Abstract
Hyperlactatemia is considered a hallmark of ongoing tissue hypoxia, but this is not always the case, and erroneous conclusions may sometimes be drawn that lead to unjustified therapeutic interventions. In this note we discuss the possible implications of hyperlactatemia
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Levy B, Sadoune LO, Gelot AM, Bollaert PE, Nabet P, Larcan A (2000) Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. Crit Care Med 28:114–119
Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, Duncan CA, Harman EM, Henderson GN, Jenkinson S (1992) A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group. N Engl J Med 327:1564–1569
Gore DC, Jahoor F, Hibbert JM, DeMaria EJ (1996) Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability. Ann Surg 224:97–102
Bellomo R, Kellum JA, Pinsky MR (1996) Transvisceral lactate fluxes during early endotoxemia. Chest 110:198–204
De Backer D, Creteur J, Zhang H, Norrenberg M, Vincent JL (1997) Lactate production by the lungs in acute lung injury. Am J Respir Crit Care Med 156:1099–1104
De Backer D, Creteur J, Silva E, Vincent JL (2001) The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis. Crit Care Med 29:256–261
Haji-Michael PG, Ladriere L, Sener A, Vincent JL, Malaisse WJ (1999) Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism 48:779–785
Levraut J, Ciebiera JP, Chave S, Rabary O, Jambou P, Carles M, Grimaud D (1998) Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 157:1021–1026
Weil MH, Afifi AA (1970) Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation 41:989–1001
Rivers E, Nguyen B, Havstadt S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368–1377
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Backer, D.D. (2009). Lactic acidosis. In: Hedenstierna, G., Mancebo, J., Brochard, L., Pinsky, M. (eds) Applied Physiology in Intensive Care Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01769-8_22
Download citation
DOI: https://doi.org/10.1007/978-3-642-01769-8_22
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-01768-1
Online ISBN: 978-3-642-01769-8
eBook Packages: MedicineMedicine (R0)