Respirator Cycle Control Modes

  • Mark J. HeulittEmail author
  • Eduardo Bancalari
  • Martin Keszler
  • Ronald C. SandersJr.
  • Nelson Claure


The goal of mechanical ventilation is to provide or improve ventilation, oxygenation, lung mechanics, and patient comfort while minimizing complications. Traditionally, volume control modes have been favored because of the ability to guarantee a preset tidal volume (V T) and minute ventilation (V E) enabling straightforward manipulation of ventilation in response to changes in the partial pressure of carbon dioxide in the blood (PaCO2). However, during volume control modes, there is no guaranteed limit of peak airway pressure. This lack of limitation of airway pressure may result in high peak airway pressures associated with changes in the patient’s compliance and resistance, causing alveolar overdistension and barotrauma. In contrast, pressure control ventilation (PCV) allows control, or limitation, of the peak inspiratory pressure (PIP) and inspiratory time (T i) with no guarantee of V T.


Pediatric Intensive Care Unit Spontaneous Breathing Pressure Support Ventilation Inspiratory Flow Peak Inspiratory Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Abd El-Moneim ES, Fuerste HO et al (2005) Pressure support ventilation combined with volume guarantee versus synchronized intermittent mandatory ventilation: a pilot crossover trial in premature infants in their weaning phase. Pediatr Crit Care Med 6(3):286–292PubMedGoogle Scholar
  2. Abubakar KM, Keszler M (2001) Patient-ventilator interactions in new modes of patient-triggered ventilation. Pediatr Pulmonol 32:71–75PubMedGoogle Scholar
  3. Abubakar K, Montazami S, Keszler M (2006) Volume guarantee accelerates recovery from endotracheal tube suctioning in ventilated preterm infants. E-PAS 59:5560.343Google Scholar
  4. American Association for Respiratory Care (1992) Consensus statement on the essentials of mechanical ventilators – 1992. Respir Care 37(9):1000–1008Google Scholar
  5. Antonelli M, Conti G, Rocco M et al (1998) A comparison of noninvasive positive-pressure ventilation and conventional mechanical ventilation in patients with acute respiratory failure. N Engl J Med 339(7):429–435PubMedGoogle Scholar
  6. Baumer JH (2000) International randomised controlled trial of patient triggered ventilation in neonatal respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed 82(1):F5–F10PubMedCentralPubMedGoogle Scholar
  7. Beck J, Tucci M, Emeriaud G et al (2004) Prolonged neural expiratory time induced by mechanical ventilation in infants. Pediatr Res 55(5):747–754PubMedGoogle Scholar
  8. Beresford MW, Shaw NJ, Manning D (2000) Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed 82(1):F14–F18PubMedCentralPubMedGoogle Scholar
  9. Bernstein G, Knodel E, Heldt GP (1995) Airway leak size in neonates and autocycling of three flow-triggered ventilators. Crit Care Med 23:1739–1744PubMedGoogle Scholar
  10. Bernstein G et al (1996) Randomized multicenter trial comparing synchronized and conventional intermittent mandatory ventilation in neonates. J Pediatr 128(4):453–463PubMedGoogle Scholar
  11. Bjork VO, Engstrom CG (1955) The treatment of ventilatory insufficiency after pulmonary resection with tracheostomy and prolonged artificial ventilation. J Thorac Surg 30(3):356–367PubMedGoogle Scholar
  12. Branson RD, MacIntyre NR (1996) Dual-control modes of mechanical ventilation. Respir Care 41:294–305Google Scholar
  13. Branson RD et al (1994) Comparison of pressure and flow triggering systems during continuous positive airway pressure. Chest 106(2):540–544PubMedGoogle Scholar
  14. Brochard L (1994) Inspiratory pressure support. Eur J Anaesthesiol 11(1):29–36PubMedGoogle Scholar
