical and pathologic rewiew. Hum Pathol 17:1189

    Article  CAS  PubMed  Google Scholar 

  9. Borchard F, Meier-Ruge W, Wiebecke B et al (1991) Innervationsstörungen des Dickdarms. Klassifikation und Diagnostik. Pathologe 12:171–174

    CAS  PubMed  Google Scholar 

  10. Bosman C, Devito R, Fusilli S, Boldrini R (2001) A new hypothesis on the pathogenesis of intestinal pseudo-obstruction by intestinal neuronal dysplasia (IND). Pathol Res Pract 197:789–796

    Article  CAS  PubMed  Google Scholar 

  11. von Boyen GBT, Krammer HJ, Süss A et al (2002) Abnormalities of the enteric nervous system in heterozygous endothelin B rezeptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia. Gut 51:414–419

    Article  Google Scholar 

  12. Bredt DS, Snyder SH (1992) Nitric oxide, a novel neuronal messenger. Neuron 8:3–11

    Article  CAS  PubMed  Google Scholar 

  13. Bredt DS, Hwang PM, Snyder SH (1990) Lokalization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 25:768–770

    Article  Google Scholar 

  14. Caniano DA, Ormsbee HS, Polito W et al (1985) Total intestinal aganglionosis. J Pediatr Surg 20:456–460

    Article  CAS  PubMed  Google Scholar 

  15. Chambonniere ML, Porcheron J, Scoazec JY et al (2003) Intestinal ganglioneuromatosis diagnosed in adult patients. Gastroenterol Clin Biol 27:219–224

    PubMed  Google Scholar 

  16. Chow CW, Chan WC, Yoc PCK (1977) Histochemical criteria for the diagnosis of Hirschsprung’s disease in rectal suction biopsies by acetylcholinesterase activity. J Pediatr Surg 12:675–680

    Article  CAS  PubMed  Google Scholar 

  17. Coerdt W, Müntefering H, Rastorguer E, Gerein V (2004) Kongenitale Innervationsstörungen des Kolon. Ein diagnostischer Leitfaden. Pathologe 25:292–298

    Article  CAS  PubMed  Google Scholar 

  18. Coerdt W, Michel JS, Rippin G et al (2004) Quantitative morphometric analysis of the submucous plexus in age-related control groups. Virchows Arch 444:239–246

    Article  PubMed  Google Scholar 

  19. d’Amore ES, Manivel JC, Pettinato G et al (1991) Intestinal ganglioneuromatosis: mucosal and transmural types. A clinicopathologic and immunhistochemical study of six cases. Hum Pathol 22:276–286

    Article  PubMed  Google Scholar 

  20. Dawson TM, Dawson VL, Snyder SH (1992) A novel neuronal messenger molecule in brain: the free radical nitric oxide. Ann Neurol 32:297–311

    Article  CAS  PubMed  Google Scholar 

  21. Dhanpat J (2004) Neuromuskular disorders of the GI-tract. In: Odze RD, Goldblum JR, Crawford JM (Hrsg) Surgical pathology of the GI-tract, liver, biliary tract and pancreas. Saunders, Philadelphia, S 105–120

    Google Scholar 

  22. Earlam RA (1985) A vascular cause of Hirschsprung’s disease ? Gastroenterology 88:1274–1276

    Article  CAS  PubMed  Google Scholar 

  23. Edery P, Lyonnet S, Mulligan LM et al (1994) Mutations of the RET protooncogene in Hirschsprung’s disease. Nature 367:378–380

    Article  CAS  PubMed  Google Scholar 

  24. Edery P, Pelet A, Mulligan LM et al (1994) Long segment and short segment familial Hirschsprung’s disease: variable clinical expression at the RET locus. J Med Genet 31:602–606

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Eng C, Marsh DJ, Robinson BC et al (1998) Germline RET codon 918 mutation in apparently isolated intestinal ganglioneuromatosis 83:4191–4194

