Virus Interactions with NK Cell Receptors

  • Vanda Juranić Lisnić
  • Iva Gašparović
  • Astrid Krmpotić
  • Stipan JonjićEmail author


Natural killer cells are among the first cells of the immune response to recognize and react to threats. They do so by surveying other cells for aberrant behavior such as altered expression of MHC class I, and molecules produced or induced by pathogens. As such, they are very important in host resistance to viral infection. Various unrelated viruses have evolved numerous evasion techniques in order to avoid detection by NK cells. The many immunoevasive techniques may be roughly divided into two main groups: camouflage of infected cells aimed at inhibitory receptors and obstruction of activating receptors. By differential downmodulation of MHC class I molecules and production of MHC class I homologues, viruses prevent CTL recognition and camouflage their presence from NK cells. Additionally, viruses have directed even greater attention towards preventing the engagement of activating receptors by interfering with the receptors per se or by down modulating their ligands and coactivating molecules, providing soluble competitors, modification and interference with translation of ligands.


Natural Killer Natural Killer Cell Natural Killer Cell Cytotoxicity NKG2D Ligand Natural Killer Cell Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Vanda Juranić Lisnić
    • 1
  • Iva Gašparović
    • 1
  • Astrid Krmpotić
    • 1
  • Stipan Jonjić
    • 1
    Email author
  1. 1.Department of Histology and EmbryologyFaculty of MedicineRijekaCroatia

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