Abstract
Background: The measurement of respiratory system resistance during mechanical ventilation is important to ascertain the causes of increase in airway pressure during volume-controlled ventilation, which may include airways resistance and decreased respiratory system compliance.
Discussion: Separation of total resistance from compliance of the respiratory system can be assessed by the end-inspiratory hold maneuver that separates peak pressure from plateau pressure.
Conclusions: Although this method assumes a homogeneous respiratory system, it has proven useful clinically to separate flow-dependence issues such as bronchospasm or endotracheal tube obstruction from stiff lungs (acute lung injury) or decrease chest wall (abdominal distension) compliance.
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Guerin, C., Richard, JC. (2009). Measurement of respiratory system resistance during mechanical ventilation. In: Hedenstierna, G., Mancebo, J., Brochard, L., Pinsky, M. (eds) Applied Physiology in Intensive Care Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01769-8_5
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DOI: https://doi.org/10.1007/978-3-642-01769-8_5
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