    CAS  Google Scholar 

  26. Erdohazi M (1974) Retarded development of the enteric nerve cells. Dev Med Child Neurol 16:225–237

    Google Scholar 

  27. Fadda B, Maier WA, Maier-Ruge W, Schärli A, Daum R (1983) Intestinale neuronale Dysplasie: eine kritische 10-Jahres-Analyse klinischer und bioptischer Diagnostik. Z Kinderchir 38:305–311

    CAS  PubMed  Google Scholar 

  28. Fava M, Borghini S, Cinti R et al (2002) HOX 11 L.1: a promotor study to evaluate possible expression defects in intestinal motility disorders. Int J Mol Med 10:101–106

    CAS  PubMed  Google Scholar 

  29. Fenoglio-Preiser CM (1999) Motility Disorders. In: Gastrointestinal Pathology. An Atlas and Text, 2. Aufl. Lippincott-Raven, Philadelphia, S 597

    Google Scholar 

  30. Garett JR, Howard ER (1981) Myenteric plexus of the hind-gut: developmental abnormalities in humans and experimental studies. In: Elliott K, Lawrenson G (Hrsg) Development of the autonomic nervous system. Ciba Foundation Symposium 83. Pitman Medical, London, S 326–354

    Google Scholar 

  31. Gershon M (1989) Colonisation of the bowel and development of the enteric nervous system by precursors from the neuronal crest. In: Nerves and the gastrointestinal tract. Lancaster, UK MTP

    Google Scholar 

  32. Gershon MD, Tennyson VM (1991) Microenvironmental faktors in the normal and abnormal development of the enteric nervous system. Prog Clin Biol Res 373:257–276

    CAS  PubMed  Google Scholar 

  33. Gershon MD, Epstein MC, Hegstrand L (1980) Colonization of the chick-gut by progenitors of enteric serotonergic neurons: distribution, differentiation and maturation within the gut. Dev Biol 77:41–51

    Article  CAS  PubMed  Google Scholar 

  34. Gershon MD, Chalazonitis A, Rothman TP (1993) From neural crest to the bowel: development of the enteric nervous system. J Neurobiol 24:199–214

    Article  CAS  PubMed  Google Scholar 

  35. Goto S, Ikeda K, Nagasaki A, Toyohara T (1984) Histochemical acetylcholinesterase reactions in total colonic aganglionosis. Jpn J Surg 14:305–310

    Article  CAS  PubMed  Google Scholar 

  36. Goto S, Ikeda K, Nagassaki A et al (1984) Hirschsprung’s disease in an adult. Special reference to histochemical determination of the acetylcholinesterase activity. Dis Colon Rectum 27:319–320

    Article  CAS  PubMed  Google Scholar 

  37. Hamoudi AB, Reiner CB, Boles ET et al (1982) Acetylthiocholinesterase staining activity of rectal mucosa. Its use in the diagnosis of Hirschsprung’s disease. Arch Pathol Lab Med 106:670–672

    CAS  PubMed  Google Scholar 

  38. Hatamo M, Aoki T, Dezawa M et al (1997) A novel pathogenesis of megakolon in Ncx/How11 L.1 deficient mice. J Clin Invest 100:795–801

    Article  Google Scholar 

  39. Heitz PU, Komminoth P (1990) Biopsy diagnosis of Hirschsprung’s disease and related disorders. Curr Topp Pathol 81:257–275

    Article  CAS  Google Scholar 

  40. Hirsig J, Briner J, Rickham PP (1979) Problems in the diagnosis of Hirschsprung’s disease due to false negative acetylcholinesterase reaction in suction biopsy in neonates. Z Kinderchir 26:242–247

    Google Scholar 

  41. Hokfelt T, Johansson O, Ljungdahl A et al (1980) Peptidergic neurons. Nature 284:515–521

    Article  CAS  PubMed  Google Scholar 

  42. Horisawa M, Watanabe Y, Torihashi S (1998) Distribution of c-Kit immunopositive cells in normal human colon and in Hirschsprung’s disease. J Pediatr Surg 33:1209–1214

    Article  CAS  PubMed  Google Scholar 

  43. Hüther W (1954) Die Hirschsprungsche Krankheit als Folge einer Entwicklungsstörung der intramuralen Ganglien. Beitr Path Anat 114:161–191