  15. Brochard L, Harf A, Lorino H, Lemaire F (1989) Inspiratory pressure support prevents diaphragmatic figure during weaning from mechanical ventilation. Am Rev Respir Dis 139(2):512–521Google Scholar
  16. Brochard L et al (1994) Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 150(4):896–903PubMedGoogle Scholar
  17. Chan V, Greenough A (1993) Randomised controlled trial of weaning by patient triggered ventilation or conventional ventilation. Eur J Pediatr 152(1):51–54PubMedGoogle Scholar
  18. Chan V, Greenough A (1994) Comparison of weaning by patient triggered ventilation or synchronous intermittent mandatory ventilation in preterm infants. Acta Paediatr 83(3):335–337PubMedGoogle Scholar
  19. Cheema IU, Ahluwalia JS (2001) Feasibility of tidal volume-guided ventilation in newborn infants: a randomized, crossover trial using the volume guarantee modality. Pediatrics 107(6):1323–1328PubMedGoogle Scholar
  20. Cheema IU, Sinha AK, Kempley ST, Ahluwalia JS (2007) Impact of volume guarantee ventilation on arterial carbon dioxide tension in newborn infants: a randomized controlled trial. Early Hum Dev 83(3):183–189PubMedGoogle Scholar
  21. Chen J, Ling U, Chen J (1997) Comparison of synchromized and conventional intermittent mandatory ventilation in neonates. Acta Paediatr Jpn 39:578–583PubMedGoogle Scholar
  22. Claure N, D'Ugard C, Bancalari E (2003) Elimination of ventilator dead space during synchronized ventilation in premature infants. J Pediatr 143(3):315–320PubMedGoogle Scholar
  23. Cleary JP et al (1995) Improved oxygenation during synchronized intermittent mandatory ventilation in neonates with respiratory distress syndrome: a randomized, crossover study. J Pediatr 126(3):407–411PubMedGoogle Scholar
  24. Cohen R (2003) Section 11: Disturbances of acid base homeostasis. In: Warrell D et al (eds) Oxford textbook of medicine. Oxford University Press, New YorkGoogle Scholar
  25. Dani C, Bertini G et al (2006) Effects of pressure support ventilation plus volume guarantee vs. high frequency oscillatory ventilation on lung inflammation in preterm infants. Pediatr Pulmonol 41(3):242–249PubMedGoogle Scholar
  26. Dawson C, Davies MW (2005) Volume-targeted ventilation and arterial carbon dioxide in neonates. J Paediatr Child Health 41(9–10):518–521PubMedGoogle Scholar
  27. de Moraes MA et al (2009) Comparison between intermittent mandatory ventilation and synchronized intermittent mandatory ventilation with pressure support in children. J Pediatr (Rio J) 85(1):15–20Google Scholar
  28. Demoule A, Girou E, Richard JC, Taillé S, Brochard L (2006) Increased use of noninvasive ventilation in French intensive care units. Intensive Care Med 32(11):1747–55Google Scholar
  29. Dimaguila MA, DiFiore JA, Martin R, Miller M (1997) Characteristics of hypoxemic episodes in very low birth weight infants on ventilatory support. J Pediatr 130:577–583PubMedGoogle Scholar
  30. Dimitriou G et al (1995) Synchronous intermittent mandatory ventilation modes compared with patient triggered ventilation during weaning. Arch Dis Child Fetal Neonatal Ed 72(3):F188–F190PubMedCentralPubMedGoogle Scholar
  31. Dimitriou G et al (1998) Comparison of airway pressure-triggered and airflow-triggered ventilation in very immature infants. Acta Paediatr 87(12):1256–1260PubMedGoogle Scholar
  32. Dimitriou G, Greenough A, Cherian S (2001) Comparison of airway pressure and airflow triggering systems using a single type of neonatal ventilator. Acta Paediatr 90(4):445–447PubMedGoogle Scholar
  33. Donn SM, Nicks JJ, Becker MA (1994) Flow-synchronized ventilation of preterm infants with respiratory distress syndrome. J Perinatol 14(2):90–94PubMedGoogle Scholar
  34. Downs JB et al (1973) Intermittent mandatory ventilation: a new approach to weaning patients from mechanical ventilators. Chest 64(3):331–335PubMedGoogle Scholar
