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Hämostaseologie pp 245–258Cite as

Thrombomodulin-Protein-C-System und Protein Z

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Zusammenfassung

Die prokoagulatorischen Mechanismen des Gerinnungssystems werden durch antikoagulatorische Systeme kontrolliert, wobei dem Thrombomodulin-Protein-C-System (TM-PC-System) eine besondere Bedeutung zukommt. Neben einer thrombinabhängigen negativen Rückkopplung der Gerinnungsaktivierung moduliert das TM-PC-System durch rezeptorabhängige Mechanismen zelluläre Funktionen. Das endotheliale TM-PC-System kontrolliert z. B. durch die Aktivierung der EPCR-PAR- Signaltransduktion (EPCR: endothelialer Protein-C-Rezeptor, PAR: proteaseaktivierbarer Rezeptor) und unabhängig von der Gerinnung per se Krankheitsverläufe im Rahmen einer Sepsis oder einer diabetischen Nephropathie. Diese Funktionen des TM-PC-Systems verdeutlichen, dass das Gerinnungssystem nicht nur als Wächter der Hämostase, sondern auch als Modulator der Homöostase verstanden werden muss.

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Authors and Affiliations

  1. Medizinische Klinik I, Deutsches Krebsforschungszentrum, Molekularbiologie der Zelle I A020, Im Neuenheimer Feld 280, D-69120, Heidelberg

    Dr. I. A. Vinnikov

  2. Innere Medizin I (Endokrinologie, Nephrologie) und Klinische Chemie, Universität Heidelberg, Im Neuenheimer Feld 410, D-69120, Heidelberg

    Prof. Dr. P. P. Nawroth & Priv.-Doz. Dr. B. Isermann

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  1. Dr. I. A. Vinnikov
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  1. Institut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53105, Bonn

    Bernd Pötzsch

  2. Kerckhoff Klinik, BenekeStraße 2-8, 61231, Bad Nauheim

    Katharina Madlener

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Vinnikov, I.A., Nawroth, P.P., Isermann, B. (2010). Thrombomodulin-Protein-C-System und Protein Z. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_26

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