NK Cells in Autoimmune and Inflammatory Diseases

  • Nicolas Schleinitz
  • Nassim Dali-Youcef
  • Jean-Robert Harle
  • Jacques Zimmer
  • Emmanuel AndresEmail author


The evidence of NK cell implication in human diseases has initially been shown for antiviral immunity and tumor surveillance. Nowadays, increased attention is being paid to the aspect of NK cells and innate immunity in studies on autoimmune diseases. However, despite a growing knowledge on NK cell function and regulation, their role in human autoimmune disease still remains controversial. In animal models, studies of NK cells have shown conflicting results toward a disease-promoting or disease-protective role. Similarly, in human diseases, available data suggest an unequivocal role of NK cells. Yet, the understanding of NK cell implication in human diseases is far from being achieved. We review here the current knowledge on NK cell biology in human autoimmune and inflammatory diseases and discuss their possible mechanisms of action in these complex pathologies.


Systemic Lupus Erythematosus Natural Killer Cell Systemic Lupus Erythematosus Patient Idiopathic Inflammatory Myopathy Natural Killer Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Nicolas Schleinitz
    • 1
  • Nassim Dali-Youcef
    • 2
  • Jean-Robert Harle
    • 1
  • Jacques Zimmer
    • 3
  • Emmanuel Andres
    • 4
    Email author
  1. 1.Department of Internal MedicineCHRU de MarseilleMarseilleFrance
  2. 2.Laboratory of general and specialized BiochemistryHôpitaux Universitaires de Strasbourg and Department of Biochemistry, Faculty of MedicineStrasbourgFrance
  3. 3.Laboratoire d’Immunogénétique-AllergologieCentre de Recherche Public de la Santé (CRP-Santé) de LuxembourgLuxembourgLuxembourg
  4. 4.Service de Médecine InterneDiabète et Maladies Métaboliques, Clinique Médicale B, Hôpital Civil – Hôpitaux Universitaires de Strasbourg, 1 porte de l’HôpitalStrasbourg CedexFrance

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