  35. Essouri S, Chevret L et al (2006) Noninvasive positive pressure ventilation: five years of experience in a pediatric intensive care unit. Pediatr Crit Care Med 7(4):329–334PubMedGoogle Scholar
  36. Esteban A, Fernandez G et al (1997) Extubation outcome after spontaneous breathing trials with t-tube or pressure support ventilation. The Spanish Lung Failure Collaborative Group. Am J Respir Crit Care Med 156(2 Pt 1):459–465PubMedGoogle Scholar
  37. Faden A (1976) Encephalopathy following treatment of chronic pulmonary failure. Neurology 26(4):337–339PubMedGoogle Scholar
  38. Farias A, Retta A et al (2001) A comparison of two methods to perform a breathing trial before extubation in pediatric intensive care patients. Intensive Care Med 27:1649–1654PubMedGoogle Scholar
  39. Figueras J et al (1997) Changes in TcPCO2 regarding pulmonary mechanics due to pneumotachometer dead space in ventilated newborns. J Perinat Med 25(4):333–339PubMedGoogle Scholar
  40. Firme SR et al (2005) Episodes of hypoxemia during synchronized intermittent mandatory ventilation in ventilator-dependent very low birth weight infants. Pediatr Pulmonol 40(1):9–14PubMedGoogle Scholar
  41. Goulet R, Hess D, Kacmarek RM (1997) Pressure vs flow triggering during pressure support ventilation. Chest 111(6):1649–1653PubMedGoogle Scholar
  42. Grace MP, Greenbaum DM (1982) Cardiac performance in response to PEEP in patients with cardiac dysfunction. Crit Care Med 10(6):358–360PubMedGoogle Scholar
  43. Greenough A, Morley CJ (1984) Pneumothorax in infants who fight ventilators. Lancet 1(8378):689PubMedGoogle Scholar
  44. Greenough A, Morley C, Davis J (1983a) Interaction of spontaneous respiration with artificial ventilation in preterm babies. J Pediatr 103(5):769–773PubMedGoogle Scholar
  45. Greenough A, Morley CJ, Davis JA (1983b) Respiratory reflexes in ventilated premature babies. Early Hum Dev 8(1):65–75PubMedGoogle Scholar
  46. Greenough A, Morley CJ, Davis JA (1984) Provoked augmented inspirations in ventilated premature babies. Early Hum Dev 9(2):111–117PubMedGoogle Scholar
  47. Gupta S, Sinha SK, Donn SM (2009) The effect of two levels of pressure support ventilation on tidal volume delivery and minute ventilation in preterm infants. Arch Dis Child Fetal Neonatal Ed 94(2):F80–F83PubMedGoogle Scholar
  48. Hastings PR et al (1980) Cardiorespiratory dynamics during weaning with IMV versus spontaneous ventilation in good-risk cardiac-surgery patients. Anesthesiology 53(5):429–431PubMedGoogle Scholar
  49. Herrera CM, Gerhardt T et al (2002) Effects of volume-guaranteed synchronized intermittent mandatory ventilation in preterm infants recovering from respiratory failure. Pediatrics 110(3):529–533PubMedGoogle Scholar
  50. Holt SJ, Sanders RC, Thurman TL, Heulitt MJ (2001) An evaluation of automode, a computer-controlled ventilator mode, with the Siemens Servo 300A, using a porcine model. Respir Care 46(1):26–36PubMedGoogle Scholar
  51. Hummler H et al (1996a) Influence of different methods of synchronized mechanical ventilation on ventilation, gas exchange, patient effort, and blood pressure fluctuations in premature neonates. Pediatr Pulmonol 22(5):305–313PubMedGoogle Scholar
  52. Hummler HD et al (1996b) Patient-triggered ventilation in neonates: comparison of a flow-and an impedance-triggered system. Am J Respir Crit Care Med 154(4 Pt 1):1049–1054PubMedGoogle Scholar
  53. John J et al (1994) Airway and body surface sensors for triggering in neonatal ventilation. Acta Paediatr 83(9):903–909PubMedGoogle Scholar
  54. Jolliet P, Tassaux D (2006) Clinical review: patient-ventilator interaction in chronic obstructive pulmonary disease. Crit Care 10(6):236PubMedCentralPubMedGoogle Scholar