    Google Scholar 

  44. Ikeda K, Goto S (1986) Total aganglionosis with or without small bowel involvement: an analysis of 137 patients. J Pediatr Surg 21:319–322

    Article  CAS  PubMed  Google Scholar 

  45. Imamura A, Puri P, O’Brian DS, Reen DJ (1992) Mucosal immune defence mechanismus in enterocolitis complicating Hirschsprung’s disease. Gut 33:801–806

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Kapur RP (1993) Contemporary approaches toward understanding the pathogenesis of Hirschsprung’s disease. Pediatr Pathol 13:83–100

    Article  CAS  PubMed  Google Scholar 

  47. Kapur RP (1999) Hirschsprung’s disease and other enteric dysganglionoses. Crit Rev Clin Lab Sci 36:225–273

    Article  CAS  PubMed  Google Scholar 

  48. Karnovsky MJ, Roots LA (1964) A „direct coloring“ thiocholine methode for cholinesterases. J Histochem Cytochem 12:219–221

    Article  CAS  PubMed  Google Scholar 

  49. Kleinhaus S, Boley SJ, Sheran M, Sieber WK (1979) Hirschsprung’s disease. A survey of the members of the surgical section of the American Academy of Pediatrics. J Pediatr Surg 14:588–597

    Article  CAS  PubMed  Google Scholar 

  50. Koletzko S, Jesch I, Faus-Kebetaler T et al (1999) Rectal biopsies for diagnosis of intestinal neuronal dysplasia in children: a prospective multi-centre study on interobserver variation and clinical autcome. Gut 44:853–861

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Lake BD (1995) Hirschsprung’s disease and related disorders. In: Whitehead R (Hrsg) Gastrointestinal and oesophageal pathology. Churchill Livingstone, Edinburgh, S 327

    Google Scholar 

  52. Lake BD (1995) Intestinal neuronal dysplasia. Why does it only occur in parts of Europe? Virchows Arch 426:537–539

    Article  CAS  PubMed  Google Scholar 

  53. Lake BD (1997) Intestinal neuronal dysplasia: A little local difficulty? Pediatr Pathol Lab Med 17:687

    Google Scholar 

  54. LeDouarin NM, Teillet MA (1974) Experimental analysis of the emigration and differentiation of neuroblasts of the autonomic nervous system and of neuroectodermal mesenchymal derivatives, using a biological cell marking techniques. Dev Biol 41:162

    Article  CAS  Google Scholar 

  55. Lefebvre MP, Leape LL, Pohl DA, Safaii H (1984) Total colonic aganglionosis initially diagnosed in an adolescent. Gastroenterology 87:1364–1366

    CAS  PubMed  Google Scholar 

  56. Lennon VA, Busk MF, Scheithauer B et al (1991) Enteric neuronal autoantibodies in pseudoobstruction with small-cell lung carcinoma. Gastroenterology 100:137–142

    Article  CAS  PubMed  Google Scholar 

  57. Louw JH (1978) Total colonic aganglionosis. Can J Surg 21:397–404

    CAS  PubMed  Google Scholar 

  58. Lumb PD, Moor L (1998) Back to the drawing board: Intestinal neuronal dysplasia type B: not a histological entity yet. Virchows Arch 432:99–102

    Article  CAS  PubMed  Google Scholar 

  59. Lumb PD, Moor L (1998) Are giant ganglia a reliable marker of intestinal neuronal dysplasia type B (IND B)? Virchows Arch 432:103–106

    Article  CAS  PubMed  Google Scholar 

  60. Meier-Ruge WA (1968) Das Megacolon. Seine Diagnose und Pathophysiologie. Virchows Arch 344:67–85

    Article  CAS  Google Scholar 

  61. Meier-Ruge WA (1971) Über ein Erkrankungsbild des Colon mit Hirschsprung-Symptomatik. Verh Dtsch Ges Path 55:506–509

    CAS  Google Scholar 

  62. Meier-Ruge WA (1974) Hirschsprung’s disease: Its aetiology, pathogenesis and differential diagnosis. Curr Top Pathol 59:131–179

