Abstract
Almost 20 years ago, Adriaan Versprille published an editorial in this journal to explain why, in his opinion, the calculation of pulmonary vascular resistance (PVR) is meaningless [1]. The uncertainties of PVR were underscored a year later by McGregor and Sniderman in the American Journal of Cardiology [2]. Obviously, both papers failed to convince. A Medline search from 1985 to the end of 2002 reveals no less than 7,158 papers with PVR calculations. What is it that could be wrong in all this literature?
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References
Versprille A (1984) Pulmonary vascular resistance. A meaningless variable. Intensive Care Med 10:51–53
McGregor M, Sniderman A (1985) On pulmonary vascular resistance: the need for more precise definition. Am J Cardiol 55:217–221
Landis EM (1982) The capillary circulation. In: Fishman AP, RichardsDW (eds) Circulation of the Blood. Men and Ideas. American Physiological Society, Bethesda, Maryland, pp 355–406
Permutt S, Bromberger-Barnea B, Bane HN (1962) Alveolar pressure, pulmonary venous pressure and the vascular waterfall. Med Thorac 19:239–260
Zhuang FY, Fung YC, Yen RT (1983) Analysis of blood flow in cat's lung with detailed anatomical and elasticity data. J Appl Physiol 55:1341–1348
Mélot C, Delcroix M, Lejeune P, Leeman M, Naeije R (1995) Starling resistor versus viscoelastic models for embolic pulmonary hypertension. Am J Physiol 267 (Heart Circ Physiol 36:H817–827)
Nelin LD, Krenz GS, Rickaby DA, Linehan JH, Dawson CA (1992) A distensible vessel model applied to hypoxic pulmonary vasoconstriction in the neonatal pig. J Appl Physiol 73:987–994
Zapol WM, Snider MT (1977). Pulmonary hypertension in severe acute respiratory failure. N Engl J Med 296:476–480
Kafi A S, Mélot C, Vachiéry JL, Brimioulle S, Naeije R (1998) Partitioning of pulmonary vascular resistance in primary pulmonary hypertension. J Am Coll Cardiol 31:1372–1376
Pagnamenta A, Fesler P, Vandivinit A, Brimioulle S, Naeije R (2003) Pulmonary vascular effects of dobutamine in experimental pulmonary hypertension. Crit Care Med (in press)
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Naeije, R. (2009). Pulmonary vascular resistance A meaningless variable?. In: Hedenstierna, G., Mancebo, J., Brochard, L., Pinsky, M. (eds) Applied Physiology in Intensive Care Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01769-8_16
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DOI: https://doi.org/10.1007/978-3-642-01769-8_16
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