  55. Jubran A, Van de Graaff WB, Tobin MJ (1995) Variability of patient-ventilator interaction with pressure support ventilation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 152(1):129–136PubMedGoogle Scholar
  56. Kapasi M et al (2001) Effort and work of breathing in neonates during assisted patient-triggered ventilation. Pediatr Crit Care Med 2(1):9–16PubMedGoogle Scholar
  57. Keszler M (2006) Volume guarantee and ventilator-induced lung injury: Goldilocks’ rules apply. Pediatr Pulmonol 41:364–366PubMedGoogle Scholar
  58. Keszler M, Abubakar KM (2004a) Volume guarantee: stability of tidal volume and incidence of hypocarbia. Pediatr Pulmonol 38:240–245PubMedGoogle Scholar
  59. Keszler M, Abubakar KM (2004b) Volume guarantee accelerates recovery from forced exhalation episodes. Pediatr Res 55:545AGoogle Scholar
  60. Keszler M, Abubakar KM, Mammel MC (2003) Response to Olsen, et al. study comparing SIMV & PSV. J Perinatol 23:434–435PubMedGoogle Scholar
  61. Keszler M, Nassabeh-Montazami S, Abubakar K (2009) Evolution of tidal volume requirement during the first 3 weeks of life in infants <800 g ventilated with volume guarantee. Arch Dis Child Fetal Neonatal Ed 94(4):F279–F282PubMedGoogle Scholar
  62. Keszler M, Montaner MB, Abubakar K (2012) Effective ventilation at conventional rates with tidal volume below instrumental dead space: a bench study. Arch Dis Child Fetal Neonatal Ed 97(3):F188–F192PubMedGoogle Scholar
  63. Khan N, Brown A, Venkataraman ST (1996) Predictors of extubation success and failure in mechanically ventilated infants and children. Crit Care Med 24(9):1568–1579PubMedGoogle Scholar
  64. Kirby RR (1977) Intermittent mandatory ventilation in the neonate. Crit Care Med 5(1):18–22PubMedGoogle Scholar
  65. Kirby R et al (1971) A new pediatric volume ventilator. Anesth Analg 50:533–537PubMedGoogle Scholar
  66. Kirby R et al (1972) Continuous flow as an alternative to assisted or controlled ventilation in infant. Anesth Analg 51:871–875PubMedGoogle Scholar
  67. Kirsch DB, Jozefowicz RF (2002) Neurologic complications of respiratory disease. Neurol Clin 20(1):247–264, viiiPubMedGoogle Scholar
  68. Levitzky M (1986) Pulmonary physiology, 2nd edn. McGraw-Hill, New York, p 276Google Scholar
  69. Lista G, Colnaghi M et al (2003) Lung injury and ventilatory strategies. Pediatr Med Chir 25(1):35–41PubMedGoogle Scholar
  70. Lista G, Colnaghi M et al (2004) Impact of targeted-volume ventilation on lung inflammatory response in preterm infants with respiratory distress syndrome (RDS). Pediatr Pulmonol 37(6):510–514PubMedGoogle Scholar
  71. Lista G, Castoldi F et al (2008) Volume guarantee versus high-frequency ventilation: lung inflammation in preterm infants. Arch Dis Child Fetal Neonatal Ed 93(4):F252–F256PubMedGoogle Scholar
  72. MacIntyre NR, McConnell R, Cheng KC, Sane A (1997) A patient ventilator flow dysynchrony : flow limited versus pressure limited breaths. Crit Care Med 25:1671–1677PubMedGoogle Scholar
  73. Mador M (1994) Chapter 7: Assist-control ventilation. In: Tobin M (ed) Principles and practice of mechanical ventilation. McGraw-Hill, Inc., New York, pp 207–219Google Scholar
  74. Manczur T, Greenough A, Rafferty GF (2000a) Comparison of the pressure time product during synchronous intermittent mandatory ventilation and continuous positive airway pressure. Arch Dis Child 83(3):265–267PubMedCentralPubMedGoogle Scholar
  75. Manczur T, Greenough A, Nicholson G, Rafferty G (2000b) Resistance of pediatric and neonatal endotracheal tubes: influence of low rate, size, and shape. Crit Care Med 28(5):1595–1598PubMedGoogle Scholar
  76. Marik P, Krikorian J (1997) Pressure-controlled ventilation in ARDS: a practical approach. Chest 112:1102–1106PubMedGoogle Scholar
  77. Marini JJ, Rodriguez RM, Lamb V (1986) The inspiratory workload of patient-initiated mechanical ventilation. Am Rev Respir Dis 134(5):902–909PubMedGoogle Scholar
