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Vitamin-K-abhängige Gerinnungsfaktoren

  • Chapter
Hämostaseologie

Zusammenfassung

Gemeinsames Merkmal der prokoagulatorischen Gerinnungsfaktoren VII, IX, X und II ist die posttranslationale γ-Carboxylierung von Glutaminsäureresten. Dieser Stoffwechselprozess erfolgt Vitamin-K-abhängig in der Leber. Die sezernierten Gerinnungsfaktoren zirkulieren im Blut als inaktive Proenzyme. Sie werden nach Bindung an negativ geladene Oberflächen durch proteolytische Spaltung im Rahmen der Gerinnungsaktivierung in die aktiven Serinproteasen überführt. Aufgrund von Mutationen oder Mangelerscheinungen dieser Faktoren kommt es zu Störungen im plasmatischen Gerinnungssystem.

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Author information

Authors and Affiliations

  1. Fachbereich Medizin/Biochemisches Institut, Justus-Liebig-Universität Gießen, Friedrichstraße 24, D-35392, Gießen

    Prof. Dr. K. T. Preissner

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  1. Prof. Dr. K. T. Preissner
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  1. Institut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53105, Bonn

    Bernd Pötzsch

  2. Kerckhoff Klinik, BenekeStraße 2-8, 61231, Bad Nauheim

    Katharina Madlener

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Preissner, K.T. (2010). Vitamin-K-abhängige Gerinnungsfaktoren. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-01544-1_17

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