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Faktoren V und VIII

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Hämostaseologie

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Zusammenfassung

Die Gerinnungsfaktoren V (FV) und VIII (FVIII) spielen als Kofaktoren enzymatischer Aktivierungsreaktionen eine zentrale Rolle in der Gerinnungskaskade. Während aktivierter FV (FVa) innerhalb des Prothrombinasekomplexes die Generierung von Thrombin beschleunigt, ermöglicht aktivierter FVIII (FVIIIa) innerhalb des Tenasekomplexes die effektive Bildung von aktiviertem Faktor X (FXa). Neben der prokoagulatorischen Eigenschaft von FVa kommt FV in Form einer entsprechend aktivierten Variante (FVac) eine antikoagulatorische Kofaktorfunktion bei der durch aktiviertes Protein C (APC) vermittelten Inaktivierung von FVIII zu.

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  1. Institut für Experimentelle-Hämatologie und Transfusionsmedizin, Universitätsklinik Bonn, Sigmund-Freud-Straße 25, D-53127, Bonn

    Dr. J. Müller

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  1. Institut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53105, Bonn

    Bernd Pötzsch

  2. Kerckhoff Klinik, BenekeStraße 2-8, 61231, Bad Nauheim

    Katharina Madlener

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Müller, J. (2010). Faktoren V und VIII. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_19

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