  78. Mathru M et al (1982) Hemodynamic response to changes in ventilatory patterns in patients with normal and poor left ventricular reserve. Crit Care Med 10(7):423–426PubMedGoogle Scholar
  79. Matic I, Majeric-Kogler V (2004) Comparison of pressure support and T-tube weaning from mechanical ventilation: randomized prospective study. Croat Med J 45(2):162–166PubMedGoogle Scholar
  80. McCallion N, Lau R, Dargaville PA, Morley CJ (2005) Volume guarantee ventilation, interrupted expiration, and expiratory braking. Arch Dis Child 90(9):865–870PubMedCentralPubMedGoogle Scholar
  81. Minuto A, Giacomini M et al (2003) Non-invasive mechanical ventilation in patients with acute cardiogenic pulmonary edema. Minerva Anestesiol 69(11):835–838PubMedGoogle Scholar
  82. Nafday SM, Green RS, Lin J, Brion LP, Ochshorn I, Holzman IR (2005) Is there an advantage of using pressure support ventilation with volume guarantee in the initial management of premature infants with respiratory distress syndrome? A pilot study. J Perinatol 25(3):193–197PubMedGoogle Scholar
  83. Nassabeh-Montazami S, Abubakar KM, Keszler M (2009) The impact of instrumental dead-space in volume-targeted ventilation of the extremely low birth weight (ELBW) infant. Pediatr Pulmonol 44(2):128–133PubMedGoogle Scholar
  84. Nikischin W et al (1996) Patient-triggered ventilation: a comparison of tidal volume and chestwall and abdominal motion as trigger signals. Pediatr Pulmonol 22(1):28–34PubMedGoogle Scholar
  85. Olsen SL, Thibeault DW, Truog WE (2002) Crossover trial comparing pressure support with synchronized intermittent mandatory ventilation. J Perinatol 22(6):461–466PubMedGoogle Scholar
  86. Osorio W, Claure N, D'Ugard C, Athavale K, Bancalari E (2005) Effects of pressure support during an acute reduction of synchronized intermittent mandatory ventilation in preterm infants. J Perinatol 25:412–416PubMedGoogle Scholar
  87. Parthasarathy S, Jubran A, Tobin MJ (1998) Cycling of inspiratory and expiratory muscle groups with the ventilator in airflow limitation. Am J Respir Crit Care Med 158(5 Pt 1):1471–1478PubMedGoogle Scholar
  88. Patel DS et al (2009) Work of breathing during SIMV with and without pressure support. Arch Dis Child 94(6):434–436PubMedGoogle Scholar
  89. Perlman JM, McMenamin JB, Volpe JJ (1983) Fluctuating cerebral blood-flow velocity in respiratory-distress syndrome. Relation to the development of intraventricular hemorrhage. N Engl J Med 309(4):204–209PubMedGoogle Scholar
  90. Pinsky MR, Summer WR (1983) Cardiac augmentation by phasic high intrathoracic pressure support in man. Chest 84(4):370–375PubMedGoogle Scholar
  91. Polimeni V, Claure N, D’Ugard C, Bancalari E (2006) Effects of volume-targeted synchronized intermittent mandatory ventilation on spontaneous episodes of hypoxemia in preterm infants. Biol Neonate 89(1):50–55PubMedGoogle Scholar
  92. Prella M, Feigl F, Domenighetti G (2002) Effects of short-term pressure-controlled ventilation on gas exchange, airway pressures, and gas distribution in patients with acute lung injury/ARDS: comparison with volume-controlled ventilation. Chest 122(4):1382–1388PubMedGoogle Scholar
  93. Randolph AG et al (2002) Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA 288(20):2561–2568PubMedGoogle Scholar
  94. Randolph AG et al (2003) The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med 167(10):1334–1340PubMedGoogle Scholar
  95. Reyes ZC et al (2006) Randomized, controlled trial comparing synchronized intermittent mandatory ventilation and synchronized intermittent mandatory ventilation plus pressure support in preterm infants. Pediatrics 118(4):1409–1417PubMedGoogle Scholar
