Abstract
Introduction: A recent report showed successful management of large diaphyseal segmental bone defects with titanium mesh cages and intramedullary nails. The purpose of the study was a quantitative evaluation of the of the mechanical role of a cylindrical titanium mesh cage and an intramedullary nail when used for the treatment of significant segmental defects of the tibia. Methods: : 28 adult rats after sustaining closed, mid shaft femur fracture, were bled to maintain a mean arterial pressure of 40 mmHg for 20 minutes while monitoring blood oxygen content. Groups: 1) no therapy; 2) 15 ml/kg Hextend infusion over 40 minutes; 3) 3 mg/kg BIIB513 (NHE-1 inhibitor) + 15 ml/kg Hextend infusion over 40 minutes. After 4 hours, the animals who survived received a second infusion of Hextend. Results: All animals in the no therapy group died within 2 hours. Group 3 showed improved hemodynamic response to fluid resuscitation, increased blood oxygen content, prevented metabolic acidosis, and improved 6 hour survival, 42%, compared to group 3, 80%. NHE-1 inhibition also resulted in reduced plasma levels of TNF-α, ICAM-1 and C-reactive protein, and attenuated neutrophil infiltration in the liver. There were no morhpologic changes found in any of the tissue samples at this early time period. Conclusion: NHE inhibition prevented early death caused by cardiac arrest, and multiple organ failure by inhibiting neutrophil infiltration and NF-(B activation, thereby, reducing systemic inflammation in a model of severe hemorrhagic shock and fracture in a rat.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsAuthor information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ostermann, P.A., Latta, L.L., Biedermann, L., Milne, E.L. (2009). Biomechanical Evaluation of the Cylindrical TI Mesh Cage for the Treatment of Segmental Defects of the Tibia. In: McGoron, A.J., Li, CZ., Lin, WC. (eds) 25th Southern Biomedical Engineering Conference 2009, 15 – 17 May 2009, Miami, Florida, USA. IFMBE Proceedings, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01697-4_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-01697-4_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-01696-7
Online ISBN: 978-3-642-01697-4
eBook Packages: EngineeringEngineering (R0)