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Hämostaseologie pp 219–225Cite as

Faktor XIII

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Zusammenfassung

Der Blutgerinnungsfaktor XIII (FXIII) spielt eine zentrale Rolle in der Hämostase, da er für die Vernetzung der Fibrinfäden zu einem festen, unlöslichen Gerinnsel verantwortlich ist. Jegliche Gerinnselbildung im menschlichen Körper, sei dies ein Thrombus in einem Koronargefäß (akuter Herzinfarkt) oder ein Embolus in einer Pulmonalarterie (akute Lungenembolie), ist also nur infolge der vernetzenden Funktion von FXIII entstanden. Aus diesem Grund wurde FXIII früher auch “fibrinstabilisierender Faktor„ genannt. Da FXIII nicht wie die anderen Gerinnungsfaktoren zur Gruppe der proteinspaltenden Serinproteasen gehört, sondern Proteine vernetzt, nimmt FXIII schon wegen seiner Funktion eine Sonderstellung unter den Gerinnungsfaktoren ein. Aufgrund dieser zentralen Funktion in der Gerinnselbildung leiden Patienten mit angeborenem, komplettem FXIII-Mangel an einer ausgeprägten und potenziell lebensgefährlichen Blutungsneigung.

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Authors and Affiliations

  1. Universitätsklinik für Hämatologie und Hämatologisches Zentrallabor, Hämostase Forschungslabor, Universität Bern/Inselspital, CH-3010, Bern

    Dr. V. Schroeder & Prof. Dr. H.-P. Kohler

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  1. Dr. V. Schroeder
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  2. Prof. Dr. H.-P. Kohler
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Editors and Affiliations

  1. Institut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53105, Bonn

    Bernd Pötzsch

  2. Kerckhoff Klinik, BenekeStraße 2-8, 61231, Bad Nauheim

    Katharina Madlener

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Schroeder, V., Kohler, HP. (2010). Faktor XIII. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_23

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  • DOI: https://doi.org/10.1007/978-3-642-01544-1_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01543-4

  • Online ISBN: 978-3-642-01544-1

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