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Pathogenese und klinische Grundlagen

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Operative und interventionelle Gefäßmedizin

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Zusammenfassung

Eine Schlüsselrolle in der Arterioskleroseentwicklung nimmt die arterielle Endothelzelle ein. In den letzten Jahren hat unser Wissen über die Endothelzellen beachtlich zugenommen, und insbesondere hat sich über die Endothelzellen eine kausale Verbindung zur Entzündung und zum metabolischen Syndrom ergeben. Die Arteriosklerose wird deswegen häufig als entzündliche Erkrankung der Endothelzellen verstanden. Dieses Verständnis hat die alte Zweiteilung in »Schädigungstheorie« und »Fett-Theorie« der Arteriosklerose durch ein umfassenderes Verständnis abgelöst. Endothelzellen, Entzündung und Blutgerinnung sind, wie wir heute wissen, verschiedene Bestandteile eines Systems. Am besten wird die große klinische Bedeutung dieses Systems durch die großen Erfolge derjenigen Bereiche der Pharmakotherapie der Arteriosklerose dokumentiert, die eine Hemmung der proinflammatorischen Reaktionen des Endothels und eine Hemmung der Blutgerinnung zum Ziel haben.

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Authors and Affiliations

  1. Klinik und Poliklinik für Gefäßmedizin, Universitäres Herzzentrum GmbH, Universitätsklinikum Hamburg-Eppendorf, Hamburg

    Univ.-Prof. Dr. med. E. Sebastian Debus

  2. GefäßCentrum Hamburg (GCH), ASKLEPIOS KLINIK Harburg, Hamburg

    Prof. Dr. med. Walter Gross-Fengels

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  1. Univ.-Prof. Dr. med. E. Sebastian Debus
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  1. Klinik und Poliklinik für Gefäßmedizin, Universitäres Herzzentrum GmbH, Universitätsklinikum Hamburg-Eppendorf, Hamburg

    E. Sebastian Debus

  2. GefäßCentrum Hamburg (GCH), ASKLEPIOS KLINIK Harburg, Hamburg

    Walter Gross-Fengels

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Debus, E., Gross-Fengels, W. (2012). Pathogenese und klinische Grundlagen. In: Debus, E., Gross-Fengels, W. (eds) Operative und interventionelle Gefäßmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01709-4_5

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