    Article  CAS  PubMed  Google Scholar 

  63. Meier-Ruge WA (1985) Der ultrakurze Morbus Hirschsprung. Ein bioptisch zuverlässig objektivierbares Krankheitsbild. Z Kinderchir 40:146–150

    CAS  PubMed  Google Scholar 

  64. Meier-Ruge WA (1985) Angeborene Dysganglionosen des Colon. Kinderarzt Prax 16:151–164

    Google Scholar 

  65. Meier-Ruge WA (1990) Das morphologische Erscheinungsbild der neuralen Dysplasie des Plexus submucosus. Kinderarzt Prax 21:837–844

    Google Scholar 

  66. Meier-Ruge WA (1992) Epidemiology of congenital innervation defects of the distal colon. Virchows Arch 420:171–177

    Article  CAS  Google Scholar 

  67. Meier-Ruge WA, Longo-Bauer CH (1997) Morphometric determination of the methodological criteria for the diagnosis of intestinal neuronal dysplasia (IND B). Pathol Res Pract 193:465–469

    Article  CAS  PubMed  Google Scholar 

  68. Meier-Ruge WA, Hunziker O, Tobler HJ, Walliser C (1972) The pathophysiology of aganglionosis of the entire colon (Zuelzer-Wilson syndrome). Morphometric investigations of the extent of sacral parasympathetic innervation of the circular muscles of the aganglionic colon. Beitr Pathol 147:228–236

    Article  CAS  PubMed  Google Scholar 

  69. Meier-Ruge WA, Lutterbeck PM, Herzog B et al (1972) Acetylcholinesterase activity in rectum suction biopsies as diagnostic in Hirschsprung’s disease. J Pediat Surg 7:11–17

    Article  CAS  PubMed  Google Scholar 

  70. Meier-Ruge WA, Brunner LA, Engert J et al (1999) A correlative morphometric and clinical investigation of hypoganglionosis of the colon in children. Eur J Pediatr Surg 9:67–74

    Article  CAS  PubMed  Google Scholar 

  71. Meier-Ruge WA, Ammann K, Bruder E et al (2004) Updated results on intestinal neuronal dysplasia (IND B). Eur J Pediatr Surg 14:384–391

    Article  CAS  PubMed  Google Scholar 

  72. Meier-Ruge WA, Bruder E, Holschneider AM et al (2004) Diagnosis and therapy of ultrashort Hirschsprung’s disease. Eur J Pediatr Surg 14:392–397

    Article  CAS  PubMed  Google Scholar 

  73. Meier-Ruge WA, Bruder E (2005) Pathology of chronic constipation in pediatric and adult coloproctology. Pathobiology 72:1–106

    Article  PubMed  Google Scholar 

  74. Meijers JHC, Tibboel D, van der Kamp AWM et al (1987) Cell division in migratory and aggregated neural crest cells in the developing gut: An experimental approach to innervation-related motility disorders of the gut. J Pediatr Surg 22:243–245

    Article  CAS  PubMed  Google Scholar 

  75. Mendelson G, Diamond MP (1984) Familial ganglioneuromatous polyposis of the large bowel. Report of a family with associated juvenile polyposis. Am J Surg Pathol 8:515–520

    Article  Google Scholar 

  76. Michalak S, Croue A, Valo I et al (2004) Diffuse colonic ganglioneuromatous polyposis. Ann Pathol 24:129–134

    Article  PubMed  Google Scholar 

  77. Monforte-Munoz H, Conzalez-Gomez I, Rowland JM et al (1998) Increased submucosal nerve trunk caliber in aganglionosis. Arch Pathol Lab Med 122:721–725

    CAS  PubMed  Google Scholar 

  78. Newman CJ, Laurini RN, Lesbros Y et al (2003) Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung’s disease. Pediatr Surg Int 19:662–668

    Article  CAS  PubMed  Google Scholar 

  79. Nezelof C, Guygrand D, Thomine E (1970) Les megacolons avec hyperplasie du plexus myenterique. Nouv Press Med 78:1501–1506

    CAS  Google Scholar 

  80. Okamoto E, Ueda T (1967) Embryogenesis of intramural ganglia of the gut and its relation to Hirschsprung’s disease. J Pediatr Surg 2:437–443

