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Permissive Hypercapnia in Neonates: Specific Experience and Limitations

  • Gonzalo Mariani
  • J. Davin Miller
  • Waldemar A. CarloEmail author
Chapter
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Abstract

Two decades ago, a consensus of experts on mechanical ventilation indicated that one of the potential strategies to reduce lung injury was to modify blood-gas targets to accept a higher-than-normal PaCO2 (Slutsky 1993). This approach to ventilator support has been called permissive hypercapnia, also termed controlled mechanical hypoventilation. In the past, many clinicians aimed to achieve PaCO2 levels of 40 mmHg or less in ventilated neonates. Experimental and clinical researches during the last two decades indicate that slightly higher PaCO2 levels may allow a reduction in ventilatory support and may reduce the risk for lung injury.

Keywords

Lung Injury VLBW Infant Hypercapnic Acidosis Permissive Hypercapnia PaCO2 Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Gonzalo Mariani
    • 1
  • J. Davin Miller
    • 2
  • Waldemar A. Carlo
    • 3
    Email author
  1. 1.Division of NeonatologyInstituto Universitario, Hospital Italiano de Buenos AiresBuenos AiresArgentina
  2. 2.Neonatology Associates of AtlantaAtlantaUSA
  3. 3.Division of Neonatology, Newborn NurseriesUniversity of Alabama at BirminghamBirminghamUSA

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