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The Regulatory Natural Killer Cells

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Natural Killer Cells

Abstract

NK cells are effector lymphocytes of the innate immune system that control tumors and microbial infection by limiting their spread and subsequent tissue damage. Recently, more and more evidence has been obtained that NK cells also display a potent regulatory function by secreting various cytokines or cell-to-cell contact and thus regulate innate and adaptive immune responses and maintain immune homeostasis. In this review, we summarize the progress in studying the positive and negative regulatory effects of NK cells in immune responses as well as the NK subsets identified in humans and mice.

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Authors and Affiliations

  1. School of Life Sciences, University of Science and Technology of China, Hefei City, Anhui, 230027, China

    Zhigang Tian

  2. School of Pharmacy, Shandong University, Jinan City, Shandong, 250012, China

    Cai Zhang

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  1. Zhigang Tian
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  2. Cai Zhang
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  1. Lab. Immuno-Allergologie, Centre de Recherche Public, Val Fleuri 84, Luxembourg, 1526, Luxembourg

    Jacques Zimmer

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Tian, Z., Zhang, C. (2010). The Regulatory Natural Killer Cells. In: Zimmer, J. (eds) Natural Killer Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02309-5_20

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