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Monozyten und Leukozyten

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Hämostaseologie

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Zusammenfassung

Monozyten und Leukozyten interagieren mit dem Hämostasesystem über verschiedene Mechanismen. Aktivierte Monozyten und Leukozyten können das plasmatische Gerinnungssystem durch die Expression von Tissue Factor aktivieren. Die daraus resultierende Fibrinbildung trägt dazu bei, den Entzündungsprozess zu begrenzen, und behindert die Ausbreitung von Bakterien und anderen Krankheitserregern. Durch direkten zellulären Kontakt können Monozyten und Leukozyten Endothelzellen aktivieren und eine prokoagulatorische Antwort induzieren. Dies wird durch die Sezernierung von Zytokinen und anderen proinflammatorischen Mediatoren verstärkt, die neben der Endothelzellaktivierung die hepatische Synthese von Gerinnungsfaktoren stimulieren können. Weiterhin sind Monozyten und Leukozyten eine Hauptquelle für die Bildung von an Tissue Factor reichen Mikropartikeln. Diese ermöglichen die Aufrechterhaltung einer basalen Gerinnungsaktivierung, sind in die Gerinnselbildung involviert und spielen wahrscheinlich eine wichtige Rolle in der Pathogenese von thromboembolischen Prozessen.

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Author information

Authors and Affiliations

  1. Institut für molekulare Herz-Kreislaufforschung, Universitätsklinikum Aachen, Pauwelsstraße 30, D-52074, Aachen

    Prof. Dr. Ch. Weber

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  1. Prof. Dr. Ch. Weber
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Editors and Affiliations

  1. Institut für Experimentelle Hämatologie und Transfusionsmedizin, Universitätsklinikum Bonn, Sigmund-Freud-Straße 25, 53105, Bonn

    Bernd Pötzsch

  2. Kerckhoff Klinik, BenekeStraße 2-8, 61231, Bad Nauheim

    Katharina Madlener

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© 2010 Springer-Verlag Berlin Heidelberg

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Weber, C. (2010). Monozyten und Leukozyten. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-01544-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01543-4

  • Online ISBN: 978-3-642-01544-1

  • eBook Packages: Medicine (German Language)

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