  96. Richard JC et al (2002) Bench testing of pressure support ventilation with three different generations of ventilators. Intensive Care Med 28(8):1049–1057PubMedGoogle Scholar
  97. Sanders RC Jr et al (2001) Work of breathing associated with pressure support ventilation in two different ventilators. Pediatr Pulmonol 32(1):62–70PubMedGoogle Scholar
  98. Sassoon C (1994) Chapter 8: Intermittent mandatory ventilation. In: Tobin M (ed) Principles and practice of mechanical ventilation. McGraw Hill, Inc., New YorkGoogle Scholar
  99. Sassoon CS et al (1994) Influence of pressure- and flow-triggered synchronous intermittent mandatory ventilation on inspiratory muscle work. Crit Care Med 22(12):1933–1941PubMedGoogle Scholar
  100. Scopesi F, Calevo MG et al (2007) Volume targeted ventilation (volume guarantee) in the weaning phase of premature newborn infants. Pediatr Pulmonol 42(10):864–870PubMedGoogle Scholar
  101. Sharma S, Abubakar KM, Keszler M (2010) Tidal volume in infants with congenital diaphragmatic hernia. E-PAS1466.146Google Scholar
  102. Smith KM et al (1997) Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation. Intensive Care Med 23(4):463–468PubMedGoogle Scholar
  103. Stark AR, Bascom R, Frantz ID 3rd (1979) Muscle relaxation in mechanically ventilated infants. J Pediatr 94(3):439–443PubMedGoogle Scholar
  104. Thiagarajan RR et al (2004) Inspiratory work of breathing is not decreased by flow-triggered sensing during spontaneous breathing in children receiving mechanical ventilation: a preliminary report. Pediatr Crit Care Med 5(4):375–378PubMedGoogle Scholar
  105. Thille AW, Lyazidi A, Richard JC, Galia F, Brochard L (2009) A bench study of intensive-care-unit ventilators: new versus old and turbine-based versus compressed gas-based ventilators. Intensive Care Med 35(8):1368–1376PubMedCentralPubMedGoogle Scholar
  106. Tobin MJ (2001) Advances in mechanical ventilation. New Engl J Med 344:1986–1995PubMedGoogle Scholar
  107. Tomlinson JR et al (1989) A prospective comparison of IMV and T-piece weaning from mechanical ventilation. Chest 96(2):348–352PubMedGoogle Scholar
  108. Upton CJ, Milner AD, Stokes GM (1990) The effect of changes in inspiratory time on neonatal triggered ventilation. Eur J Pediatr 149(9):648–650PubMedGoogle Scholar
  109. Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Jaecklin T, Levy-Jamet Y, Tourneux P, Jolliet P, Rimensberger PC (2013) Optimizing patient-ventilator synchrony during invasive ventilator assist in children and infants remains a difficult task. Pediatr Crit Care Med 14(7):e316–e325PubMedGoogle Scholar
  110. Ward ME et al (1988) Optimization of respiratory muscle relaxation during mechanical ventilation. Anesthesiology 69(1):29–35PubMedGoogle Scholar
  111. Yanez L, Yunge M et al (2008) A prospective, randomized, controlled trial of noninvasive ventilation in pediatric acute respiratory failure. Pediatr Crit Care Med 9(5):484–489PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Mark J. Heulitt
    • 1
    • 2
    • 3
    Email author
  • Eduardo Bancalari
    • 4
  • Martin Keszler
    • 5
  • Ronald C. SandersJr.
    • 6
  • Nelson Claure
    • 4
  1. 1.Department of Pediatrics, Physiology and Biophysics, College of MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Respiratory Care Services, Arkansas Children’s HospitalLittle RockUSA
  3. 3.Applied Respiratory Physiology Laboratory, Arkansas Children’s Hospital Research InstituteLittle RockUSA
  4. 4.Division of Neonatology, Department of PediatricsUniversity of Miami Miller School of MedicineMiamiUSA
  5. 5.Department of PediatricsAlpert Medical School of Brown University, Women and Infants HospitalProvidenceUSA
  6. 6.Section of Pediatric Critical Care, Department of PediatricsUniversity of Arkansas College of Medicine, Arkansas Children’s HospitalLittle RockUSA

Personalised recommendations