    Article  Google Scholar 

  81. Okamoto E, Okada A, Kuwata K, Ohmuro S (1974) In: Fujiwara M, Tanaka C (Hrsg) Amine fluorescence histochemistry. Igaku Shoin, Tokyo, S 129

    Google Scholar 

  82. Puri P, Shinkai T (2004) Pathogenesis of Hirschsprung’s disease and its variants: recent progress. Semin Pediatr Surg 13:18–24

    Article  PubMed  Google Scholar 

  83. Qualman SJ, Murray R (1994) Aganglionosis and related disorders. Hum Pathol 25:1141–1149

    Article  CAS  PubMed  Google Scholar 

  84. Rajalakshmi T, Makhija P, Babu MK, Kini U (2003) Intestinal neuronal dysplasia type A. Indian J Pediatr 70:839–841

    Article  CAS  PubMed  Google Scholar 

  85. Ratta BS, Kiely EM, Spitz L (1990) Improvements in the management of total colonic aganglionosis. Pediatr Surg Int 5:30–36

    Article  Google Scholar 

  86. Remmele W (1996) Konnatale Störungen der Innervation des Kolon. In: Remmele W (Hrsg) Pathologie, 2. Aufl. Bd 2. Springer, Berlin, S 539–546

    Google Scholar 

  87. Riccardi VM (1981) Von Recklinghausen neurofibromatosis. N Eng J Med 305:1617–1627

    Article  CAS  Google Scholar 

  88. Romeo G, Roncheto P, Luo Y et al (1994) Point mutations affecting the tyrosine kinase domain of the RET protooncogene in Hirschsprung’s disease. Nature 367:377–378

    Article  CAS  PubMed  Google Scholar 

  89. Russel MB, Russel CA, Fenger K, Niebuhr E (1994) Familial occurrence of Hirschsprung’s disease. Clin Genet 45:231–235

    Article  Google Scholar 

  90. Schärli AF, Meier-Ruge W (1981) Localized and disseminated forms of neuronal intestinal dysplasia mimicking Hirschsprung disease. J Pediatr Surg 16:164–170

    Article  PubMed  Google Scholar 

  91. Schärli AF, Sossai R (1998) Hypoganglionosis. Semin Pediatr Surg 7:187–191

    Article  PubMed  Google Scholar 

  92. Schofield DE, Yunis EJ (1991) Intestinal neuronal dysplasia. J Pediatr Gastroenterol Nutr 12:182–189

    Article  CAS  PubMed  Google Scholar 

  93. Seldenrijk CA, van der Harten HJ, Kluck P et al (1986) Zonal aganglionosis: An enzyme and immunohistochemical study of two cases. Virchows Arch 410:75–81

    Article  CAS  Google Scholar 

  94. Skekitka KM, Sobin LH (1994) Ganglioneuromas of the gastrointestinal trakt. Relation to von Recklinghausen disease and other multiple tumor syndromes. Am J Surg Pathol 18:250–257

    Article  Google Scholar 

  95. Shirasawa S, Yunker AMP, Roth KA et al (1997) Enx (Hox 11 L.1)-deficient mice develop myenteric neuronal hyperplasia and megacolon. Nat Med 3:646–650

    Article  CAS  PubMed  Google Scholar 

  96. Sidebotham EL, Kenny SE, Lloyd DA et al (2002) Location of the stem cells for the enteric nervous system. Pediatr Surg Int 18:581–585

    Article  CAS  PubMed  Google Scholar 

  97. Smith VV (1992) Isolated intestinal neuronal dysplasia. A descriptive histological pattern or a distinct clinicopathological entity? In: Hedziselimovic F, Herzog B (Hrsg) Pediatric gastroenterology. Inflammatory bowel diseases and morbus Hirschsprung. Kluwer, Dordrecht, S 203–214

    Google Scholar 

  98. Smith VV (1993) Intestinal neuronal density in childhood. A baseline for the objective assessment of hypo- and hyperganglionosis. Pediatr Pathol 13:225–237

