Drug Nebulization During Mechanical Ventilation

  • Peter DahlemEmail author
  • Anne Greenough
  • Ari Joffe
  • Anthony Milner
  • John Salyer


Humans have been using the inhalational route for administering medication, both therapeutic and recreational for many centuries (Anderson 2005). The term inhaler was first used in the English literature in the eighteenth century (Sanders 2007; Rubin 2010). A great deal of creativity has gone into the naming of inhaler devices, some of which have deservedly been cast onto the ash heap of history including the volatilizer, varoma, vapo-haler, spirit burner, vapo-cresoline, pillow inhaler, atomizer, inspirator, pipe medicator, pulverisateur, and the ammoniaphone. At one time, various forms of inhaled tobacco smoke were thought to be therapeutic. In 1571, a Spanish doctor named Nicolas Monardes wrote a history of medicinal plants of the new world, in which he claimed that tobacco could cure 36 health problems. Cigarettes were developed for the treatment of asthma that were made of an anticholinergic substance and were available for purchase up until the 1970s (Elliott and Reid 1980). This chapter will focus on the administration of medications via inhalation during mechanical ventilation of infants and children.


Beclomethasone Dipropionate Mass Median Aerodynamic Diameter Aerosol Delivery Ventilator Circuit Inertial Impaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Peter Dahlem
    • 1
    Email author
  • Anne Greenough
    • 2
    • 3
    • 4
  • Ari Joffe
    • 5
  • Anthony Milner
    • 2
    • 4
  • John Salyer
    • 6
  1. 1.Department of PediatricsMedical Center of CoburgCoburgGermany
  2. 2.Division of Asthma, Allergy and Lung BiologyMRC Centre for Allergic Mechanisms for Asthma, King’s College LondonLondonUK
  3. 3.Neonatal Intensive Care CentreKing’s College HospitalLondonUK
  4. 4.Newborn UnitKing’s College London School of Medicine, King’s College HospitalLondonUK
  5. 5.Department of Pediatrics, Pediatric Critical Care Medicine and Infectious DiseasesUniversity of Alberta, 3A3.07 Stollery Children’s HospitalEdmontonCanada
  6. 6.Department of Respiratory CareSeattle Children’s Hospital Foundation, Research InstituteSeattleUSA

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