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Use of Potent Inhalational Anesthetic Agents During Mechanical Ventilation

  • Joseph D. TobiasEmail author
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Abstract

The clinical practice of inhalational anesthesia began in the 1840s with the demonstration of the efficacy of diethyl ether by Crawford Long and WTG Morton and nitrous oxide (N2O) by Horace Wells. In 1946, Robbins reported the development of various fluorinated hydrocarbons (Robbins 1946). This work led to the synthesis in 1951 of fluroxene (2,2,2-trifluoroethyl vinyl ether), a fluorinated hydrocarbon, which was the first of this class of agents to be widely used in clinical practice (Krantz et al. 1953; Tucker et al. 1973; Johnston et al. 1973; Harris and Cromwell 1972). Halothane, a halogenated alkane, was introduced into clinical practice in 1956 (Raventos 1956). When compared with its predecessors, halothane offered several favorable properties including nonflammability, a favorable blood-gas partition coefficient, a favorable profile for inhalation induction including a rapid onset and limited pungency, bronchodilatation, relative cardiovascular stability, and a decreased incidence of nausea and vomiting. However, halothane’s potential to elicit an immune-mediated hepatotoxicity especially in the adult population favored the development of additional agents with less hepatotoxicity.

Keywords

Mean Arterial Pressure Status Epilepticus Status Asthmaticus Procedural Sedation Ventilator Circuit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. 1.Department of Anesthesiology and Pain MedicineNationwide Children’s HospitalColumbusUSA
  2. 2.Department of Anesthesiology and PediatricsThe Ohio State UniversityColumbusUSA

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