    Article  CAS  PubMed  Google Scholar 

  99. Stoss F (1990) Neuronal dysplasia considerations of pathogenesis and treatment of primary chronic constipation in adults. Int J Colorect Dis 5:106–112

    Article  CAS  Google Scholar 

  100. Szabolcs MJ, Visser J, Shelanski ML et al (1996) Peripherin: a novel marker for the immunohistochemical study of malformations of the enteric nervous system. Pediatr Pathol Lab Med 16:51–70

    Article  CAS  PubMed  Google Scholar 

  101. Taguchi T, Tanaka K, Ikeda K, Hata A (1983) Double zonal aganglionosis with a skipped oligoganglionic ascending colon. Z Kinderchir 38:312–315

    CAS  PubMed  Google Scholar 

  102. Taguchi T, Suita S, Masumoto K, Nada O (2003) Universal distribution of cit-kit-positive cells in different types of Hirschsprung’s disease. Pediatr Surg Int 19:273–279

    Article  CAS  PubMed  Google Scholar 

  103. Talwalker VC (1976) Aganglionosis of the entire bowel. J Pediatr Surg 11:213–216

    Article  CAS  PubMed  Google Scholar 

  104. Tam PKH (1980) An immunohistochemical study with neuron-specific enolase and substance of human enteric innervation. The normal developmental pattern and abnormal deviation in Hirschsprung’s disease and pyloric stenosis. J Pediatr Surg 21:227

    Article  Google Scholar 

  105. Tomita R, Ikeda T, Fujisaki S et al (2003) Hirschsprung’s disease and its allied disorders in adults’ histological and clinical studies. Hepatogastroenterology 50:1050–1053

    PubMed  Google Scholar 

  106. Tomita R, Munakata K, Howard ER, Fujisaki S (2004) Histological studies on Hirschsprung’ disease and its allied disorders in childhood. Hepatogastroenterology 51:1042–1044

    PubMed  Google Scholar 

  107. Torrisi A, Carillio G, Libra M, Lanzafame S (2003) Solitary ganglioneuroma of the ileo-cecal valve. Pathologica 95:192–195

    CAS  PubMed  Google Scholar 

  108. Touloukian RJ, Duncan R (1975) Acquired aganglionic megacolon in a premature infant: report of a case. Pediatrics 56:459–462

    CAS  PubMed  Google Scholar 

  109. Vanderwinden JM, Rumessen JJ, Liu H et al (1996) Interstitial cells of Cajal in human colon and in Hirschsprung’s disease. Gastroenterology 111:901–910

    Article  CAS  PubMed  Google Scholar 

  110. Wedel T, Roblick UJ, Ott V et al (2002) Oligoneuronal hypoganglionosis in patients with idiopathic slow transit constipation. Dis Colon Rectum 45:54–62

    Article  CAS  PubMed  Google Scholar 

  111. Weidner N, Flanders DJ, Mitros FA (1984) Mucosal ganglioneuromatosis associated with multiple colonic polyps. Am J Surg Pathol 8:779–786

    Article  CAS  PubMed  Google Scholar 

  112. Wheatley MJ, Wesley JR, Coran AG, Polley TZ (1990) Hirschsprung’s disease in adolescents and adults. Dis Colon Rectum 33:622–629

    Article  CAS  PubMed  Google Scholar 

  113. Wiebecke B, Müller-Lissner S (1990) Intestinale neuronale Dysplasie (IND) Typ B beim Erwachsenen. Verh Dtsch Ges Path 74:525

    Google Scholar 

  114. Yntema CL, Hammond WS (1954) Origin of intrinsic ganglia of trunk viscera from vagal neural crest in chick embryo. J Comp Neurol 101:515–542

    Article  CAS  PubMed  Google Scholar 

  115. Yu CS, Kim HC, Hong HK et al (2002) Evaluation of myenteric ganglion cells and interstitial cells of Cajal in patients with chronic idiopathic constipation. Int J Colorectal Dis 17:253–258

    Article  PubMed  Google Scholar 

  116. Yung-Ming J, Tsui-Liem M, Wen-Ming H et al (2000) Congenital interstitial cell of Cajal hyperplasia with neuronal intestinal dysplasia. Am J Surg Pathol 24:1568–1572

    Article  Google Scholar 

  117. Yunis E, Sieber WK, Akers DR (1983) Does zonal aganglionosis realy exist? Report of a rare variety of Hirschsprung’s disease and a review of the literature. Pediatr Pathol 1:33–49

    Article  CAS  PubMed  Google Scholar 

  118. Zuelzer WW, Wilson JL (1948) Functional intestinal obstruction on a congenital neurogenic basis in infancy. Amer J Dis Child 75:40–75

    CAS  Google Scholar 

  119. Bruder E (2007)  Gastrointestinale Motilitätsstörungen – Interdisziplinäre Darstellung eines komplexen Erkrankungsspektrums. Pathologe (Themenheft) 28:92–154

    Article  CAS  Google Scholar 

Übersichtsarbeiten

  1. Wedel T, Böttner M, Krammer HJ (2007) Enterisches Nervensystem und interstitielle Cajal-Zellen - Veränderungen bei chronischer Obstipation im Erwachsenenalter. Pathologe 28:143–148

    Article  CAS  PubMed  Google Scholar 

  2. Meier-Ruge WA, Bruder E (2007) Konventionelle histologische Diagnostik in der Koloproktologie. Pathologe 28:101–104

    Article  CAS  PubMed  Google Scholar 

  3. Bruder E, Knecht Y, Kasper M, Chaffard R, Ipsen S, Terracciano L, Meier-Ruge WA (2007) Enzymhistochemische Diagnostik gastrointestinaler Motilitätsstörungen Ein Laborleitfaden. Pathologe 28:93–100

    Article  CAS  PubMed  Google Scholar 

  4. Bruder E, Terracciano LM, Passarge L, Meier-Ruge WA (2007) Enzymhistochemie des klassischen und des ultrakurzen Morbus Hirschsprung. Pathologe 28:105–112

    Article  CAS  PubMed  Google Scholar 

  5. Passarge E, Bruder E (2007) Genetische Grundlagen des Morbus Hirschsprung. Pathologe 28:113–118

    Article  CAS  PubMed  Google Scholar 

  6. Bruder E, Meier-Ruge WA (2007) Intestinale neuronale Dysplasie Typ B: Wie verstehen wir sie heute? Pathologe 28:137–142

    Article  CAS  PubMed  Google Scholar 

  7. Meier-Ruge WA, Bruder E (2007) Morphologisches Bild der aplastischen und atrophischen Desmose des Darms. Pathologe 28:149–154

    Article  CAS  PubMed  Google Scholar 

  8. Keller J, Wedel T, Seidl H, Kreis ME, Andresen V, Preiß JC, Layer P, van der Voort I (2011) S3-Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) zu Definition, Pathophysiologie, Diagnostik und Therapie intestinaler Motilitätsstörungen (AWMF-Registriernummer: 021/018). Z Gastroenterol 49:374–390

    Article  CAS  PubMed  Google Scholar 

  9. Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress Be`la, Wedel T (2010) The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group. Gut 59:882–887

    Article  PubMed  Google Scholar 

  10. AWMF (2010) S1 Leitlinie 006/001 – Aganglionose (Morbus Hirschsprung) Version: 12/2010: http://www.awmf.org/uploads/tx_szleitlinien/006-001l-S1_Aganglionose_Morbus_Hirschsprung.pdf

  11. Holland SK, Hessler RB, Reid-Nicholson MD, Ramalingam P, Lee JR (2010) Utilization of peripherin and S-100 immunohistochemistry in the diagnosis of Hirschsprung disease. Mod Pathol 23:1173–1179

    Article  CAS  PubMed  Google Scholar 

  12. Guinard-Samuel V, Bonnard A, De Lagausie P, Alberti C, Philippe-Chomette P et al (2009) Calretinin immunohistochemsitry: a simple and efficient tool to diagnose Hirschsprung disease. Mod Pathol 22:1379–1384

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Josef Rüschoff Prof. Dr. med. .

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Alexandrakis, E.N., Rüschoff, J. (2013). Innervationsstörungen des Kolorektums. In: Stolte, M., Rüschoff, J., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02322-4_23

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